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家族性高胆固醇血症国内外诊疗异同

中国全科医学 2025年第6期28卷 655-665页

作者：马弘阳岳岸娜孙康云南京医科大学附属苏州市立医院心血管内科江苏省苏州市215000

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型... 详细信息

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型的FH病情更为严重。全球FH的流行率逐渐受到重视,但诊断和治疗仍存在不足。借着《2023年中国血脂管理指南》的发布,本文主要比较了国内外关于FH筛查、诊断的不同,用于强调筛查血脂情况的重要性,并建议早期识别FH患者。同时,基因检测也被推荐,不仅限于少数基因,还应包含其他相关基因或全基因组检测。此外,本文也比较了不同指南对于FH患者LDL-C控制管理水平的差异,以及对于不同LDL-C划分的ASCVD危险因素新要素;比较了不同指南在饮食、生活方式、药物控制等方面的差别,指出国内外一致认为他汀类药物是主要的降脂药物,联合应用尤为重要,但对于最大剂量后LDL-C控制未达标的患者国际血脂护理指南有一定更新。同时,对于纯合型FH(HoFH)患者,高强度他汀类药物联合其他药物治疗是首选,早期的治疗更为关键,适当提早脂蛋白单采术与前蛋白转换酶枯草溶菌素9(PCSK9)抑制剂的应用有助于降低ASCVD的发病率和死亡率。

关键词：高胆固醇血症分子基础诊断诊疗方案指南差异

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基于沉浸式体验的商业空间设计构建要素研究

城市建筑 2025年第1期22卷 142-148页

作者：宋红阳彭文深圳大学艺术学部

在体验式消费的大背景下,人们对于商业空间中的个性化体验和情感价值的需求日益增强。文章从沉浸式体验的角度来研究如何打破传统商业空间的限制,深入分析消费者的体验需求,探索沉浸式体验在商业空间中的构建方式,并强调了人的体验在空... 详细信息

在体验式消费的大背景下,人们对于商业空间中的个性化体验和情感价值的需求日益增强。文章从沉浸式体验的角度来研究如何打破传统商业空间的限制,深入分析消费者的体验需求,探索沉浸式体验在商业空间中的构建方式,并强调了人的体验在空间设计中的重要性。文章通过S-O-R模型,结合沉浸式体验的理论研究,对沉浸式体验下商业空间设计构建要素进行提取,并对各构建要素之间的权重进行分析,得到了3个准则层构建要素及22个因子层构建要素的沉浸式体验模型。结合定性与定量研究,验证游客对商业空间沉浸式体验的感知评价,探究游客对此体验的感知规律及未来发展的潜力。最终,归纳总结出设计策略与原则,为商业空间设计提供指导与参考。

关键词： S-O-R模型沉浸式体验商业空间构建要素设计策略

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An intelligent serological SERS test toward early-stage hepatocellular carcinoma diagnosis through ultrasensitive nanobiosensing

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Nano Research 2022年第6期15卷 5331-5339页

作者： Ningtao Cheng Bin Lou hongyang Wang State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Laboratory Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310006China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalShanghai 200438China National Center for Liver Cancer Shanghai 201805China

Early or very early detection of hepatocellular carcinoma(HCC)is an effective means to resolve the low cure rates,but there currently lacks a method that fulfills clinical *** of the most prospective approaches to detecting early-stage HCC is directly testing a compendium of disease-relevant biomolecules contained within human serum through surface-enhanced Raman scattering(SERS)nanobiosensing and recognizing the biomolecular *** report a novel Si-based bimetallic nanoensembles-functionalized SERS substrate(its analytical enhancement factor reaches 1.47×10^(12))and introduce an ultrasensitive nanobiosensing for capturing the subtle characteristic changes in SERS spectra caused by HCC,hepatitis B,or *** early diagnosis,we created an intelligent serological test with this nanobiosensing and the deep learning algorithm to gain key biomolecular phenotypes of early-stage *** clinical samples from four target populations(normal,HCC,cirrhosis,and hepatitis B),the proof-of-principle result indicates that the test yielded a predictive accuracy of 98.75%on a held-out dataset(randomly drew 4 out of 28 samples per population).On the same held-out dataset,the sensitivity and specificity of the test were both 100%for distinguishing *** a new-concept liquid biopsy could provide an opportunity for early diagnosis of HCC.

关键词： nanobiosensing intelligent serological SERS test SERS substrate early detection for liver cancer risk stratification for liver cancer screening

Synergistic effects in Mn-Co mixed oxide supported on cordierite honeycomb for catalytic deep oxidation of VOCs

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Journal of Environmental Sciences 2022年第2期34卷 231-243页

作者： hongyang Zhao Hui Wang Zhenping Qu Key Laboratory of Industrial Ecology and Environmental Engineering School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China

A series of Co-Mn mixed oxide catalyst supported on a cordierite monolith was facilely synthesized by ultrasonic *** catalytic performance was evaluated in the combustion of toluene,ethyl acetate and its *** was observed that with incorporating Mn into Co_(3)O_(4),the formation of solid solution with spinel structure could significantly improve the catalytic activity of pure phase Co_(3)O_(4).And the monolithic Co_(0.67)Mn_(0.33)O_(x) catalyst showed the best catalytic performance in the catalytic oxidation of toluene and ethyl acetate which could be completely oxidized at 220 and 180℃ respectively under the reaction velocity(WHSV)about 45,000 m L/(g·hr)and pollutant concentration of 500 ppm *** total conversion temperature of the VOCs mixture was at 230℃(500 ppm V toluene and 500 ppm V ethyl acetate)and determined by the temperature at which the most difficult molecule was *** excellent catalytic performance of monolithic Co_(0.67)Mn_(0.33)O_(x) was attributed to the higher content of Mn^(3+),Co^(3+),surface adsorbed oxygen and better redox *** prepared catalyst showed the good mechanical stability,reaction stability,and good adaptability to different reaction conditions.

关键词： Catalytic oxidation Cobalt Manganese Cordierite Monolithic catalyst

Faster split-based feedback network for image super-resolution

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High Technology Letters 2024年第2期30卷 117-127页

作者：田澍 ZHOU hongyang School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083P.R.China

Although most of the existing image super-resolution(SR)methods have achieved superior performance,contrastive learning for high-level tasks has not been fully utilized in the existing image SR methods based on deep *** work focuses on two well-known strategies developed for lightweight and robust SR,i.e.,contrastive learning and feedback mechanism,and proposes an integrated solution called a split-based feedback network(SPFBN).The proposed SPFBN is based on a feedback mechanism to learn abstract representations and uses contrastive learning to explore high information in the representation ***,this work first uses hidden states and constraints in recurrent neural network(RNN)to implement a feedback ***,use contrastive learning to perform representation learning to obtain high-level information by pushing the final image to the intermediate images and pulling the final SR image to the high-resolution ***,a split-based feedback block(SPFB)is proposed to reduce model redundancy,which tolerates features with similar patterns but requires fewer *** experimental results demonstrate the superiority of the proposed method in comparison with the state-of-the-art ***,this work extends the experiment to prove the effectiveness of this method and shows better overall reconstruction quality.

关键词： super-resolution(SR) split-based feedback contrastive learning

Properties and Application of Nanocrystalline Poly (vinyl chloride)

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Journal of Materials Science & Technology 2004年第5期20卷 547-550页

作者： ChuanxiXIONG hongyang LijieDONG QihongLIU QingminLIU SchoolofMaterialsScienceandEngineering WuhanUniversityofTechnologyWuhan430070.China ShenzheuSPECPlasticsHoldingsCO. LTD.Shenzhen518019.China

The structure and properties of nanocrystalline PVC were investigated. The crystalline region of nanocrystalline PVC was observed by TEM to be 80 nm. The melting point of nanocrystalline PVC was found to be 128℃which is obviously lower than typical PVC (210℃). The X-ray diagrar indicated that the crystal existed in nanocrystalline PVC. The evident effect of self-plasticizing and reinforcement appeared when nanocrystalline PVC was added. The optimum amount for self-plasticizing is about 10%. The maximal impact strength of 95.1 kJ/m2 was achieved by adding 20% nanocrystalline PVC and tensile strength with 56.2 MPa which was 122% of pure PVC was obtained after adding 5% nanocrystalline PVC.

关键词： Nanocrystalline PVC Melting point Self-plasticizing Reinforcement

A fine-grained privacy protection data aggregation scheme for outsourcing smart grid

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Frontiers of Computer Science 2023年第3期17卷 187-198页

作者： hongyang LI Xinghua LI Qingfeng CHENG School of Cyber Engineering Xidian UniversityXi’an 710071China Strategic Support Force Information Engineering University Zhengzhou 450001China

Compared with the traditional power grid,smart grid involves many advanced technologies and ***,due to the rapid development of various network technologies,smart grid is facing the challenges of balancing privacy,security,efficiency,and *** the proposed scheme,we design a privacy protection scheme for outsourcing smart grid aided by fog computing,which supports fine-grained privacy-protected data aggregation based on user *** fog server matches the encrypted characteristics in the received message with the encrypted aggregation rules issued by the service ***,the service provider can get more fine-grained analysis data based on user *** from the existing outsourcing smart grid schemes,the proposed scheme can achieve real-time pricing on the premise of protecting user privacy and achieving system fault ***,experiment analyses demonstrate that the proposed scheme has less computation overhead and lower transmission delay than existing schemes.

关键词： smart grid data aggregation fine-grained privacy preservation real-time pricing

Spatial Strategy for Quality Labor in Rural Development——A Case Study of Jiangsu Province, China

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Chinese Geographical Science 2007年第2期17卷 117-126页

作者： SUN Yifei WANG hongyang Department of Geography California State University Northridge Los Angeles 91330 USA Department of Urban and Resources Sciences Nanjing University Nanjing 210093 China

This study examines the issue of high-quality labor in rural enterprises of China. It develops a spatial strategy which consists of two dimensions: geographical space and administrative space. Different combinations of these two dimensions form a variety of approaches such as local internalization, local externalization, regional/national inter- nalization, and regional/national externalization. In the local internalization approach, rural enterprises hire such high-quality labor and ask them to work on site, while in the local externalization approach, rural enterprises seek help from employees working in other local enterprises. In the regional/national internalization approach, rural enterprises set up research and development centers in big cities to take advantages of the high-quality labor pool there. Finally in the regional/national externalization approach, rural enterprises hire people from big cities on temporary contracts. Three approaches, hiring retired technical workers, shuttling between the rural site and country seats, and setting up R&D centers in big cities are demonstrated through cases in Zhangjiagang, a leading county-level city in the southern Jiangsu Province. It is argued that rural enterprises need to broaden their perspectives of administrative space and geographical space and think creatively to deal with the shortage of quality labor in rural settings.

关键词： skilled labor quality labor rural development spatial strategy China

Local Circuits in the Cerebellum Interact with Biochemical Events

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Neuroscience Bulletin 2023年第4期39卷 710-712页

作者： hongyang Sun Guanghui Wang Laboratory of Molecular Neuropathology Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical SciencesSoochow UniversitySuzhou215123JiangsuChina

In a recent study published in Signal Transduction and Targeted Therapy,Liu et al.[1]studied a particular circuit from lobules IV/V in the cerebellar vermis to neurons within the fastigial nucleus(FN),which regulates ... 详细信息

关键词： Local sensor