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A review of welding simulation methods for large components

Progress in Natural Science:Materials International 2023年第5期33卷 551-568页

作者： Shuai Liu Zhiqiang Wu Wenhao zhou honggang zhou Keke Zhang Danqing Yin Yongping Lei Yongfeng Qiu Engineering Research Center of Mining Development Technology and Equipment for Deep Sea and Earth Ministry of Education Hunan University of Science and Technology Hunan Valin Xiangtan Iron & Steel Group Co. Ltd Research Institute of Technology Jianglu Electromechanical Science & Technology Co. Ltd.Xiangtan School of Materials Science and Engineering Henan University of Science and Technology School of Materials Science and Engineering Beijing University of Technology Guiyang Aluminum Magnesium Design & Research Institute Co. Ltd

The challenges posed by cross-scale effects, large computational requirements, high nonlinearity, and complex interactions of multiple physical phenomena constitute major obstacles to the effectiveness and accuracy of welding simulations for large structural components. Therefore, achieving accurate welding simulation to predict and effectively control welding deformation of substantial engineering structural parts is essential to ensure welding quality and improve production efficiency. This paper reviews the current research status of welding numerical simulation of large engineering components, including the establishment of the finite element model,optimization of the heat source model, selection of appropriate finite element calculation method, and the control of welding deformation through optimization algorithm. In addition, the strategies to improve the precision and efficiency of welding numerical simulation and control welding deformation of engineering components are analyzed and discussed. The future development of welding numerical simulation will focus on balancing simulation accuracy and simulation efficiency and optimizing welding parameters to control welding deformation efficiently.

关键词： Large welded components Algorithm optimization Welding deformation Simulation accuracy and efficiency

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Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CL^pro Inhibitors

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Chinese Journal of Chemistry 2013年第9期31卷 1199-1206页

作者： Yu Guo Ning Zhang Jian Wang Bo Sun Wei Liu honggang zhou Cheng Yang College of Sciences Tianjin University of Science and Technology Tianjin 300457 China College of Pharmacy Nankai University Tianjin 300071 China College of Life Sciences Nankai University Tianjin 300071 China High Throughput Molecular Drug Discovery Center Tianjin International Joint Academy of Biotechnology and Medicine TEDA Tianjin 300457 China

SARS CoV 3CL^pro is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome （SARS）. A quinolinone compound 1 was selected via virtual screening, and it was syn- thetized and tested for enzymatic inhibition in vitro. Compound 1 showed potent inhibitory activity （ICs0= 0.44 μmol/L） toward SARS CoV 3CL^pro. Further work on a series of quinolinone derivatives resulted in the discovery of the most potent compound 23, inhibiting SARS CoV 3CL^pro with an IC50 of 36.86 μmol/L. The structure-activity relationships were also discussed.

关键词： SARS SARS CoV 3CL^pro inhibitors quinolinone

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A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

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Protein & Cell 2011年第5期2卷 384-394页

作者： Yu Guo Jing Wang Guojun Niu Wenqing Shui Yuna Sun honggang zhou Yaozhou Zhang Cheng Yang Zhiyong Lou Zihe Rao High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and MedicineTianjin 300071China Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China College of Life Science Nankai UniversityTianjin 300074China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1(NDM-1)are a type of newly discovered antibioticresistant *** rapid pandemic spread of NDM-1 bacteria worldwide(spreading to India,Pakistan,Europe,America,and Chinese Taiwan)in less than 2 months characterizes these microbes as a potentially major global health *** drug resistance of NDM-1 bacteria is largely due to plasmids containing the blaNDM-1 gene shuttling through bacterial *** NDM-1 enzyme encoded by the blaNDM-1 gene hydrolyzes β-lactam antibiotics,allowing the bacteria to escape the action of *** the biological functions and structural features of NDM-1 have been proposed according to results from functional and structural investigation of its homologues,the precise molecular characteristics and mechanism of action of NDM-1 have not been ***,we report the threedimensional structure of NDM-1 with two catalytic zinc ions in its active *** and mass spectroscopy results revealed that D-captopril can effectively inhibit the enzymatic activity of NDM-1 by binding to its active site with high binding *** unique features concerning the primary sequence and structural conformation of the active site distinguish NDM-1 from other reported metallo-β-lactamases(MBLs)and implicate its role in wide spectrum drug *** also discuss the molecular mechanism of NDM-1 action and its essential role in the pandemic of drug-resistant NDM-1 *** results will provide helpful information for future drug discovery targeting drug resistance caused by NDM-1 and related metallo-β-lactamases.

