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Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death

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Research 2022年第4期2022卷 463-479页

作者： xiang Li Peipei Zhang Zhiyong yin Fei Xu Zhang-Hua Yang Jun Jin Jing Qu Zhilong Liu hong Qi Chenggui Yao Jianwei Shuai Department of Physics and Fujian Provincial Key Laboratory for Soft Functional Materials Research Xiamen UniversityXiamen 361005China National Institute for Data Science in Health and Medicine and State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen 361102China Complex Systems Research Center Shanxi UniversityShanxiTaiyuan 030006China College of Data Science Jiaxing UniversityJiaxing 314000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)and Wenzhou InstituteUniversity of ChineseAcademyof SciencesWenzhouZhejiang325001China

Inflammasomes are essential complexes of innate immune system, which form the first line of host defense against pathogens. Mounting evidence accumulates that inflammasome signaling is highly correlated with coronavirus disease 2019 (COVID-19). However, there remains a significant gap in our understanding of the regulatory mechanism of inflammasome signaling. Combining mathematical modeling with experimental analysis of NLRP1b inflammasome signaling, we found that only the expression levels of caspase-1 and GSDMD have the potential to individually switch cell death modes. Reduction of caspase-1 or GSDMD switches cell death from pyroptosis to apoptosis. Caspase-1 and GSDMD present different thresholds and exert distinct pathway choices in switching death modes. Pyroptosis switches to apoptosis with an extremely low threshold level of caspase-1, but with a high threshold of GSDMD. Caspase-1-impaired cells employ ASC-caspase-8-dependent pathway for apoptosis, while GSDMD-impaired cells primarily utilize caspase-1-dependent pathway. Additionally, caspase-1 and GSDMD can severally ignite the cooccurrence of pyroptosis and apoptosis. Landscape topography unravels that the cooccurrence is dramatically different in caspase-1- and GSDMD-impaired cells. Besides pyroptosis state and apoptosis state, a potential new “coexisting” state in single cells is proposed when GSDMD acts as the driving force of the landscape. The “seesaw model” is therefore proposed, which can well describe the death states that are controlled by caspase-1 or GSDMD in single cells. Our study sheds new light on NLRP1b inflammasome signaling and uncovers the switching mechanisms among various death modes, providing potential clues to guide the development of more rational control strategies for diseases.

关键词： impaired utilize rational

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Role of transport polarization in electrocatalysis:A case study of the Ni-cluster/Graphene interface

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Journal of Materials Science & Technology 2021年第33期92卷 120-128页

作者： Fang Bian Xin Ge Wu Shan Shan Li Gao Wu Qin xiang ying Meng yin Wang hong Wei Yang School of Materials Science and Engineering Northeastern UniversityShenyang 110819China College of Sciences Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China International Centre of Quantum and Molecular Structures and Department of Physics Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals Kunming Precious Metals New Materials Technology Co.Ltd.Kunming 650106China

As cathodes,iron-series(Fe,Co,Ni)clusters supported by carbon materials exhibit outstanding electrocatalytic reduction activities in many electrocatalytic *** date,this general characteristic of ironseries clusters that should be related to the inherent attributes of these electrodes has not been fully understood from the perspectives of thermodynamics and electronic structure *** transport is a necessary process in electrocatalysis,and therefore,the study of the change of the electronic state in electron transport is beneficial for understanding this general characteristic of iron-series cluster *** this work,the electron transport properties,including the conductivity and transport spin-polarization at the Ni-cluster/graphene interface are carefully investigated as an example of carbon-supported iron-series *** first-principles calculations within the framework of the nonequilibrium Green’s function density functional theory(NEGF-DFT),we reveal that the electronic transport states of the coupled Ni-cluster/graphene are strongly changed compared to those of their isolated Ni-cluster and graphene *** is found that graphene dominates the overall conductivity of the interface,while the morphology of Ni-clusters controls the spin polarization *** spin polarization can lead to the self-excitation effect of the electrons that raises the energy of the electronic system,improves the thermodynamics of the reduction reaction and promotes catalytic *** work hints that iron-series elements(Fe,Co,Ni)based electrodes may generally show transport polarization that is likely to give rise to a high electrocatalytic reduction activity and such transport polarizability can be used as a new factor in the further exploration and design for electrocatalytic materials.

