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Agricultural Sciences in China 2010年第4期9卷 598-604页

作者： TAN Gao-yi ZhanG Min-hong FENG jing-hai han Ai-yun ZHENG Shan-shan XIE Peng State Key Laboratory of Animal Nutrition Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 P.R.China

This study investigated the protective effects of ampelopsin on H2O2-induced oxidative injury in porcine kidney epithelial cell line, PK-15; cells were pretreated with medium containing 0, 15, 30, and 60 ug mL-1 ampelopsin, respectively, for 1 h prior to the addition of 100 umol L-1 H2O2. After 2 h, the cell viability, intracellular superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px） activity, cellular malondialdehyde （MDA） content, and DNA strand breakage were determined. Results showed that ampelopsin pretreatment did not modify the SOD and GSH-Px inactivation but significantly decreased MDA production; except for the medium dose （30 ug mL-1）, all the tested concentrations of ampelopsin did not significantly inhibit cell viability reduction and gave no influence on DNA damage. The results suggested that all the tested doses of ampelopsin pretreatment before H2O2 addition can protect PK-15 cell from H2O2-induced lipid peroxidation, which might not be mediated by the SOD and GSH-Px responsees. The appropriate dose of ampelopsin pretreatment prevents PK-15 cell from DNA damage and cell viability reduction.

关键词： ampelopsin PK-15 cell antioxidation hydrogen peroxide

Effect of Dual Trigger In Vitro Fertilization and Intracytoplasmic Sperm Injection During the Gonadotropin-releasing Hormone-Antagonist Cycle on Final Oocyte Maturation and Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve

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Current Medical Science 2022年第5期42卷 1066-1070页

作者： Yu-meng REN Yan-bin WANG Min FU Qiu-xiang ZhanG Huan SHEN hong-jing han Fu-mei GAO Reproductive Center of Peking University People’s Hospital Beijing100044China

Objective It is well known that a dual trigger treatment can improve clinical outcomes of in vitro fertilization(IVF)in high or normal ovarian ***,it is not clear whether dual triggering also benefits patients with diminished ovarian reserve(DOR).The aim of this study was to investigate whether a dual trigger treatment of gonadotropin-releasing hormone(GnRH)agonist combined with human chorionic gonadotropin(hCG)for final follicular maturation improves the cumulative live birth rate(CLBR)during the GnRH-antagonist cycle in patients with *** This retrospective study included patients with DOR who received a GnRH-antagonist protocol during IVF and intracytoplasmic sperm injection(IVF-ICSI)cycles at Peking University People’s Hospital from January 1,2017 through December 31,*** maturation was triggered by GnRH combined with hCG(n=110)or hCG alone(n=71).Embryos were transferred on the third day after oocyte retrieval or during a subsequent freeze-thaw *** were followed up for 3 *** The dual trigger treatment did not affect CLBR,which is an overall determinant of the success rate of assisted reproductive technology(ART).Women in the dual trigger group had significantly higher rates of fertilization than those in the hCG group(90.1%vs.83.9%,P=0.040).Conclusion Dual trigger with GnRH agonist and hCG did not improve CLBR in patients with DOR,but did slightly improve fertilization rate,oocyte count,and embryo quality.

关键词： dual trigger gonadotropin releasing hormone antagonist protocols diminished ovarian reserve cumulative live birth rate

Studies on Combination of Flow Injection and Microwave Plasma Torch-Atomic Emission Spectrometry

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Chemical Research in Chinese Universities 1993年第3期9卷 246-247页

作者： YE Dong-mei, ZHAO jing-hong, ZhanG han-qi and JIN Qin-han (Department of Chemistry, Jilin University, Changchun, 130023)DONG De-fan (Hebei College of Geology, Shijiazhuang, 050031)

Although the flow injection(FI) as a sample introduction technique has been extensively applied to atomic spectrometry, such as ICP-AES and AAS, very little has been done so far on coupling FI to microwave plasma syst... 详细信息

关键词： Microwave plasma torch Flow injection Atomic emission spectrometry

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火山活动状态及其机理的初步探讨

地震地质 2007年第3期29卷 502-512页

作者：洪汉净刘辉中国地震局地质研究所

根据火山喷发实例总结了火山喷发在不同阶段的活动状态,并探讨了可能的物理机理。火山活动从岩浆补给到岩浆喷发的物理过程可分为3个阶段:1)岩浆补给阶段,岩浆囊压力差或过剩压力的大小决定了火山活动是否休眠或扰动,岩浆补给速率对压... 详细信息

