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Enzymatic formation of curcumin in vitro and in vivo

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Nano Research 2018年第6期11卷 3453-3461页

作者： Jiaqing wang Taotao Xiong Jie Zhou hongjian he Dongdong Wu Xuewen Du Xingyi Li Bing Xu Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA Institute of Biomedical Engineering School of Ophthalmology & Optometry and Eye Hospital Wenzhou Medical University 270 Xueyuan Road Wenzhou 325027 China

The recent classification of curcumin （Cur） as a pan-assay interference compound （PAINS） and an invalid metabolic panaceas （IMPS） candidate demonstrated the controversial nature of Cur as a drug lead owing to its aggregation in aqueous phase and inherent instability in vivo. here, we report a simple prodrug approach to generate nanoparticles of Cur in situ that allow it to function reproducibly as an anticancer and an anti-inflammatory agent. Diphosphorylated curcumin （Cur-2p）, a precursor of Cur and a substrate of alkaline phosphatase （ALP）, exhibited drastically improved chemical stability and low aggregation in water. After conversion to curcumin around or inside cancer cells by ALP, Cur-2p selectively inhibited cancer cells that overexpressed ALP, but did not affect normal cells. Moreover, the intravitreal injection of Cur-2p resulted in excellent intraocular biocompatibility with no apparent damage to the morphology and visual function of retina, as shown by fundus imaging, optical coherence tomography （OCT）, and histological observation. A rodent model of uveitis showed that Cur-2p significantly suppressed the inflammation response compared with Cur. As a rational approach to investigate and apply PAINS and IMPS candidates, this work presents a straightforward method to maximize the potential of drug leads and ultimately fulfil the promises and potential clinical benefits of PAINS and IMPS candidates.

关键词： enzymatic formation curcumin nanoparticles drug discovery anti-cancer anti-inflammatory

Return to Society: A Case Study of the Psychology Impact of Taekwondo Training on the Handicapped Athlete

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Return to Society: A Case Study of the Psychology Impact of ...

Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017

作者： Ziyi Xia hongjian he Jianzhong Wu Sport Coaching College Beijing Sports University Faculty of Physical Education and Sport Charles University

This article takes advantage of the author’s taekwondo teaching opportunities for handicapped athlete in Beijing para taekwondo team. Using literature, interview and qualitative research methods to analyze the psychology impact of handicapped athletes’ participate in taekwondo on their return to society. The main contributors to improve their mental health are increased about Anti-frustration ability increased（12/12）, respect for others（7/7）, reduced inferiority and loneliness（5/5）. Participating in Taekwondo training improved mental health of handicapped people, especially their sense of identity. The results also showed the positive influence not only in evaluation by others but also their future career developments, ultimately lead them better integrate into society.

关键词： Taekwondo Psychology Impact Handicapped Athlete

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Journal of Integrative Medicine 2017年第6期15卷 411-425页

作者： arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang the american tcm association ViennaVA 22182USA the american society of acupuncturists ChicagoIL 60618USA the joint acupuncture opioid task force La VerneCA 91750USA pacific college of oriental medicine ChicagoIL 60601USA the acupuncture now foundation CA 91750USA the acupuncture evidence project ProvidenceRI 02860USA the acupuncture society of virginia ViennaVA 22182USA the national federation of chinese tcm organizations New YorkNY 11501USA the american alliance for professional acupuncture safety GreenwichCT 06878USA the american traditional chinese medicine society New YorkNY 11501USA highland hospital alameda health systemOaklandCA 94602USA indiana university school of medicine IndianapolisIN 46202USA university of california san diego school of medicineSan DiegoCA 92093USA

The United States （U.S.） is facing a national opioid epidemic, and medical systems are in need of non- pharmacologic strategies that can be employed to decrease the public＇s opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture＇s cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successfully and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care.

关键词： acupuncture opioid epidemic pain opiate dependency effectiveness safety cost-effectiveness mechanism United States

The impacts of the interaction between gender and sexual orientation on the cerebral structures in homosexual and heterosexual people

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The impacts of the interaction between gender and sexual ori...

