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Long-term efficacy,safety and biocompatibility of a novel sirolimus eluting iron bioresorbable scaffold in a porcine model

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Bioactive Materials 2024年第9期39卷 135-146页

作者： Ya-Nan Gao hong-tao yang Zi-Feng Qiu Feng Qi Qian-hong Lu Jian-Feng Zheng Zi-Wei Xi Xin Wang Li Li Gui Zhang De-Yuan Zhang Yu-Die Lu Hai-Ping Qi hong Qiu Run-Lin Gao Yu-Feng Zheng Department of Cardio-Metabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Coronary Artery Disease CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Engineering Medicine Beihang UniversityBeijingChina R&D Center Biotyx Medical(Shenzhen)Co.Ltd.ShenzhenChina Department of Cardiology Fuwai Yunnan HospitalChinese Academy of Medical SciencesAffiliated Cardiovascular Hospital of Kunming Medical UniversityKunmingChina Peking University Health Science Center BeijingChina Department of Cardiology Beijing Tsinghua Changgung HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseasesBeijingChina School of Materials Science and Engineering Peking UniversityBeijingChina

Iron is considered as an attractive alternative material for bioresorbable scaffolds(BRS).The sirolimus eluting iron bioresorbable scaffold(IBS),developed by Biotyx Medical(Shenzhen,China),is the only iron-based BRS with an ultrathin-wall *** study aims to investigate the long-term efficacy,safety,biocompatibility,and lumen changes during the biodegradation process of the IBS in a porcine model.A total of 90 IBSs and 70 cobaltchromium everolimus eluting stents(EES)were randomly implanted into nonatherosclerotic coronary artery of healthy mini *** multimodality assessments including coronary angiography,optical coherence tomography,micro-computed tomography,magnetic resonance imaging,real-time polymerase chain reaction(PCR),and histopathological evaluations,were performed at different time *** was no statistical difference in area stenosis between IBS group and EES group at 6 months,1year,2 years and 5 *** the scaffolded vessels narrowed at 9 months,expansive remodeling with increased mean lumen area was found at 3 and 5 *** IBS struts remained intact at 6 months,and the corrosion was detectable at 9 *** 5 years,the iron struts were completely degraded and absorbed in situ,without in-scaffold restenosis or thrombosis,lumen collapse,aneurysm formation,and chronic *** local or systemic toxicity and abnormal histopathologic manifestation were found in all *** from real-time PCR indicated that no sign of iron overload was reported in scaffolded ***,the IBS shows comparable efficacy,safety,and biocompatibility with EES,and late lumen enlargement is considered as a unique feature in the IBS-implanted vessels.

关键词： Bioresorbable scaffold Sirolimus eluting iron bioresorbable scaffold Preclinical study Completely bioresorbable Late lumen enlargement

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Construction of Greenbelt and Sustainable Development in Harbin City

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Journal of Northeast Agricultural University(English Edition) 2011年第3期18卷 71-74页

作者： PANG Songling hong Li yang tao CHE Daidi College of Horticulture Northeast Agricultural University Harbin 150000 China

Through analyzing the current urban greenbelt construction and relative issues during the development in northeastern parts in Harbin of China, some feasible solutions were proposed. In order to improve the urban ecological environment and upgrading the constructive level of the urban greenbelt along with the sustainable development in the future, the paper provided some solutions in details

关键词： urban greenbelt construction problem and solution sustainable development

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Research progress on non-drug treatment of diabetic kidney disease

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TMR Non-Drug Therapy 2021年第3期4卷 1-7页

作者： Bei-Liang Miao Li Yu Jing Li hong-tao yang First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Diabetic kidney disease is one of the most serious and common chronic complications of diabetes and one of the leading causes of death in diabetic *** the case of diabetic kidney disease,sustained proteinuria is irreversible until it develops into end-stage renal *** treatment of diabetic kidney disease is relatively *** and more evidences into the effectiveness and safety that related non-drug treatments not only have the characteristics of simple operation and high safety,but also can improve the clinical symptoms of patients with diabetic kidney disease,reduce laboratory indicators,and delay disease *** article summarizes the recent literature on non-drug treatment of diabetic kidney disease such as exercise therapy,acupuncture therapy,acupoint application,auricular acupoint pressing pill therapy,moxibustion therapy,in order to provide reference for clinical treatment.

