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SURFACE FUNCTIONALIZATION OF POLYSTYRENE TO BIND WITH FMRF PEPTIDES FOR NOVEL BIOCOMPATIBILITY

Chinese Journal of Polymer Science 2010年第6期28卷 895-902页

作者： Yong Chen hong-sheng lu Peng Wang Department of Applied Chemistry School of Chemical & Environmental Engineering Shandong University of Science and Technology Qingdao 266510 China Department of Environmental Science and Technology School of Chemical & Environmental Engineering Shandong University of Science and Technology Qingdao 266510 China

A generic method was described to change surface biocompatibihty by introducing reactive functional groups onto surfaces of polymeric substrates and covalently binding them with biomolecules.A block copolymer with protected carboxylic acid functionality,poly（styrene-b-tert-butyl acrylate）（PS-PtBA）,was spin coated from solutions in toluene on a bioinert polystyrene（PS） substrate to form a bilayer structure：a surface layer of the poly（tert-butyl acrylate）（PtBA） blocks that order at the air-polymer interface and a bottom layer of the PS blocks that entangle with the PS *** thickness of the PtBA layer and the area density of tert-butyl ester groups of PtBA increased linearly with the concentration of the spin coating solution until a 2 nm saturated monolayer coverage of PtBA was achieved at the concentration of 0.4%W/*** protected carboxylic acid groups were generated by exposing the tert-butyl ester groups of PtBA to trifluoroacetic acid （TFA） for bioconjugation with FMRF peptides via amide *** yield of the bioconjugation reaction for the saturated surface was calculated to be 37.1%based on X-ray photoelectron spectroscopy（XPS） *** success of each functionalization step was demonstrated and characterized by XPS and contact angle *** polymer functionalization/modification concept can be virtually applied to any polymeric substrate by choosing appropriate functional block copolymers and biomolecules to attain novel biocompatibility.

关键词： Surface functionalization Biocompatibility Bioconjugation reaction

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CO_2-sensitive Amphiphilic Triblock Copolymer Self-assembly Morphology Transition and Accelerating Drug Release from Polymeric Vesicle

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Chinese Journal of Polymer Science 2018年第1期36卷 18-24页

作者： Xian-Wu Jing Zhi-Yu Huang hong-sheng lu Bao-Gang Wang College of Chemistry and Chemical Engineering Southwest Petroleum University Engineering Research Center of Oilfield Chemistry Ministry of Education

A series of triblock copolymers, containing a CO_2-switchable block poly（2-（dimethylamino）ethyl methacrylate）（PDM） block and two symmetrical hydrophilic blocks polyacrylamide（PAM）, were synthesized using atom transfer radical polymerization（ATRP） method. The p H and conductivity tests showed that the triblock copolymer exhibited switchable responsiveness to CO_2, i.e. a relatively low conductivity of solution could be switched on and off by bubbling and removing of CO_2, and the triblock copolymer aqueous solution displayed a CO_2-switchable viscosity variation. The changes were all attributed to protonation of tertiary amine groups in PDM blocks and proven by 1 H-NMR. Cryogenic transmission electron microscopy and dynamic light scattering characterization demonstrated that the viscosity variation was the result of a unilamellar vesicle-network aggregate structure transition. The release of rhodamine B from the vesicles with and without CO_2 stimuli showed the potential application in drug delivery domains; after CO_2 bubbling, the drug release rate could be accelerated. Finally, reasonable mechanism of CO_2-switchable morphology changes and CO_2-induced drug release was proposed.

关键词： ATRP CO_2-sensitive Polymeric vesicles Drug release

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Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 500-505页

作者： hong-sheng lu Mei-fu GAN Han-song CHEN Shan-qiang HUANG Department of Pathology Taizhou Hospital Linhai 317000 China

The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare,for both tumors present usually as separate *** are only 16 such cases reported *** the best of our knowledge,the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported.A 32-year-old Chinese woman with 4-year history of hypertension was presented in our *** tomography(CT)of the abdomen showed a large heterogene- ously-enhancing mass(4.5 cm in diameter)in the left suprarenal *** history and laboratory results suggest a metabolic disorder as Conn's *** patient underwent a left adrenalectomy,and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing *** patient was postoperatively well and discharged *** the present case report,we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with Conn's syndrome,and the methods of the diagnosis and differential diagnosis.

