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Notum protects against myocardial infarction-induced heart dysfunction by alleviating cardiac fibrosis

Frigid Zone Medicine 2024年第1期4卷 41-50页

作者： Tongzhu Jin Zhen Ye Ruonan Fang Yue Li Wei Su Qianqian Wang Tianyu Li hongli shan Yanjie Lu Haihai Liang Laboratory of Frigid Zone Cardiovascular Diseases(SKLFZCD) Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Department of Pharmacy Suqian First HospitalSuqian 223800China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China

Background and Objective:Cardiac fibrosis is a pathological reparative process that follows myocardial infarctionand is associated with compromised cardiac systolic and reduced cardiac *** Wnt signaling pathway is closely implicated in organ fibrosis,and Notum,a highly conserved secreted inhibitor,modulates Wnt *** objective of this study was to explore the role and mechanism of Notum in cardiac ***:A mouse model of cardiac remodeling was established through left coronary artery ligation surgery,with the addition of Notum injection following myocardial infarction *** protective effect of Notum on myocardial infarction was assessed by evaluating cardiac function,including survival rate,echocardiographic assessment,and cardiac contraction *** cell necrosis and infiltration were confirmed through H&E and Masson *** expression of fibrosis-related genes andβ-catenin pathway markers was detected using Western blot quantificational RT-PCR(qRT-PCR).Additionally,EdU,wound healing,and immunofluorescence staining analyses were performed to detect the effect of Notum's in transforming growth factor beta-1(TGF-β1)induced myofibroblast ***:The administration of Notum treatment resulted in enhanced survival rates,improved cardiac function,and decreased necrosis and infiltration of inflammatory cells in mice subjected to left coronary artery ***,Notum effectively impeded the senescence of cardiac fibroblasts and hindered their pathological transformation into cardiac ***,it significantly reduced collagen production and attenuated the activation of the Wnt/β-catenin *** preliminary investigations successfully demonstrated the therapeutic potential of Notum in both fibroblasts in vitro and in a mouse model of myocardial infarction-induced cardiac fibrosis in ***:Notum inhibition of the Wnt/β-catenin signaling pathway and cardiac fibroblast

关键词： cardiac fibrosis Notum Wnt/β-catenin senescence myocardial infarction

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YBX1 inhibits mitochondrial-mediated apoptosis in ischemic heart through the PI3K/AKT signaling pathway

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Frigid Zone Medicine 2024年第1期4卷 51-64页

作者： Fangfang Bi Miao Cao Yuquan Wang Qingming Pan Zehong Jing Danyang Bing Lifang Lyu Tong Yu Tianyu Li Xuelian Li Haihai Liang hongli shan Yuhong Zhou Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China shanghai Frontiers Science Research Center for Druggability of Cardiovascular noncoding RNA Institute for Frontier Medical TechnologyShanghai University of Engineering ScienceShanghai 201620China Department of Basic Medicine Xiamen Medical CollegeXiamen 361023China

Background:Myocardial infarction(MI)is associated with higher morbidity and mortality in the world,especially in cold ***1 is an RNA-binding protein that is required for pathological growth of cardiomyocyte by regulating cell growth and protein *** YBX1,as an individual RNA-binding protein,regulates cardiomyocytes through signaling cascades during myocardial infarction remain largely ***:In vivo,the mouse MI model was induced by ligating the left anterior descending coronary artery(LAD),and randomly divided into sham operation group,MI group,MI+YBX1 knockdown/overexpression group and MI+negative control(NC)*** protective effect of YBX1 was verified by echocardiography and triphenyltetrazolium chloride *** vitro,mitochondrial-dependent apoptosis was investigated by using CCK8,TUNEL staining,reactive oxygen species(ROS)staining and JC-1 staining in hypoxic neonatal mouse cardiomyocytes(NMCMs).Results:YBX1 expression of cardiomyocytes was downregulated in a mouse model and a cellular model on the ischemic *** to mice induced by MI,YBX1 overexpression mediated by adeno-associated virus serotype 9(AAV9)vector reduced the infarcted size and improved cardiac *** of endogenous YBX1 by shRNA partially aggravated ischemia-induced cardiac *** hypoxic cardiomyocytes,YBX1 overexpression decreased lactic dehydrogenase(LDH)release,increased cell viability,and inhibited apoptosis by affecting the expression of apoptosis related proteins,while knockdown of endogenous YBX1 by siRNA had the opposite *** of YBX1 restored mitochondrial dysfunction in hypoxic NMCMs by increasing mitochondrial membrane potential and ATP content and decreasing *** hypoxic NMCMs,YBX1 overexpression increased the expression of phosphorylated phosphatidylinositol 3 kinase(PI3K)/AKT,and the anti-apoptosis effect of YBX1 was eliminated t by LY294002,PI3K/AKT ***:YBX1 protected the heart