关键词： New Delhi metallo-β-lactamase 1(NDM-1) drug resistance crystal structure drug discovery

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Identifi cation and functional analysis of phosphorylation residues of the Arabidopsis BOTRYTIS-INDUCED KINASE1

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Protein & Cell 2013年第10期4卷 771-781页

作者： Jinhua Xu Xiaochao Wei Limin Yan Dan Liu Yuanyuan Ma Yu Guo Chune Peng honggang zhou Cheng Yang Zhiyong Lou Wenqing Shui College of Life Sciences and Tianjin State Laboratory of Protein Science Nankai UniversityTianjin 300071China High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and MedicineTianjin 300457China Laboratory of Structural Biology and MOE Laboratory of Protein Science School of Medicine and Life SciencesTsinghua UniversityBeijing 100084China College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China

Arabidopsis BOTRYTIS-INDUCED KINASE1(BIK1)is a receptor-like cytoplasmic kinase acting early in multiple signaling pathways important for plant growth and innate *** is known to form a signaling complex with a cell-surface receptor FLS2 and a co-receptor kinase BAK1 to transduce signals upon perception of pathogen-asso-ciated molecular patterns(PAMPs).Although site-specifi c phosphorylation is speculated to mediate the activation and function of BIK1,few studies have been devoted to complete profiling of BIK1 phosphorylation ***,we identified nineteen in vitro autophosphoryla-tion sites of BIK1 including three phosphotyrosine sites,thereby proving BIK1 is a dual-specifi city kinase for the fi rst *** kinase activity of BIK1 substitution mutants were explicitly assessed using quantitative mass spec-trometry(MS).Thr-237,Thr-242 and Tyr-250 were found to most signifi cantly affect BIK1 activity in autophosphoryla-tion and phosphorylation of BAK1 in vitro.A structural model of BIK1 was built to further illustrate the molecular functions of specifi c phosphorylation *** also mapped new sites of FLS2 phosphorylation by BIK1,which are different from those by *** in vitro results could provide new hypotheses for more in-depth in vivo studies leading to deeper understanding of how phosphorylation contributes to BIK1 activation and medi-ates downstream signaling specifi city.

关键词： phosphorylation BIK1 receptor-like cytop-lasmic kinase quantitative mass spectrometry

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The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation

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Protein & Cell 2013年第6期4卷 445-455页

作者： honggang zhou Yuna Sun Ying Wang Min Liu Chao Liu Wenming Wang Xiang Liu Le Li Fei Deng Hualin Wang Yu Guo Zhiyong Lou College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China Laboratory of Structural Biology and MOE Laboratory of Protein Science School of Medicine and Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of ScienceBeijing 100101China High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and MedicineTianjin 300457China

Severe fever with thrombocytopenia syndrome virus(SFTSV),a member of the Phlebovirus genus from the Bunyaviridae family endemic to China,is the causative agent of life-threatening severe fever with thrombocyto-penia syndrome(SFTS),which features high fever and *** to other negative-sense RNA viruses,SFTSV encodes a nucleocapsid protein(NP)that is essen-tial for viral *** facilitates viral RNA encapsida-tion and is responsible for the formation of ribonucleopro-tein ***,recent studies have indicated that NP from Phlebovirus members behaves in inhomogene-ous oligomerization *** the present study,we report the crystal structure of SFTSV NP at 2.8Åresolution and demonstrate the mechanism by which it processes a ring-shaped hexameric form to accomplish RNA *** residues essential for oligomerization are identi-fi ed through mutational analysis and identifi ed to have a signifi cant impact on RNA binding,which suggests that correct formation of highly ordered oligomers is a criti-cal step in RNA *** fi ndings of this work provide new insights into the discovery of new antiviral reagents for Phlebovirus infection.

关键词： SFTSV nucleoprotein oligomer RNP as-sembly crystal structure

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研究型大学经济管理类实验教学体系建设初探

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现代财经（天津财经大学学报） 2008年第7期28卷 13-15页

作者：周红刚曾五一厦门大学经济与管理教学实验中心福建厦门361005

实验教学已经成为高校经济与管理类人才培养过程中不可欠缺的重要环节。对于研究型大学来说,更应当根据自身的特点,将人才培养的目标与社会经济发展的需求相结合,充分利用有效的实验教学体系培养具有较强的实践能力和创新能力,适应社会... 详细信息

实验教学已经成为高校经济与管理类人才培养过程中不可欠缺的重要环节。对于研究型大学来说,更应当根据自身的特点,将人才培养的目标与社会经济发展的需求相结合,充分利用有效的实验教学体系培养具有较强的实践能力和创新能力,适应社会需求的应用型、复合型人才。

