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Developments of crawler steering gearbox for combine harvester straight forward and steering in situ

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International Journal of Agricultural and Biological Engineering 2020年第1期13卷 120-126页

作者： Zhong Tang Haotian Zhang hongchang li Yaoming li Zhao Ding Jinsong Chen School of Agricultural Equipment Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Key Laboratory of Modern Agricultural Equipment and Technology of Ministry of Education Jiangsu University212013 ZhenjiangJiangsuChina

Soil compaction and accumulation are caused by crawler *** characteristics would affect the ability of crawler straight forward and steering in *** paper studied the principle of straight forward steering and steering in situ mode of traditional unilateral brake steering gearbox of a crawler combine *** a positive and negative steering gearbox model was developed and *** performance of positive and negative steering gearbox was analyzed by performing two steering modes on soil compaction *** showed that the positive and negative steering gearboxes can achieve three operating modes,such as straight forward,unilateral brake steering,and positive and negative steering in *** positive and negative steering in situ was smooth and without soil accumulation *** the crawlers center distance,crawler grounding length,crawler width were 1150 mm,1620 mm and 450 mm respectively,the rolling area and the scratch free area of positive and negative steering gearbox were 5.37 m2 and 0.36 m2 ***,the rolling area and the scratch free area produced by unilateral brake steering gearbox were 13.92 m2 and 1.88 m2 respectively,which was 8.55 m2 larger than that of positive and negative steering *** crawler with positive and negative steering gearbox has minor damage to paddy *** research can provide a theoretical basis for the smooth steering in situ and structural optimization of the crawler steering gearbox.

关键词： steering gearbox rolling soil track steering in situ rolling and scraping shaft and gear

Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity

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Journal of Genetics and Genomics 2015年第11期42卷 613-624页

作者： Ximing Shao Ke liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein hongchang li Huashun li West China Developmental and Stem Cell Institute West China Second HospitalSichuan University State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for Biotherapy Shenzhen Key Laboratory for Molecular Biology of Neural Development Laboratory of Developmental and Regenerative BiologyInstitute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health SARITEX Center for Stem Cell Engineering Translational Medicine Shanghai East HospitalTongji University School of Medicine Nerdbio Inc. SIP Biobay

Sphingosine-1-phosphate receptor 1 （S1PR1）, a G protein-coupled recep （GPCR）. controls vasct stability by stabilizing vascular endothelial （VE）-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2（VEGFR2） signaling. However, the molecular mechanisms that link S1PR1 signaling to intracellular effectors remain *** this study,we demonstrate that the heterotrimeric G protein subfamily member Gαs, encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions. The endothelial cell -spectific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized *** immunostaining results revealed that Gαs deletion remarkably reduces the junctional localization of VE-cadherin, whereas the mull cell coverage of the vessels is not *** addition, we found-that Gαs depletion blocks the S1PR1-activation induced VE-cadherin stabilization at junctons,supporting that Gαs acts downstream of S1PR1 signaling ThuS, our results demonstrate that Gαs is an essential mediator to relay S1PR1 signaling and maintain vascular integrity.

关键词： Gαs VE-eadherin S1PR1 signaling adherens junctions vascular integrity

The interaction effect between advanced paternal age and paternal obesity is associated with the low implantation rate in couples with unexplained recurrent pregnancy loss

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 197-204页

作者： Shuo li Yaqian Shen Yueting Zhu hongchang li Wenjie Jiang Junhao Yan Zi-Jiang Chen Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinanShandong250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinanShandong250012China Shandong Key Laboratory of Reproductive Medicine JinanShandong250012China Shandong Provincial Clinical Research Center for Reproductive Health JinanShandong250012China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinanShandong250012China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai200135China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200135China

