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Risk Assessment of Food Allergens

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China CDC weekly 2022年第34期4卷 771-774页

作者： hongbing chen Yongning Wu State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang CityJiangxi ProvinceChina Sino-German Joint Research Institute Nanchang CityJiangxi ProvinceChina Research Unit of Food Safety(2019RU014) Chinese Academy of Medical SciencesNHC Key Laboratory of Food Safety Risk AssessmentChina National Center for Food Safety Risk AssessmentBeijingChina

GLOBAL STRATEGIES FOR RISK ASSESSMENT OF FOOD ALLERGENS Held on the 8th of July every year,World Allergy Day is a global joint initiative launched by the World Health Organization(WHO)and the World Allergy Organization(WAO)as well as other national allergy agencies,which aims to raise the general public awareness of the importance of managing and preventing allergic *** allergies are a major source of exposure to allergens and a significant public health problem globally with increasing prevalence(1).Importantly,there is currently no effective cure for food allergies and the only strategy for preventing food allergic reactions is to practice a strict avoidance ***,implementation and adherence to a diet that is free of allergenic foods is challenging because a consumer may be allergic to more than one food or food ingredient and must face a wide variety of food choices in daily life.

关键词： allergic globally managing

Weierstrass Representation for Surfaces in the Three-Dimensional Heisenberg Group

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Chinese Annals of Mathematics,Series B 2010年第1期31卷 119-132页

作者： Qun chen hongbing QIU School of Mathematics and Statistics Wuhan University Wuhan 430072 China Corresponding author. School of Mathematical Sciences Fudan University Shanghai 200433 China

The authors define the Gauss map of surfaces in the three-dimensional Heisenberg group and give a representation formula for surfaces of prescribed mean ***,a second order partial differential equation for the Gauss m... 详细信息

关键词： Heisenberg group Mean curvature Weierstrass representation

Parametric study on contact sensors for MASW measurement-based interfacial debonding detection for SCCS

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 331-344页

作者： chen hongbing Pang Xin Gan Shiyu Li Yuanyuan Gokarna Chalise Nie Xin Research Institute of Urbanization and Urban Safety School of Civil and Resource EngineeringUniversity of Science and Technology BeijingBeijing 100083China Department of Civil Engineering Tsinghua UniversityBeijing 100084China Faculty of Infrastructure Engineering Dalian University of TechnologyDalian 116081China

Steel-concrete composite structures(SCCS)have been widely used as primary load-bearing components in large-scale civil *** the basis of the co-working ability of steel plate and concrete,the bonding status plays an essential role in guaranteeing the structural performance of ***,efficient non-destructive testing(NDT)on interfacial debondings in SCCS has become a prominent research ***-channel analysis of surface waves(MASW)has been validated as an effective NDT technique for interfacial debonding detection for ***,the feasibility of MASW must be validated using experimental *** study establishes a high-frequency data synchronous acquisition system with 32 channels to perform comparative verification experiments in ***,the current sensing approaches for high-frequency vibration and stress waves are ***,three types of contact sensors,namely,piezoelectric lead-zirconate-titanate(PZT)patches,accelerometers,and ultrasonic transducers,are selected for MASW ***,the selection and optimization of the force hammer head are *** experiments are carried out for the optimal selection of ultrasonic transducers,PZT patches,and accelerometers for MASW *** addition,the influence of different pasting methods on the output signal of the sensor array is *** results indicate that optimized PZT patches,acceleration sensors,and ultrasonic transducers can provide efficient data acquisition for MASW-based non-destructive *** research findings in this study lay a solid foundation for analyzing the recognition accuracy of contact MASW measurement using different sensor arrays.