关键词：经济管理实验教学研究型

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考虑失效性故障的火星探测器进入段姿态容错控制

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中国空间科学技术 2022年第1期42卷 73-82页

作者：戴清周洪刚刘鹏轩李爽南京航空航天大学航天学院南京211106 航天科工空间工程发展有限公司北京100039

火星进入过程中的故障和外部干扰不可避免地降低了火星进入制导和控制算法的性能。利用反步法设计了一种对转动惯量信息变化不敏感的火星进入姿态容错控制算法。首先,将虚拟控制律的微分量视作干扰量,利用自适应技术对其进行补偿,避免... 详细信息

火星进入过程中的故障和外部干扰不可避免地降低了火星进入制导和控制算法的性能。利用反步法设计了一种对转动惯量信息变化不敏感的火星进入姿态容错控制算法。首先,将虚拟控制律的微分量视作干扰量,利用自适应技术对其进行补偿,避免了传统反步法微分爆炸的缺陷。同时,控制设计过程中显式地引入了饱和函数,保证了在存在输入饱和的情况下,控制律仍然能使得探测器姿态保持稳定。最后,以“火星科学实验室”探测器为模型进行了数值仿真验证,结果表明该控制律在存在输入饱和约束、转动惯量不确定性、执行机构部分失效甚至完全失效的工况下,仍然能够完成对姿态的精准跟踪。

关键词：火星进入姿态跟踪容错控制输入饱和转动惯量未知

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试论社交媒体时代的人格政治——以2016年美国总统大选为例

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华中传播研究 2018年第2期 116-125页

作者：周宏刚陕西师范大学新闻与传播学院

政治人物历来在政治活动中扮演十分重要的角色。随着报纸、广播、电视等大众传媒的兴起,以及世俗化、工业化以后公众心理的变化,现代政党政治中政治人物的外表、动机等人格要素逐渐取代政治理念和行动,成为吸引公众支持的主要方面。社... 详细信息

政治人物历来在政治活动中扮演十分重要的角色。随着报纸、广播、电视等大众传媒的兴起,以及世俗化、工业化以后公众心理的变化,现代政党政治中政治人物的外表、动机等人格要素逐渐取代政治理念和行动,成为吸引公众支持的主要方面。社交媒体的蓬勃发展为政治人物的人格塑造带来了新的技术手段,将人格政治推到一个新高度。但是要警惕人格政治的过度发展带来政治空心化、群体分裂和滋生极端言论等负面影响。

关键词：人格政治社交媒体美国大选

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后疫情时代对外传播的多重挑战及策略应对——摩根索国际传播思想的启示

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媒介批评 2022年第2期 329-343页

作者：周宏刚陕西师范大学新闻与传播学院

新冠肺炎疫情引发的全球性公共卫生危机已外溢到政治、经济、文化等众多领域,加剧了“逆全球化”趋势,使我国的对外传播面临诸多挑战。本文在梳理国际关系经典现实主义大师摩根索对魅力、威望和宣传等相关论述的基础上,试图运用其国际... 详细信息

新冠肺炎疫情引发的全球性公共卫生危机已外溢到政治、经济、文化等众多领域,加剧了“逆全球化”趋势,使我国的对外传播面临诸多挑战。本文在梳理国际关系经典现实主义大师摩根索对魅力、威望和宣传等相关论述的基础上,试图运用其国际传播思想中的理论资源和方法论原则解答后疫情时代我国对外传播中的问题。论文最后得出一些启示:要处理好全球化融入与“回到中国”的关系,增强国家意识;要处理好话语衔接与分层突破的关系,提升话语博弈能力;要处理好“学科型学术”与“问题型学术”的关系,坚持问题导向。

关键词：摩根索魅力威望宣传对外传播

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一起220kV电流互感器引流板变形缺陷分析

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高压电器 2016年第10期52卷 201-204页

作者：黄斌周洪刚汪志祥国网江西省电力公司检修分公司南昌330029

介绍了一起220 kV电流互感器引流板变形缺陷分析及处理过程。通过对电流互感器引流板受力分析、仿真模拟及试验检测,认为引流板未达到设计厚度,不能承受现场实际应力是发生变形的主要原因。通过对这起缺陷的分析研究,对今后类似缺陷的... 详细信息

介绍了一起220 kV电流互感器引流板变形缺陷分析及处理过程。通过对电流互感器引流板受力分析、仿真模拟及试验检测,认为引流板未达到设计厚度,不能承受现场实际应力是发生变形的主要原因。通过对这起缺陷的分析研究,对今后类似缺陷的分析提供借鉴与参考。

关键词：电流互感器引流板厚度变形仿真模拟

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