关键词： First-principles calculations electrocatalysis non-equilibrium electron injection transport polarization Ni-cluster/graphene

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A Bibliometric Analysis and Visualization of Current Research Trends in Chinese Medicine for Osteosarcoma

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Chinese Journal of Integrative Medicine 2022年第5期28卷 445-452页

作者： yin Meng-chen WANG hong-shen YANG Xi XU Chong-qing WANG Tao YAN yin-jie FAN Zhao-xiang MA Jun-ming YE Jie MO Wen Department of Orthopaedics Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Division of Spine Surgery Center Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou(510120)China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China

Background:To illustrate the research framework,overall knowledge structure,and development trends of Chinese medicine(CM)treatment for osteosarcoma(OS)by using a bibliometric analysis and newly developed visualization ***:Research datasets were acquired from the Web of Science(WOS)database from January 1,1980 to September 30,*** viewer and Citespace software was used to analyze the data and generate visualization knowledge *** trends of publications,distribution of institutes,distribution of journals,citation and H-index status,co-authorship status,research hotspots and co-citation status were ***:A total of 223 publications in the WOS database met the *** number of published articles showed a rise but the citation frequency and the H-index of China were relatively *** cooperation between the countries,institutes and authors were relatively *** publications were basic *** of the previous researches focused on basic mechanisms of CM in treating OS,and therapy and improvement of dosage form may become a frontier in this research ***:Compared with other fields,the field of CM treatment for osteosarcome is still in *** distribution of researches is imbalanced and cooperation between countries,institutions and authors remains to be ***,basic research occupies an absolute dominant position,and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future.

关键词： osteosarcoma Chinese medicine bibliometric analysis visualization research trends

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Vegetation Community Convergence of Pastoralists' Pasture at Different Economic Levels in Desert Steppe

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Journal of Integrative Agriculture 2014年第6期13卷 1165-1170页

作者： yin Yan-ting REN Ji-zhou HOU xiang-yang College of Pastoral Agriculture Science and Technology Lanzhou University Grassland Research Institute Chinese Academy of Agricultural Sciences

Vegetation characteristics of pastoralist households’ pastures at different economic levels were quantiifed to compare the grassland conditions in Sunite Right Banner, Inner Mongolia, China in 2011 and 2012. The results showed that the heights of Stipa klemenzis and Cleistogenes songorica were similar among economic treatments. And the height of Allium polyrhizm had no signiifcant differences between high-economic-level （HEL） and low-economic-level （LEL） treatments. There were no signiifcant difference among treatments in the canopy cover of C. songorica. The densities of dominant species （S. klemenzis, C. songorica and A. polyrhizm） were signiifcantly similar among treatments. Aboveground community biomass in reference area （CK） was higher than that in other three treatments in 2011, but their biomass showed no signiifcant difference among three economic treatments;for 2012, biomass in HEL was higher than low-economic-level treatment （LEL）, while the biomass in middle-economic-level treatment （MEL） and CK was similar to that in HEL and LEL, respectively. Aboveground biomass of S. klemenzis and C. songorica was similar among treatments in both 2011 and 2012. Biomass of A. polyrhizum had no signiifcant difference between HEL and MEL. Households of LEL had rented out excess lands and those of HEL had leased their available lands thus resulting uniform utilization and convergence of pastoralist households’ pastures across all economic levels.

关键词： convergence mental stocking rate pastoralists decision behavior at the household scale

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Correlations between trace elements in pyrite and gold mineralization of gold deposits on the North China platform

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Acta Geochimica 2023年第6期42卷 1079-1103页

作者： Jianzhao yin ying Sun Haoyu yin hongyun Shi James Sparling Yuhong Chao Shoupu xiang College of Earth Sciences Jilin UniversityChangchun 130061China Wuhan Institute of Technology Wuhan 430074China College of Geoexploration Science and Technology Jilin UniversityChangchun 130062China Guinea Westfield Mining Company-Sarlu Jinzhong 031300China Orient Resources Ltd. RichmondBC V7A 4V5Canada Hochschild Mining Canada Corp. Suite 1700 Park Place666 Burrard StreetVancouverBC V6C 2X8Canada Ganzhongnan Institute of Geology and Mineral Exploration 658 Jiefangxilu RoadNanchang 330002China Silvercorp Metals Inc. Suite 601-Building 1China View Mansion#A2 East GongTi RoadChaoyang DistrictBeijing 100027China