关键词： Adrenal gland Myxoid adrenal cortical adenoma Myelolipoma Conn's syndrome Pathology Immunohistochemistry

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Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex

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Chinese Medical Journal 2017年第24期130卷 3017-3018页

作者： hong-sheng lu Xue-Quan Cao Wei-Fei Chen Department of Pathology Taizhou Central Hospital(Taizhou University Hospital) Taizhou Zhejiang 318000 China Department of Pathology Taizhou Hospital of Taizhou Enze Medical Group Linhai Zhejiang 317000 China

To the Editor：Tuberous sclerosis complex （TSC）,a rare autosomal dominant and variable penetrance,affects about 10 in every 100,000 people.[1] In general,it is described as a clinical triad of adenomas,mental disorders,and ***,due to incomplete penetrance,symptoms may be involved in isolated organs,which may manifest as mild incomplete diseases or involve multiple *** lymphangiomyomatosis （LAM） associated with both renal and hepatic angiomyolipomas （AMLs） in a TSC patient is very *** the best of our knowledge,only one case has been reported by Ciftci et al.[2] Here,we present such a case with clinical and pathological analysis.

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CATALYSIS OF METALLO-PORPHYRINS IN OXIDATION OF P-NITROTOluENE BY ELECTRO-GENEEATED SUPEROXIDE ION

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Chinese Chemical Letters 1992年第7期3卷 499-502页

作者： Su Fang WANG hong sheng lu Suo Bo ZHANG Yin Jie LIN Ying Kai XU Department of chemistry Jilin University.The National Laboratory of Enzyme Engineering.Changchun130023

The oxidation of pnitrotoluene with electro-generated superoxide ion in the presence or absence of metallo-porphyrins FeTPP, MnTPP and CoTPP in DMF was studied by cyclic voltammetry and controlled potential electrolysis, Metallo-porphyrins as catalysts for electroreduction of O_2, they can not only increase yields of p-nitrobensoic acid and selectivities of reaction but also enable the reaction proceed at lower negative potential.

关键词： TPP CATALYSIS OF METALLO-PORPHYRINS IN OXIDATION OF P-NITROTOluENE BY ELECTRO-GENEEATED SUPEROXIDE ION 台五

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Effect of Warming Moxibustion on Shenque Acupoint for the Treatment of Acute Diarrhea in Children with Infantile Cerebral Palsy

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Chinese Journal of Integrative Medicine 2009年第6期15卷 454-457页

作者：张红运卢圣锋肖农 Department of Rehabilitation Children's Hospital Affiliated to Chongqing Medical University College of Acupuncture Moxibustion and Massage Chengdu University of Traditional Chinese Medicine

Objective:To observe the effect of warming moxibustion on Shenque acupoint(RN8) for the treatment of acute diarrhea in children with infantile cerebral palsy(ICP).Methods:Clinical observation was performed on 60 ICP children suffering from acute diarrhea,who were randomly assigned to two groups *** Mox group was treated with warming moxibustion on Shenque acupoint(RN8) and the control group treated with *** efficacy was evaluated by markedly effective rate and total effective rate after a 6-d...

关键词： warming moxibustion Shenque acupoint cerebral palsy acute diarrhea

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基于低频调制激励的硅微陀螺仪自动模态匹配技术

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中国惯性技术学报 2016年第4期24卷 542-547,560页

作者：杨成李宏生徐露朱昆朋东南大学仪器科学与工程学院南京210096 东南大学微惯性仪表与先进导航技术教育部重点实验室南京210096

根据二阶质量-弹簧-阻尼系统的幅频特性和相频特性关于谐振频率对称的特点,提出了一种低频振荡激励的实时模态匹配技术,根据检测模态的输出响应来判别驱动模态和检测模态的匹配程度。首先简要介绍了带频率调谐功能的双质量线振动硅微陀... 详细信息

根据二阶质量-弹簧-阻尼系统的幅频特性和相频特性关于谐振频率对称的特点,提出了一种低频振荡激励的实时模态匹配技术,根据检测模态的输出响应来判别驱动模态和检测模态的匹配程度。首先简要介绍了带频率调谐功能的双质量线振动硅微陀螺仪,该陀螺利用负刚度效应来调节检测模态的谐振频率;然后通过理论推导以及系统仿真验证了基于低频调制激励的自动模态匹配技术的可行性和有效性;最后设计了一种基于现场可编程逻辑阵列(FPGA)的数字控制电路,并且对同一测试陀螺进行了模态匹配和模态不匹配下的性能对比。试验结果表明,相比模态不匹配条件下,陀螺零偏稳定性从5.89(°)/h提高到1.26(°)/h,角度随机游走从0.36(°)/√h提高到0.079(°)/√h,性能分别提高了4.7倍和4.6倍。

关键词：负刚度效应硅微陀螺仪低频振荡调制模态匹配自动频率调节

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电针对中枢Stat 5敲除所致胰岛素抵抗小鼠肝脏胰岛素信号通路的影响

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针刺研究 2018年第5期43卷 314-318页

作者：李敏慧洪浩卢圣锋王军蒙朱冰梅南京中医药大学针药结合教育部重点实验室南京210023

目的:观察电针对中枢信号传导和转录活化蛋白5条件性基因敲除(Stat 5NKO)小鼠肝脏胰岛素信号通路的影响,分析电针改善胰岛素抵抗的机制。方法:将24只造模成功的雄性Stat 5NKO小鼠随机分为模型组和电针组,每组12只;12只雄性Stat 5 fl/fl... 详细信息

目的:观察电针对中枢信号传导和转录活化蛋白5条件性基因敲除(Stat 5NKO)小鼠肝脏胰岛素信号通路的影响,分析电针改善胰岛素抵抗的机制。方法:将24只造模成功的雄性Stat 5NKO小鼠随机分为模型组和电针组,每组12只;12只雄性Stat 5 fl/fl小鼠作为正常组。电针组选取单侧"后三里""内庭"进行针刺治疗,2Hz/15Hz,0.8~1.0mA,20min/次,每日1次,双侧交替进行,6d为1个疗程,共治疗4个疗程。分别检测空腹血糖(FPG)、空腹胰岛素(FINS)的含量,计算胰岛素敏感指数(ISI)。运用Western blot法检测肝脏胰岛素信号通路相关蛋白胰岛素受体底物1(IRS 1)、胰岛素受体β(IRβ)、蛋白激酶B(Akt)的磷酸化表达水平。结果:与正常组小鼠相比,模型组小鼠胰岛素耐受和葡萄糖耐受功能受损(P0.05)。与正常组小鼠相比,模型组小鼠磷酸化的IRS 1、IRβ蛋白表达显著上升(P<0.001),磷酸化的Akt蛋白表达明显下降(P<0.01);与模型组小鼠相比,电针组小鼠磷酸化的IRS 1、IRβ蛋白表达明显下降(P<0.001,P<0.01),磷酸化的Akt蛋白表达上升(P<0.01)。结论:电针通过增强肝脏Akt信号通路的传导,从而改善中枢Stat 5敲除所引起的胰岛素抵抗。

关键词：电针胰岛素抵抗胰岛素受体底物1 胰岛素受体β 蛋白激酶B

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong luji Huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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甜菜粉与亚硝酸钠复合对中式香肠品质的影响

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食品工业科技 2017年第1期38卷 269-272,327页

作者：朱培培唐宏刚肖朝耿陈黎洪陆胜民南京农业大学食品科技学院江苏南京210095 浙江省农业科学院食品科学研究所浙江杭州310021

研究甜菜粉对中式香肠品质的影响,以期达到替代或部分替代亚硝酸钠目的。采用甜菜粉(0、0.5%、1.0%)与亚硝酸钠(0、50、100 mg/kg)正交组合添加于中式香肠中,分别于第2、7、14 d测定亚硝酸盐残留量、色泽(L*、a*、b*)、亚硝基肌红蛋白(N... 详细信息

研究甜菜粉对中式香肠品质的影响,以期达到替代或部分替代亚硝酸钠目的。采用甜菜粉(0、0.5%、1.0%)与亚硝酸钠(0、50、100 mg/kg)正交组合添加于中式香肠中,分别于第2、7、14 d测定亚硝酸盐残留量、色泽(L*、a*、b*)、亚硝基肌红蛋白(NOMb)含量、脂质氧化(TBARS)、质构(TPA)及酸度等指标。结果表明:各甜菜粉添加组的亚硝酸盐残留量显著低于100 mg/kg亚硝酸钠添加组的和国标规定(p0.05)。综合亚硝酸盐残留量、色泽、NOMb、TBARS等指标,最优的组合为0.5%甜菜粉与50 mg/kg亚硝酸钠复合组。由此可见:甜菜粉可以替代部分亚硝酸钠添加于中式香肠中。

关键词：甜菜粉中式香肠亚硝酸钠亚硝酸盐残留品质

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