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Early osteoimmunomodulation by mucin hydrogels augments the healing and revascularization of rat critical-size calvarial bone defects

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Bioactive Materials 2023年第7期25卷 176-188页

作者： Song Chen Huan Wang Dachuan Liu Jianzhong Bai Håvard Jostein Haugen Bin Li hongji yan Orthopedic Institute Department of Orthopedic SurgeryThe First Affiliated HospitalSchool of Biology&Basic Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsuChina Department of Biomaterials Institute for Clinical DentistryUniversity of OsloPO Box 1109 BlindernOslo0376Norway AIMES-Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institute and KTH Royal Institute of Technology 17177StockholmSweden Department of Neuroscience Karolinska Institute17177StockholmSweden Division of Glycoscience Department of ChemistrySchool of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of TechnologyAlbaNova University Center10691StockholmSweden

The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone *** developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in ***,their immunoregulatory activity has not yet been studied in the context of tissue ***,we synthesized mucin-monetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect *** demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and *** early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment(revascularization of the host vasculature)at weeks 6 and ***,we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.

关键词： Mucin hydrogels Monetite osteoimmunomodulation Bone Revascularization

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现代澳门天主教的社会影响简析

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基督教学术 2018年第2期20卷 431-458,460页

作者：严鸿基澳门科技大学

澳门天主教对社会的影响是以教育入手塑造健全人格为基础、以服务弱势群体为己任,以传媒唤醒市民对社会不公的关注,成为澳门道德与文化的影响力。这种舍己服务的形象赢得了市民和政府的信任。公民社会在发展中有宗教的成分和激进的一面... 详细信息

澳门天主教对社会的影响是以教育入手塑造健全人格为基础、以服务弱势群体为己任,以传媒唤醒市民对社会不公的关注,成为澳门道德与文化的影响力。这种舍己服务的形象赢得了市民和政府的信任。公民社会在发展中有宗教的成分和激进的一面,但也是一个让我们看到宗教本质的难得机会。在保持宗教对社会影响时,恰当的政教关系是不易把握的:政府既要接受宗教就社会议题表达其独特的价值观,也要让宗教在自设的范围内发挥社会所认同的作用。因此,给予宗教机会表现应有的宗教特质(仁爱和公义),就是让宗教对社会做出积极贡献。

关键词：澳门天主教社会影响政教关系公民社会

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A356铝合金光谱类标控样研制及性能检测

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特种铸造及有色合金 2018年第11期38卷 1265-1267页

作者：吕金旗尹志高李戈飞闫红集中信戴卡股份有限公司试验中心

介绍了光谱仪检测用标准样品分类。由于A356铝合金在工业中的大量应用,在光电直读光谱仪普及的情况下,验证光谱仪准确性的标准样品需求大量增加。为降低成本,自主研制了A356类标控样,检验了自制类标控样的金相组织、均匀性和稳定性,发... 详细信息

介绍了光谱仪检测用标准样品分类。由于A356铝合金在工业中的大量应用,在光电直读光谱仪普及的情况下,验证光谱仪准确性的标准样品需求大量增加。为降低成本,自主研制了A356类标控样,检验了自制类标控样的金相组织、均匀性和稳定性,发现铸锭组织致密、无气孔缩松等缺陷。通过统计计算验证了自制类标控样的均匀性和稳定性符合相关规范,可以应用到光谱仪的类标控制检测。

关键词： A356铝合金光谱仪类标控样均匀性稳定性

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几何精度衰减因子对两种到达时间差算法定位精度的影响分析

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测绘地理信息 2020年第3期45卷 61-65页

作者：严宏基舒红孙红星武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079

不同几何布局下Chan算法和Taylor算法的定位精度的对比及定位精度的克拉美罗下界(Cramér-Rao lower bound,CRLB)的接近程度尚未得到分析验证,本文仿真了三维场景下几何精度衰减因子(geometric dilution of precision,GDOP)对两种算法... 详细信息

不同几何布局下Chan算法和Taylor算法的定位精度的对比及定位精度的克拉美罗下界(Cramér-Rao lower bound,CRLB)的接近程度尚未得到分析验证,本文仿真了三维场景下几何精度衰减因子(geometric dilution of precision,GDOP)对两种算法定位精度的影响,分析了影响差异的数值计算原因。推导表明,两种算法的理论定位精度受GDOP值的影响相同,可以达到CRLB。然而,仿真结果显示,Chan算法的实际定位精度容易在CRLB上方波动,Taylor算法的实际定位精度则稳定在CRLB附近;相同GDOP值下,Taylor算法的实际定位精度优于Chan算法,Chan算法的实际定位精度随着GDOP值的增大逐渐偏离CRLB。将Chan算法和Taylor算法结合,可以有效提高Chan算法的实际定位精度。

