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Investigation of the Potential and Mechanism of Clove for Mitigating Airborne Particulate Matter Emission from Stationary Sources

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Journal of Bionic Engineering 2017年第2期14卷 390-400页

作者： Jin Tong Xin Liu Ronaldo Maghirang Kaiqi Wei Linna Liu Chun Wang Yunhai Ma Donghui Chen hongjia Yan Li Guo Key Laboratory of Bionic Engineering (Ministry of Education of China) Jilin University Changchun 130022 China College of Biological and Agricultural Engineering Jilin University Changchun 130022 China Department of Biological and Agricultural Engineering Kansas State University Manhattan KS 66506 USA Institute of Military Veterinary Academy of Military Medical Sciences Changchun 130122 China Department of Planning and Construction Jilin Agricultural University Changchun 130118 China

Vegetative Barriers （VB） have the potential to mitigate air pollutants emitted from area sources, including concentrated Animal Feeding Operations （AFOs）. However, the mechanism has not been fully investigated, thereby limiting the application of vegetation systems in practice. An experimental method with repeatable and controllable conditions was developed to measure the change of Particulate Matter （PM） concentrations at upwind and downwind of VB in the wind tunnel and observe accumulated PM on leaves with Scanning Electron Microscope （SEM）, thus evaluating the ability of VB in mitigating PM emitted from AFOs. Branch-scale vegetation, clove （syzygium aromaticum） was selected because its leaves are one of the major factors affecting PM dispersion. The results show that the branch-scale barriers, as porous medium have the ability to interfere with airflow and reduce PM, which could be influenced by wind speed, particle size fraction and surface area density of clove. Moreover, clove elements could adjust to the wind and the micro structure of clove （such as the hierarchical structures of leaves） affected on the PM deposition. These results indicate that the methods developed in this study may be used to evaluate the potential of vegetation in mitigating PM from stationary sources, and some characteristics of vegetation can be further studied as bionic prototype for exploring engineering application of reducing particulates.

关键词： vegetative barrier particulate matter wind tunnel clove animal feeding operation

Current strategies for improving limitations of proteolysis targeting chimeras

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Chinese Chemical Letters 2023年第6期34卷 144-156页

作者： Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li Medical Research Center The Third People’s Hospital of ChengduThe Affiliated Hospital of Southwest Jiaotong UniversityThe Second Chengdu Hospital Affiliated to Chongqing Medical UniversityChengdu 610031China State Key Laboratory of Biotherapy Collaborative Innovation Center of Biotherapy and Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041China

Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted *** have gained momentum as a new modality of attractive technologies in the drug discovery landscape,since it allows to degrade disease-related proteins *** some PROTACs drugs reached the clinical research,they are still facing some bottlenecks and challenges that should not be neglected,such as poor oral bioavailability and potential toxic side *** overcome these limitations,herein,we provide an overview of recent strategies for improving the durability of PROTACs by enhancing cell permeability and reducing toxic side ***,the impact of these strategies on improving oral bioavailability as well as their advantages and drawbacks will also be *** review will give a useful reference toolbox for PROTACs design and further promote its clinical application.

关键词： PROTACs Targeted protein degradation Oral bioavailability Cell permeability Tumor targeting

Computing infrastructure for big data processing

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Frontiers of Computer Science 2013年第2期7卷 165-170页

作者： ling LIU Distributed Data Intensive Systems Lab School of Computer Science Georgia Institute of TechnologyUSA Atlanta 30332

With computing systems undergone a fundamen- tal transformation from single-processor devices at the turn of the century to the ubiquitous and networked devices and the warehouse-scale computing via the cloud, the parallelism has become ubiquitous at many levels. At micro level, par- allelisms are being explored from the underlying circuits, to pipelining and instruction level parallelism on multi-cores or many cores on a chip as well as in a machine. From macro level, parallelisms are being promoted from multiple ma- chines on a rack, many racks in a data center, to the glob- ally shared infrastructure of the Internet. With the push of big data, we are entering a new era of parallel computing driven by novel and ground breaking research innovation on elas- tic parallelism and scalability. In this paper, we will give an overview of computing infrastructure for big data processing, focusing on architectural, storage and networking challenges of supporting big data paper. We will briefly discuss emerging computing infrastructure and technologies that are promising for improving data parallelism, task parallelism and encour- aging vertical and horizontal computation parallelism.

关键词： big data cloud computing data analytics elas-tic scalability heterogeneous computing GPU PCM bigdata processing

A review of the recent progress in battery informatics

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npj Computational Materials 2022年第1期8卷 284-305页

作者： Chen ling Toyota Research Institute of North America 1555 Woodridge AvenueAnn ArborMichigan48105USA

Batteries are of paramount importance for the energy storage,consumption,and transportation in the current and future *** machine learning(ML)has demonstrated success for improving lithium-ion technologies and *** in-depth review aims to provide state-of-art achievements in the interdisciplinary field of ML and battery research and engineering,the battery *** highlight a crucial hurdle in battery informatics,the availability of battery data,and explain the mitigation of the data scarcity challenge with a detailed review of recent *** review is concluded with a perspective in this new but exciting field.

关键词： battery field lithium

Structure and synthesis of graphene oxide

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2251-2260页

作者： ling Sun Beijing Guyue New Materials Research Institute College of Material Science&EngineeringBeijing University of TechnologyBeijing 100124China

Graphene oxide(GO)is one typical two-dimension structured and oxygenated planar molecular *** across multiple disciplines have paid enormous attention to it due to the unique physiochemical ***,models used to describe the structure of GO are still in dispute and ongoing to *** currently,synthesis methods for mass production are seemingly abundant but in fact,dominated by a few core *** update with the state-of-art opinions and progresses,herein we present a mini critical review regarding the synthesis of GO as well as its models and simulations of ***,we discuss the perspectives.

