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Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states： a clue for cancer inhibition through dual pathways

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Science Bulletin 2018年第6期63卷 349-355页

作者： Peng Zhang Jiao Zhai Xueyun Gao hongkang zhao Wenyong Su Lina zhao School of Physics Beijing Institute of Technology Beijing 100081 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Chemistry and Chemical Engineering. Beijing University of Technology Beijing 100124 China

The epidermal growth factor receptor(EGFR) has become an important target protein in anticancer drug development. Meanwhile, peptide-Au cluster has been proposed as potential targeted nano-drug assembled by targeting peptide. Here, we designed and synthesized a novel peptide-Au cluster as Au_(10)Peptide_5 to target to EGFR. We found Au_(10)Peptide_5 could target to the natural binding sites of all EGFRs at membrane in both active and inactive states by molecular simulations. Its targeted ability was further verified by the co-localization and blocking experiments. We also study the configuration modifications of both active and inactive EGFRs after binding by Au_(10)Peptide_5. For active EGFR, the absorbed Au_(10)Peptide_5 might replace the natural ligand in EGFR endocytosis process. Then, the peptide-Au cluster in endochylema could inhibit the cancer relating enzyme activity including thioredoxin reductase1(TrxR1) and induce the oxidative stress mediated apoptosis in tumor cells. For inactive EGFR, it was retained in inactive state by Au_(10)Peptide_5 binding to inhibit dimerization of EGFR for anticancer. Both pathways might be applied in anticancer drug development based on the theoretical and experimental study here.

关键词：生长因素指向状态受体表皮癌症小径 apoptosis

Hydrodynamics performance and tray efficiency analysis of the novel vertical spray packing tray

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2448-2454页

作者： hongkang zhao Lun Li Baohua Wang Dan Yu Qunsheng Li State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Sinopec Engineering Incorporation(SEI) Beijing 100101China College of Chinese Pharmacy Beijing University of Chinese Medicine and PharmacyBeijing 100102China

Column setup has been widely utilized in the petroleum and chemistry industries. However, with the fast progress of industries and the increasingly serious energy shortage, designing a new column setup with better performance and higher capacity becomes more urgent. In order to improve column's capacity and expand operating condition, a new type of column tray named novel vertical spray packing(NVSP) tray was designed and experimented. The performances of the novel tray, including pressure drop, weeping, entrainment and tray efficiency, were tested in a plexiglass column. In addition, performances of the novel tray were compared with that of the sieve tray and the Glitsch V1 valve tray. Based on the experiment data, the mathematical correlations of pressure drop, weeping and entrainment for the novel tray were established by regression analysis method. A fundamental model of dry pressure drop of the novel tray was promoted at the form of sum mode. The results indicate that the novel tray has wider operating condition and better performance.

关键词： Packing tray Hydrodynamics Tray efficiency High capacity

Hydrodynamics and mass transfer performance analysis of flow-guided trapezoid spray packing tray

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Chinese Journal of Chemical Engineering 2021年第11期34卷 59-67页

作者： Shuo Yang Jilong Zhang Jiaxing Xue Qingpeng Wu Qunsheng Li hongkang zhao Liqun Zhang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China China Nuclear Power Engineering Co. LtdBeijing 100840China College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Carbon Fiber and Functional Polymers Ministry of EducationBeijing University of Chemical TechnologyBeijing 100029China

Distillation is the most common separation technology utilized in the petroleum and chemistry *** to the wide usage of the distillation column,even a small improvement in performance may result in significant energy cost *** to improve the hydrodynamics and mass transfer performance,the flow-guided trapezoid spray-packing tray(FTS-PT)was designed by combining flow-guided holes and trapezoidal caps with structured *** the experimental measurements of the FTSPT,including pressure drop,clear liquid height,weeping,entrainment,and tray efficiency,were conducted in a 500 mm diameter plexiglass column with the air-water-oxygen ***,the performance of the FTS-PT was compared with that of new vertical sieve tray(New VST)and F1 valve *** results show that FTS-PT has a significant advantage in pressure drop,entrainment,and ***,the calculation model of the pressure drop was derived and used for the FTS-PT with a relative deviation of less than 5%.

