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Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics

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Journal of Genetics and Genomics 2024年第11期51卷 1237-1251页

作者： Lei Fan Boxin Liu Ru Yao Xia Gao hongjuan Wang Sanjie Jiang Xiaomin Zheng huan Chen Hongwei Hou Yong Liu Qingyuan hu Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230000China University of Science and Technology of China HefeiAnhui 230000China Beijing Life Science Academy Beijing 100000China Key Laboratory of Tobacco Biological Effects and Biosynthesis Bejing 100000China China National Tobacco Quality Supervision&Test Center ZhengzhouHenan 450000China Key Laboratory of Tobacco Biological Effects ZhengzhouHenan 450000China BGI Genomics BGI-ShenzhenGuangdong 518018China

Nicotine is widely recognized as the primary contributor to tobacco *** studies have indicated that molecular and behavioral responses to nicotine are primarily mediated by ventral tegmental area(VTA)neurons,and accumulating evidence suggests that glia play prominent roles in nicotine ***,VTA neurons and glia have yet to be characterized at the transcriptional level during the progression of nicotine ***,a male mouse model of nicotine self-administration is established and the timing of three critical phases(pre-addiction,addicting,and post-addiction phase)is ***-nucleus RNA sequencing in the VTA at each phase is performed to comprehensively classify specific cell *** changes occurred during the addicting and post-addiction phases,with the addicting phase displaying highly dynamic neuroplasticity that profoundly impacts the transcription in each cell ***,significant transcriptional changes in energy metabolism-related genes are observed,accompanied by notable structural alterations in neuronal mitochondria during the progression of nicotine *** results provide insights into mechanisms underlying the progression of nicotine addiction,serving as an important resource for identifying potential molecular targets for nicotine cessation.

关键词： Single-nucleus transcriptomics Ventral tegmental area Nicotine addiction Cell-type-specific alteration Mitochondrial dysfunction

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妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的循证护理实践

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护理管理杂志 2024年第1期24卷 20-25页

作者：王晶晶周艳辉胡红娟仝梅欧艳陈瑜马艳陈双琴吴小钦南华大学附属第一医院妇科衡阳市421000 南华大学附属第一医院护理部衡阳市421000 南华大学附属第一医院公共事业发展部衡阳市421000 复旦大学护理学院上海市200433 南华大学附属第一医院神经内科衡阳市421000

目的基于最佳证据制定妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的循证实践方案,并评价其在临床应用的有效性和安全性。方法成立循证实践项目小组,通过循证获取妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的最佳证据并... 详细信息

目的基于最佳证据制定妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的循证实践方案,并评价其在临床应用的有效性和安全性。方法成立循证实践项目小组,通过循证获取妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的最佳证据并进行应用。通过查看病志和现场查看等方式收集资料,在证据应用前后分别对两组患者及医护人员进行基线调查和两轮审查,并对证据应用进行障碍因素分析,制订针对性的改进措施。结果共形成19条质量审查指标,证据应用前后深静脉血栓发生率差异无统计学意义(P>0.05);证据应用前后妇科恶性肿瘤患者围手术期早期活动锻炼、自我监测及术后注意事项3个维度依从性的得分差异有统计学意义(P<0.001);证据应用前后医护人员各审查指标执行率差异有统计学意义(P<0.05)。结论基于最佳证据制定的妇科恶性肿瘤患者围手术期下肢深静脉血栓预防及管理的循证实践方案,可规范科室下肢深静脉血栓预防管理流程,提高患者早期下床活动的依从性,提高医护人员对证据的执行率。

关键词：妇科恶性肿瘤围手术期深静脉血栓血栓栓塞症循证实践

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Integrin β2 and β3:Two plasmatocyte markers deepen our understanding of the development of plasmatocytes in the silkworm Bombyx mori

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Insect Science 2022年第6期29卷 1659-1671页

作者： Kui Zhang Jingjing Su Xin hu Xiaomin Yan Siyuan Chen Chongyang Li Guangzhao Pan Hongbo Chang Wenli Tian Muhammad Nadeem Abbas hongjuan Cui State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqingChina Chongqing iCELL Biotechnology Co.Ltd ChongqingChina Department of Gastroenterology The Second Affliated Hospital of Chongqing Medical UniversityChongqingChina Institute of Apicultural Research Chinese Academy of Agricultural SciencesBejingChina Cancer Center Reproductive Medicine CenterMedical Research InstituteSouthwest UniversityChongqing.China

