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Kdm6a-CNN1 axis orchestrates epigenetic control of traumainduced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

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Bone Research 2024年第2期12卷 314-333页

作者： Chengjun Li Tian Qin Jinyun Zhao Yuxin Jin Yiming Qin Rundong He Tianding Wu Chunyue Duan Liyuan Jiang Feifei Yuan hongbin lu Yong Cao Jianzhong Hu Department of Sports Medicine Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceXiangya Road 87Changsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China Department of Spine Surgery and Orthopaedics Xiangya HospitalCentral South UniversityXiangya Road 87Changsha 410008China

Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory *** extensive investigations into vascular senescence associated with aging and degenerative diseases,the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress,particularly its involvement in senescence-induced inflammation,remain insufficiently *** this study,we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury(SCI).Lysine demethylase 6A(Kdm6a),commonly known as UTX,emerges as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells(SCMECs).Upregulation of UTX induces senescence in SCMECs,leading to an amplified release of proinflammatory factors,specifically the senescenceassociated secretory phenotype(SASP)components,thereby modulating the inflammatory ***,the deletion of UTX in endothelial cells shields SCMECs against senescence,mitigates the release of proinflammatory SASP factors,and promotes neurological functional recovery after *** forms an epigenetic regulatory axis by binding to calponin 1(CNN1),orchestrating trauma-induced SCMECs senescence and SASP secretion,thereby influencing neuroinflammation and neurological functional ***,local delivery of a senolytic drug reduces senescent SCMECs and suppresses proinflammatory SASP secretion,reinstating a local regenerative microenvironment and enhancing functional repair after *** conclusion,targeting the UTX-CNN1 epigenetic axis to prevent trauma-induced SCMECs senescence holds the potential to inhibit SASP secretion,alleviate neuroinflammation,and provide a novel treatment strategy for SCI repair.

关键词： inflammation epigenetic neurological

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan hongbin lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

左氧氟沙星在水环境中的赋存、风险及降解技术研究进展

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环境污染与防治 2024年第3期46卷 392-399页

作者：卢洪斌卢少勇曾泽泉黄张根中国科学院山西煤炭化学研究所煤转化国家重点实验室山西太原030001 中国环境科学研究院湖泊水污染治理与生态修复技术国家工程实验室环境基准与风险评估国家重点实验室北京100012 北京师范大学水科学研究院北京100875

水环境中的抗生素不仅诱导微生物产生抗性基因(ARGs)及耐药细菌,而且危害生物安全,对人类生命健康产生严重威胁。氟喹诺酮类抗生素(FQs)及其引发的ARGs问题已引起国内外学者广泛关注。左氧氟沙星(LVFX)是使用最广泛的FQs之一,因生物体... 详细信息

水环境中的抗生素不仅诱导微生物产生抗性基因(ARGs)及耐药细菌,而且危害生物安全,对人类生命健康产生严重威胁。氟喹诺酮类抗生素(FQs)及其引发的ARGs问题已引起国内外学者广泛关注。左氧氟沙星(LVFX)是使用最广泛的FQs之一,因生物体代谢率低且化学结构稳定,在环境中被广泛检出。因此亟需掌握LVFX在水环境中的赋存特征,厘清其对生态环境的危害,并比较分析现有技术对其去除效果。在现有研究基础上综述了LVFX在水环境中的赋存特征,从诱导微生物产生ARGs和耐药细菌及威胁水生态安全两个方面阐述了LVFX的生态风险,系统阐述了物理法、化学法和生物法去除LVFX的效果及研究进展,分析了这些技术的优缺点,以期为高效低耗降解LVFX并抑制ARGs的传播提供一定的参考。

关键词：左氧氟沙星抗性基因环境风险处理技术

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基于GRU模型的股票价格预测

山西电子技术 2024年第1期 7-8,12页

作者：卢茜妍卢洪斌浦发银行广州分行广东广州510623 百色学院广西百色533000

利用GRU模型对输入时间序列的高效处理能力,提出了一种基于GRU模型的股票价格预测方法,在输入序列中引入价格、成交量、平滑异同移动平均指数三种股票技术参数,明显提高了GRU模型股价预测的准确度。

