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Advanced oxidation protein products induce monocyte chemoattractant protein-1 expression via p38 mitogen-activated protein kinase activation in rat vascular smooth muscle cells

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Chinese Medical Journal 2006年第13期119卷 1088-1093页

作者： PENG Kan-fu WU Xiong-fei ZHAO hong-wen sun Yan Department of Nephrology Southwest Hospital Third Military Medical University Chongqing 400038 China

Background Advanced oxidation protein products （AOPPs） are new uremic toxins reported by Witko-Sarsat in 1996, which are associated with the pathogenesis of atherosclerosis. However, the mechanisms by which AOPPs enhance atherosclerosis have not been fully understood. Monocyte chemoattractant protein-1 （MCP-1） is a chemokine which stimulates migration of monocytes and plays a critical role in the development of atherosclerosis. In this study, we investigated the effect of AOPPs on MCP-1 expression in cultured vascular smooth muscle cells （VSMCs）.

关键词： atherosclerosis advanced oxidation protein products monocyte chemoattractant protein-1 mitogen-activated protein kinase myocytes, smooth muscle

Functional Connectivity Difference Detected in Bilateral Occipital Lobes Between the Abacus Experts and Control Groups: Using Nonlinear Processing Method

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第1期19卷 16-21页

作者： WANG Zhi-kang DING wen-hong sun Jian-zhong The Second Affiliated Hospital Zhejiang University College of Medicine Hangzhou 310009 China

Objective:This paper is to investigate functional connectivity differences between the abacus experts and control groups by using nonlinear processing method spatiotemporal Lyapunov ***:11 right-handed healthy control children and 12 abacus children were undergone functional magnetic resonance imaging(fMRI).After preprocessing fMRI data with SPM,linear and nonlinear methods for connectivity analysis were both ***:Connectivity differences between the two groups were statistically P<0.05 by the correlation method,while the P value by the nonlinear method were P<***:There are significant differences between the two groups in functional connectivity of bilateral occipital *** nonlinear method proposed here seems to be more specific compared with the common linear correlation method.

关键词： functional connectivity neural correlate nonlinear dynamics

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金融衍生证券在证券投资基金中的应用研究

特区经济 2010年第1期 102-104页

作者：何树红徐文涛孙文云南大学数学与统计学院云南昆明650091

金融衍生证券自其产生以来,在金融市场得到了广泛的发展和应用。它凭借其显著的特征和功能,能够克服许多传统金融工具的弊病,更好地为投资者控制风险和盈利。因此,本文从金融衍生证券的特征和功能出发,对金融衍生证券在投资基金中的应... 详细信息

金融衍生证券自其产生以来,在金融市场得到了广泛的发展和应用。它凭借其显著的特征和功能,能够克服许多传统金融工具的弊病,更好地为投资者控制风险和盈利。因此,本文从金融衍生证券的特征和功能出发,对金融衍生证券在投资基金中的应用进行研究,并提出证券投资基金金融衍生证券业务风险控制的建议。

关键词：金融衍生证券证券投资基金风险管理

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang sun hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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考虑含气量变化的浆体水击基本方程

水动力学研究与进展（A辑） 2005年第5期20卷 654-659页

作者：周云龙洪文鹏孙斌东北电力学院吉林132012

压力波的传播速度是影响液-固两相流浆体水击压强的主要因素,而波速与管道的材料和流体的成分密切相关。本文分析了含气量对浆体水击的影响,提出了考虑含气量的浆体水击波速公式,在此基础上推导了考虑含气量变化的液-固两相流浆体水击... 详细信息

压力波的传播速度是影响液-固两相流浆体水击压强的主要因素,而波速与管道的材料和流体的成分密切相关。本文分析了含气量对浆体水击的影响,提出了考虑含气量的浆体水击波速公式,在此基础上推导了考虑含气量变化的液-固两相流浆体水击的基本方程。

关键词：固液两相流水击基本方程

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu wen sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词：

同方期刊数据库

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一个多Agent设计概念学习系统

西南师范大学学报（自然科学版） 2001年第4期26卷 388-392页

作者：刘弘孙文星刘希玉山东师范大学计算机科学系山东济南250014

设计是一个复杂的问题求解和逐步求精的过程 .学习可以有效地利用经验知识改进设计者及计算系统的能力 .提出了一种面向对象的设计模型 ,并介绍了基于该模型的设计知识表示方法及用决策树进行分类的方法 .然后 ,介绍了多Agent设计概念... 详细信息

设计是一个复杂的问题求解和逐步求精的过程 .学习可以有效地利用经验知识改进设计者及计算系统的能力 .提出了一种面向对象的设计模型 ,并介绍了基于该模型的设计知识表示方法及用决策树进行分类的方法 .然后 ,介绍了多Agent设计概念学习系统DCLS (DesignConceptLearningSystem)的结构及学习过程 .

关键词：机器学习概念设计知识表示面向对象 DCLS 工业产品

Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, Jianyi sun, Yuanmiao Zhu, Jiamin Seow, Justin Zhu Yeow Zhang, hong Zhang, Nan Xi, Pinxian Xu, Zhichuan J. Yan, Chun-Hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction