检索结果-南通市图书馆

A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 754-761页

作者： Xiao-hong PAN Ying-xue chen Mei-xiang XIANG Geng XU Jian-an WANG Department of Cardiology the Seeond Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent(PES) in ST-segment elevation myocardial infarction(STEMI) patients.A systematic literature search was conducted to identify all randomized clinical trials in mortality,recurrent myocardial infarction(rMI),repeat revascularization(RR),and stent thrombosis(ST).A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent(BMS).The pooled repeat revascularization rate was 5.7% in PES group,significantly lower than 10.0% in BMS group with an odds ratio(OR) of 0.56,95% confidence interval(CI) [0.44,0.72](P<0.00001).No significant difference was found between PES and BMS groups in mortality at one year after the indexing procedure(3.9% vs.5.1%,OR 0.88,95% CI [0.63,1.21],P=0.42).Similarly,rMI rate did not differ significantly between the two groups(3.4% vs.4.1%,OR 0.80,95% CI [0.56,1.13],P=0.21).PES was also associated with the comparable pooled rate of definite stent thrombosis with BMS(2.3% vs.2.4%,OR 0.81,95% CI [0.52,1.26],P=0.35).The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety.

关键词： Myocardial infarction Paclitaxel-eluting stent Bare-metal stent Meta-analysis

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

P29 Establishment of Laboratory Teaching System of Pharmacology

在线全文

学校读者我要写书评

暂无评论

中国药理通讯 2006年第2期23卷 33-34页

作者： Qian Mu xue-hong chen Yan-tao Han Shen-bo Guo Chun-bo Wang Qingdao University Medical College Qingdao 266021 China

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen hongyu xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

Construction of an intelligent patient satisfaction assessment system and its application in emergency management

在线全文

学校读者我要写书评

暂无评论

TMR Clinical Research 2020年第1期3卷 30-30,31-35页

作者： Yi-Bo Wu Jin-Yi Meng hong-xue chen Dong-Yun Li Shu-Xian Xu Tao Wang Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencesPeking UniversityBeijingChina College of Humanities and Social Sciences Harbin Medical University HarbinChina School of Pharmacy Shenyang Pharmaceutical UniversityBenxiChina Department of Emergency Shanghai East HospitalTongji University School of MedicineShanghaiChina College of Art and Media Tongji UniversityShanghaiChina

Hospital emergency management work is of great importance which not only related to the life and health of the people but also related to social *** is necessary to construct and improve the patient satisfaction assessment system so that doctors and patients can interact in a timely and effective manner,and the hospital can alert or respond *** study constructs a closed-loop emergency management system consisting of patient-end,data center and decision-making-end,and apply the feedback information to hospital emergency *** the preliminary applications,the system has a significant effect on the hospital emergency management *** researchers will improve the system in the follow-up study。

关键词： Hospital Emergency Management Patient Satisfaction Feedback Mechanism

Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第7期28卷 1007-1014页

作者： Ming-qing GAO,Shen-bo GUO,xue-hong chen,Wei DU,Chun-bo WANG~2Medical College,Qingdao University,Qingdao 266021,China Medical College Qingdao University Qingdao 266021 China.cbwang666@***.

Aim:To investigate the mechanism of polypeptide from Chlamysfarreri (PCF)protecting HaCaT cells from apoptosis induced by UVA plus UVB in ***:An apoptotic model of UV irradiation-induced HaCaT cells *** 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromideassay,agarose gel electrophoresis,biochemical methods,and Western blottingwere employed in the ***:PCF inhibited the UV irradiation-inducedapoptosis of HaCaT *** strongly reduced the intracellular reactive oxygenspecies level,enhanced activities of superoxide dismutase and glutathione per-oxidase and increased the total anti-oxidative capacity in HaCaT cells followingUV ***,we found that PCF could inhibit the phosphorylationof c-Jun amino-terminal kinase and the activity of caspase-3 in a concentration-dependent ***:PCF protected HaCaT cells from apoptosis in-duced by UVA plus UVB,mainly through decreasing the intracellular ROS leveland increasing the activities of anti-oxidative enzymes to block the ROS-JNK-caspase-3-apoptosis signaling pathway.

关键词： polypeptide from Chlamys farreri antioxidant HaCaT apoptosis UV irradiation

TRIPLY BRIDGED BINUCLEAR COMPLEX OF OXOMOLYBDENUM(Ⅴ)WITH MERCAPTOPHENOLATE LIGANDS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1991年第4期2卷 315-316页

作者： Ling hong WENG xue Tai chen Yong Han HU Bei Sheng KANG Fuzhou Laboratoryoy Structural-Chemistry and Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences,Fuzhou,350002

Reaction of(n-Bu_4N)_xNa_(4-x)[a-Mo_8O_(26)](x=1-4)and mpH_2(mpH_2=o-mercaptophenol) leads to the formation of compound(n-Bu_4N)[Mo_2O_3(mp)_3Na(EtOH)_2(MeOH)],It crystallizes in the space group P2_1/n with four molecules per unit *** cell dimension is a=12.776(3),b=14.154(5),c=26.281(7)(?)=95.50(2)°,V=4730.5 (?),d_c=1.407 g/cm^***-matrix refinement of 496 parameters on 3348 reflection data gave final R(R_w) value of 0.072(0.072).The two oxomolybdenum-mercaptophenolate,units are triply bridged by an inorganic oxygen atom and a doubly bridging mp^(2-)ligand.

关键词： TRIPLY BRIDGED BINUCLEAR COMPLEX OF OXOMOLYBDENUM WITH MERCAPTOPHENOLATE LIGANDS chen EtOH

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo Nie hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease