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Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2798-2818页

作者： Peng Liu Caifang Gao Hongguo Chen Chi Teng Vong Xu Wu Xudong Tang Shengpeng Wang Yitao Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

Inflammatory bowel disease(IBD)is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization.With no curative therapy for IBD at present,the development of effective therapeutics is highly advocated.Drug delivery systems have been extensively studied to transmit therapeutics to inflamed colon sites through the enhanced permeability and retention(EPR)effect caused by the inflammation.However,the drug still could not achieve effective concentration value that merely utilized on EPR effect and display better therapeutic efficacy in the inflamed region because of nontargeted drug release.Substantial researches have shown that some specific receptors and cell adhesion molecules highly expresses on the surface of colonic endothelial and/or immune cells when IBD occurs,ligandmodified drug delivery systems targeting such receptors and cell adhesion molecules can specifically deliver drug into inflamed sites and obtain great curative effects.This review introduces the overexpressed receptors and cell adhesion molecules in inflamed colon sites and retrospects the drug delivery systems functionalized by related ligands.Finally,challenges and future directions in this field are presented to advance the development of the receptor-mediated targeted drug delivery systems for the therapy of IBD.

关键词： Receptor-mediated target Inflammatory bowel disease Crohn’s disease Ulcerative colitis Drug delivery Cell adhesion molecule Active target Targeted therapy

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Construction of China Osmanthus City and Intellectual Property Right Protection in Xianning City in the Context of Three New Developments

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Asian Agricultural Research 2022年第9期14卷 1-6,15页

作者： Li GAO Zhiguo SUN Yueqiu HE Jiandong LAI Hongguo Chen Centre for Cultural Studies on Southern Hubei Province Hubei University of Science and TechnologyXianning 437100China

Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry.

关键词： China Osmanthus City Three new developments(new development stage philosophy and paradigm) Osmanthus Intellectual property right High-quality development

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CPTA treatment reveals potential transcription factors associated with carotenoid metabolism in flowers of Osmanthus fragrans

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Horticultural Plant Journal 2021年第5期7卷 479-487页

作者： Wan Xi Yanhong He Linlin Zhu Shiyang Hu Shuyi Xiong Yi Zhang Jingjing Zou Hongguo Chen Caiyun Wang Riru Zheng Key Laboratory of Horticultural Plant Biology Ministry of EducationCollege of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430070China Hubei Engineering Research Center for Fragrant Plants Hubei University of Science and TechnologyXianningHubei 430070China

Osmanthus fragrans is one of the top ten traditional flowers in China.It is divided into three different groups according to its color.α-Carotene and β-carotene are the main determinants to distinguish the color differences between three groups.However,the dominant genes and transcription factors involved in carotenoid metabolism remain unclear.CPTA treatment(0.7mmol·L−1)remarkably promoted lycopene,α-carotene and β-carotene contents in flowers.Transcriptome sequencing analysis revealed that CPTA treatment could trigger chain reactions in carotenoid metabolism pathway genes.Four up-regulated and 10 down-regulated transcription factors which have close association with carotenoid variation were significantly induced by CPTA treatment.The up-regulated TFs such as MYB43,MYB123,HSF,were further subjected to transcript expression determination in different cultivars with drastic colors.Among them,transcript expression of four up-regulated TFs coincided with the carotenoid accumulation in different cultivars.We selected up-regulated OfMYB43 to verify its function,which is related to stress tolerance and transcriptional regulation.Transient overexpression of OfMYB43 in O.fragrans flowers showed that it could remarkably promote the expression of PDS,ZISO,LCYE and CCD4,leading to increased accumulation of β-branch carotenoids.OfMYB43 was a potential positive regulator of carotenoid biosynthesis in O.fragrans flowers.This study provides insight into the molecular mechanism of carotenoid metabolism in O.fragrans.

关键词： Osmanthus fragrans CPTA Carotenoid Transcriptome sequencing Transcription factor OfMYB43

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提高热电锅炉CEMS精确度的实践

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冶金动力 2022年第3期 103-105,113页

作者：陈红果攀钢集团攀枝花钢钒有限公司能源动力分公司四川攀枝花617000

对于煤粉、煤气混烧锅炉,结合锅炉固定污染源烟气排放连续监测系统(CEMS)运行实际,开展提高CEMS系统运行稳定性、精确度研究,实现了锅炉外排烟气CEMS系统合规、稳定、高效运行,提升了环保管控水平,为企业经营发展提供了保障。

关键词：环境监测数据准确度精确性

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完善赡养老人专项附加扣除政策的国际经验借鉴

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国际税收 2023年第6期 59-67页

作者：燕洪国陈祎婷杭州电子科技大学会计学院

个人所得税赡养老人专项附加扣除政策事关人口老龄化、财富代际分配和社会公平,对于实现共同富裕具有重大意义。本文深入剖析赡养老人专项附加扣除政策促进共同富裕的效应和传导机制,在借鉴美国、日本以及我国香港地区和我国台湾地区制... 详细信息

个人所得税赡养老人专项附加扣除政策事关人口老龄化、财富代际分配和社会公平,对于实现共同富裕具有重大意义。本文深入剖析赡养老人专项附加扣除政策促进共同富裕的效应和传导机制,在借鉴美国、日本以及我国香港地区和我国台湾地区制度设计的基础上,从调整被赡养人扣除范围、完善扣除标准与方式、引入物价联动机制等方面提出完善建议。

