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Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles

Acta Pharmacologica Sinica 2007年第3期28卷 410-416页

作者： hong-qi fan~(2,3) nan gu~(2,3) feng liu~2 li eei~2 xiao-qin pan~2 mei guo~2 rong-hua chen~(2,4) xi-rong guo~(2,3,4)2 department of pediatrics,Nanjing Maternal and Child Health Hospital of Nanjing Medical University,Nanjing 210004,China 3 Institute of pediatrics Medicine,nanjing medical university,nanjing 210029,China departmentofpediatrics NanjingMaternalandChildHealthHospitalofNanjingMedicalUniversityNanjing210004China InstituteofpediatricsMedicine NanjingMedicalUniversityNanjing210029China

Aim:To assess the effects and mechanisms of the action of resistin on basal andinsulin-stimulated glucose uptake in rat skeletal muscle cells.Methods:Rat myo-blasts(L6)were cultured and differentiated into myotubes followed by stimula-tion with single commercial resistin(130 ng/mL,0-24 h)or cultured supernatantfrom 293-T cells transfected with resistin-expressing vectors(130 ng/mL,0-24 h).liquid scintillation counting was used to quantitate[~3H]2-deoxyglucose uptake.The translocation of insulin-sensitive glucose transporters GLUT4 and GLUT1,synaptosomal-associated protein 23(SNAP23)and GLUT protein content,as wellas the tyrosine phosphorylation status and protein content of insulin receptorsubstrate(IRS)-1,were assessed by Western blotting.Results:Treatment of L6myotubes with single resistin or cultured supernatant containing recombinantresistin reduced basal and insulin-stimulated 2-deoxyglucose uptake and impairedinsulin-stimulated GLUT4 translocation.While SNAP23 protein content wasdecreased,no effects were noted in GLUT4 or GLUT1 protein content.Resistinalso diminished insulin-stimulated IRS-1 tyrosine phosphorylation levels withoutaffecting its protein content.The effects of recombinant resistin from 293-T cellstransfected with resistin-expressing vectors were greater than that of single resistintreatment.Conclusion:Resistin regulated IRS-1 function and decreased GLUT4translocation and glucose uptake in response to insulin.The downregulatedexpression of SNAP23 may have been partly attributed to the decrease of glucoseuptake by resistin treatment.These observations highlight the potential role ofresistin in the pathophysiology of type 2 diabetes related to obesity.

关键词： resistin insulin glucose uptake obesity diabetes

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A paradox:Insulin inhibits expression and secretion of resistin which induces insulin resistance

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World Journal of Gastroenterology 2008年第1期14卷 95-100页

作者： feng liu hong-qi fan Jie qiu Bin Wang Min Zhang nan gu Chun-mei Zhang li Fei xiao-qing pan mei guo rong-hua chen xi-rong guo department of pediatrics NanjingMaternity & Child Health Hospital of Nanjing Medical UniversityNanjing 210004 Jiangsu Province China Institute of pediatrics of nanjingmedical university Nanjing 210029 Jiangsu Province China

AIM: To confirm whether insulin regulates resistinexpression and secretion during differentiation of 3T3-L1preadipocytes and the relationship of resistin with insulinresistance both in vivo and in vitro.METHODS: Supernatant resistin was measured duringdifferentiation of 3T3-L1 preadipocytes. L6 rat myoblastsand hepatoma cell line H4IIE were used to confirm thecellular function of resistin. Diet-induced obese ratswere used as an insulin resistance model to study therelationship of resistin with insulin resistance.RESULTS: Resistin expression and secretion wereenhanced during differentiation 3T3-L1 preadipocytes.This cellular differentiation stimulated resistin expressionand secretion, but was suppressed by insulin. Resistinalso induced insulin resistance in H4IIE hepatocytes andL6 myoblasts. In diet-induced obese rats, serum resistinlevels were negatively correlated with insulin sensitivity,but not with serum insulin.CONCLUSION: Insulin can inhibit resistin expressionand secretion in vitro, but insulin is not a major regulatorof resistin in vivo . Fat tissue mass affects insulinsensitivity by altering the expression and secretion ofresistin.