浙江省神经科学学会第五届学术年会

作者：胡少华 Dandan Wang Lu Han hongjian he Yi Xu Department of Psychiatry First Affiliated HospitalZhejiang University School of Medicine The Key Laboratory of Mental Disorder's Management in Zhejiang Province College of Biomedical Engineering and Instrumental Science Zhejiang University

Background:Testosterone is thought to play a crucial role in sexual differentiation of the brain and sexual orientation are programmed into our brain structures even when we are still *** gender and sexual orientation differences have been shown respectively in a lot of brain structures,the mechanism underlying the sexual differentiation of the brain is still *** study is to investigate the interaction between gender and sexual orientation in human brain structures along with the sexual differentiation of the ***:Sexual orientation was evaluated by the Kinsey *** collected structural magnetic resonance image data of local cortical thickness,surface area and grey matter volume in all the subjects(29 homosexual and heterosexual men,17 homosexual and heterosexual women).Statistical maps were were generated by means of a general linear model(GLM) using FreeSurfer’s Query,Design,Estimate,Contrast(QDEC) *** had sexual orientation and gender as two discrete factors with two levels,allowing for generation of the interaction between sexual orientation and gender:homosexual women and heterosexual men versus heterosexual women and homosexual ***:The statistical cortical thickness maps of both hemispheres did not contain any findings that survived Monte Carlo Null-Z simulation *** women and heterosexual men did not show any region of thicker or thinner cortex than heterosexual women and homosexual *** women and heterosexual men showed significant larger surface area in the left pars opercularis(inferior frontal gyrus) and inferior temporal when compared with heterosexual women and homosexual *** regions of surface area increasing was identified in the right medial orbitofrontal,superior temporal and *** gray matter volume was detected in the left pars opercularis,to some extent aligned with the surface area analysis for the left hemisphere,in homosexual women and heterose

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迭代式特征选择的单细胞分化轨迹推断算法

计算机科学与探索 2023年第7期17卷 1609-1621页

作者：何鸿坚殷依婷谢江上海大学计算机工程与科学学院上海200444

通过单细胞轨迹推断方法从单细胞转录组学数据或蛋白质组学数据构建细胞的分化轨迹,有助于理解正常组织的发育过程或者提供病理学相关的信息。然而当前的单细胞轨迹推断算法在精确度和鲁棒性的提升上仍然是一个难题,原因之一是在单细胞... 详细信息

通过单细胞轨迹推断方法从单细胞转录组学数据或蛋白质组学数据构建细胞的分化轨迹,有助于理解正常组织的发育过程或者提供病理学相关的信息。然而当前的单细胞轨迹推断算法在精确度和鲁棒性的提升上仍然是一个难题,原因之一是在单细胞测序中检测到大量不相关的基因而产生噪声。针对这一问题,迭代式特征选择的轨迹推断方法iterTIPD被提出。其创新点体现在,将广泛用于筛选差异表达基因的特征选择方法迭代式地用于线性或分支结构的单细胞RNA测序数据上,通过筛选出对构建的分化轨迹贡献最大的基因子集来提高细胞伪时间排序的精确度和鲁棒性。在四种scRNA-seq数据集上的实验结果表明,iterTIPD可以有效地提高单细胞轨迹推断算法的精确度和鲁棒性。同样,iterTIPD也使其他的轨迹推断算法的性能得到提升,以此证明iterTIPD具有泛化性。iterTIPD算法成功重构了神经干细胞的分化轨迹,通过对比发现,该分化轨迹与已知的神经干细胞分化轨迹高度一致。同时发现Top2a和Gja1可能是定义活化的神经干细胞亚群的新的标志物。

关键词：单细胞RNA测序技术基因差异性表达单细胞分化轨迹推断迭代式特征选择生物信息学

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探索质量起源与2013年诺贝尔物理学奖

科技导报 2013年第34期31卷 15-17页

作者：邝宇平何红建清华大学高能物理研究中心.北京100084

本文首先介绍1964年Peter Higgs及Francois Englert等提出的Higgs机制及其在电弱标准模型的建立中所起的重要作用,说明为什么2012年实验上发现一个Higgs玻色子后,2013年的诺贝尔奖就颁给Englert和Higgs。然后指出,接下来重要的是在实验... 详细信息

本文首先介绍1964年Peter Higgs及Francois Englert等提出的Higgs机制及其在电弱标准模型的建立中所起的重要作用,说明为什么2012年实验上发现一个Higgs玻色子后,2013年的诺贝尔奖就颁给Englert和Higgs。然后指出,接下来重要的是在实验上进一步探测这个Higgs玻色子对标准模型预言的偏离,和探索可能的新物理。LHC的升级实验和将来的高能对撞机对实现这个目标至关重要。最后展望粒子物理的发展前景。

