检索结果-南通市图书馆

首届浙赣两省肿瘤研究交流会

作者： hong-yang lu Xiao-Jia Wang Yi-Ping Zhang Wei-Min Mao Zhen-Yi lu Qiao-Yuan Cheng Cai-Jin Lou Xin-min Yu Jing Qin Wei-Wu Ye Lei Lei Jian Huang Hui-Yi yang Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology(esophagus lung)Zhejiang ProvinceZhejiang Cancer Hospital Department of Medical OncologyZhejiang Cancer Hospital Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology(esophagus lung)Zhejiang ProvinceZhejiang Cancer Hospital Department of Oncology Xiangshan First People's Hospital Department of Traditional Chinese Medicine Zhejiang Institute for Food and Drug Control Department of Medical Oncology Zhejiang Cancer Hospital

Epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI) has been widely used in non-small cell lung cancer(NSCLC),and the incidence of EGFR mutation in NSCLC is higher in China than in the United States and European *** exons 19 and 21 mutation in NSCLC is related to response of tumors to EGFR TKIs, suggesting its usefulness as a *** case studies reported that gefitinib-responsive small cell lung cancer (SCLC) with EGFR ***,there are few large studies which reported the mutation status of SCLC *** is difficult to obtain tumor tissues to detect EGFR mutation in SCLC patients especially from *** aim of the study is to know the EGFR mutation status in SCLC patients from plasma in *** September 2011 to March 2012,35 cases of SCLC plasmas were collected at the Zhejiang cancer Hospital,Hangzhou,*** are 7 female,28 *** from 46 to 74 years old and median age is 60 years *** stage(Veterans Administration lung Study Group,VALSG):limited disease(LD) 8 cases,extensive disease(ED) 27 *** history:nonsmoker 10 cases,light smoker 0 cases,moderate smoker 3 cases and heavy smoker 22 *** technology was used to detect EGFR exon 19 and exon 21 mutations from plasma of 35 SCLC *** of 35 cases was found with mutation in exon 19 of the EGFR *** patient with EGFR exon 19 mutation is a female and *** mutation is rare in SCLC patients,and may be more easily occurred in female and non-smokers.

关键词： EGFR Gene mutation Mutant-enriched liquidchip technology SCLC Plasma

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

ITS中基于纠错诊断的知识表示模型

引用

计算机工程与应用 2004年第33期40卷 212-214页

作者：冯红杨卉王陆首都师范大学北京100037

智能教学系统是以专家系统为核心,帮助学生解决问题的教学系统。传统的辅助教学系统在测试学生学习情况时,只是简单的给学生一个分数,而没有给他们提高学习表现的机会。如果对测试结果进行分析,并提出相应的建议,将更有利于学生对各知... 详细信息

智能教学系统是以专家系统为核心,帮助学生解决问题的教学系统。传统的辅助教学系统在测试学生学习情况时,只是简单的给学生一个分数,而没有给他们提高学习表现的机会。如果对测试结果进行分析,并提出相应的建议,将更有利于学生对各知识点的学习。文章提出了一个概念图模型,并将它应用在一个基于测试与诊断的ITS系统中,通过分析学科知识和测试结果来向学生提供学习建议,从而进一步提高学生成绩。最后,我们对该模型的性能给出了一个初步的结论。

关键词：智能教学系统诊断模型概念图

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多目标的学习者模型研究

引用

计算机工程与应用 2003年第36期39卷 98-100页

作者：冯红王陆杨卉首都师范大学教育技术系北京100037

建立学习者模型几乎是所有ITS系统的普遍任务,当前的软件系统趋向于转入分布式和多代理系统,学习者模型转向零散的、由各种软件代理在特定环境下产生的模型。在“个性化课件生成子系统”中运用了这一思想,建立了基于多目标的、运行于分... 详细信息

建立学习者模型几乎是所有ITS系统的普遍任务,当前的软件系统趋向于转入分布式和多代理系统,学习者模型转向零散的、由各种软件代理在特定环境下产生的模型。在“个性化课件生成子系统”中运用了这一思想,建立了基于多目标的、运行于分布式与多代理系统之上的学习者模型,该文将主要介绍这一系统的基本构成与运行结构、系统中目标的定义与组织结构,并对目标的解释、目标的生存周期等问题做了进一步的探讨。

