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Esophageal cancer screening,early detection and treatment:Current insights and future directions

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： hong-Tao Qu Qing Li Liang Hao Yan-Jing ni Wen-Yu Luan Zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

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A modified back analysis method for deep excavation with multi-objective optimization procedure

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1373-1387页

作者： Chenyang Zhao Le Chen Pengpeng ni Wenjun Xia Bin Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Guangdong Research Center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai519000China Jiangsu Provincial Transportation Engineering Construction Bureau Nanjing210004China

Real-time prediction of excavation-induced displacement of retaining pile during the deep excavation process is crucial for construction *** paper proposes a modified back analysis method with multi-objective optimization procedure,which enables a real-time prediction of horizontal displacement of retaining pile during *** opposed to the traditional stage-by-stage back analysis,time series monitoring data till the current excavation stage are utilized to form a multi-objective ***,the multi-objective particle swarm optimization (MOPSO) algorithm is applied for parameter *** optimized model parameters are immediately adopted to predict the excavation-induced pile deformation in the continuous construction *** achieve efficient parameter optimization and real-time prediction of system behavior,the back propagation neural network (BPNN) is established to substitute the finite element model,which is further implemented together with MOPSO for automatic *** proposed approach is applied in the Taihu tunnel excavation project,where the effectiveness of the method is demonstrated via the comparisons with the site monitoring *** method is reliable with a prediction accuracy of more than 90%.Moreover,different optimization algorithms,including non-dominated sorting genetic algorithm (NSGA-II),Pareto Envelope-based Selection Algorithm II (PESA-II) and MOPSO,are compared,and their influences on the prediction accuracy at different excavation stages are *** results show that MOPSO has the best performance for high dimensional optimization task.

关键词： Multi-objective optimization Back analysis Surrogate model Multi-objective particle swarm optimization(MOPSO) Deep excavation

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The CBL-interacting protein kinase OsCIPK1 phosphorylated by SAPK10 positively regulates responses to ABA and osmotic stress in rice

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The Crop Journal 2024年第2期12卷 364-374页

作者： Caihua Qin Xing Fan Qianqian Fang Lan ni Mingyi Jiang College of Life Sciences State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationKey Laboratory of Crop Physiology Ecology and Production ManagementMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

SubclassⅢsucrose nonfermenting1-related protein kinase 2s(SnRK2s)function in ABA and abiotic stress responses by unknown *** found that osmotic stress/ABA-activated protein kinase 10(SAPK10),a member of rice SnRK2s,physically interacted with CBL-interacting protein kinase 1(OsCIPK1).OsCIPK1 expression was up-regulated by ABA and PEG treatment,and overexpression increased the ABA sensitivity of seed germination and root growth and plant osmotic stress *** stress or ABA-induced activation of OsCIPK1 is dependent on ***10 phosphorylates Thr-24 of OsCIPK1 in vitro,and this phosphorylation increases the activity of OsCIPK1 and positively regulates the function of OsCIPK1 in ABA responses and plant osmotic stress *** study suggests that OsCIPK1 is a direct phosphorylated substrate of SAPK10,and SAPK10-mediated phosphorylation of OsCIPK1 functions in ABA signaling and increases rice osmotic stress tolerance.

关键词： Rice ABA Osmotic stress OsCIPK1 SAPK10

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Decadal prediction skill for Eurasian surface air temperature in CMIP6 models

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Atmospheric and Oceanic Science Letters 2024年第1期17卷 9-13页

作者： Yanyan Huang ni Huang Qianfei Zhao Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina Nansen–Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Dalian Meteorological Bureau of Liaoning Province DalianChina

评估CMIP6年代际预测试验对季节平均SAT的预测技巧的结果表明:模式不能有效预测冬季和秋季SAT的年代际变率.IPSL-CM6A-LR和多模式集合平均对于春季SAT展现了预测技巧,其中对于变率的预测技巧好于振幅的结果.基于蒙古和我国华北地区的显... 详细信息

评估CMIP6年代际预测试验对季节平均SAT的预测技巧的结果表明:模式不能有效预测冬季和秋季SAT的年代际变率.IPSL-CM6A-LR和多模式集合平均对于春季SAT展现了预测技巧,其中对于变率的预测技巧好于振幅的结果.基于蒙古和我国华北地区的显著预测技巧,模式对于夏季SAT表现出最佳的预测水平.与外部强迫相比,模式对于SAT的预测技巧可能来自初始化.模式中的一个明显系统性误差值得注意,即模式中冬季SAT的变率可以持续到其他季节,而在观测中其他季节的SAT变化与冬季SAT相对独立.

