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Prognostic effect analysis of molecular subtype on young breast cancer patients

Chinese Journal of Cancer Research 2015年第4期27卷 428-436页

作者： hong-liang chen Ang Ding Fu-Wen Wang Department of Breast Surgery Obstetrics and Gynecology Hospital of Fudan University

Objective： To make a prognostic effect analysis of molecular subtype on young breast cancer ***： Totally 187 cases of young breast cancer patients less than 40 years old treated in Obstetrics and Gynecology Hospital of Fudan University between June 2005 and June 2011 were included in our study. We described their clinical-pathological characteristics, disease-free survival（DFS） rate, and overall survival（OS） rate after a median follow-up period of 61 months. The factors associated with prognosis were also evaluated by univariate and multivariate ***： All patients were premenopausal, with an average age of 35.36±3.88 years old. The mean tumor size was 2.43±1.53 cm. Eighty-one cases had lymph node metastasis（43.3%）, 126 cases had lymphovascular invasion（67.4%）, and 125 cases had histological grade III（66.8%） disease. Twenty-seven cases（14.4%） were Luminal A subtype, 99 cases（52.9%） were Luminal B subtype, 29 cases（15.5%） were human epidermal growth factor receptor 2（HER-2） overexpression subtype, while 32 cases（17.1%） were triple negative breast cancer（TNBC） subtype according to 2013 St Gallen expert consensus. One hundred and thirty-five cases underwent mastectomy whereas 52 cases had breast-conserving surgery. One hundred and seventy-eight cases underwent adjuvant or neoadjuvant chemotherapy. Recurrence or metastasis occurred in 29 cases, 13 of which died. The 5-year DFS and OS rates were 84% and 92%. Multivariate analysis showed that nodal status（P=0.041） and molecular subtype（P=0.037） were both independent prognostic factors of DFS, while nodal status（P=0.037） and TNBC subtype（P=0.048） were both independent prognostic factors of OS. Conclusions： Molecular subtype is an independent prognostic factor of young breast cancer patients. TNBC has a high risk of relapse and death.

关键词： Molecular subtype young breast cancer prognosis

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Self-Organized Public-Key Management for Mobile Ad Hoc Networks Based on a Bidirectional Trust Model

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 188-192页

作者： FU Cai hong Fan LI Rui-xian hong liang chen Jing College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei China

In traditional networks , the authentication is performed by certificate authoritys（CA）,which can＇t be built in distributed mobile Ad Hoc Networks however. In this pa per, we propose a fully self-organized public key management based on bidirectional trust model without any centralized authority that allows users to generate their public-private key pairs, to issue certificates, and the trust relation spreads rationally according to the truly human relations. In contrast with the traditional self-organized public-key management, the average certificates paths get more short, the authentication passing rate gets more high and the most important is that the bidirectional trust based model satisfys the trust re quirement of hosts better.

关键词： Ad Hoc networks self-organize bidirectional trust public key management.

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AN UNUSUAL BILATERAL VAGAL PARAGANGLIOMAS: ONE CASE STUDY

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Chinese Medical Sciences Journal 2006年第3期21卷 197-200页

作者： Hai-hong chen liang Chai Wei Pan Department of Otorhinolaryngology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003

VAGAL paraganglioma （VP） is an uncommon neoplasm originating from neural crest paraganglion cells located along the vagus nerve, repre-senting less than 5 % of all paragangliomas of the head and neck Despite improve... 详细信息

关键词： bilateral vagal paragangliomas treatment

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Nontraumatic convexal subarachnoid hemorrhage:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6205-6210页

作者： hong-liang chen Bin Li Chao chen Xiao-Xuan Fan Wen-Bin Ma Department of Neurology Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Clinical Medicine Binzhou Medical UniversityBinzhou 256600Shandong ProvinceChina

BACKGROUND Nontraumatic convexal subarachnoid hemorrhage(c SAH)is a rare type of atypical subarachnoid *** mainly presents as a focal and transient neurological deficit with similar manifestations as transient ischemic *** SUMMARY We report a case of a 64-year-old man who visited the hospital with paroxysmal left-sided numbness and weakness is presented in this *** tomography examination indicated a high-density image of the right frontalparietal *** subtraction angiography showed severe stenosis at the right anterior cerebral artery A2-A3 junction(stenosis rate approximately 70%).CONCLUSION The findings of this case indicate that anterior cerebral artery stenosis may lead to the occurrence of c SAH.

