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Autophagy modulates CD4^(+) T-cell lineage recommitment upon pathogen infection

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Cellular & Molecular Immunology 2020年第7期17卷 682-683页

作者： Kai Yang hongbo chi Department of Pediatrics and the Herman B Wells Center for Pediatric Research Indiana University School of MedicineIndianapolisINUSA Department of Microbiology and Immunology Indiana University School of MedicineIndianapolisINUSA Department of Immunology St.Jude Children’s Research HospitalMemphisTNUSA

The thymus provides specialized signals that support and guide the development of precursor cells into various T-cell lineages,including conventionalαβT cells comprising the CD4^(+) and CD8^(+) T-cell subsets that are key mediators of adaptive *** the thymus,a complex network of persistent T-cell receptor(TCR)activation,cytokine signals,and transcription factors dictates the development of CD4^(+) and CD8^(+) T cells.1 The fate commitment of CD4^(+) and CD8^(+) T-cell lineages is reciprocally orchestrated by the ThPOK-and Runx3-dependent transcriptome.2,3 In the periphery,mature CD4^(+) or CD8^(+) T cells are activated by specific antigens bound to major histocompatibility complex class II(MHC-II)or I(MHC-I),respectively,which facilitates their clonal expansion and effector function in defense against pathogen *** the dichotomy of CD4 and CD8 lineage decisions is considered to be stable in mature T cells,whether and how pathogens reprogram lineage commitment during an immune response remain *** this issue of Cellular and Molecular Immunology,4 Robins et *** that Vps34/Atg7-dependent autophagy inhibits the generation of MHC-II-restricted CD4−CD8^(+) T cells by restraining Runx3 expression in effector CD4^(+) T cells upon pathogen infection(Fig.1).

关键词： Runx3 lineage infection

Regulation of TH17 cell differentiation by innate immune signals

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Cellular & Molecular Immunology 2012年第4期9卷 287-295页

作者： Gonghua Huang Yanyan Wang hongbo chi Department of Immunology St Jude Children's Research Hospital Memphis TN USA

Upon antigen stimulation, naive T helper cells differentiate into distinct lineages to attain specialized properties and effector functions. TH17 cells, a recently identified lineage of CD4＋ effector T cells, play a key role in the immune defense against fungi and extracellular bacteria, but also contribute to the pathogenesis of many autoimmune conditions. The differentiation of TH 17 cells is orchestrated by an intricate network of signaling pathways and transcriptional regulators in T cells. While the involvement of T cell-intrinsic pathways has been described extensively, we are just beginning to appreciate how TH17 cell development is shaped by extrinsic pathways, espec- ially the innate immune signals. Dendritic cells （DCs）, the most important cell type to bridge innate and adaptive immunity, drive TH17 cell differentiation by providing antigenic, costimulatory and cytokine signals. This is mediated by the recognition of innate and inflam- matory signals by DCs via pattern recognition receptors, cytokine receptors and other immunomodulatory receptors that in turn activate the intracellular signaling network. In particular, p38a MAP kinase has emerged as a critical pathway to program DC-dependent TH17 cell differentiation by integrating multiple instructive signals in DCs. Here, we summarize the current knowledge on the mechanisms by which DC-derived innate immune signals drive TH17 cell differentiation.

关键词： dendritic cells innate immunity MAPK T-cell differentiation TH17 cells

Helper T cell differentiation

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Cellular & Molecular Immunology 2019年第7期16卷 634-643页

作者： Jordy Saravia Nicole M.Chapman hongbo chi Department of Immunology St.Jude Children’s Research HospitalMemphisTNUSA

CD4^(+)T helper cells are key regulators of host health and *** the original model,specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)T-cell ***,we first discuss CD4^(+)T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper *** next describe the mechanisms underlying CD4^(+)T-cell differentiation,including cytokine-induced signaling and transcriptional *** then review current and emerging topics of differentiation,including the plasticity and heterogeneity of T cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate ***,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity.

关键词： T cells Treg differentiation plasticity immunometabolism

mTOR signaling and metabolic control of T cell fate decisions

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mTOR signaling and metabolic control of T cell fate decision...

Sin1-mTORC2 signaling drives glycolysis of devetoping thymocytes

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作者： hongbo chi Department of Immunology St Jude Children’s Research Hospital

Coordination of T cell metabolic programs with cell fate decisions is a fundamental issue in adaptive *** antigen stimulation,na?ve T cells exit quiescence and undergo clonal expansion and differentiation into functional effector cells,after which they either die through apoptosis or survive as memory cells.T cells at different activation stages exhibit distinct metabolic *** evidence highlights the mechanistic target

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Journal of Molecular Cell Biology 2019年第2期11卷 91-92页

作者： hongbo chi Department of Immunology St. Jude Children's Research Hospital Memphis TN 38105 USA

Emerging studies highlight the import-ance of metabolic reprogramming in T cell development and function, although how these processes are regulated remains to be fully understood. Recent advances in dissecting the roles of Sinl-m T0RC2 signaling in early thymocyte development provide new in sight into the dynamic in terplay between immune signaling and cell metabolism, as well as the crucial role in directi ng thymocyte pro life ration and development.

