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Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian Li Deng-xing Lun Ningning Gong Gang Meng Xin-ying Du He Wang Xiangxiang Bao Xin-yang Li Ji-wu Song Kewei Hu Lala Li Si-ying Li Wenbo Liu Wanping zhu Yunlong Zhang Jikai Li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu Lin Liu hongguang zhu Yuyun Wu Bin Liu Weifang People's Hospital WeifangShandong261000China School of Life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China Xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

Fluid-solid drag models selection for simulating wheat straw particle movement in anaerobic digester

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 249-258页

作者： Yang Yang hongguang zhu College of Mechanical and Energy Engineering Tongji UniversityShanghai 201804China Institute of New Rural Development Tongji UniversityShanghai 201804China

Computational fluid dynamics(CFD)has been utilized to simulate the movements of wheat straw particles for agitator speed selection in full-scale wet *** research has found that the current drag model generally used for depicting the motion of spherical particles cannot match the movement behavior of wheat straw particles with their non-spherical *** this study,the sedimentation experiment and horizontal flow experiment of straw particles were determined using a V20-3D camera and a micro Particle Image Velocimetry(PIV)*** analyses of the experimental data and CFD simulation results,the prediction accuracies of the non-spherical drag models of Hölzer and Sommerfeld(HS),Kishore and Gu(KG),Haider and Levenspiel(HL),Richter and Nikrityuk(RN),and Fabio Dioguardi(FD)were evaluated by the motion of individual straw *** results showed that the KG model has a significant advantage over the other drag models,both simulating the particle settling velocities in a one dimensional settling experiment and simulating the predictable trajectory in a two-dimensional horizontal flow ***,the KG drag model was selected to simulate with CFD the wheat straw particle movement to select agitator ***,the realizable k-turbulence model was proven to be superior to the other turbulence models for simulating the continuous phase flow with CFD.

关键词： wheat straw particle drag model shape coefficient image analysis micro PIV measurement

Distribution of heavy metals in pig farm biogas residues and the safety and feasibility assessment of biogas fertilizer

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International Journal of Agricultural and Biological Engineering 2013年第4期6卷 35-43页

作者： Ma Jieqiong zhu hongguang Fan Min Research Institute of Modern Agricultural Science&Engineering Biomass Energy Research CenterTongji UniversityShanghai 200092China

The presence of high levels of heavy metals in anaerobic fermentation residues is a major obstacle to the resource utilization and urgent research for removal of heavy metals in the biogas slurry is *** handling of large-scale residue slurry and safely returning to field urgently needed constructive *** contents of heavy metal elements in the residue of anaerobic digestion processes of the wastewater and waste of the piggery were mainly *** contents of heavy metals in the original fluid and the centrifugal solution were determined in this *** included elements,such as Cu,Zn,Cr,Cd,Pb,As,Ni,Mn,and Se,which were compared with the existing standard including the irrigation water quality standards(GB5084-2005),comprehensive discharge standard of sewage(GB8978-1996)and water-solubility humic acid fertilizer quality standards(NY1106-2010).The preliminary data suggested that both the heavy metals before and after centrifugation were in excess of the standards to some degree and the exceeding standard rate declined significantly after *** absolute contents of heavy metals after centrifugation declined significantly compared with that before *** ratios are 91.8%,73.2%,47.6%,94.5%,93.5%,59.4%,95.8%,100%for Zn,As,Cd,Cr,Cu,Ni,Mn,Pb,respectively.A descriptive statistics as well as a correlational analysis showed that there existed strong correlation among Cu,Pb,and the total suspended solids(TS).Meanwhile,significant correlation was found among TS,Cd,Zn,As,Cr,Ni,and Mn at 0.01 *** data and the analysis above provided the theoretical and experimental support for the removal of heavy mental mainly characterized by the removal of *** to the comparison between contents of heavy mental conversed from large amount nutrients and corresponding standard(NY1110-2006),only as was found beyond *** was feasible to apply biogas residues after centrifugation as water-solubility fertilizer due to the fac

关键词： fluid biogas residue heavy metals distribution correlation fertilization

Measurement and analysis of biogas fertilizer use efficiency, nutrient distribution and influencing factors of biogas residues and slurry on pig farms

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International Journal of Agricultural and Biological Engineering 2014年第1期7卷 60-69页

作者： Fan Min zhu hongguang Ma Jieqiong Institute of Modern Agricultural Science and Engineering Biomass Energy Research CenterTongji UniversityShanghai 200092China

Although the effects of biogas residues and slurry returning to farmland are good,they still cannot be used widely in *** this study,the biogas fertilizer use efficiency,nutrient distribution and influencing factors of fertilizer use efficiency of biogas residues and slurry in 20 biogas projects in Chongming County,Shanghai,China were measured and *** correlation and a linear regression fit of parts of test indicators were also *** results show that pig farm biogas residues and slurry mixture are nutrient-rich and can be used as a high-quality organic fertilizer,while its fertilizer use efficiency is unstable because of the differences among area,raw materials,fermentation technology and operation *** are not evenly distributed in biogas residues and *** levels of organic matters,P and trace elements were detected in biogas residues and higher levels of water-soluble N and K were detected in biogas *** correlations between some test indicators of biogas residues and slurry mixture are significant,especially between total K and *** regression model fitting results of parts of test indicators are ***,the values of the other test indicators can be estimated by one known indicator which can effectively reduce the determination workload under some limited situations.