关键词： Nontraumatic convexal subarachnoid hemorrhage Subarachnoid hemorrhage Transient ischemic attack Artery atherosclerosis stenosis Case report

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Spectroscopic Studies on the Interaction of Asiatic Acid with Bovine Serum Albumin

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Chinese Journal of Chemistry 2011年第3期29卷 549-554页

作者： Yao, Di Ni, Shouhai Wen, Maogui Bian, Hedong Yu, Qing liang, hong chen, Zhenfeng Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) Ministry of Education of China Guilin Guangxi 541004 China

Fluorescence spectroscopy, Fourier transform infrared （FT-IR） spectroscopy, circular dichroism （CD） and FT-Raman spectroscopy were employed to analyze the binding of the asiatic acid （AA） to bovine serum albumin （BSA） under simulative physiological conditions. Fluorescence data revealed that the fluorescence quenching of BSA by AA was the result of the formation of BSA-AA complex. The fluorescence quenching mechanism of BSA by AA was a static quenching procedure. According to the Van＇t Hoff equation, the thermodynamic parameters enthalpy change （△H0） and entropy change （△S0） for the reaction were evaluated to be --12.55 kJ·mol^-1 and 67.08 kJomol 1, respectively, indicating that hydrophobic and electrostatic interactions played a major role in stabilizing the complex. The influence of AA on the conformation of BSA has also been analyzed on the basis of FT-IR, CD and FT-Raman spectra.

关键词： bovine serum albumin asiatic acid secondary structure fluorescence spectroscopy fourier transforminfrared (FT-IR) circular dichroism raman spectroscopy

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Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer

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World Journal of Gastroenterology 2013年第43期19卷 7788-7794页

作者： Zhen-Jun Li Xiao-Jiang Ying hong-liang chen Ping-Jiang Ye Zhi-liang chen Gang Li Hua-Feng Jiang Jiang Liu Shu-Zhen Zhou Department of Colorectal Surgery Shaoxing People’s Hospital Shaoxing Hospital of Zhejiang University

AIM:To investigate the expression of insulin-like growth factor-1(IGF-1)/insulin-like growth factor-1 receptor(IGF-1R)in colorectal cancer(CRC)tissues and to analyze their correlation with lymphangiogenesis and lymphatic ***:Immunohistochemistry was used to evaluate IGF-1 and IGF-1R expression and lymphatic vessel density(LVD)in 40 CRC *** correlation between IGF-1/IGF-1R and LVD was *** of IGF-1 on migration and invasion of CRC cells were examined using transwell chamber assays.A LoVo cell xenograft model was established to further detect the role of IGF-1 in CRC lymphangiogenesis in vivo. RESULTS:Elevated IGF-1 and IGF-1R expression in CRC tissues was correlated with lymph node metastasis(r=0.715 and 0.569,respectively,P<0.05)and tumor TNM stage(r=0.731 and 0.609,P<0.05).A higher LVD was also found in CRC tissues and was correlated with lymphatic metastasis(r=0.405,P<0.05).A positive correlation was found between LVD and IGF-1R expression(r=0.437,P<0.05).Transwell assays revealed that IGF-1 increased the migration and invasion of CRC *** vivo mouse studies showed that IGF-1 also increased LVD in LoVo cell ***:IGF-1/IGF-1R signaling induces tumorassociated lymphangiogenesis and contributes to lymphatic metastasis of CRC.

