检索结果-南通市图书馆

教育教学论坛 2017年第12期 218-220页

作者：马骏田红旭黄俊杰河南科技大学管理学院河南洛阳471003

本文基于对大学生互联网创业问卷调查结果的分析,总结影响大学生互联网创业的因素,结合当前开展创业教育的新趋势和新理念,提出改善高校创业教育教学效果的对策建议,以期为高校创业教育教学改革提供参考。

关键词：大学生互联网创业教育

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong huang Weixuan Chen Ying huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

关键词：

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu huang Jinli huang Yinfei Ouyang Bolin Bin Mingming Zhao jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

在线全文

学校读者我要写书评

暂无评论

吉兰-巴雷综合征48例临床分析

中国现代神经疾病杂志 2016年第9期16卷 611-615页

作者：闻洁曦郝洪军高枫黄一宁北京大学第一医院神经内科 100034

回顾分析48例吉兰-巴雷综合征患者的临床表现、实验室和神经电生理学特点、治疗及预后。临床以肢体无力、麻木为首发症状者占81.25%(39/48),尤以双下肢显著;四肢腱反射减弱或消失者占93.75%(45/48)。38例患者脑脊液出现蛋白-细胞分离现... 详细信息

回顾分析48例吉兰-巴雷综合征患者的临床表现、实验室和神经电生理学特点、治疗及预后。临床以肢体无力、麻木为首发症状者占81.25%(39/48),尤以双下肢显著;四肢腱反射减弱或消失者占93.75%(45/48)。38例患者脑脊液出现蛋白-细胞分离现象。42例患者神经电生理学显示,F波传导速度减慢或未引出、运动和感觉神经传导速度减慢、复合肌肉动作电位波幅下降。43例患者静脉注射免疫球蛋白,97.67%(42/43)肌力较前好转。亦有少数患者出现不典型临床症状与体征,如单侧面部痛觉减退、病理征阳性等。临床医师应结合临床表现、实验室和神经电生理学检查等综合判断,早期明确诊断,改善患者预后。

关键词：格林-巴利综合征脑脊髓液电生理学

在线全文

学校读者我要写书评

暂无评论

牛仔布的经纱上浆

四川纺织科技 2003年第5期 20-22页

作者：罗建红黄俊成都纺织高等专科学校四川成都610023

综述了牛仔布经纱上浆的目的、对浆料性能的要求 ,以及牛仔布经纱上浆用浆料的发展历程。同时对影响牛仔布上浆工艺的因素。

关键词：牛仔布经纱上浆变性淀粉上浆工艺应用效果

在线全文

学校读者我要写书评

暂无评论

FlexRay网络动态段时间参数优化

汽车科技 2017年第2期 34-39页

作者：刘红军黄斌孙旭辉合肥工业大学汽车与交通工程学院合肥230009 合肥工业大学机械工程学院合肥230009

为了提高FlexRay总线动态段的带宽利用率和通信实时性,建立了动态消息调度模型,并提出了动态消息平均响应时间概念,基于对动态消息响应时间的分析,推导出了其定量计算公式,并给出了动态消息优先级和时隙ID分配原则;在此基础上,建立了以... 详细信息

为了提高FlexRay总线动态段的带宽利用率和通信实时性,建立了动态消息调度模型,并提出了动态消息平均响应时间概念,基于对动态消息响应时间的分析,推导出了其定量计算公式,并给出了动态消息优先级和时隙ID分配原则;在此基础上,建立了以动态段长度最小为目标,以动态消息实时性为约束的FlexR ay动态段参数配置优化模型,并给出了求解该模型的ARDS算法。最后采用CANoe软件进行仿真实验,验证本文所提方法的正确性和有效性。

关键词： FlexRay 参数配置响应时间时隙ID分配

在线全文

学校读者我要写书评

暂无评论

复方甲氧那明治疗感染后咳嗽110例

中国新药与临床杂志 2010年第7期29卷 558-560页

作者：万雨明王秀红黄俊华东风汽车公司茅箭医院内科湖北十堰442012

目的观察复方甲氧那明胶囊治疗感染后咳嗽的临床疗效。方法 212例感染后咳嗽患者分为2组,治疗组110例,对照组102例。治疗组患者口服复方甲氧那明胶囊2粒,每日3次,疗程7 d。对照组患者口服枸橼酸喷托维林片25 mg,每日3次,疗程7 d。观察... 详细信息

目的观察复方甲氧那明胶囊治疗感染后咳嗽的临床疗效。方法 212例感染后咳嗽患者分为2组,治疗组110例,对照组102例。治疗组患者口服复方甲氧那明胶囊2粒,每日3次,疗程7 d。对照组患者口服枸橼酸喷托维林片25 mg,每日3次,疗程7 d。观察服药前后咳嗽严重程度的变化及不良反应。结果治疗后,2组咳嗽评分均下降,治疗组低于对照组(P<0.05)。治疗组有效率为92.7%,高于对照组的73.5%,2组疗效差异显著(P<0.05)。均未出现严重不良反应。结论复方甲氧那明胶囊治疗感染后咳嗽有效、安全。

关键词：呼吸道感染咳嗽甲氧那明氨茶碱

作者h-指数Bradford分布及其GM模型

在线全文

学校读者我要写书评

暂无评论

评价与管理 2017年第3期15卷 67-72页

作者：王宏鑫刘军黄丽珺刘洋汪银霞信阳师范学院图书馆文献信息研究所河南信阳464000

h-指数的Bradford分布规律的存在及其实证问题可以通过IPP理论和心理物理学阐释,并用GM模型描述与实证拟合。实证统计结果也表明作者h-指数具有Bradford分布特征。h-指数Bradford分布规律使得有关h-指数的研究主要关注个体评价转向群体... 详细信息

h-指数的Bradford分布规律的存在及其实证问题可以通过IPP理论和心理物理学阐释,并用GM模型描述与实证拟合。实证统计结果也表明作者h-指数具有Bradford分布特征。h-指数Bradford分布规律使得有关h-指数的研究主要关注个体评价转向群体评价成为可能。

关键词： h-指数 Bradford分布 GM模型

Relative Quasisymmetry and Quasim?bius Mappings in Quasi-metric Spaces

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2022年第3期38卷 547-559页

作者： hong jun LIU Xiao jun huang Yue FAN School of Mathematical Sciences Guizhou Normal UniversityGuiyang550001P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing401331P.R.China

The aim of this paper is to investigate the relationship between relative quasisymmetry and quasimöbius in quasi-metric spaces,and show that a homeomorphism f isη-quasisymmetric relative to A if and only if it isθ-q... 详细信息

关键词： Quasisymmetric mapping quasimobius mapping three-point condition quasi-metric space

在线全文

学校读者我要写书评

暂无评论

一九七五年天鹅座新星的偏振测光

天文学报 1976年第2期 228-231页

作者：熊大闰苏洪钩黄长春中国科学院紫金山天文台

对1975年天鹅座新星进行了偏振测光。没有发现可觉察的圆偏振。黄光波段新星的线偏振约为1.2%,蓝光波段约为1.1％。没有发现偏振的明显变化,偏振可能是属于星际起源的。

关键词：黄光蓝光光波段线偏振偏光膜新星恒星天鹅座白鸟座偏振角