根据火山喷发实例总结了火山喷发在不同阶段的活动状态,并探讨了可能的物理机理。火山活动从岩浆补给到岩浆喷发的物理过程可分为3个阶段:1)岩浆补给阶段,岩浆囊压力差或过剩压力的大小决定了火山活动是否休眠或扰动,岩浆补给速率对压力差起了决定性的作用;2)通道形成阶段,当过剩压力超过围岩破裂强度时,围岩开始破裂,之后水热活动起了重要的作用;3)岩浆运移与失稳喷发阶段,主要是岩浆运移与地壳盖层的相互作用与失稳的过程。文中还讨论了火山活动状态与火山喷发危险性等级之间的关系,7个危险性等级分别对应于火山活动的7种状态,即休眠、平静、扰动、动荡、临界、活动、灾变。

关键词：火山岩浆补给通道岩浆运移失稳喷发

.ow Programmed Cell Death 5 Expression is a Prognostic Factor in Ovarian Cancer

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Chinese Medical Journal 2015年第8期128卷 1084-1090页

作者： Li Gao Xue Ye Rui-Qiong Ma hong-Yan Cheng hong-jing han Heng Cui Li-Hui Wei Xiao-hong Chang Gynecology Oncology Center Peking University People's Hospital Beijing 100044 China Center for Reproductive Medicine Peking University People's Hospital Beijing 100044 China

Background： Ovarian cancer is a leading gynecological malignancy. We investigated the prognostic value of programmed cell death 5 （PDCD5） in patients with ovarian cancer. Methods： Expression levels of PDCD5 mRNA and protein were examined in six ovarian cancer cell lines （SKOV3, CAOV3, ES2, OV1, 3AO, and HOC 1 A） and one normal ovarian epithelial cell line （T29） using reverse transcription polymerase chain reaction, Western blotting, and flow cytolnetry. Alter inducing PDCD5 induction in SKOV3 cells or treating this cell line with taxol or doxorubicin （either alone or combined）, apoptosis was measured by Annexin V-FITC/propidium iodide staining. Correlations between PDCD5 protein expression and pathological features, histological grade, FIGO stage, effective cytoreductive surgery, and serum cancer antigen-125 values were evaluated in patients with ovarian cancer. Results： PDCD5 mRNA and protein expression were downregulated in ovarian cancer cells. Recombinant human PDCD5 increased doxorubicin-induced apoptosis in SKOV3 cells （15.96 ± 2.07%, vs. 3.17 ± 1.45% in controls）. In patients with ovarian cancer, PDCD5 expression was inversely correlated with FIGO stage, pathological grade, and patient survival （P 〈 0.05, R = 0.7139 for survival）. Conclusions： PDCD5 expression is negatively correlated with disease progression and stage in ovarian cancer. Therefore, measuring PDCD5 expression may be a good method of determining the prognosis of ovarian cancer patients.

关键词： Ovarian Cancer Poor Prognosis Programmed Cell Death 5

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近年来全球地震与火山活动分析

自然杂志 2011年第5期33卷 266-270,254页

作者：洪汉净中国地震局地质研究所

1990年日本云仙岳火山和1991年菲律宾皮那图博火山喷发,引发了菲律宾海板块西缘的活动。全球板块运动以及相应的地震、火山活动进入一个新的阶段,特大地震活动以南半球为主,发生了2004年苏门答腊Mw9.1大震(Mw是矩震级),2010年智利Mw8.8... 详细信息

1990年日本云仙岳火山和1991年菲律宾皮那图博火山喷发,引发了菲律宾海板块西缘的活动。全球板块运动以及相应的地震、火山活动进入一个新的阶段,特大地震活动以南半球为主,发生了2004年苏门答腊Mw9.1大震(Mw是矩震级),2010年智利Mw8.8级大地震。火山活动也有类似表现,两个VEI≥5(VEI是火山爆发指数)的喷发都发生在南半球。2011年日本仙台东发生Mw9.1级大震造成巨大的灾难,也影响了世界地震活动的格局。考虑到1933年日本三陆大震后的图像,日本弧大震可能没有完全改变全球活动格局。

关键词：地震火山全球微动态

岩浆活动与构造应力的相互作用及其与火山活动状态的关系

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地球物理学报 2009年第5期52卷 1263-1269页

