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Science China(Technological Sciences) 2024年第2期67卷 597-607页

作者： WU Xiao JIANG HongJie LI WangYun LIU ChongYu huang hongfeng LIU ShuHui WEI LiLi School of Material Science and Engineering Guilin University of Technology Guilin 541004China Key Laboratory of New Processing Technology for Nonferrous Metal&Materials Ministry of EducationGuilin University of Technology Guilin 541004China School of Mechanical and Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China

The NiTip/1060Al composites were prepared using a pre-aging and friction stir method(FSP)to enhance the low-temperature damping performance of the aluminum alloy and accommodate various service temperatures.The bonding between NiTi particles and the 1060Al matrix is well established after FSP,and no new phases are formed in the composites.The phasetransformation peak temperature of NiTip/1060Al composites gradually shifts to lower temperatures with increased aging temperature of NiTi particles.At room temperature,the 550℃-NiTip/1060Al composite exhibits superior damping performance,with an internal friction value 144%higher than that of the FSP-1060Al alloy.However,at-91℃,the 650℃-NiTip/1060Al composite demonstrates better damping performance,with an internal friction value 158%higher than that of the FSP-1060Al alloy.The NiTip/1060Al composites exhibit the internal friction peak of NiTi phase-transformation in the temperature range from-91℃to 60℃.This characteristic results in significantly better damping performance compared to the FSP-1060Al alloy and other high-damping aluminum matrix composites.

关键词： NiTi particle aluminum matrix composites phase transformation damping behavior friction stir processing

Circularly polarized luminescence switch based on a photochromic europium(Ⅲ) helicate derived coordination polymer

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Chinese Chemical Letters 2024年第2期35卷 272-277页

作者： Mei Li Yanyan Zhou Jingya Li Wenru huang Zhiwei Yao Yuying Li Ting Gao Pengfei Yan hongfeng Li Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Institution Baotou 014030China

Chiroptical switches based on circularly polarized luminescence(CPL)have shown the promising applications in advanced information technologies.Herein,a pair of lanthanide coordination polymer enantiomers[Eu_(2)(L^(R))_(3)(BTFPO)_(2)]_(n) and[Eu_(2)(L^(S))_(3)(BTFPO)_(2)]_(n) with light-regulated CPL property are designed,which are assembled by a chiral binuclear triple-stranded Eu^(3+) helicates[Eu_(2)(L^(R/S))_(3)]coordinated with two photochromic triphenylphosphine oxides(BTFPO).Upon the alternative UV and 526 nm light irradiation,the complexes show the reversible photochromism,PL and CPL responses.Notably,the luminescence dissymmetry factor,g lum of ^(5)D_(0)→^(7)F_(1)(591 nm)transition shows an obvious increase from 0.19 to 0.29 before and after 275 nm light irradiation.Additionally,the emission from Eu^(3+) center is not completely quenched in closed-ring state due to the low photocyclization(Ф_(o-c))quantum yield of the polymer.The partial maintenance of emissive intensity is of essential importance for the monitor of CPL signal.More importantly,the CPL photo-switching property of the complexes in solid hybrid film is maintained,and still displays the enhanced CPL emission in photostationary state.Further,the potential applications of the doping film in logic gate and anti-counterfeiting were investigated.

关键词： Chiroptical switches Coordination polymer CPL Anti-counterfeiting Logic gate

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： hongfeng Guo Qihang Sun Xiaoli huang Xiaohao Wang Feng Zhang Wenzheng Qu Jinling Liu Xuejun Cheng Qiang Zhu Wen Yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy metabolism.However,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown.We have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain development.Fut8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,respectively.Additionally,Fut8 deficiency impairs learning and memory in mice.Mechanistically,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of Itga6.Deletion of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to Itga6.Low levels of Itga6 inhibit the activity of the PI3K/Akt signaling pathway.Moreover,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 deficiency.In summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 524-529页

作者： Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG hongfeng huang Jianyong WU Jianghua CHEN Rending WANG Kidney Disease Center the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang ProvinceHangzhou 310003China National Key Clinical Department of Kidney Diseases Hangzhou 310003China Institute of Nephrology Zhejiang UniversityHangzhou 310003China Zhejiang Clinical Research Center of Kidney and Urinary System Disease Hangzhou 310003China

There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research.

关键词： kidney throm donor

Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity

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Research 2022年第3期2022卷 189-203页

作者： Jia Shen Chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen Jessica MRosenholm hongfeng huang Rending Wang Hongbo Zhang Kidney Disease Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang ProvinceChina Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityTurku 20520Finland Turku Bioscience Centre University of Turku andÅbo Akademi UniversityTurku 20520Finland Organ Donation and Coordination Office The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted kidney.The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells.However,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)development.Tfh cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune diseases.Tacrolimus(Tac),the primary immunosuppressant,prevents rejection by reducing T cell activation.However,its administration should be closely monitored to avoid serious side effects.In this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen exposure.Results showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration pathway.This study provides a promising therapeutic strategy for preventing humoral rejection in solid organ transplantation.The specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches.

