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Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy

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Biomedical and Environmental Sciences 2015年第3期28卷 206-213页

作者： JIANG Wei LIU Tuo DONG Hui XU Yan LIU Li qiu GUAN Guang Ju LIU Xiang Chun Department of Nephrology The Affiliated Hospital of Qingdao University National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and Prevention Department of Nephrology The Second Hospital of Shandong University

Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA： 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly（P〈0.05）, while the plasma level of albumin decreased significantly（P〈0.05）; The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group（P〈0.01）. Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased.

关键词： Hepatitis B virus Nephritis Pathology Proteinuria Lamivudine Adefovir dipivoxil

End-group modulation of phenazine based non-fullerene acceptors for efficient organic solar cells with high open-circuit voltage

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Journal of Energy Chemistry 2024年第1期88卷 461-468,I0011页

作者： Yahui Zhang Yafeng Li Ruixiang Peng Yi qiu Jingyu Shi Zhenyu Chen Jinfeng Ge Cuifen Zhang Zheng Tang Ziyi Ge School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Zhejiang Business Technology Institute Ningbo 315012ZhejiangChina Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201ZhejiangChina Center for Advanced Low-dimension Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Phenazine-based non-fullerene acceptors(NFAs)have demonstrated great potential in improving the power conversion efficiency(PCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increasing optical absorption,refining energy levels,and improving molecular packing in organic ***,a series of NFAs(Pz IC-4H,Pz IC-4F,Pz IC-4Cl,Pz IC-2Br)with phenazine as the central core and with/without halogen-substituted(dicyanomethylidene)-indan-1-one(IC)as the electron-accepting end group were synthesized,and the effect of end group matched phenazine central unit on the photovoltaic performance was systematically *** photophysical and morphological analyses revealed that the PM6:Pz IC-4F blend involves efficient exciton dissociation,higher charge collection and transfer rates,better crystallinity,and optimal phase ***,OSCs based on PM6:Pz IC-4F as the active layer exhibited a PCE of 16.48%with an open circuit voltage(Voc)and energy loss of 0.880 V and 0.53 e V,***,this work demonstrated a promising approach by designing phenazine-based NFAs for achieving high-performance OSCs.

关键词： Organic solar cells Non-fullerene acceptor Phenazine Central core End group

The impact of^(60)Co-γirradiation on the chemical constituents of Chuanxiong Rhizoma

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Traditional Medicine Research 2024年第1期9卷 23-32页

作者： Ting-Ting Zhu Wei-Shan qiu Rui Gu Shi-Hong Zhong School of Pharmacy Southwest Minzu UniversityChengdu 610041China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China

Background:In order to clarify the inmpat ofγirradiation on the chemical composition of traditional Chinese medicine,this paper carefully choosed Chuanxiong Rhizoma to carry on a demonstration ***:Through a meticulous assessment,a comprehensive comparison was made between the irradiated and unirradiated Chuanxiong Rhizoma *** property characteristics were investigated by colorimeter and electronic *** changes in chemical structures and contents was analyzed by fourier infrared spectroscopy,high performance liquid chromatography and *** a quest to uncover the presence of any new radiolysis products,cutting-edge techniques like ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry and gas chromatography-mass spectrometry were ***,the difference of antioxidant activity were ***:The irradiation doses within 12 kGy had no significant effects on the content of the main chemical components,characteristics and in vitro antioxidant activity of Chuanxiong Rhizoma,while changes in some functional groups and degradation of some volatile oil components containing olefins need further ***:This study indicates that^(60)Co-γirradiation is a stable method for sterilization of Chuanxiong ***’s also provide a reference for the establishment of irradiation standards for Chuanxiong Rhizoma and other aromatic medicinal plants.

关键词： ^(60)Co-γirradiation Chuanxiong Rhizoma chemical component comprehensive evaluation

Design and Evaluation of a Differential Accelerometer for Drop-Tower Equivalence Principle Test with Rotating Masses

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Chinese Physics Letters 2017年第10期34卷 13-17页

作者： Feng-Tian Han Tian-Yi Liu Xiao-Xia He qiu-Ping Wu Department of Precision Instrument Tsinghua University Beijing 100084

A differential accelerometer comprising of two rotating masses made of the same material is proposed for drop tower-based free-fall testing of the spin-spin force between the rotating mass and the Earth. The measurement is performed by placing the two concentric masses of very different momenta in a vacuum drop capsule which is falling freely in the Earth＇s gravitational field. A nonzero output of the differential aeeelerometer is an indication of possible violation of new equivalence principle （NEP）. We present the conceptual design of a modified free-fall NEP experiment which can be performed at the Belting drop tower. Design and evaluation of the differential accelerometer with a hybrid electrostatic/magnetic suspension system are presented to accommodate for operation on ground and drop-tower tests. Details specific to the measurement uncertainty are discussed to yield an NEP test accuracy of 7.2×10^-9.