关键词： GDOP值 Taylor算法 Chan算法克拉美罗下界定位精度

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基于闪存阵列的日志结构文件系统在桌面云中的应用研究

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国网技术学院学报 2020年第2期23卷 21-25页

作者：张晶华张昕源蒋同军闫洪吉国家电网有限公司技术学院分公司山东济南250002 中国邮政集团公司山东省分公司山东济南250011

云存储技术实现了桌面云数据的海量处理,此文分析了传统机械磁盘和基于闪存的固态硬盘的各自利弊,研究了一种既能屏蔽闪存阵列缺陷又能实现其性能最大化的日志结构文件系统算法,并利用这种算法来优化桌面云存储系统,为桌面云存储读写性... 详细信息

云存储技术实现了桌面云数据的海量处理,此文分析了传统机械磁盘和基于闪存的固态硬盘的各自利弊,研究了一种既能屏蔽闪存阵列缺陷又能实现其性能最大化的日志结构文件系统算法,并利用这种算法来优化桌面云存储系统,为桌面云存储读写性能的提升提供参考。

关键词：日志结构文件系统闪存 SSD 混合存储桌面云

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Two-Way Coupling Vortex Method and Its Application

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Journal of Thermal Science 1992年第3期1卷 160-165页

作者： Chenggang Xu (1) Chuanjun yan (1) hongji Wang (1) 1. Northwestern Polytechnical University 710072 Xi’an China

Because of the success of the discrete vortex method for the simulation of large-scale vortex structure, many researchers extend this method to two-phase flow simulations, especially, to the simulation of particle dispersion in mixing layer, which is characterized by large-scale vortex structure. But the previous work is limited to one-way coupling, which neglects the effect of particles on fluid flow. In this paper, a discrete vortex method involving two-way coupling for two-phase flows is first proposed and then used in numerical simulation of two-dimensional gas-particle mixing layers. The numerical results show that the introduction of particles into the mixing layer has significant effects on the creation, development and merging process of large-scale vortex structures. It makes the mean size of large-scale vortex structure larger and the distance needed for development of large-scale vortex structure shorter.

关键词： discrete vortex method shear layer turbulence coherent structure.

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Study on S-shaped region of pump turbine based on Omega vortex analysis method and entropy production theory

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International Journal of Agricultural and Biological Engineering 2023年第3期16卷 102-109,F0003页

作者： Zhenggui Li hongji Zeng Kun Wang Xiaodong Peng Shengnan yan Qin Zhao Key Laboratory of Fluid and Power Machinery Ministry of Education(Xihua University)Chengdu 610039China Key Laboratory of Fluid Machinery and Engineering of Sichuan Province Xihua UniversityChengdu 610039China

In order to comprehensively analyze the operation instability of the pump turbine S-shaped region,this paper uses DDES turbulence model to calculate the model pump turbine from the perspective of the evolution law of runner vortex and draft tube vortex rope and entropy production rate,combined with *** results show that the numerical simulation is in good agreement with the *** vortex analysis method is more accurate than other vortex recognition methods because it is not affected by the threshold *** vortices at the runner region under the runaway condition and the turbine brake condition develop towards the vaneless space and the blade pressure surface respectively,which will cause the flow obstruction and blade *** overall vorticity of the reverse pump condition is the *** vortex rope of the draft tube under runaway and turbine brake conditions is columnar in shape and has very high rotational *** vortex rope under reverse pump conditions is prone to fracture and form scattered vortices,impeding the normal movement of the *** entropy production rate of the spanwise surface near the upper ring and the lower crown is greater than the middle spanwise surface due to the boundary layer *** the energy dissipation in the runner under reverse pump conditions is characterized by high at both ends of the runner and low in the *** energy dissipation near the wall of the straight cone section of the draft tube is large due to the squeezing effect of the vortex rope on the flow.