关键词： Graphene oxide Structure Synthesis Preparation

学前教育经历对小学中低年级学生学业表现的影响——基于CFPS数据的实证研究

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北京教育学院学报 2025年第1期39卷 67-75页

作者：周玲陈静北京理工大学经济学院北京102488 青岛市西海岸新区香江路第二小学山东青岛266427

学前教育是我国国民教育体系的组成部分,是重要的社会公益事业。基于中国家庭追踪调查(CFPS)2018年数据,采用计量分析方法,探讨学前教育获得年限和学前教育获得质量(幼儿园性质)对小学中低年级学生语文、数学学业表现的影响。结果表明,... 详细信息

学前教育是我国国民教育体系的组成部分,是重要的社会公益事业。基于中国家庭追踪调查(CFPS)2018年数据,采用计量分析方法,探讨学前教育获得年限和学前教育获得质量(幼儿园性质)对小学中低年级学生语文、数学学业表现的影响。结果表明,学前教育获得年限可以预测小学中低年级学生的数学成绩,且在不同性别、年级、户口类型的学生中存在差异;学前教育获得质量对小学中低年级学生的语文、数学成绩均无显著影响。建议在确保幼儿学前教育基本获得年限的基础上,完善学前教育供给,促进家园共育,以进一步保障幼儿获得高质量的学前教育。

关键词：学前教育学业表现小学中低年级教育高质量发展

Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material

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Bioactive Materials 2021年第9期6卷 2999-3012页

作者： Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang hongjia Zhang Yunpeng ling Feng Lan Department of Cardiac Surgery Peking University Third HospitalBeijing100191China Department of Cardiovascular Physiology Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama UniversityOkayama700-8558Japan Department of Cardiovascular Surgery Tongji University East HospitalShanghai200120China Department of Neurology Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama UniversityOkayama700-8558Japan State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100037China Department of Cardiac Surgery The University of Tokyo HospitalTokyo113-8655Japan Beijing Laboratory for Cardiovascular Precision Medicine MOE Key Laboratory of Medical Engineering for Cardiovascular DiseasesAnzhen HospitalCapital Medical UniversityBeijing100029China Fuwai Hospital Chinese Academy of Medical Sciences ShenzhenShenzhenChina

Stem cell-based therapy has been used to treat ischaemic heart diseases for two ***,optimal cell types and transplantation methods remain *** study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of *** applied a temperature-responsive cell culture surface-based method to form the hUCMSC *** retention was evaluated using an in vivo bio-luminescent imaging tracking *** transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC *** and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular ***:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell *** the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute ***,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for *** effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 ***:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the *** perspective:Due to its excellent availability as wel

关键词： Mesenchymal stem cells Cell sheet Myocardial infarction Regulation of inflammatory response Ventricular remodelling

Labdane Diterpenoids from Coleus forskohlii （Willd.） Briq.

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Journal of Integrative Plant Biology 2006年第4期48卷 478-481页

作者： ling-ling Xu ling-Yi Kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

in order to investigate the active substances of Coleus forskohlii（Wiiid.） Brlq., a new labdane dlterpenold, 12- hydroxy-8,*** acid, together with two 8,13-epoxylabd-14-ene-11-one dlterpenolds, 6-acetyl-1- deoxyforskolln and 6-acetyl-1,9-dldeoxyforskolln, was Isolated on the basis of various chromatographic technlques and spectroscopic methods.

关键词： 6-acetyl-1-deoxyforskolin 6-acetyl-1 ,9-dideoxyforskolin Coleus forskohlii 12-hydroxy-8,13E-labdadien-15-oic acid labdane diterpenoid.

A Comparison of Corrosion Behavior in Saline Environment: Rare Earth Metals (Y, Nd, Gd, Dy) for Alloying of Biodegradable Magnesium Alloys

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Journal of Materials Science & Technology 2013年第9期29卷 781-787页

作者： Xu Zhao ling-ling Shi Jian Xu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

Rare earth （RE） metals are widely used as the alloying implants. However, corrosion behavior of pure RE elements in biodegradable magnesium alloys as medical metals not only in physiological media but also in chlorinated saline environment is not well understood. In the present work, the RE metals Y, Nd, Gd and Dy are selected to investigate their corrosion behavior in 0.1 mol/L NaCI solution with immersion and electrochemistry techniques. As indicated, corrosion of the currently investigated RE metals is promoted in the order of Dy, Y, Gd and Nd. In terms of electrochemical response, such a sequence correlates with the increased impedance and the decreased corrosion rate （CR）. These RE metals manifest weak ability for passivation in the native surface. Then, reaction with aqueous solution easily happens through the anodic dissolution and cathodic hydrogen evolution. The corrosion products, RE（OH）3, adhered on the surface of RE metals, do not have an appreciable power to resist the reaction proceeding with corrosive chloride ions. In contrast to pure Mg, the RE metals, including Y, Nd, Gd and Dy, exhibit significantly fragile corrosion resistance in saline media. Therefore, with the curr correlation of corrosion resistance between RE-contain ent findings, it is impossible to reveal a well-defined ng Mg alloy and RE metal itself

关键词： Rare earth Biodegradable metal Magnesium alloy Corrosion behavior