关键词： GRU模型股价预测时间序列深度学习

A Big Jump in Nacre-inspired Strong, Tough Composites

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Chemical Research in Chinese Universities 2020年第3期36卷 488-489页

作者： lu hongbin Department of Macrontolecular Science State Key Laboratory of Molecular EngineeringCollaborative Innovation Center of Polymers and Polymer CompositesFmian UniversityShanghai 200438P.R.China

To achieve structural order and strength-toughness balance similar to natural composites like nacre has been highly challenging,especially in a practically viable *** et *** a continuous preparation method to construct such high performance composites through a superspreading strategy at the oil/water/hydrogel *** the strong shear force at the interface,nanoparticles,such as nanosheets and nanotubes oriented and stacked together rapidly(as short as 358ms)and the composites revealed the tensile strength and fracture toughness far higher those of natural nacre(9.0 and 20.4 times higher).

关键词： composites toughness strength

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基于e-FCNN的电弧炉终点温度预报

钢铁 2024年第1期59卷 49-57页

作者：陆泓彬朱红春姜周华李花兵杨策东北大学冶金学院辽宁沈阳110819 东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110819

发展电弧炉炼钢短流程是实现钢铁工业绿色发展的重要战略途经,电弧炉炼钢的终点控制决定了出钢质量和冶炼效率,尤其是终点温度控制。建立电弧炉终点温度预测模型,提前预测终点温度,有助于及时调整冶炼工艺,实现快速、高效的出钢操作。... 详细信息

发展电弧炉炼钢短流程是实现钢铁工业绿色发展的重要战略途经,电弧炉炼钢的终点控制决定了出钢质量和冶炼效率,尤其是终点温度控制。建立电弧炉终点温度预测模型,提前预测终点温度,有助于及时调整冶炼工艺,实现快速、高效的出钢操作。电弧炉终点温度预测模型主要分为机理模型和数据驱动模型,数据驱动模型是目前的主要研究方向,但现有的数据驱动模型建模过程依赖大量历史数据,难以适用于在小样本数据条件下实现终点温度的准确预报。对此,紧密结合冶金机理,以人工智能算法为核心,建立了高适应性的电弧炉终点温度预报模型。通过冶金机理和皮尔逊数据相关性分析得到了模型的输入参数。以FCNN算法为基础,引入提前停止策略,提出了e-FCNN算法,防止了FCNN算法的过拟合现象,并基于e-FCNN算法建立了电弧炉终点温度预报模型。仿真结果表明,终点温度预报误差在±5℃以内,e-FCNN模型的命中率可以达到93.33%。另外,在小样本历史数据条件下,使用超参数随机网格搜索,建立了CART、RF、ε-SVR和v-SVR终点温度预报模型,结果表明,基于e-FCNN终点温度预报模型的精度明显优于其他机器学习模型。使用e-FCNN模型连续跟踪实际生产的30炉次,预报误差为±6℃时,命中率达到了96.7%,可以有效指导生产。未来,进一步提升机理和数据驱动的结合程度是电弧炉终点温度预报模型的发展方向。

关键词：电弧炉终点预报终点温度机器学习小样本

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电弧炉智能炼钢的研究进展

中国冶金 2024年第3期34卷 25-36页

作者：陆泓彬朱红春姜周华杨策东北大学冶金学院辽宁沈阳110819 东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110819

电弧炉炼钢因具备消纳城市废钢和低碳环保的优势而备受关注,随着人工智能、大数据技术在钢铁工业的应用和发展,以及电弧炉绿色、高效生产的需要,智能炼钢成为电弧炉未来发展的主要趋势。围绕近年来电弧炉智能炼钢核心技术,对电弧炉电气... 详细信息