关键词：欧亚地表温度年代际预测 CMIP6 DCPP

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Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets

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Science China(Life Sciences) 2024年第2期67卷 379-390页

作者： Jing Li Fenfen Liu Kaibin Mo Hengjia ni Yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessHunan Research Center of Livestock and Poultry SciencesSouth Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100008China Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China

Weaning piglets usually suffer from severe diarrhea(commonly known as postweaning diarrhea,PWD)along with intestinal motility *** peristalsis is mainly regulated by the longitudinal muscle-myenteric plexus(LM-MP).To understand the relationship between intestinal LM-MP function and the development of PWD,we compared the intestinal electrical activity,and the transcriptional profile of the LM-MP between 21-day-old piglets(just weaned,n=7)and 24-day-old piglets(suffered the most severe weaning stress,n=7).The results showed that 24-day-old piglets exhibited different degrees of diarrhea.A significant increase in the slow-wave frequency in the ileum and colon was observed in 24-day-old piglets,while c-kit expression in the intestinal LM-MPs was significantly decreased,indicating that PWD caused by elevated slow-wave frequency may be associated with loss of *** real-time quantitative PCR(RT-q PCR)and enzyme-linked immunosorbent assay(ELISA)showed that intestinal LM-MPs in 24-day-old piglets may undergo inflammation and oxidative *** increases in 8-hydroxy-2′-deoxyguanosine and decreases in thioredoxin suggest that weaning may lead to DNA damage in the LM-MP of 24-day-old *** addition,activating transcription factor 3 was significantly upregulated,indicating nerve damage in the LM-MP of 24-day-old *** transcriptomic results showed that most of the differentially expressed genes in the ileal LM-MP after weaning were downregulated and closely related to the cell cycle *** RT-q PCR analysis showed that the relative expression of p21 was upregulated,while the expression of cyclin A2,cyclin B1,and proliferating cell nuclear antigen was downregulated in the ileal and colonic LM-MP of 24-day-old piglets,suggesting that weaning may inhibit cell proliferation and cause G1/S cell cycle arrest in ileal and colonic *** conclusion,weaning may lead to cell cycle arrest by causing DNA damage in the LM-MP,impairing i

关键词： weaning piglets diarrhea longitudinal muscle-myenteric plexus

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Progress of vegetation modelling and future research prospects

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Science China Earth Sciences 2024年第9期67卷 2718-2738页

作者： Siqi LI Xu ZHANG Zhengyao LU Jian ni Jianhua LU State Key Laboratory of Tibetan Plateau Earth System Resources and Environment (TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences British Antarctic Survey Department of Physical Geography and Ecosystem Science Lund University College of Life Sciences Zhejiang Normal University School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)

Terrestrial vegetation is a crucial component of the Earth system, and its changes not only represent one of the most distinct aspects of climate change but also exert significant feedback within the climate system by exchanging energy, moisture,and carbon dioxide. To quantitatively and mechanistically study climate-vegetation feedback, numerical vegetation models have been developed on the theory of ecophysiological constraints on plant functional types. The models eventually can simulate vegetation distribution and succession across different spatial and temporal scales, and associated terrestrial carbon cycle processes by categorizing vegetation into biomes according different plant functional types and their associated environmental factors. Here we review the developing history of vegetation models and provide recent advances and future directions. Before 21st century, static vegetation models, as developed statistical models, can only simulate equilibrated characteristics of vegetation distribution. In last several decades, Dynamic Global Vegetation Models(DGVMs) have been developed to simulate instantaneous responses of vegetation to climate change and associated dynamics, and can be coupled with Earth system models to investigate interactions among atmosphere, ocean, and land. DGVMs are also widely applied to investigate the dynamics accounting for changes in the geographic distribution patterns of land surface vegetation at different spatial and temporal scales and to assess the impacts of terrestrial carbon and water fluxes and land use changes. We suggest that future vegetation modeling could integrate with machine learning, and explore vegetation transient response and feedback as well as impacts of process hierarchies and human activities on climate and ecosystem.

关键词： Vegetation models DGVMs Ecosystems Plant functional types Plant functional traits

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Improved Particle Swarm Optimization for Parameter Identification of Permanent Magnet Synchronous Motor

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Computers, Materials & Continua 2024年第5期79卷 2187-2207页

作者： Shuai Zhou Dazhi Wang Yongliang ni Keling Song Yanming Li School of Information Science and Engineering Northeastern UniversityShenyang110819China China Northern Vehicle Research Institute Beijing100072China

In the process of identifying parameters for a permanent magnet synchronous motor,the particle swarm optimization method is prone to being stuck in local optima in the later stages of iteration,resulting in low parameter *** work proposes a fuzzy particle swarm optimization approach based on the transformation function and the filled *** approach addresses the topic of particle swarmoptimization in parameter identification from two ***,the algorithm uses a transformation function to change the form of the fitness function without changing the position of the extreme point of the fitness function,making the extreme point of the fitness function more prominent and improving the algorithm’s search ability while reducing the algorithm’s computational ***,on the basis of themulti-loop fuzzy control systembased onmultiplemembership functions,it is merged with the filled function to improve the algorithm’s capacity to skip out of the local optimal *** approach can be used to identify the parameters of permanent magnet synchronous motors by sampling only the stator current,voltage,and speed *** simulation results show that the method can effectively identify the electrical parameters of a permanent magnet synchronous motor,and it has superior global convergence performance and robustness.

