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帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价

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药学实践与服务 2024年第8期42卷 334-340页

作者：宋雨桐夏德润顾珩唐少文易洪刚沃红梅南京医科大学第一临床医学院江苏南京211166 南京医科大学公共卫生学院江苏南京211166 南京医科大学公共医政学院江苏南京211166

目的在程序性死亡配体-1(PD-L1)肿瘤比例得分(TPS)≥1%的人群中,对帕博利珠单抗和铂类化疗作为晚期非小细胞肺癌(NSCLC)一线治疗方案进行成本效果分析,为其临床用药提供参考。方法基于Pubmed数据库,检索与帕博利珠单抗相关的随机对照试... 详细信息

目的在程序性死亡配体-1(PD-L1)肿瘤比例得分(TPS)≥1%的人群中,对帕博利珠单抗和铂类化疗作为晚期非小细胞肺癌(NSCLC)一线治疗方案进行成本效果分析,为其临床用药提供参考。方法基于Pubmed数据库,检索与帕博利珠单抗相关的随机对照试验,结合某三甲医院治疗方案建立Markov模型,模拟患者20年的成本和健康效果,并使用单因素敏感性分析和概率敏感性分析检验模型的稳定性。结果帕博利珠单抗组与化疗组的成本效果比为58517.60元/质量调整生命月(QALM)和41213.08元/QALM。与化疗组相比,帕博利珠单抗组的增量成本效果比(ICER)为104485.36元/QALM。结论当意愿支付(WTP)为30902元/QALM时,帕博利珠单抗方案与铂类化疗方案相比不具有成本效果优势,敏感性分析显示模型的结果较为稳定。

关键词：帕博利珠单抗非小细胞肺癌一线治疗 Markov模型成本效果分析经济学评价

Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province,China

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The Journal of Biomedical Research 2010年第3期24卷 207-214页

作者： Zhihang Peng Changjun Bao Yang Zhao honggang yi Letian Xia Hao Yu Hongbing Shen Feng Chen Department of Epidemiology and Biostatistics Nanjing Medical University School of Public Health Nanjing 210029 Jiangsu Province China Center for Disease Control and Prevention of Jiangsu Province Nanjing 210029 Jiangsu Province China Applied Mathematics Department Hohai University Nanjing 210029 Jiangsu Provinee China

This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence *** the paper presents a weighted Markov chain,a method which is used to predict the future incidence *** method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic *** also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision *** method is successfully validated using existing incidents data of infectious diseases in Jiangsu *** summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology.

关键词： weighted.Markov chains sequential cluster infectious diseases forecasting and analysis Markov chain Monte Carlo

Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis *** least squares

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The Journal of Biomedical Research 2015年第4期29卷 298-307页

作者： honggang yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen Department of Epidemiology and Biostatistics School of Public Health Department of Public Service Management School of KangDa Section of Clinical Epidemiology Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCancer Center Institute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and Technology State Key Laboratory of Reproductive Medicine Nanjing Medical University State Key Laboratory of Molecular Oncology and Department of Etiology and Carcinogenesis Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical College

With recent advances in biotechnology, genome-wide association study （GWAS） has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression （LR） based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression （PC-LR）, partial least squares-based logistic regression （PLS-LR）, have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor- mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism （SNP） set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis. On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data.

关键词： principal components analysis partial least squares-based logistic regression genome-wide association study,type I error power

Shor's algorithm does not factor large integers in the presence of noise

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Science China(Information Sciences) 2024年第7期67卷 305-320页

作者： Jin-yi CAI College of Letters and Science University of Wisconsin

We consider Shor's quantum factoring algorithm in the setting of noisy quantum gates. Under a generic model of random noise for(controlled) rotation gates, we prove that the algorithm does not factor integers of the form pq when the noise exceeds a vanishingly small level in terms of n—the number of bits of the integer to be factored, where p and q are from a well-defined set of primes of positive density. We further prove that with probability 1-o(1) over random prime pairs(p, q), Shor's factoring algorithm does not factor numbers of the form pq, with the same level of random noise present.

关键词： random noise Shor's algorithm rotation gates quantum computing prime factorization

Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： yi Yu Guo-Ping Liu yi Huang Peng Shi IEEE Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

Self-assembly of perovskite nanocrystals:From driving forces to applications

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Journal of Energy Chemistry 2024年第1期88卷 561-578,I0013页

作者： yi Li Fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell *** review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are ***,we summarize the collective optoelectronic properties and application areas of perovskite superlattice ***,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs.

关键词： Self-assembly Metal halide perovskite Nanocrystals Driving forces

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Effect of the yaw angle on turbulent flow structures around the submarine model

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Journal of Hydrodynamics 2024年第3期36卷 421-434页

作者： yi-jing Hu yi Qu Qin Wu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China

The objective of this paper is to investigate the turbulent flow structures around the submarine model and evaluate the effect of the yaw angle on the turbulent flow *** large eddy simulation based on the boundary data immersion method is used to *** computational domain consists of 1.2×10^(8)uniformly distributed Cartesian orthogonal grid nodes to capture the basic flow characteristics around the *** pressure coefficient,friction coefficient and wake velocity distribution are in good agreement with the experimental *** different types of vortex structures were mainly captured around the model,including horseshoe vortex,sail tip vortex and crossflow separation *** the increase of the yaw angle,the asymmetry of the horseshoe vortex and the tip vortex gradually increases,and the vortex strength of the vortex leg on the windward of the horseshoe vortex and the vortex strength of the tip vortex also increase *** the crossflow separation vortex,the flow separation zone gradually expands and migrates downstream with the increase of the yaw angle.

关键词： Vortex structure submarine model boundary data immersion method yaw angle

Embeddings Among Quantum Affine sl_(n)

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Acta Mathematica Sinica,English Series 2024年第3期40卷 792-805页

作者： yi Qiang LI Department of Mathematics University at BuffaloThe State University of New YorkBuffaloNY 14260USA

We establish an explicit embedding of a quantum affine sl_(n) into a quantum affine sl_(n)+*** embedding serves as a common generalization of two natural,but seemingly unrelated,embed-dings,one on the quantum affine Schur algebra level and the other on the non-quantum *** embedding on the quantum affine Schur algebras is used extensively in the analysis of canonical bases of quantum affine sln and gl_(n).The embedding on the non-quantum level is used crucially in a work of Riche and Williamson on the study of modular representation theory of general linear groups over a finite *** same embedding is also used in a work of Maksimau on the categorical representations of affine general linear *** further provide a more natural compatibility statement of the em-bedding on the idempotent version with that on the quantum affine Schur algebra level.A gl_(n)-variant of the embedding is also established.

关键词： Quantum affine sl_(n) embeddings