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Voluntary running delays primary degeneration in rat retinas after partial optic nerve transection

Neural Regeneration Research 2019年第4期14卷 728-734页

作者： hong-ying li Xi hong Mi Huang Kwok-Fai So Department of Anatomy School of Medicine Jinan University Guangdong-hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint Laboratory Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong

Running is believed to be beneficial for human health. Many studies have focused on the neuroprotective effects of voluntary running on animal models. There were both primary and secondary degeneration in neurodegenerative diseases, including glaucoma. However, whether running can delay primary or secondary degeneration or both of them was not clear. Partial optic nerve transection model is a valuable glaucoma model for studying both primary and secondary degeneration because it can separate primary(mainly in the superior retina) from secondary(mainly in the inferior retina) degeneration. Therefore, we compared the survival of retinal ganglion cells between Sprague-Dawley rat runners and non-runners both in the superior and inferior retinas. Excitotoxicity, oxidative stress, and apoptosis are involved in the degeneration of retinal ganglion cells in glaucoma. So we also used western immunoblotting to compare the expression of some proteins involved in apoptosis(phospho-c-Jun N-terminal kinases, p-JNKs), oxidative stress(manganese superoxide dismutase, MnSOD) and excitotoxicity(glutamine synthetase) between runners and non-runners after partial optic nerve transection. Results showed that voluntary running delayed the death of retinal ganglion cells vulnerable to primary degeneration but not those to secondary degeneration. In addition, voluntary running decreased the expression of glutamine synthetase, but not the expression of p-JNKs and MnSOD in the superior retina after partial optic nerve transection. These results illustrated that primary degeneration of retinal ganglion cells might be mainly related with excitotoxicity rather than oxidative stress; and the voluntary running could down-regulate excitotoxicity to delay the primary degeneration of retinal ganglion cells after partial optic nerve transection.

关键词： voluntary running optic nerve injury oxidative stress excitotoxicity JNKs primary degeneration secondary degeneration

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A nonlinear creep damage model for gelled waxy crude

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Petroleum Science 2022年第4期19卷 1803-1811页

作者： hong-ying li Qing-Bo Xie Hao Sun Wei Guo Feng Yan Qing Miao Chao-Fei Nie Yu Zhuang Qian Huang Jin-Jun Zhang National Engineering Laboratory for Pipeline Safety/MOE Key Laboratory of Petroleum Engineering/Bejing Key Laboratory of Urban Oil&Gas Distribution Technology/China Universityof Petroleum Beijing102249China PipeChina Pipeline R&DCenter Langfang065000China Jinan Urban Planning and Design Institute Jinan250101China

Yielding behaviors of waxy crude oil is one of the key issues of flow assurance challenges. The yielding of waxy crude under constant stress is actually a creep process of strain accumulation to structural failure,to describe the process completely and accurately is the basis of numerical simulation of restart process of the pipeline. The creep and yield behaviors of two gelled waxy crudes were investigated experimentally under different constant applied stresses. The results clearly show that the creep process of waxy crude is related to the applied stress and time. The greater the applied stress, and the longer the loaded time, the more obvious the nonlinear features. Based on the fractional calculus theory, a fractional viscous element was developed to describe the decelerated and steady creep process of gelled waxy crude. On the basis of the damage theory, an elastic damage element was proposed to describe the accelerated creep after the yielding. According to the idea of mechanical analogy, a nonlinear creep model was established by a fractional viscous element, an elastic damaged element, and an elastic element in series, which can accurately describe the whole creep and yielding process of gelled waxy crude.

关键词： Waxy crude oil Rheology Yield Creep Constitutive model Mechanical analogy

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A further investigation to mechanism of the electrorheological effect of waxy oils:Behaviors of charged particles under electric field

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Petroleum Science 2023年第2期20卷 1247-1254页

作者： Yi-Wei Xie hong-ying li Chao-Yue Zhang Yang Su Qian Huang Feng Jiang Chao-Hui Chen Shan-Peng Han Jin-Jun Zhang National Engineering Research Center of Oil and Gas Pipeline Transportation Safety China University of PetroleumBeijing 102249China MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing 102249China Beijing Key Laboratory of Urban Oil&Gas Distribution Technology China University of PetroleumBeijing 102249China PetroChina Planning and Engineering Institute Beijing 100083China