关键词： TM Design and Evaluation of a Differential Accelerometer for Drop-Tower Equivalence Principle Test with Rotating Masses NEP

HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila

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Journal of Molecular Cell Biology 2019年第2期11卷 170-181页

作者： Chen qiu Yu Zhang Yu-Jie Fan Ting-Lin Pang Yan Su Shuai Zhan Yong-Zhen Xu CAS Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China University of Chinese Academy of Sciences Shanghai 200032 China CAS Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai 200032 China CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences Shanghai 200032 China

Serine/arginine (SR)-rich proteins are critical for the regulation of alternative splicing (AS), which generates multiple mRNA isoforms from one gene and provides protein diversity for cell differentiation and tissue development. Genetic evidence suggests that Drosophila genital-specific overexpression of SR-related nuclear matrix protein of 160 kDa (SRml60), an SR prot&n with a PWI RNA-binding motif, causes defective development only in male flies and results in abnonnal male genital structures and abnormal testis. However, the molecular characterization of SRm160 is limited. Using the high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) method in two sex-specific embryonic cell lines, S2 from the male and Kc from the female, we first identified the genome-wide RNA-binding characteristics of SRm160, which preferred binding to the exonic tri-nucleotide repeats GCA and AAC. We then validated this binding through both in vitro gel-shift assay and in vivo splicing of minigenes and found that SRm160 level affects AS of many transcripts. Furthermore, we identified 492 differential binding sites (DBS) of SRm160 varying between the two sex-specific cell *** these DBS-containing genes, splicing factors were highly enriched, including transformer, a key regulator in the sex determination cascade. Analyses of fly mutants demonstrated that the SRm160 level affects AS isoforms of transformer. These findings shed crucial light on SRm160's RNA-binding specificity and regulation of AS in Drosophila sex determination and development.

关键词： SR protein SRm160 HITS-CLIP RNA-binding motif Drosophila sexual development

Octadecylamine and glucose-coderived hydrophobic carbon dots-modified porous silica for chromatographic separation

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Chinese Chemical Letters 2021年第11期32卷 3398-3401页

作者： Jia Chen Ning Yuan Danni Jiang Qian Lei Bei Liu Weiyang Tang Kyung Ho Row Hongdeng qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Laboratory on Pollution Monitoring and Control College of Chemistry and Chemical EngineeringXinjiang Normal UniversityUrumqi 830054China School of Chemistry and Chemical Engineering Cannan Normal UniversityCanzhou 341000China Department of Chemistry and Chemical Engineering Education and Research Center for Smart Energy and MaterialsInha UniversityIncheon 402-701Republic of Korea College of Chemistry Zhengzhou UniversityZhengzhou 450001China

A hydrophobic carbon dots(Glc-OCDs)derived from octadecylamine and glucose were successfully synthesized for the first time and then grafted onto the porous silica surface by the“Nano-on-Micro”strategy,which was served as a new stationary phase(Sil-Glc-OCDs)for reversed-phase liquid *** structure of this stationary phase was carefully verified by laser scanning confocal microscope,Fourier transform infrared spectrometry,elemental analysis,contact angle measurement,*** analytes including seven polycyclic aromatic hydrocarbons,eight alkylbenzenes,eight phenols and seven sulfonamides can be well separated on this stationary *** separation performance for certain analytes over commercial C_(18) column was ***,this stationary phase exhibited excellent chromatographic selectivity in the separation of the isomers of tert‑butylbenzene,sec‑butylbenzene,isobutylbenzene and *** addition,this new Sil-Glc-OCDs column was also applied for detection of calycosin-7-glucoside,ononin,calycosin,formononetin,genistein and isorhamnetin in the extract of Radix Astragali,which were found that the concentration was 0.15 g/L,0.088 g/L,0.14 g/L,0.086 g/L,0.18 g/L and 0.29 g/L,*** believe that this CDs-grafted silica materials are promising for chromatographic separation.

