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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： Ya-Xiu Fang Xiao-ming Zhou Dong Zheng Guang-Hui Liu Peng-Bo Gao Xiao-Zhen Huang Zhi-Cheng Chen Hui Zhang Lin Chen Ya-Fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： Jian-Ping Wen Shuan-Ji Ou Jia-Bao Liu Wei Zhang Yu-Dun Qu Jia-Xuan Li Chang-liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai Jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

(Ti_(60)Cr_(30)Nb_(10))_(100-x)Al_(x)轻质中熵合金的力学与腐蚀性能

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Transactions of Nonferrous Metals Society of China 2024年第1期34卷 219-235页

作者：王浩陈维平郝良彦褚晨亮熊伟付志强华南理工大学广东省金属新材料制备与成形重点实验室广州510641 华南理工大学国家金属材料近净成形工程技术研究中心广州510641 Physical Metallurgy and Materials Design Laboratory Department of Mechanical Engineering and Materials ScienceUniversity of PittsburghPittsburghPA15261USA

研究轻质(Ti_(60)Cr_(30)Nb_(10))_(100-x)Al_(x)(x=0,5,7.5,10,摩尔分数,%)中熵合金在铸态和均匀化态下的显微组织、力学性能和腐蚀行为。结果表明,随着Al含量从0增加到10%(摩尔分数),铸态合金均由相同的相组成,即体心立方(BCC)相和少... 详细信息

研究轻质(Ti_(60)Cr_(30)Nb_(10))_(100-x)Al_(x)(x=0,5,7.5,10,摩尔分数,%)中熵合金在铸态和均匀化态下的显微组织、力学性能和腐蚀行为。结果表明,随着Al含量从0增加到10%(摩尔分数),铸态合金均由相同的相组成,即体心立方(BCC)相和少量TiCr2型Laves相组成。均匀化后,所有合金均由单相BCC组成。此外,(Ti_(60)Cr_(30)Nb_(10))_(95)A_(l5)中熵合金表现出在铸态和均匀态条件下最优异的力学性能,屈服强度分别约为1048 MPa和1017 MPa,同时保持超50%压缩应变。与TC4和铸态(Ti_(60)Cr_(30)Nb_(10))_(95)A_(l5)合金相比,均匀态(Ti_(60)Cr_(30)Nb_(10))_(95)A_(l5)合金表现出更优异的耐腐蚀性能,这主要归因于均匀的显微组织与化学成分。

关键词：中熵合金轻质合金显微组织力学性能腐蚀行为

棉短绒纤维素/聚丙烯酰胺复合水凝胶的合成及絮凝性能研究

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现代化工 2024年第1期44卷 83-88页

作者：杨宏声马雪丁成立朱筱胡灿明新疆大学化工学院新疆煤炭洁净转化与化工过程重点实验室新疆乌鲁木齐830017

以棉短绒(MCC)为原料､丙烯酰胺(Acrylamide,AM)为单体､过硫酸铵(Ammonium persulfate,APS)为引发剂､N,N′-亚甲基双丙烯酰胺(N,N′-Methylenebisacrylamide)为交联剂,采用水溶液聚合的方式共聚制备水凝胶绿色絮凝材料。考察了体系共聚时... 详细信息

以棉短绒(MCC)为原料､丙烯酰胺(Acrylamide,AM)为单体､过硫酸铵(Ammonium persulfate,APS)为引发剂､N,N′-亚甲基双丙烯酰胺(N,N′-Methylenebisacrylamide)为交联剂,采用水溶液聚合的方式共聚制备水凝胶绿色絮凝材料。考察了体系共聚时间､共聚温度､APS投加量和单体质量比对接枝率的影响。利用红外光谱(FT-IR)､X射线衍射(XRD)､热重分析(TG)､扫描电镜(SEM)和Zeta电位等对所制备的材料进行表征,并考察其对高岭土模拟废水的絮凝效果。结果表明,当AM与MCC质量比为5∶1､引发剂投加质量为0.06 g､反应温度为50℃､反应时间为3 h时,可制得较高接枝率的产品,且其对pH为3､7､11高岭土悬浊液(300 mg/L)的浊度去除率分别达到98.6%､97.6%和98.3%,表现出良好的絮凝性能。