关键词： Tacrolimus treatment donor

儿童横纹肌瘤样发育不良肺隔离症15例临床病理学分析

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中华病理学杂志 2024年第2期53卷 177-179页

作者：赵淑君杨敏舒艳黄婷婷李传红朱坤汤宏峰浙江大学医学院附属儿童医院病理科国家儿童健康与疾病临床医学研究中心杭州310052 新疆维吾尔自治区乌鲁木齐市第一人民医院(乌鲁木齐儿童医院)病理科乌鲁木齐830002

目的探讨儿童横纹肌瘤样发育不良肺隔离症的临床病理特征、诊断、鉴别诊断及预后。方法对263例儿童肺隔离症进行回顾性分析,筛选出15例横纹肌瘤样发育不良肺隔离症病例,分析其临床资料、病理学特征并进行随访。结果15例横纹肌瘤样发育... 详细信息

目的探讨儿童横纹肌瘤样发育不良肺隔离症的临床病理特征、诊断、鉴别诊断及预后。方法对263例儿童肺隔离症进行回顾性分析,筛选出15例横纹肌瘤样发育不良肺隔离症病例,分析其临床资料、病理学特征并进行随访。结果15例横纹肌瘤样发育不良肺隔离症患者中男性9例,女性6例,其中14例为1岁以下婴幼儿,中位手术年龄8个月;15例患者均为左侧叶外型,其中13例位于膈肌内。大体上,它可以类似于正常的肺组织。组织学均可观察到微囊性肺发育不良,间质区含有发育不良的横纹肌组织;横纹肌纤维可以呈多种形态,如圆形、椭圆形、纺锤形或缎带状,弥漫或散在分布;在缎带状横纹肌纤维内可以看到清晰的横纹。对所有患者进行了随访,随访时间6~66个月,平均35个月,均无病生存。结论横纹肌瘤样发育不良肺隔离症是一种少见的先天性良性病变,手术切除后预后极好;与膈肌和微囊性肺发育不良密切相关;其具有独特的组织学特征,需要与胎儿型横纹肌瘤、横纹肌肉瘤肺转移、胸膜肺母细胞瘤和其他含有横纹肌样成分的肿瘤进行鉴别。

关键词：肺隔离症横纹肌瘤肺发育不良横纹肌纤维横纹肌肉瘤无病生存组织学特征肺转移

煎制成熟度对牛排挥发性风味物质及感官的影响

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食品与发酵工业 2024年第5期50卷 305-316页

作者：黄佳倪呈贾洪锋杨倩张振宇张淼四川旅游学院食品学院四川成都610100

采用感官评价以及固相微萃取-气相色谱-质谱联用技术,通过热图结合相对气味活度值对不同煎制成熟度牛排(一分熟、三分熟、五分熟、七分熟和九分熟)中挥发性风味物质和感官品质进行分析。结果表明,煎制时间的延长促进了牛排色泽、滋味和... 详细信息

采用感官评价以及固相微萃取-气相色谱-质谱联用技术,通过热图结合相对气味活度值对不同煎制成熟度牛排(一分熟、三分熟、五分熟、七分熟和九分熟)中挥发性风味物质和感官品质进行分析。结果表明,煎制时间的延长促进了牛排色泽、滋味和香气的生成,但牛排的嫩度逐渐变小;七分熟牛排的感官评分最高,挥发性风味物质含量与数量也最高。煎制牛排中关键挥发性风味物质为1-辛烯-3-醇、辛醛、壬醛、(E)-2-壬烯醛、(E)-2-癸烯醛、(E,E)-2,4-壬二烯醛、2-十一烯醛、(E,E)-2,4-癸二烯醛、3-庚酮、己酸等,醛类物质种类最多,可能是煎制牛排风味形成的重要组成部分;随煎制程度增加,牛排的蘑菇香、花香、奶油香减弱,总体香味以油脂香和肉香为主。由感官评价和相对气味活度值聚类分析可知,三分熟和五分熟为一类,七分熟和九分熟为一类,一分熟样品与其他样品存在较大差异。不同煎制牛排样品中蛋白质、脂肪和碳水化合物含量存在显著差异,且与挥发性物质的形成密切相关。