关键词：胰岛素抵抗素胰岛素抵抗糖尿病

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Identification and characterization of NYGGF4,a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation

Identification and characterization of NYGGF4,a novel gene c...

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2006（第三届）江浙沪儿科学术会议暨浙江省儿科学术年...

作者： Bin Wang Min Zhang Yu-hui Ni feng liu hong-qi fan li Fei xiao-qing pan mei guo rong-hua chen and xi-rong guo department of pediatrics, nanjing Maternity & child health hospital of nanjing medical university, 210004 nanjing. department of pediatrics, Center of Human Functional Genomics, nanjing medical university, 210029 nanjing.

目的新基因NYGGF4的鉴定以及对于脂肪前体细胞增殖、分化影响的研究。方法采用 RT-PCR方法验证NYGGF4基因在肥胖与正常人类腹膜下脂肪内的表达差异;采用Northem Blot方

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Identification and characterization of NYGGF4,a novel gene containing a phosphotyrosine-binding(PTB)domain that stimulates 3T3-L1 preadipocytes proliferation

Identification and characterization of NYGGF4,a novel gene c...

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中华医学会第十四次全国儿科学术会议

作者： department of pediatrics, nanjing Maternity & child health hospital of nanjing medical university (210004) Bin Wang, Min Zhang, Yu - hui Ni, xi - rong guo department of pediatrics, Center of Human Functional Genomics, nanjing medical university (210029) Bin Wnag, Min Zhang, Yu - hui Ni, feng liu, hong- qi fan, li Fei, xiao- qing pan, mei guo, rong - hua chen, xi - rong guo

目的:新基因NYGGF4的鉴定以及对于脂肪前体细胞增殖、分化影响的研究。方法:采用RT-PCR 方法验证NYGGF4基因在肥胖与正常人类腹膜下脂肪内的表达差异;采用Northern Blot方法观察NYGGF4 mRNA全长大小以及在人类不同组织中分布情况;构建NY...

目的:新基因NYGGF4的鉴定以及对于脂肪前体细胞增殖、分化影响的研究。方法:采用RT-PCR 方法验证NYGGF4基因在肥胖与正常人类腹膜下脂肪内的表达差异;采用Northern Blot方法观察NYGGF4 mRNA全长大小以及在人类不同组织中分布情况;构建NYGGF4绿荧光表达载体,转染293-T、 3T3-L1细胞,观察NYGGF4的亚细胞定位情况;构建NYGGF4过表达313-L1脂肪前体细胞,以空载转染和未转染细胞为对照a:培养细胞,MTT检测细胞增殖,绘制细胞生长曲线;血清饥饿,使细胞同步化,流式细胞仪观察细胞周期分布。b:IBMX刺激脂肪前体细胞分化,油红O染色观察脂质分布

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Delivery room resuscitation and short-term outcomes of extremely preterm and extremely low birth weight infants: a multicenter survey in North China

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Chinese medical Journal 2021年第13期134卷 1561-1568页