关键词： biogas residues and slurry biogas fertilizer fertilizer use efficiency nutrients influence factors environmental protection pollution control supernatant

Simulation-oriented model reuse in cyber-physical systems: A method based on constrained directed graph

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第2期13卷 91-110页

作者： Wenzheng Liu Heming Zhang Chao Tang Shuangfei Wu hongguang zhu National CIMS Engineering Research Center Tsinghua University Beijing 100084P.R.China Gridsum Holding Inc.Beijing 100086P.R.China Center of Intelligent Control and Telescience Tsinghua Shenzhen International Graduate School Shenzhen 518055 P.R.China Institute of Computing Technology China Academy of Railway Sciences Corporation Limited Beijing 100084 P.R.China

Modeling and Simulation of Cyber-Physical Systems(MSCPS)is demanding in terms of immediate response to dynamic and complex changes of ***-oriented model reuse can be used to build a whole CPS model by reusing developed models in a new sim-ulation application,which avoid repeated modeling and thus reduce the redevelopment of *** composition,one of the important methods,enables model reuse by selecting and adopting diversified integration solutions of simulation components to meet the requirements of simulation application *** this paper,a real-time model integration approach for global CPS modeling is proposed,which reuses devel-oped submodels by compositing submodel ***,a constrained directed graph of submodels for the whole system which can meet the simulation requirements is constructed by reverse *** properties,including co-simulation distance between submodel nodes,reuse benefit and simulation performance of model nodes,are *** on the properties,the model-integrated solution for the whole CPS simulation is retrieved throughout the model constrained digraph by the Genetic Algo-rithm(GA).In the experiment,the proposed method is applied to a typical model integrated computing scenario containing multiple model-integration solutions,among which the Pareto optimal solutions are *** show that the effectiveness of the model integration method proposed in this paper is verified.

关键词： CPS model reuse model composition co-simulation distance multi-objective genetic algorithm

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第三腰椎横突综合征的中医药治疗进展

长春中医药大学学报 2024年第7期40卷 805-811页

作者：朱英豪拉普你色朱洪广侯同航庄世伟汤继辉邢振龙长春中医药大学长春130117 暨南大学中医学院广州510000 长春中医药大学附属第三临床医院长春130117 广东省中西医结合医院广东佛山528200

第三腰椎横突综合征是骨伤科常见疾病,严重影响患者的生活质量。为寻找安全性高、治疗效果佳、诊疗费用低、毒副作用小的医治方法,对近5年研究该疾病的文献进行总结和梳理,并结合临床实际阐明治疗观点。认为针灸疗法可从舒筋通络方面解... 详细信息

第三腰椎横突综合征是骨伤科常见疾病,严重影响患者的生活质量。为寻找安全性高、治疗效果佳、诊疗费用低、毒副作用小的医治方法,对近5年研究该疾病的文献进行总结和梳理,并结合临床实际阐明治疗观点。认为针灸疗法可从舒筋通络方面解决气滞血瘀,缓解疼痛;中药内服和外敷可从补肾、强筋、壮骨方面进行活血化瘀,缓解疼痛;针刀疗法可从松解黏连方面加快局部血液循环,缓解疼痛;推拿疗法可从改善肌肉紧张和痉挛方面加强血液循环,缓解疼痛。通过结合针灸、中药、针刀、推拿等诊疗方法治疗第三腰椎横突综合征可安全、快速、有效解除病痛。

关键词：第三腰椎横突综合征针刺推拿针刀中医药

Experimental Study on Chloride Ion Penetration Resistance of Coal Gangue Concrete under Multi-Factor Comprehensive Action

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World Journal of Engineering and Technology 2019年第2期7卷 58-64页

作者： Hongyu Chen hongguang zhu Hongqiang Ma Mingyue Zhang School of Mechanics and Civil Engineering China University of Mining & Technology Beijing China

In order to investigate the chloride ion penetration resistance of coal gangue concrete under multi-factor comprehensive action, the non-steady-state accelerated chloride ion migration test was used to test the chloride diffusion law of coal gangue concrete specimens by crack width, curing temperature and water-cement ratio. Three groups of crack width (0 mm, 0.05 - 0.12 mm, 0.12 - 0.2 mm), three curing temperatures (high temperature 45, medium temperature 25, low temperature 10), three water cement ratios (0.3, 0.4, 0.5) were set in the experiment. The results show that when the curing temperature and water cement ratio are constant, the crack width less than 0.12 mm has little effect on the chloride content and chloride diffusion coefficient. When the crack width is larger than 0.12 mm, the chloride penetration depth increases with the crack width. The resistance to chloride ion penetration of gangue concrete is greatly influenced by the water cement ratio. The influ-ence degree of three factors on chloride ion migration coefficient of gangue concrete is as follows: water cement ratio > crack width > curing temperature.

