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CAAI Transactions on Intelligence Technology 2022年第4期7卷 582-593页

作者： Xudong Gao Wenjie Cao Qiang Yang honglin Wang Xiaolei Wang Guang jin Jun Zhang School of Artificial Intelligence/School of Future Technology Nanjing University of Information Science and TechnologyNanjingChina School of Electronic and Information Zhongyuan University of TechnologyZhengzhouChina Graduate School of Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyoJapan

The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of ***,the parameter design of the controller is a difficult *** traditional trial-and-error method is time-consuming and difficult to find optimal parameters.A parameter optimization strategy of control systems for uncertain WPT systems using the modified genetic algorithm(MGA)is ***,because the system has different characteristics at different periods,the simulation process is divided into three *** first one is the start-up stage,in which we mainly consider the overshoot and the rate of the voltage *** second one is the tracking stage,in which the tracking time and switching loss are mainly *** third one is the stabilisation stage,in which the steady-state error and switching loss are mainly ***,three cost functions are designed according to the characteristics of the three stages,and then the optimal controller parameters of each stage are obtained by using ***,the effectiveness of the proposed method is verified by *** optimization results show that compared with the previous parameter optimization method,the optimal controller parameters obtained by the proposed method make the WPT system achieve better performance.

关键词： power optimization system

Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy

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Science China Chemistry 2018年第4期61卷 497-504页

作者： jin Li Liping Qiu Sitao Xie jing Zhang Liqin Zhang honglin Liu Juan Li Xiaobing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Life SciencesAptamer Engineering Center of Hunan ProvinceHunan University Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional GenomicsHealth Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of Florida key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education) College of ChemistryFuzhou University

Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411,and a replaceable anti-biomarker probe(ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS 1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level.

关键词： aptamer drug delivery personalized medicine antisense oligonucleotides

Regulating single-atom Mn sites by precisely axial pyridinic-nitrogen coordination to stabilize the oxygen reduction

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Journal of Energy Chemistry 2023年第5期80卷 542-552,I0012页

作者： Yuan Qin Chaozhong Guo Zihao Ou Chuanlan Xu Qi Lan Rong jin Yao Liu Yingchun Niu Quan Xu Yujun Si honglin Li Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing University of Arts and SciencesChongqing 402160China School of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400054China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Biogas Upgrading UtilizationChina University of Petroleum-BeijingBeijing 102249China College of Chemistry and Environmental Engineering Sichuan University of Science and EngineeringZigong 643000SichuanChina School of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China

Designing single-atom catalysts for oxygen reduction reaction(ORR)are fashionable but challenging to boost the zinc-air battery *** enhanced ORR activity by manganese(Mn)singleatom catalysts can be achieved by accurately regulating the coordination number of isolated Mn *** calculations indicate that the single Mn-N5sites possess lower free energy barrier and higher oxygen adsorption performance than single Mn-N4sites to accelerate the ORR *** to it,here we synthesize an atomically dispersed Mn-N5catalyst by precisely axial coordination of pyridinic-N doped into two-dimensional(2D)porous nanocarbon sheets(~3.56 nm thickness),which reveals outstanding catalytic activity and ultrahigh stability for the ORR in zinc-air battery owing to the inhomogeneous charge distribution of Mn-N5sites compared to the conventional single-site Mn-N4catalyst and Pt/*** work gives a new strategy for in situ regulating the electronic structure of metal single-atoms and further promoting the overall ORR performance in energy systems.

关键词： Single-atom manganese catalyst Mn-N5 active moiety Oxygen reduction reaction,Coordination number Axial pyridinic-nitrogen coordination

Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2： Synthesis, Molecular Docking and SAR Analysis

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Chinese Journal of Chemistry 2013年第9期31卷 1192-1198页

作者： Jun Yuan Ye Zhong Shiliang Li Xue Zhao Guoqin Luan Zhenjiang Zhao jin Huang honglin Li Yufang Xu Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor Engineering School of Pharmacy East China University of Science & Technology Shanghai 200237 China

A series of triazole and benzotriazole derivatives as novel p90 ribosomal S6 protein kinase 2 （RSK2） inhibitors were designed and synthesized. The in vitro activities against RSK2 were evaluated, and among 14 compounds, compounds 5, 6, 11, 12, 13 and 14 exhibited enzyme IC50 values of 8.91, 2.86, 3.19, 3.05, 4.49 and 2.09 μmol/L re- spectively. The proposed binding modes were simulated using molecular docking method, and the docking results coupled with the stmcture-activi1：y relationship （SAR） analysis indicated that all these active compounds bound to the RSK2 ATP binding site at NTKD, and the electron-donating groups on the 4-position of phenyl were the deter- minant point for the inhibitory activity.

