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Retrospective analysis of sentinel lymph node biopsy using methylene blue dye for early breast cancer

Chinese Medical Journal 2021年第3期134卷 318-325页

作者： Shan Yang hong-yu xiang Ling Xin hong Zhang Shuang Zhang yuan-Jia Cheng Qian Liu Ling Xu Ting Li Xue-Ning Duan Jing-Ming Ye Yin-Hua Liu Breast Disease Center Peking University First HospitalBeijing 100034China Department of Pathology Peking University First HospitalBeijing 100034China

Background:Methylene blue is the most commonly used tracer for sentinel lymph node(SLN)biopsy(SLNB)in *** study aimed to investigate the feasibility of clinical application of SLNB using methylene blue dye(MBD)for early breast cancer and the prognosis of patients with different SLN and non-SLN ***:We retrospectively analyzed the clinicopathological data of patients with early breast cancer treated at the Peking University First Hospital between 2013 and *** calculated the SLN identification rate(IR)in SLNB with MBD and the false-negative rate(FNR),and analyzed the prognosis of patients with different SLN and non-SLN statuses using Kaplan-Meier ***:Between January 2013 and December 2018,1603 patients with early breast cancer underwent SLNB with *** SLN IR was 95.8%(1536/1603).Two SLNs(median)were detected per *** were significant differences in FNR between patients with SLN micrometastasis and macrometastasis(19.0%vs.4.5%,χ^(2)=12.771,P<0.001).Chi-square test showed that there were significant differences in SLN successful detection rates among patients with different vascular tumor embolism status(96.3%vs.90.8%,χ^(2)=9.013,P=0.003)and tumor(T)stages(96.6%vs.94.1%,χ^(2)=5.189,P=0.023).Multivariate analysis showed that vascular tumor embolism was the only independent factor for SLN successful detection(odds ratio:0.440,95%confidence interval:0.224-0.862,P=0.017).Survival analysis showed a significant difference in disease-free survival(DFS)between patients with non-SLN metastasis and patients without non-SLN metastasis(P=0.006).Conclusion:Our single-center data show that,as a commonly used tracer in SLNB in China,MBD has an acceptable SLN IR and a low FNR in frozen *** finding is consistent with reports of dual tracer-guided *** SLNs with non-SLN metastasis are associated with DFS.

关键词： Breast cancer Identification rate Methylene blue dye Prognosis Sentinel lymph node biopsy

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Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： yuzhu Li yumeng Gao Feng Tian yu Wang yuan Yao Shaoliang Lin xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

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Effects of Aluminum Trichloride on Structure and Function of Kidney in Chickens

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Journal of Northeast Agricultural University(English Edition) 2012年第3期19卷 83-86页

作者： Zhang Ji-hong Luo Ji-long yu hong-xiang Bai Chong-sheng Han Yan-fei Xia Shi-liang Li Yan-fei College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China

To investigate the effects of aluminum trichloride （AlCl3） on renal structure and function in chickens, the chickens were injected continuously with different gradient AlCl3 for 60 days to establish sub-chronic aluminum （Al） intoxication model. The AI concentration in serum and kidney, contents of creatinine （Cr） and blood urea nitrogen （BUN） in serum were detected, and the renal structure was also observed by optical microscope. The results showed that the A1 concentration in serum and kidney, the contents of Cr and BUN in serum were significantly higher in Al-treated chickens than those in the control group （P〈0.05; P〈0.01） and there was an AlCl3 dose-depended manner. Histopathologically, in the low dose group, acinus renis swelled mildly and there were no apparent pathological changes in nephric tubule and proximal convoluted tubule. In the middle and high dose group, acinus renis swelled, glomerular cells increased, nephric tubule cloudy swelled, and epithelial cells of proximal convoluted tubule swelled. The results indicated that sub-chronic Al exposure impaired the renal structure and function in chickens.

关键词： aluminum trichloride structure and function kidney chicken

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao xiang Feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie Jia-Lin Li Ling Gong xiang-Li Zhong hong-Jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

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顶点覆盖变体问题的确定参数可解算法研究

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计算机工程与科学 2008年第12期30卷 79-81,84页

作者：洪翔宇蔡晟复旦大学信息工程学院计算机系上海200433

参数复杂性作为算法研究的一个重要分支,近十年来在国际上受到了广泛的关注,确定参数可解算法是参数复杂性研究的一类重要问题,因此被广泛研究。本文主要研究了顶点覆盖问题的两个变体问题:一个是连接的顶点覆盖问题,二是含权的树型顶... 详细信息

参数复杂性作为算法研究的一个重要分支,近十年来在国际上受到了广泛的关注,确定参数可解算法是参数复杂性研究的一类重要问题,因此被广泛研究。本文主要研究了顶点覆盖问题的两个变体问题:一个是连接的顶点覆盖问题,二是含权的树型顶点覆盖问题。这两个问题都是对原始的顶点覆盖问题加入了一些限制的变体问题。本文给出了这两个问题的确定参数可解算法,并且是目前的最好结果。

关键词：参数复杂性确定参数可解算法顶点覆盖连接顶点覆盖

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PD-YOLO:Colon Polyp Detection Model Based on Enhanced Small-Target Feature Extraction

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Computers, Materials & Continua 2025年第1期82卷 913-928页

作者： Yicong yu Kaixin Lin Jiajun hong Rong-Guei Tsai yuanzhi Huang New Engineering Industry College Putian UniversityPutian351100China Engineering Research Center of Big Data Application in Private Health Medicine(Putian University) Fujian Province UniversityPutian351100China Computer College Guangdong University of Science&TechnologyDongguan523668China

In recent years,the number of patientswith colon disease has increased *** polyps are the precursor lesions of colon *** not diagnosed in time,they can easily develop into colon cancer,posing a serious threat to patients’lives and health.A colonoscopy is an important means of detecting colon ***,in polyp imaging,due to the large differences and diverse types of polyps in size,shape,color,etc.,traditional detection methods face the problem of high false positive rates,which creates problems for doctors during the diagnosis *** order to improve the accuracy and efficiency of colon polyp detection,this question proposes a network model suitable for colon polyp detection(PD-YOLO).This method introduces the self-attention mechanism CBAM(Convolutional Block Attention Module)in the backbone layer based on YOLOv7,allowing themodel to adaptively focus on key information and ignore the unimportant *** help themodel do a better job of polyp localization and bounding box regression,add the SPD-Conv(Symmetric Positive Definite Convolution)module to the neck layer and use deconvolution instead of *** results indicate that the PD-YOLO algorithm demonstrates strong robustness in colon polyp *** to the original YOLOv7,on the Kvasir-SEG dataset,PD-YOLO has shown an increase of 5.44 percentage points in AP@0.5,showcasing significant advantages over other mainstream methods.

关键词： Polyp detection YOLOv7 SPD-Conv CBAM deconvolution

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含硼铁精矿选择性还原-选分新工艺的实验研究

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东北大学学报（自然科学版） 2013年第7期34卷 966-970页

作者：付小佼于洪翔柳政根储满生东北大学材料与冶金学院辽宁沈阳110819

针对现有含硼铁精矿硼铁分离工艺所存在的弊端,提出了含硼铁精矿选择性还原-选分新工艺,并通过热力学分析和实验室研究进行了验证.研究表明:对于辽宁凤城Fe和B2O3质量分数分别为56.05%和3.86%的含硼铁精矿,最佳的选择性还原-选分工艺参... 详细信息

针对现有含硼铁精矿硼铁分离工艺所存在的弊端,提出了含硼铁精矿选择性还原-选分新工艺,并通过热力学分析和实验室研究进行了验证.研究表明:对于辽宁凤城Fe和B2O3质量分数分别为56.05%和3.86%的含硼铁精矿,最佳的选择性还原-选分工艺参数如下:配碳比0.8～1.0,还原温度1 275～1 300℃,还原时间不小于20 min,还原煤粒度为-0.075 mm,分选时的磁场强度为50 mT.得到的选分产物为高金属化率的金属铁粉,可进一步处理用于钢铁生产;选分尾矿为高品位的含硼资源,可作为硼工业的优质原料.

关键词：含硼铁精矿选择性还原选分磁场硼铁分离

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一类弱耦合非线性波动方程组的精确可控性

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浙江大学学报（理学版） 2006年第6期33卷 613-618页

作者：洪裕祥薛儒英浙江大学数学系浙江杭州310027

用Hilbert惟一性方法Schauder不动点定理,得到一类弱耦合非线性波动方程组Dirichlet边值问题的精确可控性.

关键词： Hilbert惟一性方法精确可控性 Schauder不动点定理

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基于社会网络的农村群体负面情绪传播机制

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计算机应用研究 2015年第1期32卷 85-88页

作者：李从东洪宇翔暨南大学管理学院广州510632

针对我国社会经济转型期间农村的社会稳定风险,认为群体负面情绪是导致农村群体事件的主导要素,急需对其传播机制进行识别和测度。在分析了我国农村社会强网络嵌入性特征的基础上,基于社会网络理论提出了农村群体负面情绪传播的网络影... 详细信息

针对我国社会经济转型期间农村的社会稳定风险,认为群体负面情绪是导致农村群体事件的主导要素,急需对其传播机制进行识别和测度。在分析了我国农村社会强网络嵌入性特征的基础上,基于社会网络理论提出了农村群体负面情绪传播的网络影响要素及其计算方法;并且通过运用和优化元胞自动机建模方法,对农村群体负面情绪传播进行动态建模。仿真结果验证了社会网络特征属性,如意见领袖、干群关系等,对于农村群体负面情绪传播的影响作用显著。

关键词：农村群体事件群体负面情绪社会网络元胞自动机

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