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Study on the evolution of solid–liquid–gas in multi-scale pore methane in tectonic coal

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Chinese Journal of Chemical Engineering 2024年第7期71卷 122-131页

作者： Junjie Cai Xijian Li Hao Sui honggao Xie College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Mining College Guizhou UniversityGuiyang 550025China

The rich accumulation of methane(CH_(4))in tectonic coal layers poses a significant obstacle to the safe and efficient extraction of coal seams and coalbed *** coal samples from three geologically complex regions were selected,and the main results obtained by using a variety of research tools,such as physical tests,theoretical analyses,and numerical simulations,are as follows:22.4–62.5 nm is the joint segment of pore volume,and 26.7–100.7 nm is the joint segment of pore specific surface *** the dynamic gas production process of tectonic coal pore structure,the adsorption method of methane molecules is“solid–liquid adsorption is the mainstay,and solid–gas adsorption coexists”.Methane stored in micropores with a pore size smaller than the jointed range is defined as solid-state *** within the jointed range,which transition from micropore filling to surface adsorption,are defined as gaseous *** outside the jointed range,where solid–liquid adsorption occurs,are defined as liquid *** evolution of pore structure affects the methane adsorption mode,which provides basic theoretical guidance for the development of coal seam resources.

关键词： Tectonic coal Multiscale pore structure Methane adsorption Micropore filling Monolayer Molecular simulation

New mutation points in 23S rRNA gene associated with Helicobacter pyloriresistance to clarithromycin in northeast China

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World Journal of Gastroenterology 2004年第7期10卷 1075-1077页

作者： QingHao YanLi Zhi-JieZhang YongLiu honggao DepartmentofGastroenterology the2ndAffiliatedHospitalChinaMedicalUniversityShenyang110004LiaoningProvinceChina ClinicalCenterofMicrobiology the2ndAffiliatedHospitalChinaMedicalUniversityShenyang110004LiaoningProvinceChina TheMajorHealthMinistryLabForCongenitalMalformation ChinaMedicalUniversityShenyang110004LiaoningProvinceChina

AIM: TO investigate the resistance rate of Helicobacter pylori(H pylori) to clarithromycin, metronidazole, amoxicillin and tetracycline to guide clinical practice, and to study the mechanism of Hpylori resistant to clarithromycin. METHODS: Thirty Hpyloristrains were isolated from the mucosa of peptic ulcer, gastric tumor and chronic gastritis patients, then the minimal inhibitory concentration (MIC) to clarithromycin, metronidazole, amoxicillin and tetracycline was evaluated by E-test method. The sequence analysis of PCR fragments was conducted in 23S rRNA gene of H pylori resistant to clarithromycin to get the resistance mechanism of the bacteria. RESULTS: Among 30 Hpyloristrains, 7 cases were resistant to clarithromycin, 12 to metronidazole, 2 to tetracycline and no strain was found to be resistant to amoxicillin. The resistance rates were 23.3%, 40%, 6.7% and 0%, respectively. Three new mutation points were found to be related to the clarithromycin resistance in Hpyloriisolates, which were G2224A, C2245T and T2289C. CONCLUSION: In northeast China, H pylori shows high resistance to metronidazole, while sensitive to amoxicillin. The mechanism of resistance to clarithromycin may be related to the mutation of G2224A, C2245T and T2289C in the 23S rRNA gene.

关键词：克拉霉素幽门螺杆菌耐药性基因突变聚合酶链反应消化道溃疡

Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor

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World Journal of Gastroenterology 2004年第14期10卷 2010-2013页

作者： honggao Ji-YaoWang Xi-ZhongShen Yong-HuiDeng WeiZhang DepartmentofGastroenterology ZhongshanHospitalFudanUniversityShanghai200032China DepartmentofMacromolecularSciences FudanUniversityShanghai200032China DepartmentofGastroenterology HuadongHospitalShanghai200040China