关键词： RSK2 structure-activity relationships molecular docking

HOX基因在喉癌组织与癌旁正常组织中的表达谱研究

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中国中西医结合耳鼻咽喉科杂志 2018年第1期26卷 5-7页

作者：曲灵美徐光达李昕于洋印明娜金宏林呼晓孙亚男哈尔滨医科大学附属第五医院耳鼻咽喉科大庆163318 哈尔滨医科大学附属第五医院急诊科哈尔滨医科大学附属第二医院耳鼻咽喉科黑龙江大庆163318

目的应用长链非编码RNA基因芯片研究HOX基因在喉癌组织与癌旁正常组织中的表达谱。方法设立5组经过严格配对的实验组(人喉癌组织)与对照组(同一患者癌旁正常组织)。手术中切取人喉癌组织及癌旁正常组织,应用Triozl法抽提所取标本总RNA,... 详细信息

目的应用长链非编码RNA基因芯片研究HOX基因在喉癌组织与癌旁正常组织中的表达谱。方法设立5组经过严格配对的实验组(人喉癌组织)与对照组(同一患者癌旁正常组织)。手术中切取人喉癌组织及癌旁正常组织,应用Triozl法抽提所取标本总RNA,纯化RNA后,将等量的两组RNA样本逆转录为荧光标记的cRNA混合物,与长链非编码RNA基因芯片进行杂交。应用Agilent扫描仪对芯片荧光信号图像进行扫描,及对原始数据进行计算机统计学分析,结果得到实验组与对照组两种组织之间HOX基因的LncRNA和mRNA的差异表达谱。结果在LncRNA表达谱的统计结果中,筛选出差异表达HOX基因簇的LncRNA有18条,表达上调的有8条,表达下调的有10条。在mRNA表达谱的统计结果中,筛选出差异表达的HOX基因簇的mRNA有17条,表达上调的有15条,表达下调的有2条。结论与癌旁正常组织相比,HOX基因在喉癌组织中的表达谱发生了显著变化。

关键词：长链非编码RNA基因芯片 HOX基因喉癌

Low-frequency and dual-band microwave absorption properties of novel VB-group disulphides(3R–TaS_(2))nanosheets

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Nano Materials Science 2024年第5期6卷 635-646页

作者： Liquan Fan honglin Ai Meiye Jiao Yao Li Yongheng jin Yiru Fu jing Wang Yuwei Wang Deqing Zhang Guangping Zheng Junye Cheng College of Materials Science and Engineering Heilongjiang Provincial Key Laboratory of Polymeric Composite MaterialsQiqihar UniversityNo.42Wenhua StreetQiqihar161006PR China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhenGuangdong Province517182PR China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

As electromagnetic technology advances and demand for electronic devices grows,concerns about electromagnetic pollution *** has spurred focused research on innovative electromagnetic absorbers,particularly chalcogenides,noted for their superior absorption *** this study,we successfully synthesize 3R–TaS_(2)nanosheets using a straightforward calcination method for the first *** nanosheets exhibit significant absorption capabilities in both the C-band(4–8 GHz)and Ku-band(12–18 GHz)frequency *** optimizing the calcination process,the complex permittivity of TaS_(2)is enhanced,specifically for those synthesized at 1000℃for 24 *** nanosheets possess dual-band absorption properties,with a notable minimum reflection loss(RLmin)of41.4 dB in the C-band,and an average absorption intensity exceeding 10 dB in C-and Ku-bands,in the absorbers with a thickness of 5.6 ***,the 3R–TaS_(2)nanosheets are demonstrated to have an effective absorption bandwidth of 5.04 GHz(3.84–8.88 GHz)in the absorbers with thicknesses of 3.5–5.5 *** results highlight the multiple reflection effects in 3R–TaS_(2)as caused by their stacked structures,which could be promising low-frequency absorbers.