Insect hemocytes play important biological roles at developmental stages,metamorphosis,and innate *** one of the most abundant cell types,plasmatocytes can participate in various innate immune responses,especially in encapsulation and node ***,2 molecular markers of plasmatocytes,consisting of integrinβ2 andβ3,were identified and used to understand the development of *** are widely distributed in the hematopoietic system,including circulating hemolymph and hematopoietic organs(HPOs).HPOs constantly release plasmatocytes with high proliferative activity in vitro;removal of HPOs leads to a dramatic reduction in the circulating plasmatocytes,and the remaining plasmatocytes gradually lose their ability to proliferate in *** results demonstrated that the release of plasmatocytes from HPOs is regulated by insulin-mediated signals and their downstream pathways,including PI3K/Akt and MAPK/Erk *** insulin/PI3K/Akt signaling pathway can significantly irritate the hematopoiesis,and its inhibitor LY294002 could inhibit the hemocytes discharged from *** the insulin/MAPK/Erk signaling pathway plays a negative regulatory role,inhibiting its activity with U0126 can markedly promote the discharge of plasmatocytes from *** results indicate that the circulating plasmatocytes are mainly generated and discharged by *** process is co-regulated by the PI3K/Akt and MAPK/Erk signals in an antagonistic manner to adjust the dynamic balance of the *** findings can enhance our understanding of insect hematopoiesis.

关键词： Bombyx mori hematopoiesis MAPK/Erk PI3K/Akt plasmatocytes

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大同黄花菜产业“双高两化”高质量发展对策

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食品工程 2022年第3期 10-13页

作者：王勇亮陈敏郭文娟胡红娟李琼王涛贾欣刘春连吴相如山西省食品研究所(有限公司) 山西太原030024

阐述了国内外黄花菜生产概况及国内相关产品开发现状,指出了制约黄花菜产业链终端发展存在的问题,凝练了产业发展中的高质化精深加工、高值化综合利用、工业化精准实施、产业化推广应用(称“双高两化”)4个核心环节,提出了大同黄花菜产... 详细信息

阐述了国内外黄花菜生产概况及国内相关产品开发现状,指出了制约黄花菜产业链终端发展存在的问题,凝练了产业发展中的高质化精深加工、高值化综合利用、工业化精准实施、产业化推广应用(称“双高两化”)4个核心环节,提出了大同黄花菜产业发展路线总体思路及综合深度开发方向,为大同黄花菜产业的高质量发展及产品开发提供指导。

关键词：黄花菜营养成分综合利用深度开发产业发展

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Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1468-1483页

作者： Yacong Ji Chongyang Li Sicheng Wan Zhen Dong Chaolong Liu Leiyang Guo Shaomin Shi Mingxin Ci Minghao Xu Qian Li huanrong hu hongjuan Cui Yaling Liu Department of Dermatology The Third Hospital of Hebei Medical UniversityShijiazhuang050051China State Key Laboratory of Resource Insects Medical Research InstituteSouthwest UniversityChongqing400715China Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China JinFeng Laboratory Chongqing400715China Engineering Research Center for Cancer Biomedical and Translational Medicine Southwest UniversityChongqing400715China

Tetrandrine(TET),a natural bisbenzyl isoquinoline alkaloid extracted from Stephania tetrandra ***,has diverse pharmacological ***,its effects on melanoma remain *** prolif-eration assays,multi-omics analyses,and xenograft models were used to determine the effect of TET on *** direct target of TET was identified using biotin-TET pull-down liquid chromatograph-mass spectrometry(LC-MS),cellular thermal shift assays,and isothermal titration calorimetry(ITC)*** findings revealed that TET treatment induced robust cellular autophagy depending on activating transcription factor 6(ATF6)-mediated endoplasmic reticulum(ER)***,it hindered autophagic flux by inducing cytoskeletal protein depolymerization in melanoma *** treatment resulted in excessive accumulation of reactive oxygen species(Ros)and simultaneously triggered *** 5(SIRT5)was ultimately found to be a direct target of ***,TET led to the degradation of SIRT5 via the ubiquitin(Ub)-26S proteasome ***5 knockdown induced ROS accumulation,whereas SIRT5 overexpression attenuated the TET-induced ROS accumula-tion and ***,TET exhibited anti-cancer effects in xenograft models depending on SIRT5 *** study highlights the potential of TET as an antimelanoma agent that targets *** findings provide a promising avenue for the use of TET in melanoma treatment and underscore its potential as a therapeutic candidate.

