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Exploitation of fractured shale oil resources by cyclic CO_2 injection

Petroleum Science 2018年第3期15卷 552-563页

作者： Tao Wan hong-xian liu Faculty of Petroleum China University of Petroleum(Beijing)

With shale oil reservoir pressure depletion and recovery of hydrocarbons from formations, the fracture apertures and conductivity are subject to reduction due to the interaction between stress effects and proppants. Suppose most of the proppants were concentrated in dominant fractures rather than sparsely allocated in the fracture network, the fracture conductivity would be less influenced by the induced stress effect. However, the merit of uniformly distributed proppants in the fracture network is that it increases the contact area for the injection gas with the shale matrix. In this paper, we address the question whether we should exploit or confine the fracture complexity for CO2-EOR in shale oil reservoirs. Two proppant transport scenarios were simulated in this paper： Case 1-the proppant is uniformly distributed in the complex fracture system, propagating a partially propped or un-propped fracture network; Case 2-the proppant primarily settles in simple planar fractures. A series of sensitivity studies of the fracture conductivity were performed to investigate the conductivity requirements in order to more efficiently produce from the shale reservoirs. Our simulation results in this paper show the potential of CO2 huff-n-puff to improve oil recovery in shale oil reservoirs. Simulation results indicate that the ultra-low permeability shales require an interconnected fracture network to maximize shale oil recovery in a reasonable time period. The well productivity of a fracture network with a conductivity of 4 mD ft achieves a better performance than that of planar fractures with an infinite conductivity. However, when the conductivity of fracture networks is inadequate,the planar fracture treatment design maybe a favorable choice. The available literature provides limited information on the relationship between fracture treatment design and the applicability of CO2 huff-n-puff in very low permeability shale formations. Very limited field test or laboratory data

关键词： CO2-enhanced oil recovery Huff-n-puff Shale oil reservoirs Recovery simulation

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A novel derivative of geldanamycin and its antitumor activity

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Chinese Chemical Letters 2009年第4期20卷 391-392页

作者： Liang Li hong liu xian Dong Xu Yong Su Zhen Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

A new derivative of geldanamycin was synthesized by introducing the 6-cinnamamido-hexyl-amino group into the 17-site of geldanamycin, a heat shock protein 90 （Hsp90） inhibitor, to obtain 17-（6-cinnamamido-hexylamino）-17-demethoxygel-danamycin （CNDG）. Its in vitro and in vivo antitumor effects were evaluated by MTT assay and xenograft in nude mice.

关键词： 17-(6-Cinnamamido-hexylamino)-17-demethoxygeldanamycin Hsp90 inhibitor

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Physical simulation of rock burst induced by stress waves

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Journal of China University of Mining and Technology 2008年第3期18卷 401-405页

作者： LU Ai-hong MAO xian-biao liu Hai-shun School of Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The behavior of stress wave propagation in rock walls and the process of rock bursts were simulated by application tests of material similar to rock. Results show that 1) the attenuation characteristics of stress waves were related to the material proper-ties, stress waves attenuate more quickly in soft material and 2) when the explosion load was applied at the top of the roadway, the number and the length of the cracks increased with a decrease in the distance between the explosive point and roof of the roadway. When the distance was 280 mm, only some chips appeared near the source, when the distance was 210 mm, some small cracks started to appear near the road-rib and when the distance was reduced to 140 mm, larger cracks appeared at the road-rib. It can be concluded that, under a given stress the number of cracks is closely related to the intensity of stress waves. The cracks in the sur-rounding rock can be reduced by controlling the intensity of the stress waves and rock bursts can be avoided to some extent by pre-venting the formation of layered crack structures. A new experimental approach has been provided for studying rock bursts by using physical simulation.

关键词： similar material stress wave physical simulation rock burst

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Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins

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Chinese Chemical Letters 2007年第11期18卷 1335-1338页

作者： Di Zao Li Yan Li Xiao Guang Chen Chen Gen Zhu Jing Yang hong Yan liu xian Dao Pan Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 possessed the best efficacy on six human cancer cell lines in the six classes of CPTs＇ derivatives. In vivo testing results indicated that 9 had better antitumor activity against mouse liver carcinoma H22 than topotecan.

关键词： Camptothecin Synthesis Heterocyclic acid Antitumor activity

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TNF-α up-regulates Nav1.3 in dorsal root ganglion after nerve injury

TNF-α up-regulates Nav1.3 in dorsal root ganglion after ne...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ying ZANG,Xu-hong WEI,xian-Guo liu Pain research Center of Sun Yat-sen University,Guangzhou,510080