关键词： 3R-TaS_(2) Nanosheets Electromagnetic wave absorption Reflection loss

Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa

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Journal of Animal Science and Biotechnology 2018年第2期9卷 351-360页

作者： Linghong jin Wei Wang Jeroen Degroote Noémie Van Noten honglin Yan Maryam Majdeddin Mario Van Poucke Luc Peelman Anne Goderis Kurt Van De Mierop Ronny Mombaerts Stefaan De Smet Joris Michiels Department of Applied Biosciences Ghent University Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Production Ghent University Department of Nutrition Genetics and EthologyFaculty of Veterinary Medicine Ghent University Nutrex

Background: Deoxynivalenol(DON) is a mycotoxin produced by Fusarium species in the field, commonly found in cereal grains, which negatively affects performances and health of animals. Mycotoxin binders are supposed to reduce the toxicity of ***: The effect of a mycotoxin binder(containing acid-activated bentonite, clinoptilolite, yeast cell walls and organic acids) on growth performance and gut health was studied. Hundred and twenty weaning piglets were allocated to 4 treatments, with 5 pens of 6 piglets each, arranged in a 2 × 2 factorial design: control diet; control diet with 1 kg/t binder; control diet with DON; and control diet with DON and 1 kg/t binder. From d0–14,the diet of DON-challenged groups was artificially contaminated with a mixture of DON(2.6 mg/kg), 3-acetyldeoxynivalenol(0.1 mg/kg) and 15-acetyl-deoxynivalenol(0.3 mg/kg), after which the total contamination level was reduced to 1 mg/kg, until d37. On d14, one pig from each pen was euthanized and distal small intestinal mucosa samples were collected for the assessment of intestinal permeability, and gene expression of tight junction proteins, toll-like receptor 4, inflammatory cytokines and intestinal alkaline ***: After 37 d, there were no differences in growth performance between control and DON-challenged groups(P > 0.05). Nevertheless, groups that received diets with binder had a significantly higher average daily gain(ADG) and average daily feed intake(ADFI) for the first 14 d as well as for the whole period, compared to groups without binder(P ≤ 0.05). Groups with binder in the diet also exhibited lower expression of toll-like receptor 4 in distal small intestinal mucosa at d14, compared to groups without binder(P ≤ 0.05). Interestingly, comparing the two DON treatments, piglets fed DON and binder had significantly higher ADFI and ADG compared to those with only DON for the first 14-d(P ≤ 0.05). Addition of binder to DON contaminated diets, also down-regulated th

关键词： Binder Deoxynivalenol Gut barrier Gut health Mycotoxin Pigs

肿瘤组织微小RNA-542-3p、血管细胞黏附分子-1表达特征与脑胶质瘤术后复发的关系及预测价值

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陕西医学杂志 2025年第1期54卷 132-137页

作者：张列祥王协峰何裕超蔡畅付宪华李猛徐进姜宁陈宏璘江苏省人民医院宿迁医院神经外科江苏宿迁223800 江苏省人民医院神经外科江苏南京212028

目的:探讨肿瘤组织中微小RNA-542-3p(miR-542-3p)、血管细胞黏附分子-1(VCAM-1)表达与脑胶质瘤手术后复发的关系及其预测价值。方法:选取实施手术治疗的脑胶质瘤患者91例进行临床研究,其中43例患者于术后1年出现术后复发(复发组)、48例... 详细信息