作者： Shuai-Jun li qi feng xiu-Ying Tian Ying Zhou Yong Ji Yue-mei li Shu-Fen Zhai Wei guo fang Zhang rong-xiu Zheng Hai-Ying He xia liu Jun-Yi Wang hua mei hong-Yun Wang hua xie Chao-mei Zeng li Ma Ping-Ping Zhang Jin-Yu li xiao-Ying Wang li-hua li hong Cui Shu-Lan Yang Lu chen xiao-hong gu Yan-Ju Hu Sheng-Shun Que li-xia Sun Ming Yang Wen-li Zhao qiu-Yan Ma Hai-Juan Wang Jiu-Ye guo department of pediatrics Peking University First HospitalBeijing 100034China department of Neonatology Tianjin Central Hospital of Gynecology ObstetricsTianjin 300100China department of pediatrics Peking University Third HospitalBeijing 100191China Neonatal Intensive Care Unit Children's Hospital of ShanxiTaiyuanShanxi 030031China department of Neonatology The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China department of Neonatology Handan Central HospitalHandanHebei 056004China department of Neonatology Xingtai People's HospitalXingtaiHebei 054031China department of Neonatology Tangshan Maternal and Child Health HospitalTangshanHebei 071023China department of pediatrics Tianjin Medical University General HospitalTianjin 300052China department of pediatrics Baogang Third Hospital of HongCi GroupBaotouInner Mongolia Autonomous Region 014010China department of Neonatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China department of pediatrics The First Hospital of Tsinghua UniversityBeijing 100016China department of Neonatology The Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner Mongolia Autonomous Region 010050China department of Neonatology Inner Mongolia Maternal and Child Health HospitalHohhotInner Mongolia Autonomous Region 010020China department of Neonatology Affiliated Hospital of Chifeng UniversityChifengInner Mongolia Autonomous Region 024005China department of pediatrics Peking University People's HospitalBeijing 100044China department of Neonatology Hebei Children's HospitalShijiazhuangHebei 050000China department of Neonatology Tianjin First Central HospitalTianjin 300384China department of pediatrics Peking Union Medical College HospitalBeijing 100730China department of Neonatology Children's Hospital Capital Institute of PediatricsBeijing 100020China department of pediatrics Beijing Luhe Hospital.Capital Medical UniversityBeijing 101149China department of pediatrics Beijing Fri

Background:Delivery room resuscitation assists preterm infants,especially extremely preterm infants(EPI)and extremely low birth weight infants(ELBWI),in breathing support,while it potentially exerts a negative impact on the lungs and outcomes of preterm infants.This study aimed to assess delivery room resuscitation and discharge outcomes of EPI and ELBWI in China.Methods:The clinical data of EPI(gestational age[GA]28 weeks)and ELBWI(birth weight[BW]2 h of birth in 33 neonatal intensive care units from five provinces and cities in North China between 2017 and 2018,were analyzed.The primary outcomes were delivery room resuscitation and risk factors for delivery room intubation(DRI).The secondary outcomes were survival rates,incidence of bronchopulmonary dysplasia(BPD),and risk factors for BPD.Results:A cohort of 952 preterm infants were enrolled.The incidence of DRI,chest compressions,and administration of epinephrine was 55.9%(532/952),12.5%(119/952),and 7.0%(67/952),respectively.Multivariate analysis revealed that the risk factors for DRI were GA28 weeks(odds ratio[OR],3.147;95%confidence interval[CI],2.082–4.755),BW2.240;95%CI,1.606–3.125),and antepartum infection(OR,1.429;95%CI,1.044–1.956).The survival rate was 65.9%(627/952)and was dependent on GA.The rate of BPD was 29.3%(181/627).Multivariate analysis showed that the risk factors for BPD were male(OR,1.603;95% CI,1.061–2.424),DRI(OR,2.094;95% CI,1.328–3.303),respiratory distress syndrome exposed to≥2 doses of pulmonary surfactants(PS;OR,2.700;95%CI,1.679–4.343),and mechanical ventilation≥7 days(OR,4.358;95% CI,2.777–6.837).However,a larger BW(OR,0.998;95% CI,0.996–0.999),antenatal steroid(OR,0.577;95%CI,0.379–0.880),and PS use in the delivery room(OR,0.273;95%CI,0.160–0.467)were preventive factors for BPD(all Plivery room resuscitation and management of respiratory complications are imperative during early management of the health of EPI and ELBWI.

关键词： Extremely preterm Extremely low birth weight infants Delivery room resuscitation Survival rate BPD Risk factors

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Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China： A Multi-center Study

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Chinese medical Journal 2015年第20期128卷 2743-2750页