关键词：棉短绒丙烯酰胺接枝共聚和绿色絮凝材料

Efficient DIPA-CRISPR-mediated knockout of an eye pigment gene in the white-backed planthopper,Sogatella furcifera

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Insect Science 2024年第4期31卷 1015-1025页

作者： Meng-Qi Zhang Lang-Lang Gong Ya-Qin Zhao Yun-Feng Ma Gui-Jun Long Huan Guo Xuan-Zheng Liu J.Joe Hull Youssef Dewer Chao Yang Ning-Ning Zhang ming He Peng He National Key Laboratory of Green Pesticides Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyangChina Pest Management and Biocontrol Research Unit US Arid Land Agricultural Research CenterUSDA Agricultural Research ServicesMaricopaArizonaUSA Phytotoxicity Research Department Central Agricultural Pesticide LaboratoryAgricultural Research CenterDokkiGizaEgypt Guizhou Jifeng Seed Industry Limited Liability Company XingyiGuizhou ProvinceChina Shandong Facility Horticulture Bioengineering Research Center Weifang University of Science and TechnologyWeifangShandong ProvinceChina

Although CRISPR/Cas9 has been widely used in insect gene editing,the need for the microinjection of preblastoderm embryos can preclude the technique being used in insect species with eggs that are small,have hard shells,and/or are difficult to collect and maintain outside of their normal *** is the case with Sogatella furcifera,the white-backed planthopper(WBPH),a significant pest of Oryza sativa(rice)that oviposits inside rice *** extraction from the stem runs the risk of mechanical damage and hatching is heavily influenced by the micro-environment of the rice *** bypass these issues,we targeted embryos prior to oviposition via direct parental(DIPA)-CRISPR,in which Cas9 and single-guide RNAs(sgRNAs)for the WBPH eye pigment gene tryptophan 2,3-dioxygenase were injected into the hemocoel of adult *** at varying numbers of days posteclosion were evaluated to determine at what stage their oocyte might be most capable of taking up the gene-editing *** evaluation of the offspring indicated that the highest G0 gene-edited efficacy(56.7%)occurred in females injected 2 d posteclosion,and that those mutations were heritably transmitted to the G1 *** study demonstrates the potential utility of DIPA-CRISPR for future gene-editing studies in non-model insect species and can facilitate the development of novel pest management applications.

关键词： CRISPR/Cas9 DIPA-CRISPR gene editing tryptophan 2,3-dioxygenase WBPH

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PCB标准热图像建立的相关问题研究

舰船电子工程 2024年第3期44卷 4-8页

作者：李夫洪亮尹延涛海军航空大学烟台264010

故障诊断的首要工作是建立PCB标准热图像,研究了在建立标准热图像过程中样本热图像的处理方法,并提出了采用主成分分析法代替加权平均法,效果比较理想;研究了单样本电路板相邻通电期间完全合理冷却时间和理想通电时间的计算方法,对于今... 详细信息

故障诊断的首要工作是建立PCB标准热图像,研究了在建立标准热图像过程中样本热图像的处理方法,并提出了采用主成分分析法代替加权平均法,效果比较理想;研究了单样本电路板相邻通电期间完全合理冷却时间和理想通电时间的计算方法,对于今后研究PCB标准红外图像提供了依据。

关键词： PCB标准热图像主成分分析法完全合理冷却理想通电时间

Ultrafast pulse-dilation framing camera and its application for time-resolved X-ray diagnostic

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Nuclear Science and Techniques 2024年第7期35卷 101-114页

作者： Hou-Zhi Cai Qiu-Yan Luo Kai-Xuan Lin Xuan Deng Jun-Kai Liu Kai-Zhi Yang Dong Wang Jia-Jie Chen Jia-Heng Wang Jing-Hua Long Li-hong Niu Yun-Fei Lei Jin-Yuan Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen Key Laboratory of Photonics and BiophotonicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were *** camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic *** spatial resolution characteristics of the camera were studied both theoretically and *** results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the ***,the camera was used to detect the X-rays produced by the laser-targeting *** diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.