关键词：智能教学系统学习者模型软件系统软件代理学生模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于DART模型的众包模式下顾客参与价值共创路径研究

引用

河北工业大学学报（社会科学版） 2017年第3期9卷 28-35页

作者：刘宏杨路芬河北工业大学经济管理学院天津300401

价值共创理论引发了商业模式的变革,在此背景下众包模式应运而生。本文基于价值共创的DART模型和价值创造三阶段理论,以海尔众创汇定制平台和苏宁众包平台等为例研究顾客参与价值共创的实现路径。研究发现,众包模式下顾客参与价值共创... 详细信息

价值共创理论引发了商业模式的变革,在此背景下众包模式应运而生。本文基于价值共创的DART模型和价值创造三阶段理论,以海尔众创汇定制平台和苏宁众包平台等为例研究顾客参与价值共创的实现路径。研究发现,众包模式下顾客参与价值共创的路径有两种:直接网站型与众包平台型。不同路径下顾客参与价值共创的运作流程、互动方式和各主体产出价值不同,据此本文构建出顾客参与价值共创的路径模型,并提出加强对话建设、完善资源获取途径、降低风险和增强主体间透明性等建议,为企业激励顾客参与价值共创提供参考。

关键词： DART模型众包模式顾客参与价值共创

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microspheres trigged-stress concentration regulating piezoelectric properties of PVDF/elastomer composites

引用

Science China Chemistry 2025年

作者： Wenxian Zhang Jiahong yang Qijun Sun lu Peng Tong Lin Shouke Yan Xiaoli Sun State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences State Key Laboratory of Separation Membranes and Membrane Processes School of Textile Science and EngineeringTiangong University Key Laboratory of Rubber-Plastics of Ministry of Education Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science & Technology

Wearable self-powered piezoelectric pressure sensors are attracting tremendous ***,fabricating a high-sensitive elastic piezoelectric sensor for a broad response range remains ***,we assemble polar poly（vinylidene fluoride）(PVDF) microsphere-elastomer composites,achieving high-sensitive and wide-responsive pressure *** polar PVDF microspheres are produced cost-effectively through phase separation,enabling *** piezoelectric composite （PC） film demonstrates low Young’s modulus,and excellent anti-fatigue ***,the PC-based piezoelectric sensor exhibits a rather high sensitivity of 540 mV N-1in a wide sensing range （5–40 N）,240 times greater than the PVDF film-based sensor and comparable to the inorganic piezoelectric *** excellent performance is attributed to the highest average stress concentration on the spherical PVDF coupled with the remarkable deformation of dipoles of spherical PVDF in the flexible *** on excellent performance,this piezoelectric sensor achieves precise recognition of motions and sound *** high-sensitive flexible piezoelectric sensor enabling large area production with ultralow price exerts great potential in smart monitoring and intelligent robots.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The neurovascular imaging in cerebral ischemia by laser speckle contrast analysis

The neurovascular imaging in cerebral ischemia by laser spec...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shan-Bao TONG~*,Peng MIAO,Min-Heng LI,hong-yang lu,Qi LIU,Yao LI School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 2000240,China

＜正＞Objective Laser speckle contrast analysis has been used in imaging the cerebral vasculature and cerebral blood flow（CBF）.However,in practice,the estimation of the CBF may be biased by the ambient background field, dark current and other anomalies in the circuits of CCD camera,non-uniform distributed laser illumination,cortical curvature,breathing/heart beating of the subjects,and the nonstationary change of CBF under functional stimulation, and the motion artifacts if applied to the behavioring *** In order to obtain a stable and high spatiotemporal resolution CBF imaging in the study of the ischemic brain injury,we developed several techniques to improve the current techniques of laser speckle contrast analysis,including（1） enhanced laser speckle contrast analysis （eLASCA）;（2） model Based LSI reconstruction;（3） registered laser speckle contrast analysis（rLASCA）;（4） Random process estimator for laser speckle *** finally we integrate these techniques and designed a miniature headstage imaging system which can be used to obtain the CBF imaging when the animal（***） is moving freely. Results By using the above techniques,high resolution CBF information can be obtained in real time for either anesthetized or freely moving *** We developed high-resolution optical imaging technique for CBF monitoring,which can be used for real time monitoring both structural and functional neurovascular changing in ischemic brain injury.