关键词： YBX1 PI3K/AKT apoptosis mitochondrial function myocardial infarction

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尿沉渣评分对急性肾损伤诊断的临床应用研究

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中华检验医学杂志 2024年第5期47卷 548-553页

作者：张慧续薇曲林琳赵春贺单洪丽张勤高洪臣孙文瑞朱丽娜张月闫欣杨笑权王婉宁张东付尧赵旭何亮吉林大学第一医院检验科长春130021 北华大学医学技术学院吉林132013 吉林大学第一医院肾病内科长春130021 吉林大学第一医院重症医学科长春130021 吉林大学第一医院肝胆胰内科长春130021 吉林大学第一医院普通外科中心胃结直肠外科长春130021

目的:评估尿沉渣评分(USS)在急性肾损伤(AKI)的早期诊断、病因鉴别、分期及预后判断中的临床应用,探讨独立的USS及其联合血尿素氮(Bun)、血清肌酐(sCr)和尿酸(UA)对AKI的诊断效能。方法:收集2023年8月23日至9月28日期间吉林大学第一医... 详细信息

目的:评估尿沉渣评分(USS)在急性肾损伤(AKI)的早期诊断、病因鉴别、分期及预后判断中的临床应用,探讨独立的USS及其联合血尿素氮(Bun)、血清肌酐(sCr)和尿酸(UA)对AKI的诊断效能。方法:收集2023年8月23日至9月28日期间吉林大学第一医院住院患者9020份晨尿标本,经Sysmex UF5000检测,筛出小而圆形上皮细胞(SRC)>1/μl和/或管型(CAST)>1/μl 3226份进行尿沉渣镜检,选取肾小管上皮细胞和/或CAST阳性的404例入组,其中男218例,女186例,年龄59.5(49.0,71.0)岁。404例分组方法:依据镜检结果的USS分为USS AKI组(345例)和USS非AKI组(59例);依据改善全球肾脏病预后组织(KDIGO)标准,分为KDIGO标准AKI组(63例)和KDIGO标准非AKI组(341例);依据病历记载的临床诊断,分为临床诊断AKI组(29例)和临床诊断非AKI组(375例);通过查阅病历,对KDIGO标准AKI组按病因分为肾性AKI组(33例)和非肾性AKI组(30例)。采用χ^(2)检验或Fisher精确检验比较不同AKI病因、分期的USS。采用Logistic回归法计算发生肾性AKI及3期AKI的优势比。应用受试者工作特征曲线下面积评价USS、sCr、UA、Bun单独及联合诊断AKI的敏感度、特异度并计算诊断AKI的最佳截断值、敏感度与特异度。结果:以USS对KDIGO标准AKI组进行病因鉴别,肾性与非肾性AKI的USS比较差异有统计学意义(χ^(2)=11.070,P<0.001)。与USS=1相比,当USS≥2分时肾性AKI的优势比为8.125(95%CI 2.208~29.901)。以USS进行AKI分期研究,各期USS的组间比较差异有统计学意义(χ^(2)=15.724,P<0.05)。与USS=1分相比,当USS≥2分时发生3期AKI优势比为9.714(95%CI 1.145~82.390)。独立的USS诊断AKI的AUC为0.687(95%CI 0.618~0.757,P<0.001),特异度65.7%,敏感度61.9%;USS联合Bun、sCr、UA诊断AKI的AUC为0.794(95%CI 0.608~0.980,P<0.05),特异度82.4%,敏感度88.9%。结论:USS≥2分提示发生肾性AKI或3期AKI的可能性增加,USS联合Bun、sCr、UA可提高AKI诊断效能。