AIM: To evaluate the effect of aclacinomycin A-loaded magnetic polybutylcyanoacrylate nanoparticles on gastric tumor growth in vivo and in ***: Magnetic polybutylcyanoacrylate (PBCA)nanospheres encapsulated with aclacinomycin A (MPNS-ACM) were prepared by interracial polymerization. Particle size, shape and drug content were examined. Female BABL/c nude mice were implanted with MKN-45 gastric carcinoma tissues subcutaneously to establish human gastric carcinoma model. The mice were randomly divided into 5 groups of 6 each: ACM group (8 mg/kg bin); group of high dosage of MPNS-ACM (8 mg/kg bin); group of low dosage of MPNS-ACM (1.6 mg/kg bin); group of magnetic PBCA nanosphere (MPNS) and control group(normal saline). Magnets (2.5 T) were implanted into the tumor masses in all of the mice one day before the ***-mentioned drugs were administered intravenously to the mice of every group on the first day and sixth *** the mice were sacrificed, tumor weight was measured, and the assay of granulocyte- macrophage colony forming-unit (CFU-GM) was performed on semi-solid culture. White blood cell, alanine aminotransferase and creatine were examined. 3-[4-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was used to examine the viability of MKN-45 cells afger incubation with different concentrations of ACM, MPNS and MPNS-ACM suspension respectively for 48 ***: Content of ACM in MPNS-ACM was 12.0% and the average diameter of the particles was 210 nm. The inhibitory rates of ACM (8 mg/kg bin), high dosage of MPNS-ACM (8 mg/kg bin), low dosage of MPNS-ACM (1.6 mg/kg bin)and MPNS on human gastric carcinoma in nude mice were 22.63%, 52.55%, 30.66% and 10.22%, respectively. There was a significant decrease in the number of CFU-GM of bone marrow in ACM group compared with control group,whereas no obvious change was observed in that of the nanosphere groups. The values of 50% inhibition concentration (IC50) of ACM, MPNS and MPNS-ACM were 0.09,

关键词：聚丁烯氰丙烯酸酯胶囊阿克拉霉素A 胃癌肿瘤

Chromic-P32 phosphate treatment of implanted pancreatic carcinoma: Mechanism involved

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World Journal of Gastroenterology 2005年第14期11卷 2101-2108页

作者： LuLiu Guo-ShengFeng honggao Guan-ShengTong YuWang WenGao YingHuang ChengLi InstituteofNuclearMedicineTechnologyofSoutheastUniversity Nanjing210009JiangsuProvinceChina BeijingRailwayGeneralHospital Beijing100038China

AIM: To study the effects of chromic-P32 phosphate (32p colloids) interstitial administration in Pc-3 implanted pancreatic carcinoma, and investigate its anticancer ***: Ninety-eight tumor bearing nude mice werekilled at different time points after the injection of 32Pcolloids to the tumor core with observed radioactivity. The light microscopy, transmission electron microscopy (TEM) and immuno-histochemistry and flow cytometry were used to study the rates of tumor cell necrosis, proliferating cell nuclear antigen index, the micro vessel density (MVD). The changes of the biological response to the lymphatic transported 32p colloids in the inguinal lymph node (ILN) were dynamically observed, and the percentage of tumor cell apoptosis, and Apo2.7, caspase-3, Bcl-2, Baxrelated gene expression were observed ***: The half-life of effective medication is 13 dafter injection of 32P colloids to the tumor stroma, in 1-6groups, the tumor cell necrosis rates were 20%, 45%,65%, 70%, 95% and 4%, respectively (F= 4.14-105.36, P＜0.01). MVD were 38.5±4.0, 28.0±2.9, 17.0±2.9, 8.8±1.5,5.7±2.3 and 65.0±5.2 (t= 11.9-26.1, P＜0.01), *** TEM fairly differentiated Pc-3 cells were found. Thirty days after medication, tumors were shrunk and dried with scabs detached, and those in control group increased in size prominently with plenty of hypodermic blood vessels. In all animals the ILN were enlarged but in medicated animals they appeared later and smaller than those in control group. The extent of irradiative injury in ILN was positively correlated to the dosage of medication. Typical tumor cell apoptosis could be found under TEM inanimals with intra-tumoral injection of low dosed 32P colloids. The peak of apoptosis occurred in 2.96 MBq group and 24 h after irradiation. In the course of irradiationinduced apoptosis, the value of Bcl-2/Bax was down regulated; Apo2.7 and caspase-3 protein expression were prominently increased dose dependently. CONCLUSION: 32

关键词： Chromic-P32 phosphate Pancreatic carcinoma

Polypore funga and species diversity in tropical forest ecosystems of Africa,America and Asia,and a comparison with temperate and boreal regions of the Northern Hemisphere

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Forest Ecosystems 2024年第4期11卷 391-400页

作者： Heng Zhao Yingda Wu Zhirong Yang honggao Liu Fang Wu Yucheng Dai Yuan Yuan State Key Laboratory of Efficient Production of Forest Resources School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083China Key Laboratory of Forest and Grassland Fire Risk Prevention Ministry of Emergency ManagementChina Fire and Rescue InstituteBeijing 102202China Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology Zhaotong UniversityZhaotong 657000China Yunnan Engineering Research Center of Green Planting and Processing of Gastrodia Zhaotong UniversityZhaotong 657000China

Polypores play a cru cial role in energy recycling and forest regeneration in forest *** majority of them are wood degraders;some are forest pathogens and others are ectomycorrhizal *** basidiocarps provide food and shelter for many organisms,mostly invertebrates,but also some vertebrates,as well as food and medicine for *** extensive research on the species diversity and phylogenetic relationships of polypores in recent years,there remains a lack of comprehensive understanding of their distribution patterns and species composition at the large *** of polypores from the tropical zone,including tropical Africa,tropical America,and tropical Asia,were analyzed for species diversity,distribution patterns,major taxa,and nutritional modes.A total of 1,902 polypore species was found in the three regions,representing 8 orders,46families,and 250 genera of *** orders Polyporales(especially the family Polyporaceae)and Hymenochaetales(especially the family Hymenochaetaceae)had the most prolific taxa,with their species accounting for 93.4%of the total polypores *** of 1,565(or 82.3%)of the total 1,902 species were found in only one of the three regions studied,and we treat them temporarily as"regional endemic species".Only 141species were shared among all three regions,accounting for a mere 7.4%.Tropical Africa and tropical America had the greatest number of shared species and the highest S?rensen similarity index(SC)*** forests had a higher species richness compared with temperate to boreal forests of the Northern Hemisphere,and in addition,also a higher proportion of white rot polypores compared to brown rot and ectomycorrhizal *** study outlines the distribution patterns and species diversity of polypores in the world,shedding light on their ecological significance in diverse ecosystems.

关键词： Agaricomycetes Macrofungi Species composition Wood-decay fungi

Emergence of ancient cities in relation to geopolitical circumstances and climate change during late Holocene in northeastern Tibetan Plateau, China

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Frontiers of Earth Science 2016年第4期10卷 669-682页

作者： Guanghui DONG honggao LIU Yishi YANG Ying YANG Aifeng ZHOU Zhongxin WANG XiaoyanREN Fahu CHEN Key Laboratory of Western China's Environmental Systems (Ministry of Education) College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China College of Agronomy and Biotechnology Yunnan Agricultural University Kunming 650201 China Qinghai Provincial Institute of Cultural Relics and Archaeology Xining 810007 China

The study of the history of human activities in ancient cities has provided valuable evidences for under- standing the evolution of human-land relations during the late Holocene. Numerous ancient cities were discovered through archaeological surveys of the east Qinghai Province, located on the northeastern border of the Tibetan Plateau, China; however, the mystery of when or why these cities were built remains unsolved. As recorded in this paper, we sampled reliable dating materials from 47 ancient cities in the area, determined their ages by radiocarbon dating, and compared the dating results with historical documents and high resolution paleoclimate records to explore the influencing factors for the develop- ment of these ancient cities. The 54 radiocarbon dates indicated that most of these cities were built or repaired during the Han Dynasty （202 BC-AD 220）, Tang Dynasty （AD 618-AD 907）, the Five Dynasties and Ten Kingdoms period （AD 907-AD 960）, the Song dynasty （AD 960-AD 1279）, and the Ming Dynasty （AD 1368-AD 1644）. The radiocarbon dates correspond well with historical records of the area. Our work suggests the ancient cities in east Qinghai Province were likely built primarily for military defense, and may have also have been affected by climate change.