关键词： Hiaas机制 Hiaasc玻色子标准模型新物理

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赭曲霉毒素A脱毒菌株的筛选与鉴定

食品科学 2018年第14期39卷 73-78页

作者：胡海宁袁国强何鸿建梁志宏中国农业大学北京食品营养与人类健康高精尖创新中心食品科学与营养工程学院北京100083

赭曲霉毒素A(ochratoxin A,OTA)是一种广泛分布于各类农产品中的真菌毒素,对人类和动物的健康造成威胁。为探究OTA的体外生物脱毒方法,本实验尝试从小鼠肠道中筛选出脱除OTA的菌株。首先以1 kg体质量添加210 μg OTA的饲料饲喂BALB/c小... 详细信息

赭曲霉毒素A(ochratoxin A,OTA)是一种广泛分布于各类农产品中的真菌毒素,对人类和动物的健康造成威胁。为探究OTA的体外生物脱毒方法,本实验尝试从小鼠肠道中筛选出脱除OTA的菌株。首先以1 kg体质量添加210 μg OTA的饲料饲喂BALB/c小鼠,收集其粪便,然后利用添加一定质量浓度OTA的LB固体培养基从粪便中逐步筛选出12株在高质量浓度OTA环境下依然能够大量生长繁殖的菌株,全部接种于LB液体培养基培养20 h后,以高效液相色谱法检测该12株菌体外脱除OTA的效果。结果发现其中1株菌YH7能够高效脱除OTA,脱毒效率达到84.6%。从生理学、16S rDNA序列比对等方面分析,最终确定YH7为大肠杆菌(Escherichia coli)。通过单因素优化法确定YH7的最适生长条件为pH 7.5、37℃和200 r/min的摇床速率。

关键词：赭曲霉毒素A 肠道微生物生物脱毒筛选鉴定

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大跨预应力次梁楼盖结构体系设计

工业建筑 1999年第10期29卷 22-26页

作者：李唐宁秦士洪周晓雪何洪建重庆建筑大学重庆400045

介绍与传统设计手法不同的“大跨预应力次梁楼盖结构体系”，并对该体系结构中结构布置、主梁设计、预应力次梁设计予以介绍说明。

关键词：大跨度预应力次梁楼盖结构体系结构方案

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亚急性脑卒中患者静息态功能磁共振成像

中国医学影像技术 2016年第3期32卷 338-342页

作者：姚小曼何宏建张敏鸣杜一平浙江大学生物医学工程学系浙江杭州310027 浙江大学医学院附属第二医院放射科浙江杭州310009

目的探讨应用静息态功能磁共振成像(rs-fMRI)对缺血性脑卒中患者病灶区进行检测的可行性。方法收集14例亚急性缺血性脑卒中患者,分析其rs-fMRI数据,包括病灶区和正常对照区平均信号的低频振幅、两区域间相位延迟前后的功能连接和相位延... 详细信息

目的探讨应用静息态功能磁共振成像(rs-fMRI)对缺血性脑卒中患者病灶区进行检测的可行性。方法收集14例亚急性缺血性脑卒中患者,分析其rs-fMRI数据,包括病灶区和正常对照区平均信号的低频振幅、两区域间相位延迟前后的功能连接和相位延迟3项主要指标。结果 1低频振幅分析:4例患者病灶区低频振幅增强,10例病灶区低频振幅减弱;14例患者病灶区和正常对照区低频振幅的差异无统计学意义(t=-1.6290,P=0.1273)。2功能连接分析:42.86%(6/14)的患者病灶区与正常区的功能信号存在相位差异。3相位延迟分析:对于正常区,6例患者与全脑信号无相位差异,4例相位超前,4例相位落后;对于病灶区,8例相位超前,6例相位落后。14例患者两侧区域相对全脑的时间延迟值差异无统计学意义(t=0.6288,P=0.5404)。结论缺血性脑卒中会引起rs-fMRI相关特异性指标的改变,但各指标个体差异明显,一致性不高。

关键词：静息态功能磁共振成像脑卒中低频振荡幅值功能连接相位延迟