关键词： Diabetic kidney disease External therapy Modern rehabilitation treatment methods Traditional non-drug therapy Acupuncture

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Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI Feng WANG tao DUAN Kaijie yang Bin yang Chunmei WANG Xin TIAN Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第1期68卷 273-287页

作者： Shuguang yang Lijun Hu hong Xiao Zecong Xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词： fluorescent molecular probes self-amplifying myeloperoxidase photodynamic therapy

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Influence of astragalus polysaccharide on kidney status and fibrosis indices of a ratmodel of streptozotocin-induced diabetic nephropathy

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Traditional Medicine Research 2018年第4期3卷 173-180页

作者： Yue Ji Xue-Rou Yan hong-tao yang Kang yang Qing-Yun Zhao Shou-Ci Hu Qi-Hang Su Tianjin University of Traditional Chinese Medicine Tianjin China The First Teaching Hospital of Tianjin Universityof Traditional Chinese Medicine Tianjin China

Object： To examine the effect of astragalus polysaccharide （APS） on kidney status and fibrosis indices of rats withdiabetic nephropathy. Methods： 72 male rats were randomly divided into three groups： negative control group （NC, n =24）; diabetic nephropathy model group （DNM, n = 24）; and diabetic nephropathy model with APS group （DNM ＋ APS,n = 24）. Rats of the DNM and DNM ＋ APS groups were subjected to both unilateral nephrectomy and administeredstreptozotocin （STZ） injection （65 mg/kg）. DNM ＋ APS group rats were administered 50 IU/kg/d APS by subcutaneousinjection from the first week after operation until death. The NC and DNM group rats were subcutaneously injected withan identical volume of physiological saline. At weeks 3, 8, and 13 after the operation, 6 rats from each group wererandomly sacrificed and blood was collected to measure serum creatinine and blood urea nitrogen. On the day beforesacrifice, the rats were placed in a metabolic cage for 24 h to collect urine. At week 14 after the operation, 6 rats fromeach group were randomly selected to measure body weight and kidney index. Blood was collected to measure bloodglucose. The kidneys were harvested to detect pathological changes by hematoxylin and eosin staining. Results：Histological assessment of DNM rats suggested damage symptoms as evidenced by hyperplasia of the glomerularmesangial matrix, atrophia of the kidney tubules, and thickening of the basement membrane. In contrast, STZ-induceddiabetic nephropathy rats treated with APS （50 IU/kg/d） showed significantly improved histological results, suggestingthat APS has beneficial effect on renal tissues in STZ-induced DNM rats. Our results also indicated that APS relievedrenal injury and effectively improved body weight in DNM rats. The ratio of kidney weight to body weight was reducedand the early stage of renal function damage was improved after APS treatment. In the later stages of the disease, the 24h urinary protein significantly decreased. Moreover, AP

关键词： Diabetic Nephropathy Astragalus polysaccharide Renal index Fibrosis TGF-β1 α-SMA

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Secure beamforming and deployment design for rate-splitting multiple access-based UAV communications

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Science China(Information Sciences) 2025年第1期68卷 342-356页

作者： Bing WANG Xiaofeng tao Shujun HAN Huici WU Kai yang Zhu HAN National Engineering Research Center of Mobile Network Technologies Beijing University of Posts and Telecommunications Peng Cheng Laboratory Department of Electrical and Computer Engineering University of Houston

Rate-splitting multiple access(RSMA) has recently gained attention as a potential robust multiple access(MA)scheme for upcoming wireless networks. Given its ability to efficiently utilize wireless resources and design interference management strategies, it can be applied to unmanned aerial vehicle(UAV) networks to provide convenient services for large-scale access ground users. However, due to the line-of-sight(LoS) broadcast nature of UAV transmission, information is susceptible to eavesdropping in RSMA-based UAV networks. Moreover, the superposition of signals at the receiver in such networks becomes complicated. To cope with the challenge, we propose a two-user multi-input single-output(MISO) RSMA-based UAV secure transmission framework in downlink communication networks. In a passive eavesdropping scenario, our goal is to maximize the sum secrecy rate by optimizing the transmit beamforming and deployment location of the UAV-base station(UAV-BS),while considering quality-of-service(QoS) constraints, maximum transmit power, and flight space limitations. To address the non-convexity of the proposed problem, the optimization problem is first decoupled into two subproblems. Then, the successive convex approximation(SCA) method is employed to solve each subproblem using different propositions. In addition, an alternating optimization(AO)-based location RSMA(L-RSMA) beamforming algorithm is developed to implement joint optimization to obtain the suboptimal solution. Numerical results demonstrate that(1) the proposed L-RSMA scheme yields a28.97% higher sum secrecy rate than the baseline L-space division multiple access(SDMA) scheme;(2) the proposed L-RSMA scheme improves the security performance by 42.61% compared to the L-non-orthogonal multiple access(NOMA) scheme.