作者： Hui-Jia lin li-Zhong Du xiao-Lu Ma li-Ping Shi Jia-hua pan xiao-mei Tong qiu-Ping li Jian-guo Zhou Bing Yi ling liu Yun-Bing chen qiu-Fen Wei Hui-qing Wu mei li Cui-qing li xi-rong Gao Shi-Wen xia Wen-Bin li Chao-Ying Ya ling He Kun liang xiao-Yu Zhou Shu-Ping Han qin Lyu Yin-Ping qiu Wen li Dong-mei chen hong-Ru Lu xiao-hong liu hong liu Zhen-Lang lin li liu Jia-Jun Zhu hong xiong Shao-Jie Yue Si-qi Zhuang department of Neonatal Intensive Care Unit Children's Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310053 China department of Neonatology Anhui Provincial Hospital Hefei Anhui 230001 China department of pediatrics Peking University Third Hospital Beijing 100191 China department of Neonatology BaYi Children's Hospital of the General Military Hospital of Beijing People's Liberation Army Beijing 100000 China department of Neonatology Children's Hospital of Fudan University Shanghai 200032 China department of Neonatology Gansu Provincial Maternity and Children-care Hospital Lanzhou Gansu 730050 China department of Neonatotogy Guiyang Maternal and Child Health Care Hospital Guiyang Guizhou 550003 China department of Neonatology Women and Children Hospital of Guangdong Province Guangzhou Guangdong 510010 China department of Neonatology Guangxi Maternal and Child Health Hospital Nanning Guangxi 530003 China department of Neonatology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510150 China department of Neonatology Harbin Children's Hospital Harbin Heilongjiang 150010 China department of Neonatology Children's Hospital of Hebei Province Shijiazhuang Hebei 050031 China department of Neonatology Hunan Children's Hospital Changsha Hunan 410007 China department of Neonatology Hubei Maternity and Child Heath Hospital Wuhan Hubei 430070 China department of pediatrics Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China department of Neonatology The First Hospital of Jilin University Changchun Jilin 130021 China department of Neonatology Jiangxi Provincial Children's Hospital Nanchang Jiangxi 330006 China department of Pediatric First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China department of Neonatotogy Nanjing Children's Hospital of Nanjing Medical University Nanjing Jiangsu 320100 China De

Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW）〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

关键词： Extremely Low Birth Weight Infant Mortality National Survey

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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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WORLD JOURNAL OF HEPATOLOGY 2024年第5期16卷 809-821页

作者： Zhang, Yuan-Yao Luo, Sen li, Hai Sun, Shu-Ning Wang, xian-Bo Zheng, xin huang, Yan li, Bei-ling Gao, Yan-Hang qian, Zhi-Ping liu, feng Lu, xiao-Bo liu, Jun-Ping Ren, Hao-Tang Zheng, Yu-Bao Yan, hua-Dong Deng, guo-hong qiao, liang Zhang, Yan gu, Wen-Yi xiang, xiao-mei Zhou, Yi Hou, Yi-xin Zhang, Qun xiong, Yan Zou, Cong-Cong chen, Jun huang, Ze-Bing Jiang, xiu-hua qi, Ting-Ting chen, Yuan-Yuan Gao, Na liu, Chun-Yan Yuan, Wei mei, Xue li, Jing li, Tao Zheng, rong-Jiong Zhou, xin-Yi Zhao, Jun Meng, Zhong-Ji Hubei Univ Med Taihe Hosp Hubei Prov Clin Res Ctr Precise Diag & Treatment L Dept Infect DisInst Biomed ResRegulatory Mech & Shiyan 442000 Hubei Peoples R China Hubei Univ Med Taihe Hosp Dept Infect Dis 32 South Renmin Rd Shiyan 442000 Hubei Peoples R China Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Gastroenterol Shanghai 200120 Peoples R China Third Mil Med Univ Army Med Univ Southwest Hosp Dept Infect Dis Chongqing 400000 Peoples R China xinjiang Med Univ Affiliated Hosp 1 Infect Dis Ctr Urumqi 830054 Xinjiang Uygur Peoples R China Capital Med Univ Beijing Ditan Hosp Ctr Integrat Med Beijing 100020 Peoples R China huazhong Univ Sci & Technol Union Hosp Inst Infect & Immunol Dept Infect DisTongji Med Coll Wuhan 430020 Hubei Peoples R China Cent South Univ Xiangya Hosp Dept Infect Dis Hunan Key Lab Viral Hepatitis Changsha 110051 Hunan Peoples R China Southern Med Univ Nanfang Hosp Dept Infect Dis Hepatol Unit Guangzhou 510515 Guangdong Peoples R China First Hosp Jilin Univ Dept Hepatol Changchun 130021 Jilin Peoples R China Fudan Univ Shanghai Publ Hlth Clin Ctr Dept Liver Intens Care Unit Shanghai 200093 Peoples R China nankai Univ Peoples Hosp 2 Tianjin Inst Hepatol Tianjin 300192 Peoples R China Shandong Univ Hosp 2 Dept Infect Dis & Hepatol Jinan 250000 Shandong Peoples R China Zhejiang Univ Affiliated Hosp 1 Collaborat Innovat Ctr Diag & Treatment Infect Dis Sch MedState Key Lab Diag & Treatment Infect Dis Hangzhou 310000 Zhejiang Peoples R China Sun Yat Sen Univ Affiliated Hosp 3 Dept Infect Dis Guangzhou 510630 Guangdong Peoples R China Univ Chinese Acad Sci Ningbo Hosp 2 Dept Infect Dis Dept Infect Dis Ningbo 315153 Zhejiang Peoples R China 455th Hosp Chinese Peoples liberat Army Dept Gastroenterol Shanghai 200052 Peoples R China Cent South Univ Nation Clin Res Ctr Geriatr Disorders Hunan Key Lab Viral Hepatitis Dept Infect DisXiangya Hosp Changsha 410008 Hunan Peoples R China Hubei Univ Med Sch Publ Hl

