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强直性脊柱炎患者血清PGLYRP-1、PTX3水平及其与炎症水平、骨密度的相关性

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检验医学与临床 2024年第20期21卷 3063-3067页

作者：田洪波汲会静胡敬暖中国中医科学院广安门医院济南医院(济南市中医医院)骨伤一科山东济南250000

目的探讨血清肽聚糖识别蛋白1(PGLYRP-1)、正五聚蛋白3(PTX3)水平及其与强直性脊柱炎(AS)患者炎症水平、骨密度(BMD)的相关性。方法选取2021年1月至2023年1月该院收治的68例AS患者作为AS组,另选取同期健康体检者68例作为非AS组。检测所... 详细信息

目的探讨血清肽聚糖识别蛋白1(PGLYRP-1)、正五聚蛋白3(PTX3)水平及其与强直性脊柱炎(AS)患者炎症水平、骨密度(BMD)的相关性。方法选取2021年1月至2023年1月该院收治的68例AS患者作为AS组,另选取同期健康体检者68例作为非AS组。检测所有研究对象血清PGLYRP-1、PTX3水平。采用Pearson相关分析AS患者血清PGLYRP-1、PTX3水平与炎症相关因子水平及不同部位处BMD的相关性。采用多因素Logistic回归分析PGLYRP-1、PTX3对AS发生的影响。结果AS组与非AS组工作状况、身高、身体质量指数、体质量、婚姻状况比较,差异均无统计学意义(P>0.05)。AS组红细胞沉降率、巴氏强直性脊柱炎疾病活动性指数评分、巴氏强直性脊柱炎功能指数评分均明显高于非AS组,差异均有统计学意义(P<0.05)。AS组PGLYRP-1、PTX3水平均高于非AS组,差异均有统计学意义(P<0.05)。AS组IL-1β、IL-6、IL-17、IL-18、TNF-α、CRP水平均高于非AS组,差异均有统计学意义(P<0.05)。AS组腰椎、股骨颈、华氏三角、股骨粗隆处的BMD显著低于非AS组(P<0.05)。AS患者血清PGLYRP-1、PTX3水平与IL-1β、IL-6、IL-17、IL-18、TNF-α、CRP水平均呈正相关(P<0.05)。AS患者血清PGLYRP-1、PTX3水平与腰椎、股骨颈、华氏三角、股骨粗隆处BMD均呈负相关(P<0.05)。多因素Logistic回归分析结果显示,PGLYRP-1、PTX3水平升高均是AS发生的独立危险因素(P<0.05)。结论AS患者血清PGLYRP-1、PTX3表达水平较高,与炎症因子水平的上升有关,且与患者不同部位BMD呈负相关,可能成为AS病情监测的有效标志物。

关键词：强直性脊柱炎肽聚糖识别蛋白1 正五聚蛋白3 炎症水平骨密度相关性

基于“一网统管、跨省通办”模式下的矿产资源综合管理平台设计与实现

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城市勘测 2024年第1期 60-63页

作者：张西军田宏博袁浩查显洋沈阳市勘察测绘研究院有限公司辽宁沈阳110004

矿产资源综合管理平台是按照国家矿产资源管理改革、矿业权审批“一网统管、跨省通办”、加强矿产资源监督监管的要求设计并开发。本系统构建了省市县三级管理的综合平台,涵盖了规划、探矿、储量、采矿、治理、监察六大矿产资源业务,建... 详细信息

矿产资源综合管理平台是按照国家矿产资源管理改革、矿业权审批“一网统管、跨省通办”、加强矿产资源监督监管的要求设计并开发。本系统构建了省市县三级管理的综合平台,涵盖了规划、探矿、储量、采矿、治理、监察六大矿产资源业务,建成了矿业权审批、资源管理、监管监察三大子系统,实现了与部、省、市相关政务系统对接,实现矿产资源全生命周期管理与网上便民服务,为矿产资源管理提供了一体化管理服务。

关键词：矿产资源矿业权监管跨省通办

Functionally Gradient Material Made by IncrementalMelting and Solidification Process

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International Journal of Minerals,Metallurgy and Materials 1999年第3期13卷 205-207页

作者： Chengchang Jia hongbo tian Tao Lin Zhimeng Guo Nobuyoshi Sasaki(Material Science and Engineering School. University of Science and Technology Beijing. Beijing, 100083. China)(CADIC Cooperation. Kawasaki, 213. Japan) Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China CADIC Cooperation Kawasaki 213 Japan

A new technique IMS (Incremental Melting and Solidification Process) has been introduced. A kind of cast steel high Mn foundry alloy gradient rnalerial was produced by this process. The microstructure and mechanical properties of the alloy were tested. Fe and Mn in the samples were measured by EPMA. The experimental results show that the content and hardness of Fe-Mn alloy vary continuously and the IMS process is an alternative way in producing metal matrix gradient material. It is possible for these materials to be made into some parts such as camshaft.