关键词： pump turbine S-shaped region vortex analysis method vortex evolution entropy production rate

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Chronic electrical stimulation induces functional network changes in cortical neuron cultures

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Science China(Technological Sciences) 2020年第4期63卷 637-647页

作者： WU SongFang WANG LuBin ZHAO YuWei SUN hongji LANG YiRan WANG ChangYong HAN JiuQi WANG yan HAN Yao Department of Neural Engineering and Biological Interdisciplinary Studies Institute of Military Cognition and Brain SciencesAcademy of Military Medical SciencesBeijing 100850China

Recent studies demonstrated that a functional brain network could be regarded as a complex *** the help of network theory,neuroscientists can identify common organizational principles of the functional brain *** a consequence,some non-random organizational features,such as"small world"(most of the nodes are not connected directly but can communicate with few intermediate relay steps)and"rich club"(nodes that are rich in connections tend to form strongly interconnected clubs),have been found in functional brain ***,the"small world"organizational feature of neuronal functional networks in vitro was found to be influenced by external ***,little is known about the influence of chronic electrical stimulation on functional networks of dissociated cortical cultures during network *** the present study,cortical cultures were electrically stimulated at a frequency of 0,0.02,and 0.2 Hz,between 7 and 26 days in vitro(DIV).The spontaneous activity of the cortical cultures was recorded using ***,a cross-covariance method and graph theory were applied to investigate organizational feature of functional *** results showed that over 3 weeks of stimulation,the network density significantly increased with maturation in the control and 0.02 Hz stimulation groups,but not in 0.2 Hz stimulation ***,all the cultures had a small-world topology at 14,18,22,and 26 DIV,free from the effect of chronic electrical ***,we found an asymmetry effect that partial electrical stimulation inhibited the formation of node connections in stimulated *** effect was more pronounced at 0.2 Hz than at 0.02 Hz *** results suggest that electrical stimulation does not affect the small-world properties of neural ***,electrical stimulation modulates connectivity patterns,and neurons within the stimulated area are less connected than neurons outside the stimulated area.

关键词： neural culture graph theory connectivity microelectrode arrays electrical stimulation

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Ultrasonic-assisted rapid cold welding of bulk metallic glasses

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Science China Materials 2022年第1期65卷 255-262页

作者： Zhiyuan Huang Jianan Fu Xin Li Wenxin Wen hongji Lin yan Lou Feng Luo Zhenxuan Zhang Xiong Liang Jiang Ma Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China

Glass-forming ability is a long-standing concern in the field of metallic glasses(MGs),which greatly limits their maximum casting size and extensive *** this work,we report an ultrasonic-assisted rapid cold welding of bulk MGs without using any *** with various compositions are welded together under a 20,000-Hz highfrequency ultrasonic vibration without losing their amorphous *** ultrasonic technology offers the advantages of rapid bonding(<1 s)at low temperature(near room temperature)and low stress(<1 MPa).According to the phenomenon observed in the experiment,the activated fresh atoms diffuse through the broken channel port under continuous rupture of the oxide layer,and the ultrasonic vibration accelerates the atomic-diffusion ***,stable bonding of the MG interface is *** universal ultrasonic-assisted welding process can realize the composition design of dissimilar MGs as well as tuning of new materials with new performance.

关键词： metallic glass glass-forming ability ultrasonicassisted welding atomic diffusion composition design

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基于二苯甲酮框架的多功能有机发光材料

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化学进展 2023年第10期35卷 1461-1485页

作者：汤炜邴研刘旭东姜鸿基有机电子与信息显示国家重点实验室(南京邮电大学) 南京210023 聚合物分子工程国家重点实验室(复旦大学) 上海200438 发光材料与器件国家重点实验室(华南理工大学) 广州510641

有机发光材料的光电性能与分子的化学结构、构象变化的灵活性以及分子间相互作用密切相关。从结构上看,二苯甲酮的羰基和苯环具有很高的可化学修饰性,本文从材料合成角度首先综述了近年来基于二苯甲酮框架的多功能有机发光材料的构建策... 详细信息

有机发光材料的光电性能与分子的化学结构、构象变化的灵活性以及分子间相互作用密切相关。从结构上看,二苯甲酮的羰基和苯环具有很高的可化学修饰性,本文从材料合成角度首先综述了近年来基于二苯甲酮框架的多功能有机发光材料的构建策略,主要包括多取代二苯甲酮、用杂原子作为桥连基团以及以C=C偶联和苯环为中心直接偶联等三种策略。已经基于此开发了多种多功能有机发光材料,主要包括荧光材料、贵金属磷光配合物的主体、热激活延迟荧光材料、聚集诱导发光材料和纯有机室温磷光材料等。最后,还展望了基于二苯甲酮框架的多功能有机发光材料未来的研究重点和发展前景。

关键词：二苯甲酮化学改性多功能有机发光材料荧光主体热活化延迟荧光聚集诱导发光纯有机室温磷光

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