关键词： neurovascular imaging cerebral blood flow laser speckle imaging laser speckle contrast analysis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

土体劈裂注浆加固主控因素模拟试验

引用

浙江大学学报（工学版） 2018年第11期52卷 2058-2067页

作者：朱明听张庆松李术才李卫随海通杨红鲁山东大学岩土与结构工程研究中心山东济南250061

为了分析注浆挤密及浆脉骨架对注浆加固效果的影响,确定注浆加固主控因素,提出注浆挤密系数及浆脉骨架系数和其计算方法,设计土体劈裂注浆加固三维模拟试验系统,开展土体注浆加固模拟试验.采用凝固时间显著不同的水泥浆液及水泥-水玻璃... 详细信息

为了分析注浆挤密及浆脉骨架对注浆加固效果的影响,确定注浆加固主控因素,提出注浆挤密系数及浆脉骨架系数和其计算方法,设计土体劈裂注浆加固三维模拟试验系统,开展土体注浆加固模拟试验.采用凝固时间显著不同的水泥浆液及水泥-水玻璃浆液分别对土体进行注浆加固,形成不同空间分布状态的浆脉骨架;通过测定注浆压力、土压力、土体密度及浆脉空间分布特征确定注浆挤密系数及浆脉骨架系数;监测隧道收敛变形以评价注浆加固效果,定性分析注浆挤密及浆脉骨架作用对注浆加固效果的影响.研究结果表明,水泥-水玻璃浆液注浆挤密程度大于水泥浆液,水泥-水玻璃浆液骨架作用小于水泥浆液;注浆挤密作用对于注浆加固效果的影响程度大于浆脉骨架作用,注浆挤密作用是影响土体劈裂注浆加固效果的主控因素.

关键词：土体加固水泥浆液水泥-水玻璃浆液注浆挤密浆脉骨架主控因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wetland and habitat dynamics in the evolving landscape of the Middle yangtze River Basin

引用

Journal of Geographical Sciences 2025年第1期35卷 88-111页

作者： yang Peng SUN Kaiya ZHU Yanchao XIA Jun HUANG Heqing SONG Jingxia SHI Xiaorui lu Xixi Hubei Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information Engineering China University of Geosciences Department of Geography National University of Singapore State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

Wetlands play a critical role in the global environment. The Middle yangtze River Basin(MYRB), known for its abundant wetland resources, has experienced notable changes resulting from the complex interplay of environmental factors. Therefore, we investigated the spatiotemporal characteristics of wetland ecological quality in the MYRB from 2001 to *** the random forest(RF) regression algorithm and patch-generated land-use simulation(PluS) model, we forecasted variations in wetland habitat quality and their determinants under the Shared Socioeconomic Pathway-Representative Concentration Pathway(SSPRCP) framework from 2035 to 2095. The main findings are as follows:(1) The RF algorithm was optimal for land-use and land-cover(luLC) classification in the MYRB from 2001 to 2020,when notable changes were observed in water bodies and buildings. However, the forested area exhibited an increase and decrease of 3.9% and 1.2% under the SSP1-2.6 and SSP5-8.5 scenarios, respectively, whereas farmland exhibited a diminishing trend.(2) Wetlands were primarily concentrated in the central and eastern MYRB, with counties in the southwest exhibiting superior ecological-environmental quality from 2001 to 2020. Notably,wetland coverage revealed significantly high level, significant changes, frequent but relatively minor changes under the SSP1-2.6, SSP2-4.5, and SSP 5-8.5 scenarios, respectively.(3)Regions with lower habitat quality were primarily concentrated in urbanized areas characterized by frequent human activities, indicating a clear degradation in habitat quality across different scenarios. In conclusion, we established a foundational framework for future investigations into the eco-hydrological processes and ecosystem quality of watersheds.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

引用

Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi yang Miao Bai Yuan Zhuang Shenghua lu Qianqian Ge Hao Li Yu Deng hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：