关键词： IMS process FGM melting solidification

Radiation-based immunogenic vaccine combined with a macrophage“checkpoint inhibitor”for boosting innate and adaptive immunity against metastatic colon cancers

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2247-2262页

作者： hongbo Xu Xianya Qin Yuanyuan Guo Siyu Zhao Xingxing Feng Runzan Zhang tianyi tian Li Kong Conglian Yang Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Center for Novel Drug Delivery System Wuhan 430030China Wuhan Liyuan Hospital of Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430077China

Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic ***,X-ray-induced dying tumor cells are rich in highly immunogenic tumor-associated antigens and self-generated dsDNA as potent ***,we found that the X-ray induction process can result in the excessive exposure of phosphatidylserine in cancer vaccines,which can specifically bind with the MerTK receptor on macrophages,acting as a“checkpoint”to facilitate immune silence in the tumor ***,we developed a novel strategy combining X-ray-induced cancer vaccines with UNC2250,a macrophage MerTK“checkpoint inhibitor,”for treating peritoneal carcinomatosis in colon *** incorporating UNC2250 into the treatment regimen,immunosuppressive efferocytosis of macrophages,which relies on MerTK-directed recognition of phosphatidylserine on vaccines,was effectively ***,the immune analysis revealed that this combination strategy promoted the maturation of dendritic cells and M1-like repolarization of macrophages,thereby simultaneously eliciting robust adaptive and innate *** innovative approach utilizing X-ray-induced vaccines combined with a checkpoint inhibitor may provide valuable insights for developing effective cancer vaccines and immunotherapies targeting colon cancer.

关键词： Immunogenic cell death Cancer vaccine X-ray Efferocytosis Macrophage STING Adaptive immunity Innate immunity

Pushing the high-k scalability limit with a superparaelectric gate layer

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Journal of Advanced Ceramics 2024年第4期13卷 539-547页

作者： Kun Wang Chao Liu Yuan Zhang Fuyu Lv Jun Ouyang Houbing Huang Rui-Long Yang Yu-Yao Zhao hongbo Cheng Hanfei Zhu Xiaoming Shi Yun tian Institute of Advanced Energy Materials and Chemistry Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China Advanced Research Institute of Multidisciplinary Science and School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China

To meet the expectation set by Moore’s law on transistors,the search for thickness-scalable high dielectric constant(k)gate layers has become an emergent research *** investigations have failed to solve the“polarizability–scalability–insulation robustness”*** this work,we show that this trilemma can be solved by using a gate layer of a high k ferroelectric oxide in its superparaelectric(SPE)*** the SPE,its polar order becomes local and is dispersed in an amorphous matrix with a crystalline size down to a few nanometers,leading to an excellent dimensional scalability and a good field-stability of the k *** an example,a stable high k value(37±3)is shown in ultrathin SPE films of(Ba_(0.95),Sr_(0.05))(Zr_(0.2),Ti_(0.8))O_(3)deposited on LaNiO_(3)-buffered Pt/Ti/SiO_(2)/(100)Si down to a 4 nm thickness,leading to a small equivalent oxide thickness of~0.46 *** aforementioned characteristic microstructure endows the SPE film a high breakdown strength(~10.5 MV·cm^(−1)for the 4 nm film),and hence ensures a low leakage current for the operation of the complementary metal oxide semiconductor(CMOS)***,a high electrical fatigue resistance is displayed by the SPE *** results reveal a great potential of superparaelectric materials as gate dielectrics in the next-generation microelectronics.

关键词： high-k transistors Moore's law superparaelectric insulation robustness

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服务质量约束下的虚拟集群资源分配策略研究

高技术通讯 2012年第7期22卷 683-688页

作者：刘菲菲董小社田红波西安交通大学计算机科学与技术系西安710049 武警工程大学通信工程系西安710086

为了有效实现基于虚拟机技术的高性能计算环境资源调度与分配，以满足用户不同服务质量请求，提出了一种动态可调节的资源分配策略。该策略以用户任务被放缓程度为核心指标，并允许用户根据该指标提出相应的服务质量约束，从资源提供者... 详细信息

为了有效实现基于虚拟机技术的高性能计算环境资源调度与分配，以满足用户不同服务质量请求，提出了一种动态可调节的资源分配策略。该策略以用户任务被放缓程度为核心指标，并允许用户根据该指标提出相应的服务质量约束，从资源提供者的角度保证了用户获得相关服务的开销最低，同时总的资源收益最大。对该分配模式下的静态资源分配问题进行了形式化的描述，并结合该策略提出混合背包算法。实验结果表明：面对大规模应用时，该算法较其它一般性算法更易得到效能较优的资源分配方案。