By studying both the microscopic physical and chemical typomorphic characteristics of typical mineral pyrite samples associated with representative gold deposits on the north-central margin of the North China Platform,this paper seeks to identify macroscopic metallogenic mechanisms of gold deposits and to reveal the formation mechanism of lattice gold in *** characteristics of pyrite reveal that pyrite grain size has a negative correlation with gold *** pyrite,as the dominant crystal form,contains more gold than pentagonal dodecahedral *** pyrite crystal forms and chemical compositions indicate that the replacement style of gold deposit formed in a low saturability,low sulfur fugacity,and at temperatures either much higher or much lower than its best forming temperature;comparatively,that of the quartz vein style of gold deposit occurred under conditions with the best temperature,rich in sulfur,and with high sulfur *** Au/Ag ratios of the pyrites show that both the replacement and quartz vein styles of deposits are mesothermal and hypothermal,while the Co/Ni ratios of the pyrites indicate that the quartz vein style is of magmatic-hydrothermal *** X-ray diffraction intensity of pyrite rich in gold is lower than that of pyrite poor in gold at the quartz vein *** general,with an increase in gold content in pyrite,the total sum intensityΣI *** pyroelectricity coefficient has a negative correlation trend with the values of(Co+Ni+Se+Te)-As and(Co+Ni+Se+Te)/*** pyrite pyroelectricity of the replacement style is N-type,indicating that it formed under low sulfur fugacity,while that of the quartz vein style is a mixture of P-N types,indicating that it formed under high sulfur *** the pyroelectricity-temperature diagram,pyrite of the replacement style is mainly distributed between 200 and 270°C,while that of the quartz vein style varies between 90–118 and274–386°C,demonstrating a multistage forming proc

关键词： Unit cell parameter Pyroelectricity Electron paramagnetic resonance Infrared spectrum Pyrite Gold deposit

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Improved side information generation algorithm for Wyner-Ziv video coding

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The Journal of China Universities of Posts and Telecommunications 2014年第1期21卷 109-115页

作者： ZHANG Deng-yin WU Yuan-yuan WAN Ming-xiang Sci-Tech Park of Internet of Things Nanjing University of Posts and Telecommunication Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Nanjing University of Posts and Telecommunication

Side information has a significant influence on the rate-distortion（RD） performance of distributed video coding（DVC）. In the conventional motion compensated frame interpolation scheme, all blocks adopt the same side-information generation method regardless of the motion intensity inequality at different regions. In this paper, an improved method is proposed. The image blocks are classified into two modes, fast motion and slow motion, by simply computing the discrete cosine transformation（DCT） coefficients at the encoder. On the decoder, it chooses the direct interpolation and refined motion compensated interpolation correspondingly to generate side information. Experimental results show that the proposed method, without increasing the encoder complexity, can increase the average peak signal-to-noise ratio（PSNR） by up to 1~ 2 dB compared with the existing algorithm. Meanwhile, the proposed algorithm significantly improves the subjective quality of the side information.

关键词： DVC side information motion estimation motion compensation

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Design and Kinematic Analysis of a Novel Humanoid Robot Eye Using Pneumatic Artificial Muscles

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Journal of Bionic Engineering 2008年第3期5卷 264-270页

作者： Xuan-yin Wang Yang Zhang Xiao-jie Fu Gui-shan xiang State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 P. R. China

This paper proposed a novel humanoid robot eye, which is driven by six Pneumatic Artificial Muscles （PAMs） and rotates with 3 Degree of Freedom （DOF）. The design of the mechanism and motion type of the robot eye are inspired by that of human eyes. The model of humanoid robot eye is established as a parallel mechanism, and the inverse-kinematic problem of this flexible tendons driving parallel system is solved by the analytical geometry method. As an extension, the simulation result for saccadic movement is presented under three conditions. The design and kinematic analysis of the prototype could be a sig- nificant step towards the goal of building an autonomous humanoid robot eye with the movement and especially the visual functions similar to that of human.