关键词： Carbon dots Stationary phase Chromatographic separation Liquid chromatography Deep eutectic solvents

Endoscopic transsphenoidal approach to pituitary adenomas invading the cavernous sinus

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Chinese Medical Journal 2010年第24期123卷 3519-3523页

作者： TAO Yu-xin QU qiu-yi WANG Zhen-lin ZHANG qiu-hang Department of Otolaryngology-Head and Neck Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Background Surgery of pituitary adenomas invading cavernous sinus has always been thought as a challenge due to the complex anatomical structures and high risk of complications. The purpose of this study was to evaluate endoscopic trarssphenoidal approach to pituitary adenomas invading cavernous *** The clinical data of 22 patients who admitted to Xuanwu Hospital with pituitary adenomas invading cavernous sinus were analyzed retrospectively. All patients underwent endoscopic transsphenoidal surgery. To expose the surgical field sufficiently, the opening of sellar floor was exceeded the bone overlying the invaded cavernous sinus, and synthetic dura was used to repair and strengthen the sella floor for preventing the leak of cerebrospinal *** Among 22 patients, total resection was achieved in 14, subtotal resection in 5, and partial resection in 3; no patient underwent insufficient resection. Visual symptoms improved in 7 of 9 patients. In one patient diplopia *** was relieved to various extents in all patients. No serious complications were found. Patient＇s hospital stay ranged from 7 to 20 *** These data suggest that the endoscopic transsphenoid approach is a safe, minimally invasive, and efficient surgical technique, which might be an important therapeutic strategy for the pituitary adenoms invading cavernous sinus.

关键词： endoscopy pituitary adenorna cavernous sinus invasion

Proteomics and Metabolomics of Arabidopsis Responses to Perturbation of Glucosinolate Biosynthesis

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Molecular Plant 2012年第5期5卷 1138-1150页

作者： Ya-zhou Chen qiu-Ying Pang Yan He Ning Zhu Isabel Branstrom Xiu-Feng Yan Sixue Chen Department of Biology Genetics Institute Plant Molecular and Cellular Biology Program University of Florida Gainesville FL 32610 USA Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field Northeast Forestry University Harbin 150040 China Interdisciplinary Center for Biotechnology Research (ICBR) University of Florida Gainesville FL 32610 USA

To understand plant molecular networks of glucosinolate metabolism, perturbation of aliphatic glucosinolate biosynthesis was established using inducible RNA interference （RNAi） in Arabidopsis. Two RNAi lines were chosen for examining global protein and metabolite changes using complementary proteomics and metabolomics approaches. Pro- teins involved in metabolism including photosynthesis and hormone metabolism, protein binding, energy, stress, and defense showed marked responses to glucosinolate perturbation. In parallel, metabolomics revealed major changes in the levels of amino acids, carbohydrates, peptides, and hormones. The metabolomics data were correlated with the pro- teomics results and revealed intimate molecular connections between cellular pathways/processes and glucosinolate me- tabolism. This study has provided an unprecedented view of the molecular networks of glucosinolate metabolism and laid a foundation towards rationale glucosinolate engineering for enhanced defense and quality.

关键词： Arabidopsis thaliana RNAi glucosinolate perturbation proteomics metabolomics molecular networks.

Computational Medicine:Past,Present and Future

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Chinese Journal of Integrative Medicine 2022年第5期28卷 453-462页

作者： LYU Lan-qing CUI Hong-yan SHAO Ming-yi FU Yu ZHAO Rui-xia CHEN qiu-ping The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou(450003)China

Computational medicine is an emerging discipline that uses computer models and complex software to simulate the development and treatment of *** in computer hardware and software technology,especially the development of algorithms and graphics processing units(GPUs),have led to the broader application of computers in the medical *** vision based on mathematical biological modelling will revolutionize clinical research and diagnosis,and promote the innovative development of Chinese medicine,some biological models have begun to play a practical role in various types of *** paper introduces the concepts and characteristics of computational medicine and then reviews the developmental history of the field,including Digital Human in Chinese ***,this study introduces research progress in computational medicine around the world,lists some specific clinical applications of computational medicine,discusses the key problems and limitations of the research and the development and application of computational medicine,and ultimately looks forward to the developmental prospects,especially in the field of computational Chinese medicine.

关键词： computational medicine model computational Chinese medicine artificial intelligence big data