BACKGROUND Acute-on-chronic liver disease (AoCLD) accounts for the majority of patients hospitalized in the department of Hepatology or Infectious Diseases. AIM To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of AoCLD. METHODS Patients with AoCLD from the Chinese Acute-on-Chronic liver Failure (ACLF) study cohort were included in this study. The clinical characteristics and outcomes, and the 90-d survival rate associated with each clinical type of AoCLD were analyzed, using the Kaplan-meier method and the log-rank test. RESULTS A total of 3375 patients with AoCLD were enrolled, including 1679 (49.7%) patients with liver cirrhosis acute decompensation (LC-AD), 850 (25.2%) patients with ACLF, 577 (17.1%) patients with chronic hepatitis acute exacerbation (CHAE), and 269 (8.0%) patients with liver cirrhosis active phase (LC-A). The most common cause of chronic liver disease (CLD) was HBV infection (71.4%). The most common precipitants of AoCLD was bacterial infection (22.8%). The 90-d mortality rates of each clinical subtype of AoCLD were 43.4% (232/535) for type-C ACLF, 36.0% (36/100) for type-B ACLF, 27.0% (58/215) for type-A ACLF, 9.0% (151/1679) for LC-AD, 3.0% (8/269) for LC-A, and 1.2% (7/577) for CHAE. CONCLUSION HBV infection is the main cause of CLD, and bacterial infection is the main precipitant of AoCLD. The most common clinical type of AoCLD is LC-AD. Early diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis FIBROSIS

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XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)

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Cancer Communications 2022年第4期42卷 314-326页

作者： xiao-Dong Zhu Ming-Zhu huang Yu-Sheng Wang Wan-Jing feng Zhi-Yu chen Yi-Fu He xiao-Wei Zhang xin liu chen-chen Wang Wen Zhang Jie-Er Ying Jun Wu Lei Yang Yan-Ru qin Jian-feng Luo xiao-Ying Zhao Wen-hua li Zhe Zhang li-xin qiu qi-rong Geng Jian-ling Zou Jie-Yun Zhang hong Zheng Xue-feng Song Shu-Sheng Wu cheng-Yan Zhang Zhe Gong qin-qin liu xiao-feng Wang qi Xu qi Wang Jian-mei Ji Jian Zhao Wei-Jian guo department of Gastrointestinal medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China department of Gastroenterology Shanxi Cancer HospitalTaiyuanShanxi 030013P.R.China department of medical Oncology The First Affiliated HospitalDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031P.R.China department of Abdominal medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310005P.R.China department of medical Oncology The First People’s Hospital of ChangzhouChangzhouJiangsu 213004P.R.China department of Gastroenterology Nantong Tumor HospitalNantongJiangsu 226006P.R.China department of Oncology Zhengzhou University First Affiliated HospitalZhengzhouHenan 450052P.R.China department of Biostatistics School of Public HealthFudan UniversityShanghai 200032P.R.China department of medical oncology Cancer Hospital of Fudan UniversityMinhang BranchShanghai 200032P.R.China

Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.