关键词： Colorectal cancer Insulin-like growth factor-1 Insulin-like growth factor-1 receptor Lymphangiogenesis Lymphatic metastasis

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Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： Yang-Gang Luo Mei Wu hong-Guang chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

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基于生产数据挖掘的吹灰需求度置信规则库研究

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热力发电 2017年第6期46卷 113-118页

作者：钱虹宋亮陈琪琪陈纲上海电力学院自动化工程学院上海200090 华能上海石洞口第一电厂上海200942

为对锅炉积灰结渣受热面吹灰优化,以锅炉燃烧特性和吸热特性为理论依据对生产数据进行挖掘处理,建立吹灰需求度置信规则库。运用数理统计、贝叶斯理论,结合现场运行专家经验,完成吹灰策略集和征兆集的提取、规则的表示和规则变量的设定... 详细信息

为对锅炉积灰结渣受热面吹灰优化,以锅炉燃烧特性和吸热特性为理论依据对生产数据进行挖掘处理,建立吹灰需求度置信规则库。运用数理统计、贝叶斯理论,结合现场运行专家经验,完成吹灰策略集和征兆集的提取、规则的表示和规则变量的设定,并对规则库进行测试。结果表明,本吹灰需求度置信规则库对领域专家吹灰经验的知识描述符合电厂实际吹灰需求,达到了吹灰优化的目的。

关键词：锅炉积灰结渣吹灰优化置信规则库数据挖掘贝叶斯理论生产数据

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Link Reliability Assessment Based on Grey Relational Analysis for Wireless Ad Hoc Networks

Link Reliability Assessment Based on Grey Relational Analysi...

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第二十九届中国控制会议

作者： hong liang,WU chen,ZHANG Guoqing College of Automation,Northwestern Polytechnical University,Xi''an 710072,P.R.China

One crucial issue for routing in wireless ad hoc networks is how to select a reliable path which depends on the availability of the links constituting the *** a good estimation of link reliability between neighboring nodes could permit the selection of a more reliable *** to the nature of the wireless ad hoc networks,mobility and radio propagation etc.,it is not easy to collect enough information or find some regular pattern to assess the link status between the neighboring *** solve this,we propose a link reliability assessment method based on grey relational analysis which computes the probability of being a good quality link from limited *** simulation and analysis show this scheme is an efficient method for link reliability assessment in wireless ad hoc networks.

关键词： Wireless Ad Hoc Networks Link reliability Assessment Grey Relational Analysis

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底吹炼铅炉内流动的数值模拟

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中国有色金属学报 2017年第3期27卷 637-647页

作者：张红亮汤卓陈永明叶龙刚中南大学冶金与环境学院长沙410083

以工业实践的底吹炼铅炉为对象,在炉内渣相和金属相的物性参数测定的基础上,利用FLUENT软件平台,建立一个与实际体系一致的底吹炼铅炉模型,并耦合VOF三相流模型和标准κ-ε湍流模型对底吹炼铅炉内气-渣-金属三相流动过程进行模拟。通过... 详细信息

以工业实践的底吹炼铅炉为对象,在炉内渣相和金属相的物性参数测定的基础上,利用FLUENT软件平台,建立一个与实际体系一致的底吹炼铅炉模型,并耦合VOF三相流模型和标准κ-ε湍流模型对底吹炼铅炉内气-渣-金属三相流动过程进行模拟。通过分析数值模拟的相界面结构、速度场分布、流线分布结果,发现氧枪上方区域搅动剧烈,渣层中存在涡流,强化了传递和反应过程。另外,所建立的模型在优化底吹炉炉体结构和改善运行条件方面有着重要作用,经过分析不同条件下炉内流体流动形态,能有效地引导完善底吹炼铅炉工况。对入口流速和喷枪倾角的优化讨论中,发现增大入口流速能提高熔炼效果,最佳喷枪倾角为5°~7°。

关键词：底吹炉多相流 FLUENT 结构优化

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