关键词： bionic robotics bio-inspiration humanoid robot eye air muscle inverse-kinematic

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Facile Synthesis of the Magnetic Metal Organic Framework Fe_3O_4@UiO-66-NH_2 for Separation of Strontium

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Biomedical and Environmental Sciences 2018年第6期31卷 483-488页

作者： yin Liang Liang KONG xiang yin ZHANG Yao JI Yan Qin Key Laboratory of Radiological Protection and Nuclear Emergency National Institute for Radiological ProtectionChinese Center for Disease Control and Prevention

A magnetic metal organic framework（MMOF） was synthesized and used to separate Sr^2＋ in aqueous solution. The shape and structure of prepared Fe3O4@UiO-66-NH2 were characterized, and the absorbed concentration of strontium was determined through inductively coupled plasma mass spectrometry. The results indicated that Fe3O4 and UiO-66-NH2 combined through chemical bonding. The experimental adsorption results for separation of Sr^2＋ in aqueous solution indicated that the adsorption of Sr^2＋ to Fe3O4@UiO-66-NH2 increased drastically from pH 11 to pH 13. The adsorption isotherm model indicated that the adsorption of Sr^2＋ conformed to the Freundlich isotherm model（R2 = 0.9919）. The MMOF thus inherited the superior qualities of magnetic composites and metal organic frameworks, and can easily be separated under an external magnetic field. This MMOF thus has potential applications as a magnetic adsorbent for low level radionuclide （90）Sr.

关键词： Magnetic metal organic framework(MMOF) Fe3O4@UiO-66-NH2 Radioactivity Strontium Adsorbents

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A time-sharing multi-channel pulse amplitude analyzer

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Nuclear Science and Techniques 2017年第4期28卷 91-96页

作者： Lian-Jun Jiang xiang Zhou Tong-Yu Wu Ze-Jie yin State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Department of Modern Physics University of Science and Technology of China

A conventional multi-channel pulse amplitude analyzer acquires single energy spectrum,but provides no information on its tendency with *** address the limitation,we propose a scheme of time-sharing multichannel pulse amplitude analyzer(TSMCA).A dual-port random access memory is divided into two storage spaces,one for current energy spectrum data acquisition and another for previous energy spectrum data *** two tasks can be performed simultaneously,and the time-related variation tendency of energy spectrum can be obtained.A prototype system of TSMCA is *** performs nicely,with maximum channel number of 4096 in capacity of 2^(32)/Ch,minimal time-sharing slice of 25 ms,the differential nonlinearity of <1.5%,and the integral nonlinearity of <0.3%.

关键词： Multi-channel pulse amplitude analyzer MCA Time-sharing ADC Dual-port RAM

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Impact Analysis of Air Gap Motion with Respect to Parameters of Mooring System for Floating Platform

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China Ocean Engineering 2017年第2期31卷 141-150页

作者： SHEN Zhong-xiang HUO Fa-li NIE Yan LIU yin-dong Transportation Equipments and Ocean Engineering College Dalian Maritime University Dalian 116026 China School of Naval Architecture and Offshore Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China Grenland Group (China) Ltd. Shanghai 201206 China

In this paper, the impact analysis of air gap concerning the parameters of mooring system for the semi-submersible platform is conducted. It is challenging to simulate the wave, current and wind loads of a platform based on a model test simultaneously. Furthermore, the dynamic equivalence between the truncated and full-depth mooring system is still a tuff work. However, the wind and current loads can be tested accurately in wind tunnel model. Furthermore, the wave can be simulated accurately in wave tank test. The full-scale mooring system and the all environment loads can be simulated accurately by using the numerical model based on the model tests simultaneously. In this paper, the air gap response of a floating platform is calculated based on the results of tunnel test and wave tank. Meanwhile, full-scale mooring system, the wind, wave and current load can be considered simultaneously. In addition, a numerical model of the platform is tuned and validated by ANSYS AQWA according to the model test results. With the support of the tuned numerical model, seventeen simulation cases about the presented platform are considered to study the wave, wind, and current loads simultaneously. Then, the impact analysis studies of air gap motion regarding the length, elasticity, and type of the mooring line are performed in the time domain under the beam wave, head wave, and oblique wave conditions.

关键词： mooring system air gap floating platform

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