关键词： Melanoma Tetrandrine Sirtuin 5(SIRT5) Mitophagy Cytoskeletal protein depolymerization Reactive oxygen species(ROS)

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Surface property and in vitro toxicity effect of insoluble particles given by protein corona:Implication for PM cytotoxicity assessment

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Eco-Environment & Health 2024年第2期3卷 137-144页

作者： Sisi Chen Yexuan Zhang hongjuan Chen Weijuan Zheng Xin hu Li Mao Xuewen Guo Hongzhen Lian State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry&Chemical Engineering and Center of Materials AnalysisNanjing UniversityNanjing 210023China State Key Laboratory of Pharmaceutical Biotechnology School of Life ScienceNanjing UniversityNanjing 210023China Ministry of Education(MOE)Key Laboratory of Modern Toxicology School of Public HealthNanjing Medical UniversityNanjing 211166China

In vitro toxicological assessment helps explore key fractions of particulate matter(PM)in association with the toxic *** studies mainly discussed the toxicity effects of the water-soluble and organic-soluble fractions of ***,the toxicity of insoluble fractions is relatively poorly understood,and the adsorption of proteins is rarely *** this work,the formation of protein corona on the surface of insoluble particles during incubation in a culture medium was *** was found that highly abundant proteins in fetal bovine serum were the main components of the protein *** adsorbed proteins increased the dispersion stability of insoluble ***,the leaching concentrations of some metal elements(e.g.,Cu,Zn,and Pb)from PM increased in the presence of *** toxicity effects and potential mechanisms of the PM insoluble particle–protein corona complex on macrophage cells RAW264.7 were *** results revealed that the PM insoluble particle–protein corona complex could influence the phagosome pathway in RAW264.7 ***,it promoted the intracellular reactive oxygen species generation and induced a greater degree of cell differentiation,significantly altering cell ***,this work sheds new light on the combination of insoluble particles and protein corona in terms of PM cytotoxicity assessment.

关键词： Atmospheric particulate matter Insoluble particles Protein corona Cytotoxicity Proteomics

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Measuring the Internal Velocity of Debris Flows Using Impact Pressure Detecting in the Flume Experiment

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Journal of Mountain Science 2011年第2期8卷 109-116页

作者： YANG hongjuan WEI Fangqiang hu Kaiheng Sergey CHERNOMORETS HONG Yong LI Xiaoyu XIE Tao Key Laboratory of Mountain Hazards and Surface Process ChineseAcademy of Sciences Chengdu 610041 China Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China Faculty of Geography Moscow State University Moscow Russia

Measuring the internal velocity of debris flows is very important for debris flow dynamics research and designing debris flow control works. However, there is no appropriate method for measuring the internal velocity because of the destructive power of debris flow process. In this paper, we address this problem by using the relationship between velocity and kinetic pressure, as described by surface velocity and surface kinetic pressure data. Kinetic pressure is the difference of impact pressure and static pressure. The former is detected by force sensors installed in the flow direction at the sampling section. Observations show that static pressure can be computed using the formula for static water pressure by simply substituting water density for debris flow density. We describe the relationship between surface velocity and surface kinetic pressure using data from seven laboratory flume experiments. It is consistent with the relationship for single phase flow, which is the measurement principle of the Pitot tube.

关键词： Internal velocity Measurement Debris flow Impact pressure

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Study on the interaction between engineering construction and ecosystem changes in the Longitudinal Range-Gorge Region

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Chinese Science Bulletin 2007年第A02期52卷 21-32页

作者： CUI BaoShan hu Bo ZHAI hongjuan WEI GuoLiang WANG Juan School of Environment,Beijing Normal University State Key Joint Laboratory of Environmental Simulation and Pollution Contro,Beijing 100875,China Beijing Normal Univ Sch Environm State Key Joint Lab Environm Simulat and Pollut Con Beijing 100875 Peoples R China.

这份报纸拿在作为主要科学问题设计构造和生态系统变化之间的相互作用。基于 DPSIR ( Drive-Press-State-Impact-Response )框架，这研究分析在从开车，出版社，状态，影响和反应的方面设计构造和生态系统变化之间的相互作用的通匝，向... 详细信息

这份报纸拿在作为主要科学问题设计构造和生态系统变化之间的相互作用。基于 DPSIR ( Drive-Press-State-Impact-Response )框架，这研究分析在从开车，出版社，状态，影响和反应的方面设计构造和生态系统变化之间的相互作用的通匝，向前带相互作用模型，相互作用情形分析方法和相互作用索引(开车反应索引， IIDR ，开车影响索引， IIDI ，影响反应索引，红外，影响索引， IIII )，并且预付相应计算模型和相互作用索引 sy 并且也，这份报纸采用不同相互作用索引到尊重影响在上和对设计建设的反应，并且作为例子在纵的范围峡区域(LRGR ) 拿 Manwan 水力发出的电力车站和道路交通建设分析并且验证相互作用模型。由建设的结果和 Manwan 水力发出的电力的操作的系统的分析，车站是分别地 3.67， 3.92， 14.35 和 0.35。没有在相互作用系统，和利用的通匝元素的显著变化水力发出的电力车站基于想象有益于地区性的环境和社会的持续发展没有考虑环境费用，散开效果，潜在的否定效果和潜力，水力发出的电力的回答驻扎建设。通过一些案例研究，我们造了的相互作用模型在相互作用显示出很好的实际价值量的分析并且相互作用索引系统构造。

关键词：纵向岭谷区工程结构生态系统变化特征

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Spatio-temporal analysis, climate factors for malaria in China's mainland, 2004-2013

Spatio-temporal analysis, climate factors for malaria in Chi...

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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Qiang huang Lin hu Qibing Liao hongjuan Peng Department of Pathogen Biology Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Southern Medical University

Objectives: Malaria used to be a devastating and persistent mosquito-borne disease in China. The cases of infection have been sharply decreased to a very low level in recent years. The new transmission pattern is needed to be identified for better prevention and control of malaria. The purpose of this study was to characterize the spatio-temporal heterogeneities of malaria distribution at a provincial level and investigate the association between malaria incidence and some climate factors in China, so as to provide a reference for malaria prevention and control. Methods: The raw malaria incidence was calculated with the reported cases number devided by the permanent resident population of each province, and then smoothed with empirical Bayes model with Geoda 1.6 software. The Global spatial autocorrelations and Local Spatial Autocorrelations were analyzed by geographic information system(GIS) to detect the spatial association in global and local regions. The purely spatial, temporal and spaio-temporal analysis was applied to identify the clusters of space and time with Sa TScan 9.3 software. The spearman correlation analysis was conducted to study the relationship between climate factors and malaria incidence. Results: The descriptive analysis of malaria incidence appears a peak in 2006, and the proportion of imported case had increased from 4.6% in 2004 to 98.1% in 2013. The results of global spatial autocorrelation, local spatial autocorrelation and purely spatial cluster analysis have revealed that malaria was endemic in Hainan, Anhui, and Yunnan up to 2011, and then gradually clustered in Yunnan and Guangxi, sharing the border with Myanmar, Laos, and Vietnam in 2012-2013. The purely temporal clusters were transformed from April-November to May-August. The space-time analysis detected a most likely cluster in Anhui province(2004/6/1-2008/10/31). The correlation coefficients have been gradually decreased during 2004 to 2013, with a different lag effect of climate

关键词： malaria spatial autocorrelation scan statistics climate factor

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Effects of Cs Doping on Structural and UV-photochromic Properties of Sodalite

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Journal of the Chinese Ceramic Society 2016年第3期3卷 111-119页

作者： hu Xiaoqiang PENG Tongjiang SUN hongjuan XIE Ruishi XIAN Haiyang SONG Pengcheng School of Materials Science and Engineering Southwest University of Science and Technology Institute of Mineral Materials and Application Southwest University of Science and Technology Analytical and Testing Center Southwest University of Science and Technology Mianyang Environmental Monitoring Central station

The NaAlO_2,Na_2SiO_3-9H_2O,NaOH and CsOH·H_2O were used as raw materials to synthesize Cs-doped sodahte samples by a chemical synthetic *** effects of different Cs doping contents on structural and UV-photochromic properties of sodalite were *** results suggested that the maximum doping content of Cs in sodalite was about 2.9%,and the impure phase CsAlSiO_4·H_2O arose exceeding the doping *** lattice parameters(a and v) of sodalite decreased integrally due to the effect of hydrated Cs ions on sodalite ***,the surface morphology of Cs-doped sodalite consisted of petal shaped aggregated particles at the maximum Cs doping content,which was basically similar as pristine *** addition,the ultraviolet(UV) absorptance of the Cs-doped sodalite,compared with pure sodalite,increased about 1.3%-2.3%from 225 to 280 nm and about 1.8%-2.8%from 280 to 350 nm,respectively.

关键词： sodalite Cs doping structure UV-photochromic properties

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