Exposing waxy oils to an electric field may significantly improve their cold flowability.Our previous study has shown that interfacial polarization,i.e.,charged particle accumulation on the wax particle surface,is the primary mechanism of the electrorheological behavior of waxy oils.However,the way that charged particles interact with wax particles under an electric field remains unknown.In this study,we found no viscosity and impedance change for two waxy crude oils after their exposure to a high-voltage electric field.However,the yield stresses were reduced obviously.We thus proposed that the collision of colloidal particles such as resins and asphaltenes with the wax particles could be an essential mechanism that the wax particle structure was weakened.To verify this hypothesis,a series of ad hoc experiments were carried out,i.e.,by performing electrorheological tests on model waxy oils containing additives removable under an electric field,including electrically-neutral colloidal particles(Fe3O4),charged colloidal particles(resins),and oil-soluble electrolyte(C22H14CoO4),respectively,and demonstrated that upon application of a high-voltage electric field,charged particles in a waxy oil may move and thus collide with wax particles,and consequently adhere to the wax particle surface.The particle collision results in damage to the wax particle network,and the electrostatic repulsion arising from the adhesion of the charged particle on the wax particle diminishes attraction between wax particles.This study clarifies the process of interfacial polarization.

关键词： Waxy oil Electrorheological effect Interfacial polarization Charged particle motion

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Efficacy and Safety of Ixekizumab in Chinese Patients With Moderate-to-Severe Plaque Psoriasis: 60-Week Results From a Phase 3 Study

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International Journal of Dermatology and Venereology 2022年第4期5卷 181-190页

作者： Xia li Jie Zheng Wei-li Pan Min Zheng Yan Lu Fu-Qiu li Yang-Feng Ding Jian-Zhong Zhang hong-ying li Wen-Long Rui Department of Dermatology Ruijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 314408China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology Jiangsu Province HospitalNanjingJiangsu 210029China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology Shanghai Skin Disease HospitalShanghai 130041China Department of Dermatology Peking University People’s HospitalBeijing 130041China China Drug Development and Medical Affairs Center Eli Lilly and CompanyShanghai 200041China.

Objective:Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A and is approved for treating moderate-to-severe psoriasis.This phase 3,multicenter,randomized,double-blind,placebo-controlled trial(NCT03364309;registered December 6,2017)evaluated the safety and efficacy of ixekizumab in Chinese patients with moderate-to-severe psoriasis.Methods:438 patients were randomized 2:2:1 to 80 mg ixekizumab every 2 weeks(IXE Q2W,n=176),80 mg ixekizumab every 4 weeks(IXE Q4W,n=174),or placebo(n=88).Efficacy was assessed by evaluating the static Physician’s Global Assessment score of 0 or 1(sPGA[0,1])and Psoriasis Area and Severity Index(PASI)75/90/100 responses,and nonresponder imputation was used for handling missing data.The safety profile was evaluated by assessing treatment emergent adverse events(AEs)and serious AEs.Results:At week 12,the sPGA(0,1)response rates were 3.4%,79.9%,and 86.4%in the placebo,IXE Q4W,and IXE Q2W groups,respectively.The PASI 75/90/100 response rates were 8.0%/2.3%/0.0%,87.4%/75.9%/29.3%,and 93.8%/82.4%/33.0%in the placebo,IXE Q4W,and IXE Q2W groups,respectively.Ixekizumab led to rapid PASI 50 responses,as early as week 1,whereas PASI 75 and sPGA(0,1)responses were observed from week 2.sPGA(0,1)and sPGA(0)responses were maintained through week 60 in a higher proportion of patients receiving IXE Q4W vs.placebo.The safety profile was consistent with previous studies of ixekizumab in psoriasis.Conclusion:Ixekizumab showed a rapid onset of action and high efficacy that was maintained through 60 weeks and was well tolerated with no unexpected AEs,in Chinese patients with moderate-to-severe plaque psoriasis.

关键词： China efficacy ixekizumab psoriasis rapid onset safety

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System Size Resonance Associated with Canard Phenomenon in a Biological Cell System

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Chinese Journal of Chemical Physics 2008年第6期21卷 521-525页

作者： Juan Ma hong-ying li Zhong-huai Hou Hou-wen Xin Department of Chemical Physics University of Science and Technology of China Hefei 230026 China Hefei National Lab of Physical Science at Microscale University of Science and TechnoloEy of China Hefei 230026 China Department of Chemistry Hefei Teachers College Hefei 230000 China

钙摆动上的内部噪音的影响被学习。内部噪音什么时候被考虑，被发现随机的钙摆动发生，当相应确定的动力学仅仅产出一个稳定的状态时。另外，如此的摆动的性能与系统尺寸的变化显示出二最大值，显示系统尺寸回声的出现。这行为被发现亲... 详细信息

钙摆动上的内部噪音的影响被学习。内部噪音什么时候被考虑，被发现随机的钙摆动发生，当相应确定的动力学仅仅产出一个稳定的状态时。另外，如此的摆动的性能与系统尺寸的变化显示出二最大值，显示系统尺寸回声的出现。这行为被发现亲密地与虚报现象被连接。有趣地，最佳的系统之一与真实房间尺寸缩放匹配很好，这也被发现，并且如此的匹配对控制参数的变化柔韧。

关键词：共振现象生物细胞系统噪声钙化学分析

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Mechanisms of secondary degeneration after partial optic nerve transection

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Neural Regeneration Research 2014年第6期9卷 565-574页

作者： hong-ying li Yi-Wen Ruan Chao-Ran Ren Qi Cui Kwok-Fai So Department of Ophthalmology the University of Hong Kong State Key Laboratory of Brain and Cognitive Science the University of Hong Kong GHM Institute of CNS Regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as microglia, astrocytes and oligodendrocytes, have also been demon- strated to take part in the process of secondary injury. Partial optic nerve transection is a useful model which was established about 13 years ago. The merit of this model compared with other optic nerve injury models used for glaucoma study, including complete optic nerve transection model and optic nerve crush model, is the possibility to separate primary degeneration from secondary degeneration in location. Therefore, it provides a good tool for the study of secondary degeneration. This review will focus on the research progress of the mechanisms of secondary degeneration using partial optic nerve transection model.

关键词： secondary degeneration partial injury optic nerve oxidative stress excitotoxicity calci-um overload mitochondrion macrophage astrocyte oligodendrocyte

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Kai Xin San ameliorates scopolamine-induced cognitive dysfunction

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Neural Regeneration Research 2019年第5期14卷 794-804页

作者： Yu-Min Xu Xin-Chen Wang Ting-Ting Xu hong-ying li Shang-Yan Hei Na-Chuan Luo hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong liang Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine First Affiliated Hospital of Henan University of Chinese Medicine School of Food and Pharmaceutical Engineering Zhaoqing University First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Neurology The First Affiliated Hospital Guangzhou Medical University Guangdong Provincial Hospital of Chinese Medicine

Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups(which received physiological saline), the doses of KXS(0.7, 1.4 and 2.8 g/kg per day) and donepezil(3 mg/kg per day) were gastrointestinally administered once daily for 2 weeks. On day 8 after intragastric treatment, the behavioral tests were carried out. Scopolamine group and intervention groups received scopolamine 3 mg/kg per day through intraperitoneal injection. The effects of KXS on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. The results confirmed the following.(1) KXS shortened the escape latency and increased residence time in the target quadrant and the number of platform crossings in the Morris water maze.(2) KXS increased the percentage of alternations between the labyrinth arms in the mice of KXS groups in the Y-maze.(3) Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining revealed that KXS promoted the production of Nissl bodies and inhibited the formation of apoptotic bodies.(4) Western blot assay showed that KXS up-regulated the expression of anti-apoptotic protein Bcl-2 and inhibited the expression of pro-apoptotic protein Bax. KXS up-regulated the expression of postsynaptic density 95, synaptophysin, and brain-derived neurotrophic factor in the cerebral cortex and hippocampus.(5) KXS increased the level and activity of choline acetyltransferase, acetylcholine, superoxide dismutase, and glutathione peroxi

关键词： Kai Xin San cognitive dysfunction scopolamine hydrobromide neuroprotection oxidative stress synaptic dysfunction apoptosis cholinergic system dysfunction donepezil neural regeneration

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Pulmonary embolism secondary to acute anterior ST-elevation myocardial infarction:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 139-141页

作者： lin Yuan hong li Yuhong Mi ying liang Emergency Critical Center Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Thrombophilia denotes a condition,whether acquired or hereditary,characterized by increased susceptibility to hypercoagulation.[1]This condition was first described in 1965,coinciding with the discovery of an inherited predisposition to venous thromboembolism(VTE)in patients deficient in antithrombin III.[2]While arterial and venous thromboses are common in hospitalized patients,acute myocardial infarction(AMI)and pulmonary embolism(PE)stand out as lifethreateningconditions.However,theoccurrenceof AMI complicated by PE is exceedingly rare,especially when considering cases where paradoxical embolism originating from a patent foramen ovale is absent.This report presents a case of AMI complicated with PE.A comprehensive understanding of the pathophysiology of this rare yet critical condition is important for ensuring prompt diagnosis and treatment.

关键词： embolism infarction acute

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Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 226-232页

作者： lin Wang Bi-Qiang Zhou ying-hong li Qian-Qian Jiang Wei-hong Cong Ke-Ji Chen Xiao-Min Wen Zheng-Zhi Wu The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhen Institute of GeriatricsShenzhenGuangdong ProvinceChina The First Affiliated Hospital of Shenzhen University Shenzhen Second People’s HospitalShenzhenGuangdong ProvinceChina China Academy of Chinese Medical Sciences Xiyuan HospitalBeijingChina School of Chinese Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that berberine has neuroprotective effects against Alzheimer’s disease,including antagonizing tau phosphorylation,and inhibiting acetylcholinesterase activity and neural cell apoptosis.However,its low bioavailability and adverse reactions with conventional administration limit its clinical application.In this study,we prepared berberine nanoliposomes using liposomes characterized by low toxicity,high entrapment efficiency,and biodegradability,and modified them with lactoferrin.Lactoferrin-modified berberine nanoliposomes had uniform particle size and high entrapment efficiency.We used the lactoferrin-modified berberine nanoliposomes to treat a mouse model of Alzheimer’s disease established by injection of amyloid-beta 1-42 into the lateral ventricle.Lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus,reduced tau over-phosphorylation in the cerebral cortex,and improved mouse behavior.These findings suggest that modification with lactoferrin can enhance the neuroprotective effects of berberine nanoliposomes in Alzheimer’s disease.

关键词： acetylcholinesterase Alzheimer’s disease apoptosis berberine brain targeting lactoferrin nanoliposomes neuroprotective effects Tau phosphorylation

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Micro-aluminum powder with bi-or tri-component alloy coating as a promising catalyst:Boosting pyrolysis and combustion of ammonium perchlorate

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Defence Technology（防务技术） 2024年第3期33卷 100-113页

作者： Chao Wang ying liu Mingze Wu Jia li ying Feng Xianjin Ning hong li Ningfei Wang Baolu Shi School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

A novel design of micro-aluminum(μAl)powder coated with bi-/tri-component alloy layer,such as:Ni-P and Ni-P-Cu(namely,Al@Ni-P,Al@Ni-P-Cu,respectively),as combustion catalysts,were introduced to release its huge energy inside Al-core and promote rapid pyrolysis of ammonium perchlorate(AP)at a lower temperature in aluminized propellants.The microstructure of Al@Ni-P-Cu demonstrates that a three-layer Ni-P-Cu shell,with the thickness of~100 nm,is uniformly supported byμAl carrier(fuel unit),which has an amorphous surface with a thickness of~2.3 nm(catalytic unit).The peak temperature of AP with the addition of Al@Ni-P-Cu(3.5%)could significantly drop to 316.2℃ at high-temperature thermal decomposition,reduced by 124.3℃,in comparison to that of pure AP with 440.5℃.It illustrated that the introduction of Al@Ni-P-Cu could weaken or even eliminate the obstacle of AP pyrolysis due to its reduction of activation energy with 118.28 kJ/mol.The laser ignition results showed that the ignition delay time of Al@Ni-P-Cu/AP mixture with 78 ms in air is shorter than that of Al@Ni-P/AP(118 ms),decreased by 33.90%.Those astonishing breakthroughs were attributed to the synergistic effects of adequate active sites on amorphous surface and oxidation exothermic reactions(7597.7 J/g)of Al@Ni-P-Cu,resulting in accelerated mass and/or heat transfer rate to catalyze AP pyrolysis and combustion.Moreover,it is believed to provide an alternative Al-based combustion catalyst for propellant designer,to promote the development the propellants toward a higher energy.

关键词： Micro-aluminum powder(μAl) Nano-sized alloy coating Combustion catalyst Ammonium perchlorate Pyrolysis behavior Ignition and combustion

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