Objective:To explore the roles of advanced paternal age(APA)and abnormal paternal weight on embryo quality and pregnancy outcomes for unexplained recurrent pregnancy loss(uRPL)couples who underwent preimplantation genetic testing for aneuploidies(PGT-A).Methods:This study included 779 uRPL couples who underwent their first PGT-A cycles between 2014 and *** patients’aging and nutritional status were quantified by paternal age and body mass index(BMI).Routine semen parameters and sperm DNA fragmentation index(DFI)were used to reflect the seminal *** formation rate and aneuploidy rate were used to reflect the embryo *** cancellation rate,implantation rate,pregnancy loss rate,and live birth rate were measured to evaluate the treatment efficiency from *** remove the interference of maternal age,only the women younger than 38 years old were *** univariate screening,interaction tests were performed in a generalized linear model(GLM)to further examine the effects of paternal age and BMI on each outcome ***:In the total population(779 cycles),there were no statistical differences in aneuploidy rate,cycle cancellation rate,implantation rate,pregnancy loss rate,and live birth rate,whether stratified by paternal age or paternal *** results occurred in the younger men(lity,progressive motility,and total motile sperm count),implantation rate,and live birth *** interaction testing,the results of GLM suggested that the interaction effect between APA and paternal obesity was associated with the low implantation rate of uRPL ***:For the uRPL couples seeking for PGT-A treatment,if the male patients have both advanced age and obesity,their spouses are at higher risks for embryo implantation failure

关键词： Advanced paternal age Implantation rate live birth rate Obesity Preimplantation genetic test Unexplained recurrent pregnancy loss

Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy

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Chinese Chemical Letters 2022年第9期33卷 4339-4344页

作者： Chunlei Wu Yanyan li Zhehong Cheng Pengxin Wang Zhilong Ma Ke liu Yulian Cheng Yimin Zhou Xian lin Ximing Shao Yong Yang hongchang li lijing Fang Guangdong Key Laboratory of Nanomedicine Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China

Riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural photosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by its poor cellular *** this study,using cell-penetrating peptides Arg8,(Cha-Arg)3 and small molecule triphenylphosphine(TPP)as delivery compounds,three RF conjugates were prepared to increase the accumulation of RF in cells,termed as Arg8-RF,(Cha-Arg)3-RF and TPP-RF,*** with TPP-RF and Arg8-RF,(Cha-Arg)3-RF exhibited better cell internalization and stronger cytotoxicity against HeLa cells upon exposure to blue *** researches proved that(Cha-Arg)3-RF generated reactive oxygen species(ROS)under irradiation,which could indiscriminately destroy endogenous proteins and mitochondria,ultimately inducing cell *** work provides a new approach to explore RF as a natural photosensitizer for antitumor photodynamic therapy.

关键词： Riboflavin Antitumor Photodynamic therapy Cell-penetrating peptides

Synchronous injection-production energy replenishment for a horizontal well in an ultra-low permeability sandstone reservoir: A case study of Changqing oilfield in Ordos Basin, NW China

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Petroleum Exploration and Development 2020年第4期47卷 827-835页

作者： WANG Jing liU Jungang li Zhaoguo li hongchang ZHANG Jiaosheng li Wenqing ZHANG Yuanli PING Yi YANG Huanying WANG Ping Exploration and Development Research Institute of PetroChina Changqing Oilfield Company Xi’an 710018China National Engineering Laboratory for Exploration and Development of Low-Permeability Oil&Gas Fields Xi’an 710018China

It is difficult to build an effective water flooding displacement pressure system in the middle section of a horizontal well in an ultra-low permeability sandstone *** solve this problem,this study proposes to use packers,sealing cannula and other tools in the same horizontal well to inject water in some fractures and produce oil from other *** new energy supplement method forms a segmental synchronous injection-production system in a horizontal *** method can reduce the distance between the injection end and the production end,and quickly establish an effective displacement *** the displacement between wells to displacement between horizontal well sections,and point water flooding to linear uniform water flooding,the method can enhance water sweeping volume and shorten waterflooding response *** research shows that:(1)In the synchronous injection and production of horizontal well in an ultra-low-permeability sandstone reservoir,the water injection section should select the section where the natural fractures and artificial fractures are in the same direction or the section with no natural fractures,and the space between two sections should be 60?80 m.(2)In addition to controlling injection pressure,periodic water injection can be taken to reduce the risk of re-opening and growth of natural fractures or formation fracture caused by the gradual increase of water injection pressure with water injection going on.(3)Field tests have verified that this method can effectively improve the output of single well and achieve good economic benefits,so it can be widely used in the development of ultra-low permeability sandstone reservoirs.