作者：陈会仙洪汉净刘辉中国地震局地质研究所北京100029

本文考虑一个包含岩浆囊和火山隆起的三维黏弹性地壳有限元模型,通过数值模拟的方法揭示了岩浆活动与构造应力之间的相互作用.首先,在底部岩浆的持续补给作用下,总结了火山地表形变、应力大小和岩浆囊过剩压力在岩浆补给不同状态下的特... 详细信息

本文考虑一个包含岩浆囊和火山隆起的三维黏弹性地壳有限元模型,通过数值模拟的方法揭示了岩浆活动与构造应力之间的相互作用.首先,在底部岩浆的持续补给作用下,总结了火山地表形变、应力大小和岩浆囊过剩压力在岩浆补给不同状态下的特征和表象;同时本文研究了构造应力场变化对火山岩浆囊应力的影响,发现10 MPa的板块应力作用能够引起岩浆囊内±1.2～1.6 MPa的压力变化,这个基级足以对岩浆囊形成扰动,从而引发各种火山活动.

关键词：有限元数值模拟岩浆与构造的相互作用岩浆囊岩浆补给地表形变构造应力

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子宫内膜异位症对输卵管的结构和功能的影响

生殖与避孕 2011年第5期31卷 354-358页

作者：韩红敬关菁北京大学人民医院生殖医学中心北京100044

子宫内膜异位症（endometriosis,EMs）定义为子宫内膜组织生长于子宫腔以外,其在普通人群中的患病率为5%,育龄女性为10%,而在不孕患者中则高达25%~50%[1]。尽管EMs与不孕之间的关联性尚无法确定,但大多数研究报道EMs患者比正常对照组妊... 详细信息

子宫内膜异位症（endometriosis,EMs）定义为子宫内膜组织生长于子宫腔以外,其在普通人群中的患病率为5%,育龄女性为10%,而在不孕患者中则高达25%~50%[1]。尽管EMs与不孕之间的关联性尚无法确定,但大多数研究报道EMs患者比正常对照组妊娠率低,而具体机制还知之甚少。

关键词：子宫内膜异位症(EMs) 输卵管

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Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun han Ming LU Shaomin YU jing JU hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

Endometrial MicroRNA Signature during the Window of Implantation Changed in Patients with Repeated Implantation Failure

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Chinese Medical Journal 2017年第5期130卷 566-573页

作者： Cheng Shi Huan Shen Li-Juan Fan jing Guan Xin-Bang Zheng Xi Chen Rong Liang Xiao-Wei Zhang Qing-Hua Cui Kun-Kun Sun Zhu-Ran Zhao hong-jing han Reproductive Medical Center Peking University People's Hospital Beijing 100044 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Biomedical Informatics School of Basic Medical Sciences Peking University Beijing 100191 China Department of Pathology Peking University People's Hospital Beijing 100044 China Department of Paediatrics Peking University People's Hospital Beijing 100044 China

Background： At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA （miRNA） signatures for impaired endometrial receptivity by microarray analysis. Methods： A total of 12 repeated implantation failure （RIF） patients and I0 infertile patients, who conceived and delivered after one embryo transfer attempt, were recruited as RIF and control groups, respectively. Endometrial specimens from the window of implantation （WOI） were collected from these two groups. MiRNA microarray was conducted on seven and five samples from the RIF and control groups, respectively. Comparative, functional, and network analyses were performed for the microarray results. Quantitative real-time polymerase chain reaction （PCR） was performed on other samples to validate the expression of specific miRNAs. Results： Compared with those in the control group, the expression levels of 105 miRNAs in the RIF group were found to be significantly up- or down-regulated （at least 2-fold） by microarray analysis. The most relevant miRNA functional sets of these dysregulated miRNAs were miR-30 family, human embryonic stern cell regulation, epithelial-mesenchymal transition, and miRNA tumor suppressors by tool for annotations ofmicroRNA analysis. Network regulatory analysis found 176 miRNA-mRNA interactions, and the top 3 core miRNAs were has-miR-4668-5p, has-miR-429, and has-miR-5088. Expression levels of the 18 selected miRNAs in new samples by real-time PCR were found to be regulated with the same trend, as the result ofmicroarray analysis. Conclusions： There is a significant different expression of certain miRNAs in the WOI endometrium for RIF patients. These miRNAs may contribute to impaired endometrial receptivity.

关键词： Embryo Implantation Endometrial Receptivity MicroRNA Microarray Repeated Implantation Failure Window of Implantation