关键词：尿尿沉渣评分急性肾损伤尿沉渣镜检检验临床应用

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MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics

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Acta Pharmaceutica Sinica B 2016年第6期6卷 531-539页

作者： Huimin Li Xiaoguang Zhao hongli shan Haihai Liang Department of Pharmacology College of Pharmacy Harbin Medical University

MicroRNAs(miRNAs) are a class of phylogenetically conserved, non-coding short RNAs,19–22 nt in length which suppress protein expression through base-pairing with the 30-untranslated region of target m RNAs. mi RNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some mi RNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of mi RNAs in the pathogenesis, diagnosis and treatment of IPF.

关键词： Idiopathic pulmonary fibrosis MicroRNA Pathogenesis Early diagnosis Therapeutic target lncRNA

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甘蔗黑穗病研究状况文献计量分析

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中国糖料 2024年第3期46卷 80-90页

作者：王长秘罗志明单红丽李银煳张荣跃李婕王晓燕尹炯云南省农业科学院甘蔗研究所/云南省甘蔗遗传改良重点实验室/云南省蔗糖产业工程研究中心云南开远661699

本文以甘蔗黑穗病和Sugarcane smut为主题词分别在CNKI和SCI-E数据库中进行检索,并应用文献计量分析方法对文献发文趋势、期刊、机构、基金和被引用文献进行了统计分析。共检索到中文文献284篇和外文文献495篇。其中甘蔗黑穗病的中文文... 详细信息

本文以甘蔗黑穗病和Sugarcane smut为主题词分别在CNKI和SCI-E数据库中进行检索,并应用文献计量分析方法对文献发文趋势、期刊、机构、基金和被引用文献进行了统计分析。共检索到中文文献284篇和外文文献495篇。其中甘蔗黑穗病的中文文献占中英文总文献的35.54%,我国甘蔗黑穗病相关研究文献占甘蔗主要病害文献的48.97%。近年来国内外甘蔗黑穗病研究的发文量逐渐增加,这些文献主要来自于糖业和病理学领域的机构、作者和期刊。国内期刊主要发表关于甘蔗黑穗病防治、发生规律以及抗黑穗病相关研究的文献,而国外期刊则侧重于甘蔗黑穗病的致病机理和病原菌与甘蔗互作的研究。本文通过统计分析甘蔗黑穗病研究领域的文献发文概况,旨在了解甘蔗黑穗病研究的基本情况和趋势,并结合当前的研究热点方向,为下一步的甘蔗黑穗病研究提供参考。

关键词：甘蔗黑穗病文献计量 CNKI Web of science

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LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3602-3617页

作者： Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan hongli shan Haihai Liang Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200433China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao(SAR)China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China Zhuhai People's Hospital Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and TreatmentZhuhai Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China

Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic *** of fibroblasts is a prominent feature of pulmonary *** we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung ***1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung ***,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM ***,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of *** expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung ***,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of *** addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β***,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis.