关键词： steel-concrete composite structures(SCCS) interface debonding detection multi-channel analysis of surface waves(MASW) sensor selection comparative experimental study

Interventional effect of phycocyanin on mitochondrial membrane potential and activity of PC12 cells after hypoxia/reoxygenation

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Neural Regeneration Research 2006年第2期1卷 137-139页

作者： Nan Jiang Yunliang Guo hongbing chen Institute of Cerebrovascular Diseases Affiliated Hospital of Medical College Qingdao University Qingdao 266003Shandong Province China

BACKGROUND： Phycocyanin can relieve decrease of mitochondrial membrane potential through reducing production of active oxygen so as to protect neurons after hypoxia/reoxygenation. OBJECTIVE： To observe the effect of phycocyanin on activity of PC12 cells and mitochondrial membrane potential after hypoxia/reoxygenation. DESIGN： Randomized controlled study SETTING ： Cerebrovascular Disease Institute of Affiliated Hospital, Medical College of Qingdao University MATERIALS： The experiment was carried out at the Key Laboratory of Prevention and Cure for cerebropathia in Shandong Province from October to December 2005. PC12 cells, rat chromaffin tumor cells, were provided by Storage Center of Wuhan University; phycocyanin was provided by Ocean Institute of Academia Sinica; Thiazoyl blue tetrazolium bromide （MTT） and rhodamine 123 were purchased from Sigma Company, USA; RPMI-1640 medium, fetal bovine serum and equine serum were purchased from Gibco Company, USA. METHODS： ① Culture of PC12 cells： PC12 cells were put into RPMI-1640 medium which contained 100 g/L heat inactivation equine serum and 0.05 volume fraction of fetal bovine serum and incubated in CO2 incubator at 37℃. Number of cells was regulated to 4 × 10^5 L 1, and cells were inoculated at 96-well culture plate. The final volume was 100μL. ② Model establishing and grouping： Cultured PC12 cells were randomly divided into three groups： phycocyanin group, model control group and non-hypoxia group. At 24 hours before hypoxia, culture solution in phycocyanin group was added with phycocyanin so as to make sure the final concentration of 3 g/L , but cells in model control group did not add with phycocyanin. Cells in non-hypoxia group were also randomly divided into adding phycocyanin group （the final concentration of 3 g/L） and non-adding phycocyanin group. Cells in model control group and phycocyanin group were cultured with hypoxia for 1 hour and reoxygenation for 1, 2 and 3 hours; meanwhile, cells in non-hypo

关键词： Interventional effect of phycocyanin on mitochondrial membrane potential and activity of PC12 cells after hypoxia/reoxygenation PC

Phycocyanin for protecting brain ischemia-reperfusion injury and its effect on the expression of Caspase-3 mRNA

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Neural Regeneration Research 2006年第3期1卷 201-203页

作者： Xuewei Yang Yunliang Guo hongbing chen Institute of Cerebrovascular Disease Affiliated Hospital of Medical College of Qingdao University Qingdao 266003 Shandong Province China

BACKGROUND ; Phycecyanin can anti-oxidize and clear free radial. Whether its protective effect on brain is related to Caspase-3, the promoter and operator of apoptosis, is highly concerned. OBJECTIVE： To observe phycocyanin for protecting nerve function and reducing the size of cerebral infarction of rats with brain ischemia-reperfusion and its effect on the expression of Cespese-3 mRNA. DESIGN ： A randomized controlled experiment. SETTING ： Institute of Cerebrovascular Disease, Affiliated Hospital of Medical College of Qingdao University MATERIALS： Totally 84 adult healthy female Wistar rats, weighing 210 to 250 g, of clean grade, were provided by the Animal Experimental Center of Shandong University. Phycocyanin （Institute of Oceanography of Chinese Academy of Sciences） was used. METHODS： This experiment was carried out in the Key Laboratory for Prevention and Treatment of Brain Diseases during May to December 2005. ① The rats were randomized into sham-operation group （n=4）, control group （n=-40） and phycocyanin-treated group （n=-40）. Middle cerebral artery occlusion/reperfusion （MACO/R） models were created on the rats of control and phycocyanin-treated groups with suture-occluded method by inserting a thread into left side extemal-internal carotid artery. In the sham-operatien group, inserting suture was omitted. After ischemia for 1 hour and reperfusion for 2 hours, suspension of phycocyanin was intragastdcaUy administrated into the rats of the phycocyanin-treated group at 100 mg/kg , and the same volume of normal saline was isochrenously administrated into the rats of control group as the same. ② Six rats were chosen respectively from the control group and phycocyanin-treated group, then neurologic impairment degrees of rats were evaluated according to Bederson＇s grading. ③ Six rats were chosen respectively from the control and phycocyanin-treated groups. The isolated brain tissue was stained with tdphenyltetrazolium chloride, and then the size of cerebral infa