关键词： Inertial confinement fusion Plasma diagnostics Framing camera Combined lenses Pulse-dilation

超声引导下髂筋膜联合坐骨神经阻滞对下肢血运重建患者术后主要心血管不良事件的影响

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实用医学杂志 2024年第11期40卷 1531-1536页

作者：刘曼曼熊万霞应美晶梁超丁明复旦大学附属中山医院厦门医院麻醉科福建厦门361000 复旦大学附属中山医院麻醉科上海200032

目的评价超声引导下髂筋膜联合坐骨神经阻滞对下肢ASO患者血运重建术后主要心血管不良事件和预后的影响。方法选择性下肢血运重建手术ASO患者353例。根据术中采取不同的麻醉方式将患者分为两组:超声引导下髂筋膜联合坐骨神经阻滞组(B组... 详细信息

目的评价超声引导下髂筋膜联合坐骨神经阻滞对下肢ASO患者血运重建术后主要心血管不良事件和预后的影响。方法选择性下肢血运重建手术ASO患者353例。根据术中采取不同的麻醉方式将患者分为两组:超声引导下髂筋膜联合坐骨神经阻滞组(B组)和手术监测麻醉(MAC)(M组);主要观察指标:ASO患者行下肢血运重建术后的主要心血管不良事件(MACE)发生率。次要观察指标:非心脏术后心肌损伤(MINS)、术后截肢、其他不良反应(如术后谵妄、恶心呕吐等)的发生率、术后实验室指标。通过倾向性得分匹配平衡术前基线,对匹配后的数据分析不同麻醉方式对下肢ASO患者血运重建术后MACE和预后的影响。结果在倾向性得分匹配后,与M组相比,B组的MACE发生率更低(10%vs.3.4%,P=0.038);B组的MINS发生率(33%vs.25%,P=0.200);B组的截肢率(4.2%vs.3.4%,P>0.99);B组的并发症发生率为(6.8%vs.4.2%,P=0.39);两组术后实验室指标差异无统计学意义(P>0.05)。多因素分析显示神经阻滞(OR=0.25,95%CI:0.05~0.93)、术后HBG(OR=0.95,95%CI:0.91~0.99)是降低MACE发生的保护。结论超声引导下髂筋膜联合坐骨神经阻滞可以降低下肢ASO患者血运重建术后发生MACE的风险。

关键词：髂筋膜坐骨神经阻滞主要心血管不良事件倾向性得分匹配

杜仲法呢基焦磷酸合酶EuFPS1互作蛋白筛选及分析

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植物生理学报 2024年第3期60卷 585-595页

作者：曾琴梁青赵丹贵州大学生命科学学院/农业生物工程研究院山地植物资源保护与种质创新教育部重点实验室贵阳550025

法呢基焦磷酸合酶(farnesyl diphosphate synthase,FPS)是杜仲胶生物合成途径中的关键酶之一,EuFPS1基因对杜仲胶积累有促进作用,但对其调控的分子机制尚不清楚。本研究采用SMART同源重组技术构建了杜仲酵母cDNA表达文库,以EuFPS1基因... 详细信息

法呢基焦磷酸合酶(farnesyl diphosphate synthase,FPS)是杜仲胶生物合成途径中的关键酶之一,EuFPS1基因对杜仲胶积累有促进作用,但对其调控的分子机制尚不清楚。本研究采用SMART同源重组技术构建了杜仲酵母cDNA表达文库,以EuFPS1基因为诱饵筛选互作蛋白,经测序和BLAST比对初步筛选出41个互作蛋白。GO和KEGG分析结果显示,互作蛋白主要参与卟啉化合物代谢调控、紫外线与冷响应、叶片发育等生物进程,MEP代谢、卟啉代谢、泛素介导的蛋白质水解等代谢途径。选取3个互作蛋白(EuUFM1、EuLHC1、EuKS1)进一步验证互作关系,qRT-PCR分析发现EuFPS1与EuUFM1、EuLHC1、EuKS1基因在杜仲不同组织中均表达,其中EuFPS1与EuKS1的表达呈负相关。本研究为解析杜仲EuFPS1及其与互作蛋白的作用机制奠定了基础。

关键词：杜仲法呢基焦磷酸合酶酵母双杂交互作蛋白基因表达

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