关键词： Idiopathic pulmonary fibrosis LncRNA DACH1 SRSF1 CTNNB1 Fibroblast Myofibroblast Extracellular matrix Proliferation

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低纬高原甘蔗中后期灾害性真菌病害综合防控技术系统构建

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甘蔗糖业 2024年第2期53卷 33-39页

作者：王晓燕徐宏李有荣赵曌李婕孙石凤王雪梅单红丽张荣跃黄应昆云南省农业科学院甘蔗研究所/云南省甘蔗遗传改良重点实验室云南开远661699 云南紫辰农业发展有限公司云南大理672100 新平县经济作物工作站云南玉溪653400

针对低纬高原甘蔗中后期灾害性真菌病害防控难题,在明确甘蔗中后期灾害性真菌病害种类及病原种类、地理分布、危害损失和灾害特性的基础上,提出利用“早期诊断预警、抗病品种、温水脱毒种苗、农艺调控、无人机飞防、生物制剂及复合高效... 详细信息

针对低纬高原甘蔗中后期灾害性真菌病害防控难题,在明确甘蔗中后期灾害性真菌病害种类及病原种类、地理分布、危害损失和灾害特性的基础上,提出利用“早期诊断预警、抗病品种、温水脱毒种苗、农艺调控、无人机飞防、生物制剂及复合高效配方药剂”等构建低纬高原甘蔗中后期灾害性真菌病害综合防控技术系统。同时,从病害流行动态精准监测技术、抗病基因挖掘与利用技术、抗病精准评价技术、生防制剂和复合高效药剂配方及施药技术和飞防施药技术等方面系统剖析了实现甘蔗中后期灾害性真菌病害综合防控系统构建的关键技术方法。2021~2022年该技术在低纬高原云南8个甘蔗主产州市累计推广应用32.3万hm^(2)(无人机飞防6.7万hm^(2)),共挽回甘蔗损失388万t,增加蔗糖49.7万t,新增销售额42.09亿元,新增利润13.24亿元,增税1.99亿元,经济、社会和生态效益显著,为低纬高原蔗糖业可持续高质量发展、减损增效提供了技术支撑,为边疆民族经济发展和农民增收及乡村振兴做出了重大贡献。

关键词：甘蔗中后期真菌病害低纬高原综合防控

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Investigation on Outbreak of Sesamia inferens and Smut in Cane-growing Regions of Yunnan Province

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Agricultural Biotechnology 2023年第2期12卷 63-66,72页

作者： Yongde MA Xiaoyan WANG Yinhu LI hongli shan Rongyue ZHANG Yingkun HUANG Agricultural and Rural Affairs Bureau of Gengma County Gengma 677500China Sugarcane Research Institute Yunnan Academy of Agricultural SciencesKaiyuan 661699China

[Objectives]This study was conducted to clarify the outbreak and disaster characteristics of Sesamia inferens Walker and smut in cane-growing regions in the low-latitude plateau of Yunnan Province,where there is continuous high temperature and drought in spring and summer.[Methods]A systematic investigation and analysis was conducted on different varieties in different types of fields in 16 cane-growing regions with outbreak of *** and smut in Yunnan from 2019 to 2021.[Results]The outbreak of *** and smut in cane-growing regions in the low-latitude plateau of Yunnan Province resulted in an average percent of dry hearts in the range of 17.3%-56.3%,and as high as 84.0%in severe cases.70%thiamethoxam seed treatment dispersible powder and clothianidin or thiamethoxam fertilizer granules were ineffective against ***,while 10%monosultap·thiamethoxam or 10%clothianidin·monosultap granules had a significant control efficacy on *** average diseased plant rate ranged from 14.8%to 89.7%in susceptible varieties with smut,and was as high as 100%in severe *** 1,Yuetang 93-159,Yuetang 00-236,and Liucheng 05-136 had strong resistance,with an average diseased plant rate of 0-5.5%and the highest rate of 7.6%.*** and smut both broke out in cane-growing regions with an altitude below 1200 *** is recommended to pay attention to disease and pest monitoring in cane-growing regions with an altitude below 1200 m,and combine it with the management of new plants and ratoon plants to effectively prevent and control the first and second generation of ***-infested seedlings from March to *** is also recommended to strengthen the promotion and application of excellent disease-resistant varieties,so as to achieve a reasonable distribution of varieties and fundamentally control the outbreak and epidemic of sugarcane smut.[Conclusions]This study provides a basis for the effective prevention and control of catastrophic *** and smut caused