关键词： Phycocyanin for protecting brain ischemia-reperfusion injury and its effect on the expression of Caspase-3 mRNA

发芽粟米活性肽减轻铜诱导秀丽隐杆线虫氧化损伤及其分子机制

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食品工业科技 2025年第1期46卷 384-393页

作者：张惠琪陈晓金雪玲黎晶晶袁娟丽高金燕陈红兵武涌南昌大学食品科学与资源挖掘全国重点实验室江西南昌330047 南昌大学食品学院江西南昌330047 南昌大学中德联合研究院江西南昌330047 南昌大学第一附属医院江西南昌330006 南昌大学药学院江西南昌330047 江西省食物过敏重点实验室江西南昌330047

目的:以秀丽隐杆线虫(Caenorhabditis elegans,***)为模型,探究发芽粟米活性肽(Germinated foxtail millet bioactive peptides,GRBPs)对铜诱导的体内氧化损伤的缓解作用和相关机制。方法:将野生型N2秀丽隐杆线虫随机分为对照组、GRBPs... 详细信息

目的:以秀丽隐杆线虫(Caenorhabditis elegans,***)为模型,探究发芽粟米活性肽(Germinated foxtail millet bioactive peptides,GRBPs)对铜诱导的体内氧化损伤的缓解作用和相关机制。方法:将野生型N2秀丽隐杆线虫随机分为对照组、GRBPs组,观察喂食GRBPs对线虫接受铜刺激后运动能力和存活率的影响;通过检测活性氧(Reactive oxygen species,ROS)、谷胱甘肽(Glutathione,GSH)、过氧化氢酶(Catalase,CAT)和超氧化物歧化酶(Superoxide disumutase,SOD)活性,评估GRBPs对铜诱导线虫氧化损伤的影响;进一步,通过基因组及转录组测序技术(RNA-seq)以及非靶向代谢组学分析,探讨GRBPs的作用机制。最后对抗氧化相关基因进行逆转录和实时定量PCR(qPCR)验证。结果:GRBPs可明显提高铜刺激后线虫的存活率和运动能力;1 mg/mL浓度的GRBPs可极显著降低丙二醛(Malondialdehyde,MDA)含量(P<0.0001),增加CAT和SOD活性,同时调节特定基因(如ctl-1、ctl-2的上调和sod-1、sod-2的下调)的表达量。在基因水平上,GRBPs对线虫的影响主要是调控编码角质层结构成分和活性以及细胞色素酶P450的相关基因表达;在代谢水平上,GRBPs对线虫的影响主要是调控植物次生代谢产物的含量。结论:发芽粟米活性肽可以有效减轻铜诱导的氧化损伤,其作用机制可能是通过提高抗氧化酶活性、降低角质层和细胞色素酶P450相关基因表达和调节植物次生代谢产物的含量来实现。

关键词：发芽粟米活性肽秀丽隐杆线虫铜诱导氧化损伤

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Daylight and thermal performance of a switchable ethylene tetra-fluoro-ethylene cushion with dynamic control in different climates

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Building Simulation 2022年第1期15卷 29-40页

作者： Wanfang Zhao Wei He Zhongting Hu Xiaoyu Zheng Sheng Zhang Gaofei Xu hongbing chen Yanping Yuan Department of Building Environment and Equipment Hefei University of TechnologyHefei 230009China Anhui KEEN New Energy Co. LtdHefei 230000China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China