关键词：牛排成熟度感官品质挥发性风味物质相对气味活度值

职业院校劳动教育与汽车专业课程教学融合的探索与实践

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时代汽车 2024年第4期 67-69页

作者：江鸿丰黄晓赫广西生态工程职业技术学院广西柳州市545004

职业教育与专业课教学的融合是实现新时代培养“德智体美劳”全面发展的社会主义建设者和接班人的必然要求。近年来,各职业院校在积极探索不同的劳动教育路径,针对职业教育中存在的劳动教育缺乏顶层设计、与专业教学内容关联性不足、“... 详细信息

职业教育与专业课教学的融合是实现新时代培养“德智体美劳”全面发展的社会主义建设者和接班人的必然要求。近年来,各职业院校在积极探索不同的劳动教育路径,针对职业教育中存在的劳动教育缺乏顶层设计、与专业教学内容关联性不足、“双师型”教师缺乏、评价体系不完善等系列问题,文章以广西生态工程职业技术学院汽车专业与劳动教育融合实践为例,探讨了劳动教育与汽车专业课程教学融合的方法和策略,促进学生综合素质提升和就业能力培养,创新突破劳动教育困境。

关键词：职业院校劳动教育专业课教学融合

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耐磨零部件的电刷镀铬修复

电镀与涂饰 2024年第5期43卷 22-30页

作者：许剑飞喻世臣朱平黄宁王宏锋沈长斌徐常恩黄诗铭大连交通大学辽宁大连116028 沈阳飞机工业(集团)有限公司辽宁沈阳110034 大连华锐重工特种备件制造有限公司辽宁大连116000

[目的]某耐磨镀铬零部件长期依赖进口,在服役过程中会出现磨损、腐蚀等问题,对其进行修复再制造不仅符合绿色制造的理念,更可以大幅降低设备的运维成本,减少材料消耗。[方法]使用电刷镀铬技术对该零部件进行修复,对比了修复件和全新件表... 详细信息

[目的]某耐磨镀铬零部件长期依赖进口,在服役过程中会出现磨损、腐蚀等问题,对其进行修复再制造不仅符合绿色制造的理念,更可以大幅降低设备的运维成本,减少材料消耗。[方法]使用电刷镀铬技术对该零部件进行修复,对比了修复件和全新件表面Cr镀层的微观组织、表面粗糙度、显微硬度、耐磨性及耐蚀性,以探究电刷镀铬修复用于该零件的可行性。[结果]修复件的Cr镀层为光亮的银灰色,其微观形貌、显微硬度、表面粗糙度和耐蚀性都与全新件的Cr镀层相近,耐磨性则更优。[结论]电刷镀铬可用于修复该类零件,本文的研究结果有助于提高相应设备的国产化程度。

关键词：电刷镀铬耐磨零部件修复摩擦磨损显微硬度

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镍-钴-氧化铝复合电刷镀工艺及其性能

电镀与涂饰 2024年第6期43卷 1-12页

作者：蔡铭泽喻世臣朱平黄宁王宏锋沈长斌徐常恩黄诗铭大连交通大学辽宁大连116028 沈阳飞机工业(集团)有限公司辽宁沈阳110034 大连华锐重工特种备件制造有限公司辽宁大连116000

[目的]研究不同工艺参数和Al_(2)O_(3)纳米颗粒用量对45钢表面复合电刷镀Ni-Co-Al_(2)O_(3)的影响,提升45钢的耐磨性。[方法]通过扫描电子显微镜观察不同条件下所得镀层的表面形貌及截面形貌,以确定合适的工艺参数。再在此基础上研究了A... 详细信息

[目的]研究不同工艺参数和Al_(2)O_(3)纳米颗粒用量对45钢表面复合电刷镀Ni-Co-Al_(2)O_(3)的影响,提升45钢的耐磨性。[方法]通过扫描电子显微镜观察不同条件下所得镀层的表面形貌及截面形貌,以确定合适的工艺参数。再在此基础上研究了Al_(2)O_(3)纳米颗粒质量浓度对Ni-Co-Al_(2)O_(3)复合镀层显微硬度和耐磨性的影响,结合磨损形貌观察和元素组成分析,探讨了复合镀层的磨损机理。[结果]复合电刷镀的较佳工艺参数为:电压10 V,温度40~50℃,镀笔速率6~8 m/min。镀液中Al_(2)O_(3)纳米颗粒的质量浓度为20 g/L时,Ni-Co-Al_(2)O_(3)复合镀层的显微硬度最高(约为850 HV),耐磨性最好。Ni-Co-Al_(2)O_(3)复合镀层的磨损机理以疲劳磨损为主,并伴随轻微的粘着磨损。[结论]通过电刷镀技术可在45钢表面获得高硬度、耐磨损的Ni-Co-Al_(2)O_(3)复合镀层。

关键词：复合电刷镀镍钴纳米氧化铝显微硬度耐磨性

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