＜正＞TTX-sensitive（TTX-S） Nav1.3 sodium channel is barely detectable in adult DRG or spinal *** nerve injury,however,the channel is up-regulated dramatically,which may contribute to neuropathic *** previous studies have shown TNF-a in DRG is increased after selective damage of motor fibers by L5 ventral root trancection（L5-VRT）.In the present work,we tested the hypothesis that TNF-a up-regulates Nav 1.3 after nerve *** found that Nav 1.3 in ipsilateral L4 and L5 DRG was increased following L5-VRT,starting on day 1,reached a peak on day 7 and persisted for at least 5 weeks after *** staining revealed that Nav 1.3 is mainly located in the C-type neurons and to a less extent in A-type neurons;More than 85%of neurons that express Nav 1.3 is TNF-α -*** confirm the relationship between TNF-α and Nav1.3,we applied TNF-α directly on to sciatic nerve without nerve injury and found that TNF-α alone produced mechanical allodynia and up-regulation of Navl.3 in DRG ***,we observed pretreatment with thalidomide,an inhibitor of TNF-α synthesis,significantly inhibited the expression of Nav 1.3 in DRG and the behavioral signs of neuropathic pain induced by *** conclude that apart from transient activation of sensory neurons as reported previously,TNF-α may produce long-lasing excitability change of neurons by up-regulation of Nav 1.3.

关键词： TNF-α Nav1.3 neuropathic pain dorsal root ganglion

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Microencapsulation of Lactobacillus brevis and preliminary evaluation of their therapeutic effect on the diarrhea of neonatal calf

Microencapsulation of Lactobacillus brevis and preliminary e...

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第四届第十次全国学术研讨会暨动物微生态企业发展战略论坛

作者： Xue-Feng Qi,hong-Ming liu,xian-Jun Zhao~* (College of Veterinary Medicine of Northwest A & F University,Yangling,Shaanxi,712100,China

Microcapsules of Lactobacillus brevis were prepared using spray drying technique,and the resistance of the microencapsulated form of this microorganism to drying at high temperature and simulated gastrointestinal conditions were *** therapeutic effect of these microcapsules on the diarrhea of neonatal calf was also evaluated using *** results showed that the completely release of the encapsulated bacteria took place after 60 min in contact with simulated intestinal *** bacteria were resistant at least for 90 min to simulated gastric juice(pH 1.2) or simulated intestinal juice(pH 7.2),and microencapsulated form of the microorganisms was more resistant to drying at 85℃than free ***-PCR profiles of diarrhea calves treated with probiotic capsules were similar to that of control health calves at 3 days post administration,suggesting that administration of these probiotic capsules may have strong positive effect on the treatment of neonatal calf diarrhea.

关键词： Microencapsulation Lactobacillus brevis Diarrhea of neonatal calf ERIC-PCR

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A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo Zhang Yinfan liu xian Jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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土贝母正丁醇部位化学成分研究

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华中师范大学学报（自然科学版） 2016年第5期50卷 721-725页

作者：李娟何峰尹娴洪宗国刘新桥向梅先中南民族大学药学院武汉430074

采用薄层色谱,正相、反相硅胶,葡聚糖凝胶,半制备高效液相柱对土贝母正丁醇部位进行了分离研究.分离得到10个化合物,分别为:6-C-葡萄糖-5,7,3′,4′-四羟基黄酮(1),胡萝卜苷(2),胡萝卜苷棕榈酸酯(3),豆甾醇(4),β-谷甾醇(5),β-谷甾醇... 详细信息

采用薄层色谱,正相、反相硅胶,葡聚糖凝胶,半制备高效液相柱对土贝母正丁醇部位进行了分离研究.分离得到10个化合物,分别为:6-C-葡萄糖-5,7,3′,4′-四羟基黄酮(1),胡萝卜苷(2),胡萝卜苷棕榈酸酯(3),豆甾醇(4),β-谷甾醇(5),β-谷甾醇棕榈酸酯(6),正丁基-β-D-吡喃果糖苷(7),大黄素(8),大黄素甲醚(9),麦芽酚(10).除化合物(8)外,其余化合物都是首次从该植物中分离得到.

关键词：土贝母正丁醇部位化学成分研究

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The maximal Lyapunov exponent of a co-dimension two-bifurcation system excited by a bounded noise

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Acta Mechanica Sinica 2012年第2期28卷 511-519页

作者： Sheng-hong Li xian-Bin liu State Key Lab of Mechanics and Control for Mechanical Structures College of Aerospace EngineeringNanjing University of Aeronautics and Astronautics210014 NanjingChina School of Mathematics and Physics Jiangsu University of Science and Technology212003 ZhenjiangChina

In the present paper, the maximal Lyapunov ex- ponent is investigated for a co-dimension two bifurcation system that is on a three-dimensional central manifold and subjected to parametric excitation by a bounded noise. By using a perturbation method, the expressions of the invari- ant measure of a one-dimensional phase diffusion process are obtained for three cases, in which different forms of the matrix B, that is included in the noise excitation term, are assumed and then, as a result, all the three kinds of singular boundaries for one-dimensional phase diffusion process are analyzed. Via Monte-Carlo simulation, we find that the an- alytical expressions of the invariant measures meet well the numerical ones. And furthermore, the P-bifurcation behav- iors are investigated for the one-dimensional phase diffusion process. Finally, for the three cases of singular botmdaries for one-dimensional phase diffusion process, analytical ex- pressions of the maximal Lyapunov exponent are presented for the stochastic bifurcation system.

关键词： Maximal Lyapunov exponent Perturbationmethod. Bounded noise. Diffusion process

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