关键词： Flow-guided hole Spray mode Hydrodynamics Mass transfer Calculation model

Effect of defects on the electronic structure of a PbI2/MoS2 van der Waals heterostructure: A first-principles study

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Science China(Physics,Mechanics & Astronomy) 2020年第3期63卷 64-69页

作者： Wen He HuaWei Li HuiQiong Zhou hongkang zhao Hui Wang XingHua Shi School of Physics Beijing Institute of TechnologyBeijing 100081China Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory for Nanosystem and Hierarchy FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

PbI2/MoS2,as a typical van der Waals(vdW)heterostructure,has attracted intensive attention owing to its remarkable electronic and optoelectronic *** this work,the effect of defects on the electronic structures of a PbI2/MoS2 heterointerface has been systematically *** manner in which the defects modulate the band structure of PbI2/MoS2,including the band gap,band edge,band alignment,and defect energy-level density within the band gap is discussed *** is shown that sulfur defects tune the band gaps,iodine defects shift the positions of the band edge and Fermi level,and lead defects realize the conversions between the straddling-gap band alignment and valence-band-aligned gap,thus enhancing the light-absorption ability of the material.

关键词： defect engineering electronic structures PbI2/MoS2 van der Waals heterostructure first-principles study

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苏州宏海国际广场超限高层结构设计

建筑结构 2022年第7期52卷 24-27,36页

作者：陈磊赵宏康陈光潘勇启迪设计集团股份有限公司苏州215021 苏州工业园区苏相合作区建设管理局苏州215127 无锡市广盈电力设计有限公司无锡214100

对苏州宏海国际广场超限高层结构设计要点进行了说明与分析。针对工程“工”字形平面不规则提出布置方案,在工字形平面“翼缘”与“腹板”相交处设两个围合成整体的钢筋混凝土筒,并在凹口两侧布置剪力墙与混凝土筒相连。采用SATWE和MIDA... 详细信息

对苏州宏海国际广场超限高层结构设计要点进行了说明与分析。针对工程“工”字形平面不规则提出布置方案,在工字形平面“翼缘”与“腹板”相交处设两个围合成整体的钢筋混凝土筒,并在凹口两侧布置剪力墙与混凝土筒相连。采用SATWE和MIDAS Building软件对结构进行整体分析,采用PKPM-SAUSAGE软件进行弹塑性时程分析,结果表明结构布置合理,整体抗震性能良好。针对抗震薄弱部位和关键构件制定抗震性能化指标,底部加强部位剪力墙和框架柱受剪承载力按中震弹性控制,偏心受压承载力按中震不屈服设计;连接薄弱部位、竖向收进楼层的楼板按中震弹性设计。对设防烈度地震作用下名义拉应力大于混凝土抗拉强度标准值的墙体,设置型钢承担全部拉力,以保证结构安全。

关键词：超限高层结构性能化设计动力弹塑性时程分析

常熟龙腾希尔顿酒店复杂连体超限高层结构设计

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建筑结构 2022年第7期52卷 65-72页

作者：赵宏康戴雅萍陈磊丁锐潘苏辰启迪设计集团股份有限公司苏州215021

常熟龙腾希尔顿酒店造型独特,采用框架-剪力墙结构,存在高位收进、双塔连体、平面超长、穿层斜柱等多项不规则。介绍了其结构方案、主要分析结果和性能化设计,包括控制标准、温度及地震作用的影响等。针对工程的特点,结构设计通过多程... 详细信息

常熟龙腾希尔顿酒店造型独特,采用框架-剪力墙结构,存在高位收进、双塔连体、平面超长、穿层斜柱等多项不规则。介绍了其结构方案、主要分析结果和性能化设计,包括控制标准、温度及地震作用的影响等。针对工程的特点,结构设计通过多程序仿真,进行了高位收进-连体影响分析、连接体钢曲梁多尺度应力分析、温度和地震作用下的楼板应力分析等专项分析,采取了一系列相应措施,保证了结构的安全可靠和经济合理。

关键词：框架-剪力墙结构高位收进双塔连体结构超限高层结构性能化设计

框架-双核心筒高层建筑结构性能研究及设计建议

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建筑结构 2017年第11期47卷 53-60页

作者：赵宏康启迪设计集团股份有限公司苏州215021

框架-双核心筒结构是适用于标准楼层平面为长形或异形的高层建筑的一种结构形式。讨论了此种结构设计对标准层平面为长形或异形的高层建筑的适用性和合理性,对其性能及影响因素进行了基于非线性纤维束杆系模型、细分网格非线性分层壳模... 详细信息

框架-双核心筒结构是适用于标准楼层平面为长形或异形的高层建筑的一种结构形式。讨论了此种结构设计对标准层平面为长形或异形的高层建筑的适用性和合理性,对其性能及影响因素进行了基于非线性纤维束杆系模型、细分网格非线性分层壳模型的动力弹塑性分析研究,并与框架-单核心筒结构进行了对比分析,最后提出了相应的结构设计建议。

关键词：框架-双核心筒地震响应楼板应力抗震性能动力弹塑性分析

苏州国际博览中心东桥厅带巨型钢桁架复杂结构设计

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建筑结构 2014年第14期44卷 75-80页

作者：赵宏康戴雅萍苏州设计研究院股份有限公司苏州215021

苏州国际博览中心东桥厅是一个采用巨型钢桁架跨越市政道路的复杂结构,通过在特定位置设置滑移支座来释放温度应力。介绍了结构设计要点、关键节点构造以及带软钢阻尼球形钢支座的设计、工作原理及模型试验。分析结果表明,合理布置竖向... 详细信息

苏州国际博览中心东桥厅是一个采用巨型钢桁架跨越市政道路的复杂结构,通过在特定位置设置滑移支座来释放温度应力。介绍了结构设计要点、关键节点构造以及带软钢阻尼球形钢支座的设计、工作原理及模型试验。分析结果表明,合理布置竖向传力系统和抗侧力系统是复杂大跨度结构设计的关键;在结构整体计算模型中建入用于调整基础不均匀沉降的拉梁,并按实际考虑基础刚度是有必要的;合理设置滑移支座能够在有效减小结构温度应力的同时保证结构的抗震性能;带软钢阻尼球形钢支座能够在基本不增加造价的情况下提供结构所需要的阻尼力,性价比较高。

关键词：巨型桁架球形钢支座温度应力地震反应

苏州国际博览中心屋盖结构分析和并联K形圆钢管相贯节点研究

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建筑结构学报 2006年第4期27卷 51-60页

作者：赵宏康戴雅萍吕西林苏州市建筑设计研究院有限责任公司江苏苏州215002 同济大学土木工程防灾国家重点实验室上海200092

本文介绍了苏州国际博览中心大跨变高度立体管桁架屋盖结构整体性能分析和并联K形圆钢管相贯节点的大比例试验及非线性有限元分析。分析表明以下弦双钢管为特征的倒梯形立体管桁架的动力特性非常理想;将部分支座改为可滑移支座能有效减... 详细信息

本文介绍了苏州国际博览中心大跨变高度立体管桁架屋盖结构整体性能分析和并联K形圆钢管相贯节点的大比例试验及非线性有限元分析。分析表明以下弦双钢管为特征的倒梯形立体管桁架的动力特性非常理想;将部分支座改为可滑移支座能有效减小大面积屋盖的温度内力,同时也有利于减小结构的地震反应;考虑大跨结构P-δ效应,对桁架上下弦杆的影响较明显,对腹杆的影响相当小。并联K形圆钢管相贯节点试验和有限元分析结果表明这种节点在正常使用状态下带一定范围塑性区工作是安全的,且具有较高承载能力和较好的延性;其破坏模式不同于平面K形节点,连系支管能起到有效的约束作用并影响到主管壁上的应力分布和发展。研究成果为这种规范尚未涵盖的空间相贯节点的设计提供了可靠依据。

关键词：钢管桁架相贯节点并联K形圆钢管相贯节点极限承载力