关键词：共同富裕个人所得税赡养老人专项附加扣除

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Combined Fenton process and sulfide precipitation for removal of heavy metals from industrial wastewater:Bench and pilot scale studies focusing on in-depth thallium removal

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Frontiers of Environmental Science & Engineering 2019年第4期13卷 23-34页

作者： Huosheng Li hongguo Zhang Jianyou Long Ping Zhang Yongheng chen Institute of Environmental Studies at Greater Bay Key Laboratory for Water Quality and Conservation of Pearl River Delta(Ministry of Education)Guangzhou UniversityGuangzhou 510006China Guangzhou University-Linkdping University Research Center on Urban Sustainable Development Guangzhou UniversityGuangzhou 510006China School of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Thallium (Tl) in industrial wastewater is a public health concern due to its extremely high toxicity. However, there has been limited research regarding Tl removal techniques and engineering practices to date. In this investigation, bench and pilot studies on advanced treatment of industrial wastewater to remove Tl to a trace level were conducted. The treatment process involved a combination of hydroxide precipitation, Fenton oxidation, and sulfide precipitation. While hydroxide precipitation was ineffective for Tl^+ removal, it enabled the recovery of approximately 70%-80% of Zn as Zn hydroxide in alkaline conditions. The Fenton process provided good Tl removal (>95%) through oxidation and precipitation. Tl was then removed to trace levels (< 1.0 μg/L) via sulfide precipitation. Effective removal of other heavy metals was also achieved, with Cd < 13.4 μg/L, Cu < 39.6 μg/L, Pb < 5.32 μg/L, and Zn < 357 μg/L detected in the effluent. X-ray photoelectron spectroscopy indicated that T12S precipitate formed due to sulfide precipitation. Other heavy metals were removed via the formation of metal hydroxides during hydroxide precipitation and Fenton treatment, as well as via the formation of metal sulfides during sulfide precipitation. This combined process provides a scalable approach for the in-depth removal of Tl and other heavy metals from industrial wastewater.

关键词： Thallium Pilot Fenton Sulfide precipitation Heavy metal Industrial wastewater

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基于速度监测的自动扶梯防逆转装置与附加制动器的类型

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中国电梯 2020年第17期31卷 31-36页

作者：陈洪国天津市特种设备监督检验技术研究院天津300192

通过对自动扶梯的3种典型循环运行模式进行分析,从不同维度说明了相关的速度监测模式与原理。分析了速度监测与防非操纵逆转之间的联系,并以速度监测为基础介绍了几种典型的防非操纵逆转的形式和附加制动器中的执行机构的工作原理。

关键词：自动扶梯速度监测非操纵逆转附加制动器

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基于数据-知识混合驱动的电梯制动性能动态监测诊断系统研究

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中国电梯 2020年第21期31卷 21-25页

作者：陈洪国天津市特种设备监督检验技术研究院天津300192

针对电梯整体制动性能,研究一种基于数据-知识混合驱动的监测诊断方法。分析电梯制动性能动静态模型,分析制动性能失效机理,建立失效数据库,确定输入数据;设计基于时间敏感的制动器振动采集系统,开发基于嵌入式智能网关,实现电梯制动性... 详细信息

针对电梯整体制动性能,研究一种基于数据-知识混合驱动的监测诊断方法。分析电梯制动性能动静态模型,分析制动性能失效机理,建立失效数据库,确定输入数据;设计基于时间敏感的制动器振动采集系统,开发基于嵌入式智能网关,实现电梯制动性能监测;研究基于数据-知识混合驱动的推理方法,实现可推广的电梯制动性能动态监测及诊断。

关键词：数据驱动知识驱动电梯制动性能失效机理动态监测

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Pricing European Call Currency Option Based on Fuzzy Estimators

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Applied Mathematics 2011年第4期2卷 461-464页

作者： Xing Yu hongguo Sun Guohua chen The Department of Mathematics & Applied Mathematics Humanities & Science and Technology Institute of Hunan Loudi

In this paper we present an application of fuzzy estimators method to price European call currency option. We make use of fuzzy estimators for the volatility of exchange rate which based on statistical data to obtain the fuzzy pattern of G-K model. A numerical example is presented to get the -level closed intervals of the European call currency option fuzzy price.

关键词： Currency Option Fuzzy Estimators Fuzzy Volatility G-K Model

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“枫桥经验”与中国特色的法治生成模式

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法律科学（西北政法大学学报） 2009年第1期27卷 17-28页

作者：谌洪果西北政法大学刑事法学院陕西西安710063

"枫桥经验"具有丰富而独特内涵,包括组织的网络和工作机制的构建、格式化治理方式、标语口号等教化治理的传统、调解与感化的实践等。中国特色的法治建设模式与"枫桥经验"之间具有内生性、衍生性和共生性三方面的联系。因此,"枫桥经验"... 详细信息

"枫桥经验"具有丰富而独特内涵,包括组织的网络和工作机制的构建、格式化治理方式、标语口号等教化治理的传统、调解与感化的实践等。中国特色的法治建设模式与"枫桥经验"之间具有内生性、衍生性和共生性三方面的联系。因此,"枫桥经验"尽管存在一些需要从理论高度进一步总结的问题,但它有可能成为我们寻求中国未来独特民主和法治道路的一个契机。

关键词：枫桥经验治理方式法治道路

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