关键词： rate-splitting multiple access UAV communication precoding optimization deployment location physical layer security

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Smart Gas Sensors:Recent Developments and Future Prospective

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Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang Zong Shufang Wu Yuehong yang Qiuju Li Tian tao Shun Mao College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

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中生代砂岩细观结构对强度和能量耗散的影响

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煤炭学报 2017年第2期42卷 452-459页

作者：赵永川刘洪磊杨天鸿徐涛李杨侯宪港秦涛东北大学资源与土木工程学院岩石破裂与失稳研究所辽宁沈阳110819 东北大学深部金属矿山安全开采教育部重点实验室辽宁沈阳110819

对取自东北部和西部侏罗白垩系煤矿中粒砂岩进行镜下观察,对比其矿物颗粒,胶结成分和结晶程度上的异同点,进行了三轴压缩试验和循环加载声发射试验,分析东北部和西部砂岩的强度和能量耗散特征,并用Kaiser效应和加卸载响应比理论研究了... 详细信息

对取自东北部和西部侏罗白垩系煤矿中粒砂岩进行镜下观察,对比其矿物颗粒,胶结成分和结晶程度上的异同点,进行了三轴压缩试验和循环加载声发射试验,分析东北部和西部砂岩的强度和能量耗散特征,并用Kaiser效应和加卸载响应比理论研究了循环加载中的声发射规律。试验表明:以钙质胶结为主的东北部砂岩在Mohr-Coulomb准则下承载能力高于以钙泥质胶结为主的西部砂岩,随着压力的增大,耗散能所占比例呈现迅速降低、稳定、缓慢升高的趋势,且同等应力水平下东北部砂岩耗散能低于西部砂岩,Kaiser效应往往出现在低应力的弹性阶段,且在东北部砂岩中出现的频率和持续阶段要高于西部砂岩,加卸载响应比则出现急剧降低、缓慢平稳下降的趋势,在强度峰值点达到最小值,且东北部砂岩的加卸载响应比低于西部砂岩。东北部和西部砂岩的胶结物中泥质含量和重结晶成岩程度是产生上述力学性质和能量耗散特征差异的根本原因。

关键词：细观结构能量耗散声发射 Kaiser效应加卸载响应比

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CKD4期患者营养状态与肠道黏膜免疫屏障的关系及中药结肠透析干预的疗效

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世界华人消化杂志 2017年第10期25卷 940-945页

作者：郝娜杨洪涛天津中医药大学第一附属医院肾病科天津市300382

目的探讨慢性肾脏病(chronic kidney disease,CKD)相关营养不良与肠黏膜免疫屏障功能的相关性,观察中药结肠透析的治疗效果.方法本研究通过MQSGA量表评价患者营养状态,通过检测CKD患者粪便slg A含量来研究其的肠黏膜免疫屏障功能,评价... 详细信息

目的探讨慢性肾脏病(chronic kidney disease,CKD)相关营养不良与肠黏膜免疫屏障功能的相关性,观察中药结肠透析的治疗效果.方法本研究通过MQSGA量表评价患者营养状态,通过检测CKD患者粪便slg A含量来研究其的肠黏膜免疫屏障功能,评价其相关性;将284例CKD4期患者分为治疗组(口服中药汤剂+自愿接受中药结肠透析治疗)和对照组(仅口服辨证中药汤剂组),观察治疗前后中医症状积分及临床化验指标,初步分析天津中医药大学第一附属医院中药结肠透析应用成效.结果研究显示CKD4期患者存在肠道黏膜免疫屏障功能障碍,肠道slgA水平作为黏膜免疫屏障功能的评价指标与患者营养状态评分呈负向相关的关系,随白蛋白、血红蛋白水平降低而升高,相关系数r=-0.533(P<0.05),与血肌酐、尿素氮水平呈正相关,相关系数r=0.486(P<0.05),随中医证候积分减低而降低,相关系数r=0.419(P<0.05).中医证候积分较高(即症状明显)患者,其营养状态评分与slgA表达量呈线性相关,相关系数r=-0.823(P<0.05),提示营养状态与肠道黏膜免疫屏障功能明显相关,且随肾脏病进展相关性逐步增加.结论本研究证实可以通过研究肠道内slgA水平来评估肠黏膜免疫屏障功能.中药结肠透析可通过改善CKD4期患者肠黏膜免疫屏障功能,改善患者的营养状况,从而改善预后,提高患者生存质量,延缓CKD进展.

关键词：营养不良肠道黏膜免疫屏障中药结肠透析

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