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Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning

Infectious Disease Modelling 2024年第4期9卷 1081-1094页

作者： hong-mei li Jin-Xin Zheng Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China National Institute of Health Research Ministry of Health and Child CareHarareZimbabwe University of Rwanda College of Medicine and Health SciencesSchool of Medicine and PharmacyDepartment of Microbiology and ParasitologyRwanda Ingerod 407 SE-45494BrastadSweden

Zimbabwe,located in Southern Africa,faces a significant public health challenge due to *** investigated this issue with emphasis on risk prediction of schistosomiasis for the entire *** this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public *** studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly *** machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and *** *** found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher *** prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher *** *** random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for ***,and with the corresponding figures for *** being 0.053;0.082;and *** on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of *** at 13.8% and that of *** at 7.1%,requiring annual MDA based on a population of 3,003,*** MDA,the current total schistosomiasis prevalence would

关键词： Machine-learning Transmission risk model Schistosomiasis Zimbabwe

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Preparation of Hydroxyapatite Fibers by the Homogeneous Precipitation Method

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Journal of Wuhan University of Technology(Materials Science) 2002年第3期17卷 39-41页

作者：王友法 WuhanUniversityofTechnology

This paper discussed the preparing process of hydroxyapatite fibers which were widely used as reinforcement for biomedical materials by homogeneous precipitation *** needle like hydroxyapatite crystals were synthesized in an aqueous *** were transferred from precursors dicalcium phosphate anhydrate and octacalcium phosphate *** reaction conditions were well controlled in order to obtain crystals in given *** products were characterized by X ray powder diffractometry(XRD),scanning electron microscopy (SEM) and infrared spectroscopy(IR).They were verified to be hydroxyapatite crystals with needle like in shape.

关键词： hydroxyapatite fibers homogeneous precipitation precursor

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Industrialization Process of Pesticide Residue Grade n-Hexane

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Advances in Materials Physics and Chemistry 2012年第4期2卷 197-199页

作者： Can Quan Xiongwei Yan Ting Huang hong mei li Junsu Jin Beijing university of chemical technology 10029Beijing National institute of metrology 10013Beijing P.R.China

This project is funded by the China government to develop the industrialization process of pesticide residue grade n-hexane, in which the industrial n-Hexane is used as crude purified by decoloration, distillation and filtration process. The products are validated by National Research Center for Environmental Analysis and Measurement (CNEAC), National Research Center for Geoanalysis, Chinese Academy of Inspection and Quarantine (CAIQ), Chinese Academy of Agricultural Sciences (CAAS) and other government originations for polychlorinated biphenyls, organochlorine pesticide or chiral pesticides analysis and further confirmed that it’s competitive to all others imported n-Hexane currently occupied in China. This patented technique will meet pesticide residue grade n-Hexane market in China and seek for cooperation globally.

关键词： Pesticide Residue Analysis Grade n-Hexane Purification Distillation

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Impact of migraine attacks on the blood-brain barrier

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Chinese Medical Journal 2010年第18期123卷 2559-2561页

作者： GAO hong-mei li Le ZHANG Ke-ling CHEN Xu-hui TIAN Shu-qing ZHANG Zhong-ling Department of Neurology the First Affiliated Hospital Harbin Medical University Harbin 150001 China

Background Cortical spreading depression can cause migraine attack, and up-regulate matrix metalloproteinase-9 （MMP-9） expression in animal. This study aimed to determine the impact on the structure and function of the blood-brain barrier by measuring plasma MMP-9 levels in patients at the acute and late stages of migraine attacks in order to elucidate the pathological mechanisms involved. Methods We recruited a case-control cohort of 38 adult migraine patients and 20 age- and gender-matched healthy control subjects. Five milliliter blood samples were collected at the acute and late stages of migraine （days 1-7）, and also from the control subjects. Solid phase double antibody sandwich enzyme-linked immunosorbent assay was used to determine plasma MMP-9 levels. Statistical analysis was performed using the SAS version 9.1. Results Initial plasma MMP-9 levels of migraine patients were significantly higher than those of controls （（12.612±0.016） μg/L vs. （6.069±0.023）μg/L, respectively, P 〈0.05）. High MMP-9 expression was observed during days 1-6 of migraine attacks, with highest expression occurring on day 3 （（17.524±0.035） μg/L）. During attacks, MMP-9 levels were similar in migraine patients with and without aura （P 〉0.05）; in addition, levels were not correlated with degree of headache pain （P 〉0.05）. Conclusions We hypothesize that migraine could lead to increased plasma MMP-9 levels resulting in blood-brain barrier damage. MMP-9 levels increase during days 1-6 of migraine attacks, peaking on day 3. Therefore, MMP-9 could be used as a biological marker to guide treatment of migraine attacks.