关键词： Advanced gastric cancer chemotherapy XELOX doublet regimen EOX triplet regimen noninferiority quality of life phase III trial

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI guang-yan chen xiang-mei FU Ping chen Jiang-hua DING xiao-qiang YU Xue-qing liN hong-li liu Jian xiE Ru-juan WANG li-ning NI Zhao-hui liu Fu-you YIN Ai-ping xiNG Chang-ying WANG li SHI Wei liu Jian-she HE Ya-ni DING guo-hua li Wen-ge WU guang-li MIAO li-ning chen nan SU Zhen mei Chang-lin ZHAO Jiu-yang gu Yong BAI Yun-kai LUO Hui-min liN Shan chen Meng-hua GONG li YANG Yi-bin YANG xiao-ping li Ying WAN Jian-xin WANG Nian-song li Hai-ying xi Chun-sheng HAO li XU Yan fanG Jing-ai liu Bi-cheng li rong-shan WANG rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO feng-min mei feng liu Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG ling ZHOU Chun-hua chen qin-kai JIA Shun-lian GONG Zhi-feng guAN guang-ju xiA Tian Zhong liang-bao department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are limited.The aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in China.Methods The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized protocol.Hypertension was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive medications.BP 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension control.In multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD patients.Results The analysis included 8927 non-dialysis CKD patients.The prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,respectively.Of hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,respectively.With successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was suboptimal.With successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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2019 Chinese expert consensus statement on diagnosis and treatment of syphilis

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Chinese medical Journal 2020年第19期133卷 2335-2337页

作者：无 qian-qiu Wang Rui-li Zhang Yue-Ping Yin Quan-Zhong liu Shu-Zhen qi Dong-mei Xu Yu-Ye li xiao-fang li xiao-hong Su Min-Zhi Wu xian-Biao Zou li-Gang Yang xiang-Sheng chen Ping-Yu Zhou Jin-hua Xu xiang-Dong Gong guo-Jun liang Juan Jiang Hao cheng feng-qin Ge National Center for Sexually Transmitted Disease Control China Centers for Disease Control and Prevention Committee of Sexually Transmitted Disease Branch of DermatovenereologyChinese Medical Association Committee of Sexually Transmitted Disease Branch of DermatologistsChinese Medical Doctor Association Institute of Dermatology Chinese Academy of Medical Science&Peking Union Medical CollegeNational Center for Sexually Transmitted Disease ControlChina Centers for Disease Control and PreventionNanjingJiangsu 210042China department of Dermatology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China department of Dermatology General Hospital of Tianjin Medical UniversityTianjin 300052China department of Neurology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China department of Dermatology The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China department of Dermatology The 5th People’s Hospital of SuzhouSuzhouJiangsu 215131China department of Dermatology The First Affiliated Hospital of General Hospital of People’s Liberation ArmyBeijing 100037China department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China department of Sexually Transmitted Disease Institute Shanghai Skin Disease HospitalShanghai 200071China department of Dermatology Huashan Hospital of Fudan UniversityShanghai 200040China department of Dermatology Sir Run Run Shaw Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310016China

Syphilis,caused by Treponema pallidum subsp pallidum(T.pallidum),is a chronic,systemic human disease transmitted through sexual contact.The incidence and prevalence of syphilis is still high in China.[1]To guide the prevention measures and management of this disease,we renew the guidelines on diagnosis and treatment of syphilis[Supplementary file,http://***/CM9/A292].Manifestations and diagnosis of all stages of syphilis are presented in Table 1,and management in Table 2.

关键词： diagnosis prevention treatment

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