关键词： Coal Gangue Concrete Chloride Ion Penetration Water Cement Ratio Crack Width Curing Temperature

Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma

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Chinese Medical Journal 2014年第2期127卷 272-278页

作者： Huang Wei Jin Yi Yuan Yunfeng Bai Chunxue Wu Ying zhu hongguang Lu Shaohua Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China Department of Pathology Shanghai Medical College Fudan University Shanghai 200032 China Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai 200032 China Department of Pulmonary Medicine Zhongshan Hospital Fudan University Shanghai 200032 China Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 China Department of T'horacic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China

Background Lung cancers are classified as squamous cell carcinoma （SQ）,adenocarcinoma （AC） and small cell lung carcinoma （SCLC）.SQ is the major subtype of lung ***,there are no targeted therapies for SQ due to lack of understanding its driving *** this study,we validated an SQ specific biomarker hsa-miR-205 in Chinese patients with lung cancer and screened its candidate target genes for further functional studies to enrich knowledge in SQ target *** Quantitative reverse-transcription PCR （quantitative RT-PCR）was performed on 197 macro-dissected （cancerous cells ＞75％） surgical lung tissues （45 SQ,44 AC,54 SCLC and 54 adjacent normal tissues） to validate the expression profiles of ***,the targets of this microRNA were predicted through the gateway miRecords and mapped to lung cancer-associated pathways using the KEGG （Kyoto Encyclopedia of Genes and Genomes） *** quantitative RT-PCR was performed on an independent cohort of 44 snap-frozen surgical lung tissues to concurrently assess the expression profiles of miR-205 and its 52 putative targeted *** MicroRNA-205 yielded high diagnostic accuracy in discriminating SQ from AC with an area under the curve （AUC） of 0.985,and discriminating SQ from SCLC with an AUC of 0.978 in formalin-fixed paraffin-embedded （FFPE）surgical lung *** targets of miR-205 were associated with 52 key members of lung cancer signaling *** target genes （ACSL1,AXIN2,CACNA2D2,FOXO3,PPP1R3A,PRKAG3,RUNX1,SMAD4,STK3 and TBL1XR1） were significantly down-regulated in SQ and had a strong negative correlation with miR-205,while one target gene （CDH3） was up-regulated in SQ and exhibited a strong positive correlation with *** We confirmed the high diagnostic accuracy of miR-205 in discriminating SQ from AC and SCLC in Chinese ***,we identified 11 significant target genes of miR-205 which could be used for further functional studies as t

关键词： squamous cell carcinoma hsa-miR-205 microRNA targeted gene

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混凝预处理厌氧发酵液对超滤膜通量的影响

农业机械学报 2012年第4期43卷 93-99,118页

作者：朱洪光王旦一同济大学现代农业科学与工程研究院生物上海200092

膜滤方法浓缩沼液成为商品化液体有机肥工艺中,超滤膜堵塞现象严重。采用氯化铁、硫酸亚铁、硫酸铝、硫酸铝钾、硅酸钠和聚合氯化铝6种常见无机混凝剂,通过在线混凝-超滤的试验方法预处理沼液,研究其对超滤膜通量的影响。试验分2组进行... 详细信息

膜滤方法浓缩沼液成为商品化液体有机肥工艺中,超滤膜堵塞现象严重。采用氯化铁、硫酸亚铁、硫酸铝、硫酸铝钾、硅酸钠和聚合氯化铝6种常见无机混凝剂,通过在线混凝-超滤的试验方法预处理沼液,研究其对超滤膜通量的影响。试验分2组进行,分别优选了最佳混凝剂及其最优投加量。研究结果表明:氯化铁效果最优,用量最省,在质量浓度8 g/L时可增加原水稳定通量14.38倍,用量仅为同等效果聚合氯化铝的1/3;随着氯化铁投加量的增加,相对通量呈现先增后降的趋势,并在质量浓度10 g/L处达到峰值,这与混凝过程中的再稳现象密切相关;综合考虑通量改善效果、污染物去除率和混凝剂用量等因素,认为投加氯化铁质量浓度8 g/L最佳。

关键词：厌氧发酵液沼液超滤膜通量在线混凝