电弧炉炼钢因具备消纳城市废钢和低碳环保的优势而备受关注,随着人工智能、大数据技术在钢铁工业的应用和发展,以及电弧炉绿色、高效生产的需要,智能炼钢成为电弧炉未来发展的主要趋势。围绕近年来电弧炉智能炼钢核心技术,对电弧炉电气控制、温度控制、成分控制以及配料优化4个方面的研究进展进行了综述。目前,电弧炉智能炼钢研究已经取得了一定的进展,实现了电极自动调节、电能质量智能预测、电能消耗智能预测、温度和成分自动预测、泡沫渣自动控制、废钢自动评级、配料和成本优化等技术,但仍存在控制精度较低、预测模型的鲁棒性较差等缺点。而随着生产数据的不断积累以及智能制造车间精益生产需求的提高,未来电弧炉炼钢将向生产全流程数字化监控、全自动设备控制、高精度智能预测和控制、精细化生产管控和优化等方面发展。同时,还需要进一步耦合各个环节的智能技术,提高智能炼钢技术在不同电弧炉上的适配性,降低其在生产现场的实施难度和成本,实现电弧炉生产全流程的智能控制,从而提高生产安全性、减少废气废物排放、提高生产效率、降低生产成本,实现可持续发展。

关键词：电弧炉智能炼钢电气控制温度控制成分控制配料优化

Statistics of gravity waves in the lower stratosphere over Beijing based on high vertical resolution radiosonde

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Science China Earth Sciences 2005年第9期48卷 1548-1558页

作者： BIAN Jianchun CHEN hongbin lu Daren Institute of Atmospheric Sciences Chinese Academy of Sciences Beijing 100029 China Institute of Atmospheric Sciences Chinese Academy of Sciences Beijing 100029 China Institute of Atmospheric Sciences Chinese Academy of Sciences Beijing 100029 China

The seasonal variation of inertia gravity-wave activity in the lower stratosphere (17―24 km) over Beijing is studied based on the high vertical resolution radionsonde observa- tions (from December 2001 to February 2003) of Beijing Observatory (116°28′E, 39°48′N). Some of the important gravity-wave parameters, such as intrinsic frequency, and propagation direction, are estimated according to the polarized relation among gravity-wave wind components and temperature. Time series of wave energy show that the largest wave amplitudes occur during the winter and the least during the summer, and the average of the KE:PE ratios is about 2.6. Zonal and meridional wind perturbations have almost the same roots of mean variances, which shows that the wave energy in the lower stratosphere is isotropic horizontally. The motion and tem- perature fields are dominated by waves with vertical wavelengths of 1.5―3 km, which occupy above 80% samples, with a mean value of about 2.3 km. The horizontal wavelengths are mainly distributed between 100―800 km, averaging 445 km. The ratio of the mean horizontal to vertical wavelength is about 200:1, which indicates that the wave propagates nearly horizontally, with a very small vertical angle. The intrinsic frequency is estimated by fitting a polarized ellipse to the wind perturbations after band-filtering waves with a wavelength of 1.5―3 km, and the results show that the intrinsic frequency is dominated by 1f―3.5f, with an averaging value of 2f, corre- sponding to an intrinsic time period of 9 hours. Wave energy is found to propagate mainly upward, and in the horizontal direction, there is clear azimuthal anisotropy, with predominate northwest propagation against the prevailing wind.

关键词： inertia gravity waves, lower stratosphere, polarized relation, intrinsic frequency, propagation direction.

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多波长转换及注入锁定全光3R再生技术

山西电子技术 2024年第1期 69-71页

作者：卢洪斌梁祚铨百色学院广西百色533000 广州市隆光信息技术有限责任公司广东广州511458

根据相干光注入半导体激光器产生的注入锁定和增益开关特性,提出了一种基于非简并四波混频多波长转换及注入锁定定时的全光3R再生技术,能同时实现基于NDFWM的多波长转换和信号3R再生,避免了交叉增益和交叉相位调制仅适用于单波长转换的... 详细信息

根据相干光注入半导体激光器产生的注入锁定和增益开关特性,提出了一种基于非简并四波混频多波长转换及注入锁定定时的全光3R再生技术,能同时实现基于NDFWM的多波长转换和信号3R再生,避免了交叉增益和交叉相位调制仅适用于单波长转换的限制。

关键词：注入锁定波长转换 3R再生非简并四波混频