Switchable multi-layer ethylene tetra-fluoro-ethylene(ETFE)cushion controls the natural light and heat flux passing through the cushion with varying outdoor conditions by dynamically modifying its *** this paper,the switchable ETFE cushions with ink printing of different optical and thermal properties were adopted as the window in a typical office model,and the indoor daylight and energy consumption were simulated by using Grasshopper *** model was built to validate the numerical *** locations representing five climate zones in China were selected to analyze the feasibility of the switchable ETFE cushion in different *** hourly indoor daylight and heat gain in a single day revealed the effects of the dynamic mechanism of ETFE cushion in improving indoor natural light and thermal *** addition,the annual daylight performance at the working area(1.5 m from the window)was *** cushion with printing of the lowest transmittance(ETFE1)was the optimal option for most cities and window-to-wall ratios,with the percentage of annual useful daylight hours up to 78.6%,except for the cases where the window-to-wall ratio(WWR)was 0.35 in Harbin,Beijing,and *** distribution of useful daylight hours revealed that ETFE cushions with low,medium,and high printing transmittance were suitable for offices where people work in the front,medium,and back region of the room,*** consumption calculation revealed that ETFE1 showed advantages over other windows in most cities except for cities highly dominated by ***1 delivered up to 33%of energy saving over a year in Kunming compared with the conventional double glazing but was not superior in cities with high heating and low cooling demands,such as Harbin.

关键词： ethylene tetra-fluoro-ethylene(ETFE) useful daylight illuminance(UDI) energy consumption office building double glazing

A Methodology of Epidemiologic Study in the General Population Focusing on Food Allergy—China, 2020

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China CDC weekly 2022年第34期4卷 749-755页

作者： Hua Feng Yan chen hongbing chen chengwei Liu Wei Zhou Lianglu Wang Yongning Wu State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang CityJiangxi ProvinceChina School of Public Health Nanchang UniversityNanchang CityJiangxi ProvinceChina Research Unit of Food Safety Chinese Academy of Medical Sciences(No.2019RU014):NHC Key Laboratory of Food Safety Risk AssessmentChina National Center for Food Safety Risk Assessment(CFSA)BeijingChina Jiangxi Provincial Center for Disease Control and Prevention Nanchang CityJiangxi ProvinceChina Department of Pediatrics Peking University Third HospitalBeijingChina Department of Allergy Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina

Introduction:Adverse reactions to food(ARF)are a major worldwide public health and food safety *** the various causes of ARF,food allergies(FA)are particularly serious as the immune response that is triggered can be fatal even at very low ***,the prevalence of ARF and FA in the general population in China is presently *** study aims to determine the epidemiological characteristics and risk factors for ARF and FA,which can be a basis for estimating thresholds for major food ***:This is a multicenter,cross-sectional,epidemiologic survey with a case-control study nested among a selected population in *** individuals were recruited using stratified cluster random sampling;ARF and FA were comprehensively assessed using modified EuroPrevall FA Project questionnaires as well as structured interviews,sensitization testing,and double-blind placebocontrolled food challenges(DBPCFC).Results:This method of epidemiologic study on ARF and FA was a pilot application in Jiangxi Province from January 2020;among the total 21,273 children and adults that completed the questionnaire,5.8%reported ARF and 4.3%reported *** were determined to be associated with age,gender,and ***-derived foods were the dominant offending foods,especially shrimp,and skin symptoms were the most commonly reported ***:This is the first multi-center,largescale,epidemiologic study on ARF and FA using standardized methods,including DBPCFC,in the Chinese general *** study presents an important approach to assessing ARF and FA,provides significant insights about the prevalence of ARF and FA,and facilitates support for updating the list of allergenic food labels:which will be essential for improving ARF prevention and management in China.

关键词： prevention doses Focus

Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004–2014

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Science China(Life Sciences) 2017年第1期60卷 72-80页

作者： Jinzhang Wang hongbing chen Meng Huang Yongjun Zhang Jianfeng Xie Yansheng Yan Kuicheng Zheng Yuwei Weng Fujian Center for Disease Control and Prevention Fuzhou 350001 China College of public health Fujian Medicine University Fuzhou 350001 China

Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004–2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612(83.5%) occurred during the peak period from August to October. Additionally, 76%(190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes(I, IV, V) of DENV1, and one genotype each of DENV2(cosmopolitan) and DENV3(I) circulated in Fujian during 2004–2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.

关键词： dengue virus E gene phylogenetic tree epidemiology etiology