关键词：资源分配虚拟集群服务质量(QoS)

Dynamic metabolite QTL analyses provide novel biochemical insights into kernel development and nutritional quality improvement in common wheat

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Plant Communications 2024年第5期5卷 42-56页

作者： Bo Yin Jingqi Jia Xu Sun Xin Hu Min Ao Wei Liu Zhitao tian hongbo Liu Dongqin Li Wenfei tian Yuanfeng Hao Xianchun Xia Nir Sade Yariv Brotman Alisdair RFernie Jie Chen Zhonghu He Wei Chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China National Wheat Improvement Center Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijingChina School of Plant Sciences and Food Security The Institute for Cereal Crops ImprovementTel Aviv UniversityTel Aviv 69978Israel Max Planck Institute of Molecular Plant Physiology 14476 Potsdam-GolmGermany Yazhouwan National Laboratory Sanya 572025China

Despite recent advances in crop metabolomics,the genetic control and molecular basis of the wheat kernel metabolome at different developmental stages remain largely ***,we performed widely tar-geted metabolite profiling of kernels from three developmental stages(grain-filling kernels[FKs],mature kernels[MKs],and germinating kernels[GKs])using a population of 159 recombinant inbred *** de-tected 625 annotated metabolites and mapped 3173,3143,and 2644 metabolite quantitative trait loci(mQTLs)in FKs,MKs,and GKs,*** 52 mQTLs were mapped at all three stages,indicating the high stage specificity of the wheat kernel *** candidate genes were functionally vali-dated by in vitro enzymatic reactions and/or transgenic approaches in wheat,three of which mediated the tricin metabolic ***ﬂux efficiencies within the tricin pathway were evaluated,and su-perior candidate haplotypes were identified,comprehensively delineating the tricin metabolism pathway in ***,additional wheat metabolic pathways were re-constructed by updating them to incorporate the 177 candidate genes identified in this *** work provides new information on variations in the wheat kernel metabolome and important molecular resources for improvement of wheat nutritional quality.

关键词： mQTL wheat kernel development gene validation nutritional quality wheat

Physical Prior-Guided Semi-Supervised Variable Selection and Relative Contribution Localization Network for Key Performance Indicator Process Monitoring

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Physical Prior-Guided Semi-Supervised Variable Selection and...

第35届中国过程控制会议

作者： Hongyu tian Zhengheng Ding hongbo Shi School of Information Science and Engineering East China University of Science and Technology

With the advancement of modern industry, the coupling and information interaction among process variables have become increasingly complex. Current key-performance-indicators-related(KPIs) process monitoring methods typically assume that the training data is sufficient and ignore the scarcity of labeled data. Additionally, not all variables are correlated with KPIs, making it inappropriate to use all variables to construct statistic for fault detection and to directly locate faults using contribution plots. To solve the above problems, we propose semi-supervised KPIs generation and faulty variable localization methods. Firstly, a physical prior-guided KPIs generation method is proposed for combining unsupervised learning and supervised learning for KPIs under the guidance of physical knowledge. Secondly, a relative contribution plot method for relevant variables is proposed for fault variable localization through the hierarchical correlation calculation of process variables and KPIs. Finally, the experiment validates the monitoring and localization performance of the proposed method in the industrial case.

关键词： Semi-supervised Learning Process Monitoring Physical Prior Variable Selection

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基于辅助粒子滤波的盲多用户检测快速算法

西安交通大学学报 2007年第6期41卷 636-639页

作者：田红波殷勤业张红邓科西安交通大学电子与信息工程学院

针对粒子滤波在盲多用户检测中计算复杂的问题，构建了一种低复杂度的辅助粒子滤波盲多用户检测快速算法．在同步快变平衰落信道下，该算法对超过门限数目的粒子进行分类，并以匹配滤波检测器的检测值作为相应类别粒子权系数的加速依据... 详细信息

针对粒子滤波在盲多用户检测中计算复杂的问题，构建了一种低复杂度的辅助粒子滤波盲多用户检测快速算法．在同步快变平衰落信道下，该算法对超过门限数目的粒子进行分类，并以匹配滤波检测器的检测值作为相应类别粒子权系数的加速依据，以不同类别粒子的概率差闽值及匹配滤波检测器的检测值作为粒子滤波所需粒子数目是否足够的判断准则，自动调节不同情况下所需的粒子数目，通过降低粒子数目来降低粒子滤波盲多用户检测算法的计算复杂度．仿真结果表明，辅助粒子滤波快速算法在多用户检测性能上可与原粒子滤波算法相比拟，且计算量可降低30％～40％．

关键词：辅助粒子滤波盲多用户检测快速算法计算复杂度