关键词： ultra-low permeability reservoir sandstone reservoir horizontal well staged fracturing synchronous injection-production intersegment displacement development effect

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Analysis of Wholesome Elements and Heavy Metals in Red Soybean by Inductively Coupled Plasma Mass Spectrometry

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American Journal of Analytical Chemistry 2019年第4期10卷 137-142页

作者： Hui li Xia Lei hongchang li Yunchu Hu Ruizhi Wen School of Sciences Central South University of Forestry & Technology Changsha China

Objective: To study wholesome elements and heavy metals in red soybean of Heilongjiang Province. Methods: Samples preparation with hydrodigestion, and twenty-four elements quantitative analysis in red soybean by inductively coupled plasma mass spectrometry technique (ICP-MS) with indium, platinum, ruthenium as internal standard. Results: The red soybean contained many elements necessary to human health, the sequence of elements (higher than mg/kg) was K > Mg > Ca > Fe ≈ Zn > Na > Mn > Ti > Cu > Sr ≈ Ni > Ba > Mo. Besides the trace elements, the contents of heavy metals were very low than National standard. With reference standard substance and added standard recovery for the quality control of analytical method, the results were credibility, recovery 85% - 114%, the detect limit 0.2 - 20 ng/g, linearity range 0 - 200 μg/g (r > 0.999), RSD (n = 6) Conclusion: The established method could be applied to the element quantitative analysis in food, simple and high sensitivity.

关键词： ICP-MS Red Soybean Wholesome Elements Heavy Metals

lipopolysaccharide “Two-hit” Induced Refractory Hypoxemia Acute Respiratory Distress Model in Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第4期29卷 470-475页

作者：李玉梅卫洪昌 Department of Pathology College of Basic MedicinesShanghai University of Traditional Chinese Medicine

To establish a stable and reliable model of refractory hypoxemia acute respiratory distress syndrome （ARDS） and examine its pathological mechanisms, a total of 144 healthy male Wistar rats were randomized into 4 groups： group Ⅰ （saline control group）, group Ⅱ （LPS intravenous ＂single-hit＂ group）, group Ⅲ （LPS intratracheal ＂single-hit＂ group） and Group IV （LPS ＂two-hit＂ group）. Rats were intravenously injected or intratracheally instilled with a large dose of LPS （10 mg/kg in 0.5 mL） to simulate a single attack of ARDS, or intraperitoneally injected with a small dose of LPS （1 mg/kg） followed by tracheal instillation with median dose of LPS （5 mg/kg） to establish a ＂two-hit＂ model. Rats in each group were monitored by arterial blood gas analysis and visual inspection for three consecutive days. Arterial blood gas values, lung wet/dry weight ratio and pathological pulmonary changes were analyzed to determine the effects of each Ali/ARDS model. Concentrations of TNF-α, IL-1 and IL-10 in the bronchoalveolar lavage fluid （BALF） and blood plasma were meastired by using enzyme-linked immunosorbent assays （EliSA）. Our resulsts showed that single LPS-stimulation, whether through intravenous injection or tracheal instillation, could only induce ALl and temporary hypoxemia in rats. A two-hit LPS stimulation induces prolonged hypoxemia and specific pulmonary injury in rats, and is therefore a more ideal approximation of ARDS in the animal model. The pathogenesis of LPS two-hit-induced ARDS is associated with an uncontrolled systemic inflammatory response and inflammatory injury. It is concluded that the rat ARDS model produced by our LPS two-hit method is more stable and reliable than previous models, and closer to the diagnostic criteria of ARDS, and better mimics the pathological process of ARDS.

关键词： acute respiratory distress syndrome (ARDS) acute lung injury (ALl) lipopolysaccharide (LPS) rat animal model systemic inflammatory response syndrome (SIRS) tumor necrosis factor-α (TNF-α) IL- 1 IL- 10