关键词： High temperature Drought Sesamia inferens Smut Outbreak

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Efficacy of High-efficiency Formula Pesticides for Controlling Sesamia inferens Walker and Ceratovacuna lanigera Zehntner

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Agricultural Biotechnology 2023年第2期12卷 42-44,47页

[Objectives]This study was conducted to screen high-efficiency formula pesticides and precise and efficient application techniques for the prevention and control of Sesamia inferens Walker and Ceratovacuna lanigera Zehntner.[Methods]Field efficacy trials were conducted using different combinations of 70%directed enhanced thiamethoxam seed treatment dispersible powder and 46%monosultap·Bacillus thuringiensis wettable powder.[Results]70%directed enhanced thiamethoxam ZF 450 g/hm^(2)+46%monosultap·*** WP 2250 g/hm^(2)had good control effects on both *** and ***,so it was an ideal high-efficiency formula pesticide for controlling sugarcane *** and *** January to May,combining with new plant or perennial root cultivation management,70%directed enhanced thiamethoxam ZF 450 g/hm^(2)can be evenly spread on sugarcane ditches and sugarcane stumps after being well mixed with fertilizers applied per hectare,and covered with soil in a timely manner,and during the peak incubation period of the first and second generation of *** eggs from March to May,46%monosultap·*** WP 2250 g/hm^(2)was sprayed to the leaf surface in the mixture with water 675 kg with an electric backpack or a motorized *** such a way,the control efficacy on dead heart seedlings could reach over 89.8%,and that on *** could reach 100%.Meanwhile,it could effectively and concurrently control thrips,and the increases in yield and sugar content could reach 29310 kg/hm^(2)and 5.9 percentage points,respectively.[Conclusions]The promotion and application of the formula pesticide could achieve precise application and control of sugarcane pests,and improvement of sugarcane quality and planting efficiency,and help promote green prevention and control of sugarcane diseases and pests and the sustained high-quality development of the sugar industry.

关键词： Sugarcane Efficient formula pesticide Accurate application of pesticides Sesamia inferens Walker Ceratovacuna lanigera Zehntner Control efficacy evaluation

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Evaluation of the Effect of High-efficiency Compound Formulations on the Prevention and Control of Sugarcane Brown Stripe

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Agricultural Biotechnology 2022年第3期11卷 29-32,37页

作者： Wenfeng LI Xiaoyan WANG hongli shan Rongyue ZHANG Yinhu LI Jie LI Yingkun HUANG Sugarcane Research Institute Yunnan Academy of Agricultural SciencesKaiyuan 661699China

[Objectives]This study was conducted to screen high-efficiency compound formulations and precise application technologies for the prevention and control of sugarcane brown stripe disease.[Methods]Carbendazim,benomyl,chlorothalonil,azoxystrobin,pyraclostrobine and difenoconazole·azoxystrobin were selected for field efficacy tests.[Results]Three formulations,(50%carbendazim WP 1500 g+75%chlorothalonil WP 1500 g+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2),(50%benomyl WP 1500 g+75%chlorothalonil WP 1500 g+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2) and(25%pyraclostrobin 600 ml+potassium dihydrogen phosphate 2400 g+agricultural synergist 300 ml)/hm^(2) had good control effects on sugarcane brown stripe disease,and showed disease index below 14.02 and control efficacy above 84.41%.The three formulations are ideal high-efficiency compound formulations for the prevention and control of sugarcane brown stripe *** can be sprayed manually and by unmanned aerial vehicles on the foliar surface from July to August,once every 7 to 10 d,continuously for 2 times.[Conclusions]This study provides new technical support for accurate and efficient prevention and control of sugarcane brown stripe disease.

关键词： Sugarcane High-efficiency compound formulation Precise application Brown stripe disease Control efficacy evaluation

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