关键词： migraine atrix metalloproteinase 9 blood-brain barrier

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Psychology Research 2012年第4期2卷 260-265页

作者： li hong-zheng Lei mei-ying Zhao Dong-hai Zhao li-qiong liu Geng Zhou hong-kui Qin mei li Jie-feng Wen Jian Huang Pin-de li Yi Wang Chuang Wang Zhou-ran The 303rd Hospital of PLA Nanning China

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Exome sequencing identifies compound heterozygous PKHD1 mutations as a cause of autosomal recessive polycystic kidney disease

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Chinese Medical Journal 2012年第14期125卷 2482-2486页

作者： ZHANG Da LU lin YANG hong-bo li mei SUN Hao ZENG Zheng-pei li Xin-ping XIA Wei-bo XING Xiao-ping Department of Endocrinology Key Laboratory of EndocrinologyMinistry of Health

Background Autosomal recessive polycystic kidney disease （ARPKD） is a rare inherited disease, which is a disorder with multiple organ involvement, mainly the kidney and liver. It is caused by mutations in the PKHD1 gene. Here, we reported the clinical characteristics of a case with ARPKD and analyze the genetic features of this patient as well as of his father using targeted exome sequencing and Sanger sequencing. Methods Genomic DNA was extracted from peripheral blood leukocytes obtained from a patient with ARPKD. The mutations were identified using exome sequencing and confirmed by Sanger sequencing. Results The patient was diagnosed as ARPKD based on ultrasonography and abdominal computed tomography which showed polycystic changes, multiple calcinosis of both kidneys, and multiple dilated bile ducts of the liver. Compound heterozygous PKHD1 gene mutations A979G and G5935A, which lead to substitution of an asparagine for an aspartate at amino acid 327 （N327D） and a glycine for an arginine at amino acid 1979 （G1979R） respectively, were identified using targeted exome sequencing and confirmed by Sanger sequencing for the patient. In addition, the father of the patient was identified to be a carrier of heterozygous A979G mutation of this gene. Conclusions We identified that the compound heterozygous PKHD1 gene mutations are the molecular basis of the patient with ARPKD. Targeted exome sequencing is suitable for genetic diagnosis of single-gene inherited diseases like ARPKD in which the pathogenic gene is a large.

关键词： polycystic kidney, autosomal recessive PKHD1, mutation, exome sequencing

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Assessment of China’s contributions to the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses:a questionnaire survey

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Global Health Research and Policy 2021年第1期6卷 438-446页

作者： hong-mei li Ying-Jun Qian Kun Yang Wei Ding Lu-Lu Huang Xue-Jiao Ma Lei Duan Duo-Quan Wang Ya-Yi Guan Ning Xiao Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China Jiangsu Institute of Parasitic Diseases Wuxi 214064China

Background:The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses(RNAS^(+))was established in 1998,which has developed close partnerships with Asian countries endemic for schistosomiasis and other helminthiasis in ***^(+)has provided an ideal regional platform for policy-makers,practitioners and researchers on the prevention,control and research of parasitic diseases in Asian ***,one of the initiating countries,has provided significant technical and financial support to the regional ***,its roles and contributions have not been explored so *** purpose of this study was to assess China's contributions on the supporting of RNAS^(+)***:An assessment research framework was developed to evaluate China’s contributions to RNAS^(+)in four aspects,including capacity building,funding support,coordination,and *** anonymous web-based questionnaire was designed to acquire respondents’basic information,and information on China’s contributions,challenges and recommendations for RNAS^(+)*** participant scored from 0 to 10 to assess China’s contribution:“0”represents no contribution,and“10”represents 100%*** who included their e-mail address in the 2017-2019 RNAS^(+)annual workshops were invited to participate in the ***:Of 71 participants enrolled,41 responded to the survey.37(37/41,90.24%)of them were from RNAS^(+)member countries,while the other 4(4/41,9.76%)were international *** of the respondents(38/41,92.68%)were familiar with RNAS^(+).Respondents reported that China’s contributions mainly focused on improving capacity building,providing funding support,coordination responsibility,and joint application of cooperation programs on RNAS^(+)*** average scores of China’s contributions in the above four fields were 8.92,8.64,8.75,and 8.67,respectively,with an overall assessment score of 8.81(10 for a maximum score).The challenge o