关键词： Transformation function filled function fuzzy particle swarm optimization algorithm permanent magnet synchronous motor parameter identification

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Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy:Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits

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Current Medical Science 2024年第2期44卷 450-461页

作者： Xiao-yun DING Hao ZHANG Yu-mei QIU Meng-die XIE Hu WANG Zheng-yu XIONG Ting-ting LI Chun-ni HE wei DONG Xi-lan TANG School of Pharmacy Jiangxi Science&Technology Normal UniversityNanchang 330013China Key Laboratory of Modern Preparation of Chinese Medicine Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation Nanchang 330013China

Objective:Cymbopogon citratus(DC.)Stapf is a medicinal and edible herb that is widely used for the treatment of gastric,nervous and hypertensive *** this study,we investigated the cardioprotective effects and mechanisms of the essential oil,the main active ingredient of Cymbopogon citratus,on isoproterenol(ISO)-induced cardiomyocyte ***:The compositions of Cymbopogon citratus essential oil(CCEO)were determined by gas chromatography-mass *** were pretreated with 16.9µg/L CCEO for 1 h followed by 10µmol/L ISO for 24 *** hypertrophy-related indicators and NLRP3 inflammasome expression were ***,transcriptome sequencing(RNA-seq)and target verification were used to further explore the underlying ***:Our results showed that the CCEO mainly included citronellal(45.66%),geraniol(23.32%),and citronellol(10.37%).CCEO inhibited ISO-induced increases in cell surface area and protein content,as well as the upregulation of fetal gene ***,CCEO inhibited ISO-induced NLRP3 inflammasome expression,as evidenced by decreased lactate dehydrogenase content and downregulated mRNA levels of NLRP3,ASC,CASP1,GSDMD,and IL-1β,as well as reduced protein levels of NLRP3,ASC,pro-caspase-1,caspase-1(p20),GSDMD-FL,GSDMD-N,and pro-IL-1β.The RNA-seq results showed that CCEO inhibited the increase in the mRNA levels of 26 oxidative phosphorylation complex subunits in ISO-treated *** further experiments confirmed that CCEO suppressed ISO-induced upregulation of mt-Nd1,Sdhd,mt-Cytb,Uqcrq,and mt-Atp6 but had no obvious effects on mt-Col ***:CCEO inhibits ISO-induced cardiomyocyte hypertrophy through the suppression of NLRP3 inflammasome expression and the regulation of several oxidative phosphorylation complex subunits.

关键词： Cymbopogon citratus essential oil cardiac hypertrophy NLRP3 inflammasome oxidative phosphorylation complex subunits

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空间引力波探测现状与展望

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中国科学：物理学、力学、天文学 2024年第7期54卷 2-63页

作者：倪维斗中国科学院大学国际理论物理中心(亚太地区) 北京100190 中国科学院精密测量科学与技术创新研究院武汉物理与数学研究所武汉430071

空间引力波探测是依据引力理论推导出的天文动力学方程来探测引力波所引起航天器/天体间距离的改变和/或其状态的变化.基本方法是使用电磁波(包括射电、微波、光波、X光、伽马射线等)多普勒跟踪与发射接收两端的稳定频率标准(源)比对,... 详细信息

空间引力波探测是依据引力理论推导出的天文动力学方程来探测引力波所引起航天器/天体间距离的改变和/或其状态的变化.基本方法是使用电磁波(包括射电、微波、光波、X光、伽马射线等)多普勒跟踪与发射接收两端的稳定频率标准(源)比对,如微波多普勒跟踪、光钟引力波探测、原子干涉引力波探测和激光干涉引力波探测等.若两端的频率源稳定性不足,则需使用基于多普勒跟踪组合的双路径广义迈克尔逊干涉.现在正在建造、规划的空间引力波探测器主要的是激光干涉仪,涵盖中频(0.1–10 Hz)、与低频(毫赫兹0.1–100 mHz和微赫兹0.1–100μHz)波段引力波的探测.本文评述这些引力波探测的现况和展望.

关键词：引力波空间引力波探测空间时延干涉激光迈克尔逊干涉引力波探测毫赫兹引力波微赫兹引力波分赫兹引力波多普勒跟踪光钟引力波探测原子干涉引力波探测

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Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： wei-Long Xu Pei-Pei Zhou Xu Yu Ting Tian Jin-Jing Bao Chang-Rong ni Min Zha Xiao Wu Jiang-Yi Yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(DN).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which myricetin influences the progression of DN remains *** To investigate the effects of myricetin on DN and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

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