关键词： Sin1-mTORC2 thymocytes glycolysis

Tunable antiferroelectric-like polarization behavior and enhanced energy storage characteristics in symmetric BaTiO_(3)/BiFeO_(3)/BaTiO_(3) heterostructure

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Journal of Materiomics 2024年第6期10卷 1290-1298页

作者： Ying Wang Hanfei Zhu Hongyu Luo Jianting Li Yu Huan Yuyao Zhao Li Li hongbo Cheng Chao Liu Qingguo chi Jun Ouyang School of Chemistry and Chemical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China Key Laboratory of Engineering Dielectrics and Its Application(Ministry of Education) Harbin University of Science and TechnologyHarbin150080China School of Material Science and Engineering University of JinanJinan250022China State Key Laboratory of Metal Matrix Composites School of Material Sciences and EngineeringShanghai Jiao Tong UniversityShanghai200240China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) Hunan Provincial Key Laboratory of Thin Film Materials and DevicesSchool of Material Sciences and EngineeringXiangtan UniversityXiangtan411105China

The excellent energy storage performances of dielectric materials,a high energy density and efficiency,the stability in a wide range of temperature,frequency and cycling time,are surely desirable for the energy storage devices.A trade-off relationship between polarization and breakdown strength,however,limits the enhancement of energy storage properties of dielectric *** effectively boost the energy density and efficiency of dielectric capacitors,by inserting a BiFeO3 layer into the BaTiO3 film in present case,the symmetric BaTiO3/BiFeO3/BaTiO3 tri-layer film heterostructure with antiferroelectric-like characteristics was constructed based on the dual-interlayer coupling effect,what's more,its antiferroelectric-like characteristics will evolve with electric *** the tunable polarization behavior endows it with an enhanced maximum polarization but a reduced remnant one,a delayed saturation of polarization and a high breakdown strength,which are synergistically accountable for a large energy density(Wrec∼109 J/cm^(3))and a high efficiency(η∼82.6%),together with the good thermal(TR∼200℃,ΔWrecching the performance tuning of ferroelectrics,especially in enhancing their energy storage characteristics.

关键词： Antiferroelectric-like Tri-layer film heterostructure Tunable polarization behavior Interlayer coupling Energy storage

COVID-19患者血液嗜酸性粒细胞的动态变化及临床意义

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中华检验医学杂志 2021年第12期44卷 1190-1194页

作者：周凯赵新转池宏波阮金素浙江省台州医院台州恩泽医疗中心(集团)恩泽医院检验科路桥318000

目的探讨嗜酸性粒细胞在预测COVID-19疾病进程和预后中的临床意义。方法回顾性分析2020年1月22日至2月12日在台州市公共卫生中心诊治的115例COVID-19患者, 按疾病严重程度分为轻症(n=90)和重症(n=25)。115例患者中位年龄46岁, 其中男性6... 详细信息

目的探讨嗜酸性粒细胞在预测COVID-19疾病进程和预后中的临床意义。方法回顾性分析2020年1月22日至2月12日在台州市公共卫生中心诊治的115例COVID-19患者, 按疾病严重程度分为轻症(n=90)和重症(n=25)。115例患者中位年龄46岁, 其中男性65例, 女性50例。利用ROC曲线分析嗜酸性粒细胞对COVID-19患者疾病和严重程度诊断的性能;相关性分析首次嗜酸性粒细胞计数与住院时间(LOS)之间的相关性分析。使用GraphPad Prism 5和SPSS 19.0统计软件进行数据分析, 连续变量比较使用Mann-WhitneyU检验。结果入院时重症患者嗜酸性粒细胞计数低于轻症患者(P<0.001);重症患者入院1~7 d嗜酸性粒细胞计数保持在正常以下, 21~28 d嗜酸性粒细胞上升到正常水平;ROC显示嗜酸性粒细胞对COVID-19严重程度的曲线下面积(AUC)为0.781(95%CI:0.693~0.869);入院首次嗜酸性粒细胞计数与住院时长呈负相关。结论嗜酸性粒细胞减少在COVID-19重症患者辅助诊断上具有重要意义, 嗜酸性粒细胞的动态监测有助于预后判断。

关键词：新型冠状病毒肺炎嗜酸性粒细胞计数疾病进展和预后

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腹腔镜结直肠癌根治术的临床疗效评价

中国继续医学教育 2015年第2期7卷 63-64页

作者：池洪波辽宁本溪市中心医院普外肿瘤一病房 117000

目的：研究腹腔镜结直肠癌根治术的临床疗效。方法选取2011年6月-2014年6月于本院进行治疗的80例结直肠癌患者，分为对照组40例和观察组40例，对照组采用传统开腹根治术进行治疗，观察组采用腹腔镜结直肠癌根治术进行治疗，对比观察两... 详细信息

目的：研究腹腔镜结直肠癌根治术的临床疗效。方法选取2011年6月-2014年6月于本院进行治疗的80例结直肠癌患者，分为对照组40例和观察组40例，对照组采用传统开腹根治术进行治疗，观察组采用腹腔镜结直肠癌根治术进行治疗，对比观察两组患者的临床疗效。结果观察组患者的术中出血量、肛门排气时间、住院时间和并发症发生率结果均显著优于对照组，P＜0.05，差异具有统计学意义。结论腹腔镜结直肠癌根治术的临床疗效显著。

关键词：腹腔镜结直肠癌根治术传统开腹根治术

Retinoic acid signaling acts as a rheostat to balance Treg function

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Cellular & Molecular Immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar Scott N.Furlan Chrysothemis C.Brown Yu-chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey C.Rathmell hongbo chi Randolph J.Noelle Bruce R.Blazar Department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA Center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA Department of Pediatrics University of WashingtonSeattleWAUSA Fred Hutchinson Cancer Research Center SeattleWAUSA Howard Hughes Medical Institute Immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Microbiology and Immunology.Geisel School of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA Department of Immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia Departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia Cancer Center Augusta UniversityAugustaGAUSA Department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston children's Hospital and the Dana-Farber Cancer Institute BostonMAUSA Department of Immunology St.Jude Children's ResearchHospitalMemphisTNUSA

Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and ***,it is unknown how RA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T *** the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTORC1 signaling and supersuppressor ***,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-RAR ***,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA *** findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： Retinoic acid Tregulatory cells Autoimmunity Metabolism mTORC1 STAT5