关键词： China RNAS^(+) Assessment Schistosomiasis Regional cooperation Contribution

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Application of prostate resectoscope in the treatment of massive rectal bleeding after transrectal prostate puncture

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World Journal of Clinical Cases 2024年第18期12卷 3438-3443页

作者： hong-mei li Fa-Ying Yang Song Tu Peng Yan Jun Qian Jia-Xi Yao Department of Urology Hexi University Affiliated Zhangye People’s HospitalHexi UniversityZhangye 734000Gansu ProvinceChina Department of General Surgery II Hexi UniversityZhangye 734000Gansu ProvinceChina

BACKGROUND Ultrasound-guided prostate biopsy is a reliable diagnostic procedure for prostate cancer diagnosis with minimal procedure-related ***,complications,such as massive rectal bleeding may occur after the *** hypothesized that using a transrectal resectoscope could help treat massive rectal bleeding after transrectal prostate *** To identify a simple and effective treatment for massive rectal bleeding after transrectal prostate *** Patients requiring treatment for massive rectal bleeding after transrectal prostate punctures were included.A SIMAI resectoscope was inserted through the *** electrocoagulation was performed for superficial bleeding *** of the rectal mucosa or surface muscle layer was removed to expose deep bleeding points,followed by *** electric cutting ring was used to compress and stop the bleeding for jet-like points before *** fluid color in the drainage tube was monitored postoperatively for continuous *** Eight patients were included from 2012 to *** of the patients with massive rectal bleeding after the transrectal prostate punctures improved with conventional conservative and blood transfusion *** patients had an inferior artery embolism,and digital subtraction angiography was *** patients received emergency transanal prostate resection,which immediately stopped the *** days after the procedure,the patients had recovered and were *** Using a transanal prostate resection instrument is a simple,safe,and effective method for treating massive rectal bleeding after transrectal prostate punctures.

关键词： Electrocoagulation Hemostasis Transanal prostate resection instrumentation Prostate puncture

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Generation of Four-atom Cluster States in Thermal Cavity and Implementing Remote Controlled Not Gate

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量子光学学报 2006年第B8期12卷 80-80页

作者： Rong-can Yang hong-cai li mei-xiang Chen Xiu lin School of Physics and OptoElectronics Technology Fujian Normal University Fuzhou 350007 China

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Real value oftheoocyteswith smooth endoplasmic reticulum aggregates in in vitro fertilization/intracytoplasmic sperm injection cycle: a retrospective cohort study

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Reproductive and Developmental Medicine 2023年第3期7卷 142-148页

作者： Zheng Zhang Xiao-Na liu Ying Wang Xue-Yao Bai Tao Shangguan hong-mei li lin Zhu Yu-Yan li Wei He Departments of Obstetrics and Gynecology Center of Reproductive medicineFirst Affiliated Hospital of Army Medical UniversityChongqingChina

objective:The management of oocytes affected by smooth endoplasmic reticulum aggregates(SERa)remains *** understand how to manage SERa+oocytes and cycles,we performed a retrospective cohort study and analyzed the impact of SERa+cycles and oocytes on clinical and neonatal ***:We included 4856 cycles(149 SERa+and 4707 SERa-)from 4201 women(age:21-42 years)who received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSl)treatments at the Center of Reproductive Medicine,First Affliated Hospital of Army Military University,from 2016 to ***+cycles had at least one SERa oocyte in the oocyte *** 1722 oocytes in the SERa+cycle were divided into SERa+(405)and SERa-(1317)***:The rates of two pronuclei(2PN)and high-quality embryos were lower in SERa+cycles than in SERa-cycles,regardless of IVF or ICSI(Plity embryos declined gradually(Plinical pregnancy rate and spontaneous abortion rate were observed between SERa+and SERa-cycles or between SERa+and SERa-oocytes(P>0.05).conclusion:Normal fertilization with SERa+cycles and oocytes was substantially reduced,regardless of the insemination *** originating from SERa+oocytes can be transferred when there are no other options,but fully informed consent and strict follow-up of fetal development are mandatory.

关键词： Smooth endoplasmic reticulum aggregates In vitro fertilization Intracytoplasmic sperm injection Outcome

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