关键词： radiocarbon dating ancient city historicrecords war climate change

Prehistoric agriculture development in the Yunnan-Guizhou Plateau, southwest China： Archaeobotanical evidence

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Science China Earth Sciences 2016年第8期59卷 1562-1573页

作者： LI HaiMing ZUO XinXin KANG LiHong REN LeLe LIU FengWen LIU honggao ZHANG NaiMeng MIN Rui LIU Xu DONG GuangHui Key Laboratory of Western China’s Environmental Systems (Ministry of Education) College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Yunnan Province Institute of Cultural Relics and Archaeology Kunming 650118 China College of Agronomy and Biotechnology Yunnan Agricultural University Kunming 650201 China

The origin, development and expansion of prehistoric agriculture in East Asia have been widely investigated over the past two decades using archaeobotanical analysis from excavated Neolithic and Bronze Age sites. Research on prehistoric agriculture has predominantly focused in the valleys of the Yellow River and the Yangtze River. Agricultural development during the Neolithic and Bronze Age periods in the Yunnan-Guizhou Plateau of southwest China, an important passageway for human migration into Southeast Asia, still remains unclear. In this paper, based on macrofossil and microfossil analysis and radiocarbon dating at the Shilinggang site, we investigate plant subsistence strategies in the Nujiang River valley during the Bronze Age period. Combined with previous archaeobotanical studies in the Yunnan-Guizhou Plateau, we explore agricultural development processes in this area during the Neolithic and Bronze Age. Our results indicate that rice and foxtail millet were cultivated in Shilinggang around 2500 cal a BP. Three phases of prehistoric agricultural development in the Yunnan-Guizhou Plateau can be identified: rice cultivation from 4800–3900 cal a BP, mixed rice and millet crop(foxtail millet and broomcorn millet) cultivation from 3900–3400 cal a BP, and mixed rice, millet crop and wheat cultivation from 3400–2300 cal a BP. The development of agriculture in the Yunnan-Guizhou Plateau during the Neolithic and Bronze Age periods was primarily promoted by prehistoric agriculture expansion across Eurasia, agricultural expansion which was also affected by the topographic and hydrological characteristics of the area.

关键词： Nujiang River valley Yunnan-Guizhou Plateau Neolithic Bronze Age Macrofossil analysis Phytolith analysis Radiocarbon dating

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论公共利益的法律界定--从要素解释的路径

中国法学 2008年第4期 56-67页

作者：胡鸿高复旦大学法学院教授、博士生导师

公共利益是一个非常重要但又相当模糊的法律概念,公共利益内涵的法律界定处于理论困惑与实践需求的矛盾之中。这个不确定的法律概念,包含价值选择概念和历史性概念。尽管公共利益基于自身的特性而无法厘清其确切、绝对的边界,但亦非不... 详细信息

公共利益是一个非常重要但又相当模糊的法律概念,公共利益内涵的法律界定处于理论困惑与实践需求的矛盾之中。这个不确定的法律概念,包含价值选择概念和历史性概念。尽管公共利益基于自身的特性而无法厘清其确切、绝对的边界,但亦非不可捉摸。本文采用要素解释的方法,通过对公共利益的历史解释、公共利益的本体解释、公共利益的主体解释和公共利益的程序解释,进而阐述公共利益的内涵,并通过要素解释描绘公共利益的可能景象。

关键词：公共利益公益法律界定

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斜拉桥锚箱式索梁锚固区应力及传力途径分析

西南交通大学学报 2006年第2期41卷 179-183页

作者：张育智李乔满洪高西南交通大学土木工程学院四川成都610031

为给出索力在主要焊缝间分配的定量描述及主要板件的受力特点和产生应力集中的原因,用有限单元法对锚箱式索梁锚固区应力进行了计算分析.研究表明:锚垫板传递总索力的约20%,其主要作用不是承担索力,而是将索力传给2块锚箱腹板;2块锚箱... 详细信息

为给出索力在主要焊缝间分配的定量描述及主要板件的受力特点和产生应力集中的原因,用有限单元法对锚箱式索梁锚固区应力进行了计算分析.研究表明:锚垫板传递总索力的约20%,其主要作用不是承担索力,而是将索力传给2块锚箱腹板;2块锚箱腹板与箱梁腹板的焊缝传递总索力的约80%,且2条焊缝传递的索力相近,剪应力沿焊缝长度方向呈“马鞍形”分布;各主要板件在面内、面外集中力及弯矩作用下有应力集中现象.

关键词：锚箱式索梁锚固区有限单元法传力途径应力集中