目的:探讨肿瘤组织中微小RNA-542-3p(miR-542-3p)、血管细胞黏附分子-1(VCAM-1)表达与脑胶质瘤手术后复发的关系及其预测价值。方法:选取实施手术治疗的脑胶质瘤患者91例进行临床研究,其中43例患者于术后1年出现术后复发(复发组)、48例患者手术后1年检查未出现复发病灶(非复发组),对比两组第一次手术后病灶组织标本中的miR-542-3p、VCAM-1蛋白表达差异,并分析miR-542-3p、VCAM-1蛋白表达与胶质瘤术后复发的关系及其预测复发的价值。结果:复发组患者脑胶质瘤组织中miR-542-3p表达水平低于非复发组,复发组患者脑胶质瘤组织中VCAM-1蛋白阳性表达率高于非复发组,差异具有统计学意义(均P<0.05);复发组患者脑胶质瘤组织病理学分级≥Ⅲ级患者占比、低分化患者占比、非全切手术方式患者占比、肿瘤浸润率均高于非复发组,复发组患者术后放化疗患者占比低于非复发组,差异具有统计学意义(均P<0.05)。miR-542-3p表达降低、VCAM-1蛋白阳性表达、手术范围非全切是脑胶质瘤手术后复发的独立危险因素(均P<0.05);miR-542-3p表达、VCAM-1蛋白预测脑胶质瘤手术后复发的曲线下面积AUC值分别为0.784(95%CI:0.690~0.877)、0.725(95%CI:0.621~0.829)。结论:脑胶质瘤组织中miR-542-3p表达、VCAM-1蛋白表达与肿瘤手术后复发有密切关系,用于临床预测有一定的参考价值。

关键词：胶质瘤微小RNA-542-3p 血管细胞黏附分子-1 复发预测

Influence of carbon and yttrium co-doping on the photocatalytic activity of mixed phase TiO_2

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Chinese Journal of Catalysis 2017年第10期38卷 1688-1696页

作者： honglin Gao Jianmei Liu jin Zhang Zhongqi Zhu Genlin Zhang Qingju Liu nano Materials & Technology Yunnan University Kunming 650091 Yunnan China School of Materials Science and Engineering Yunnan Key Laboratory for Micro Kunming 650091 Yunnan China

Mixed phase TiO2photocatalysts doped with C and Y were synthesized by a sol‐gel *** effects of C and Y doping and annealing temperatures on the structural and optical properties,and photocatalytic activity were *** found that both C and Y doping can broaden the absorption spectrum of TiO2to the visible light region and inhibit recombination of photogenerated electron/hole *** incorporation of Y into the TiO2lattice inhibited growth of crystalline grains,which increased the specific surface area and enhanced the photocatalytic *** photocatalytic performance of the samples was investigated in the photocatalytic degradation of methyl blue under visible light *** rate of methyl blue degradation over the(C,Y)‐co‐doped TiO2sample was much higher than those of undoped TiO2,C‐TiO2,and Y‐***,the apparent first‐order rate constant of the co‐doped sample was3.5times as large as that of undoped mix phase TiO2under the same experimental *** enhanced photocatalytic activity can be attributed to the synergic effect of(C,Y)‐co‐doping and the formation of an appropriate crystalline structure.

关键词： Titanium dioxide Co‐doping Mixed phase Phase control Visible light photocatalysis

Experiencing Traditional Culture to Promote Exchanges and Cooperation Notes on Exchanges between the mainland and Hong Kong and Macao cultural circles

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China & The World Cultural Exchange 2017年第6期83卷 39-40页

作者： Liu honglin

A cultural exchange activity between the mainland and Hong Kong and Macao entitled ＂ Yi Hal Liu jin＂ was held in Jiangsu from May 17 to 23, which was organized by the Ministry of Culture and the People＇s Government of Jiangsu Province, specially supported by the Hong Kong and Macao Affairs Office of the State Council and undertaken by the Culture Department of Jiangsu Province. During the one-week activity, nearly 100 guests including government＇s cultural officers, heads of the culture and art institutions and celebrities in the culture and art circles from Hong Kong and Macao as well as heads of related institutions and experts from the mainland made field visits to the cultural institutions in Nanjing, Yangzhou and Suzhou through all sorts of exchange activities to expand cultural exchanges and cooperation between the mainland and Hong Kong and Macao so as to boost cultural and artistic coprosperity and development.

关键词：传统文化交流活动澳门香港合作笔记文化艺术人民政府