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Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

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World Journal of Gastroenterology 2024年第11期30卷 1588-1608页

作者： Xing-Nian Zhou Quan Zhang hong peng Yu-jie Qin Yu-hong Liu Lu Wang Ming-Liang Cheng Xin-Hua Luo hong Li Department of Infectious Diseases The Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550001Guizhou ProvinceChina

BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and *** silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and *** To investigate the association between ferroptosis and pyroptosis and the upstream regulatory *** This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce *** D(GSDMD)^(-/-)mice were used as an experimental *** changes in liver tissue were monitored by hematoxylin and eosin ***,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial ***-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain ***1,p53,and GSDMD were assessed by immunofluorescence *** Serum AST and ALT levels were elevated in patients with ***1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver *** the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was *** mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were *** vitro,knockdown of p53 and overexpression of GPX

关键词： Silent information regulator sirtuin 1 Ferroptosis Pyroptosis p53/glutathione peroxidase 4/gasdermin D Acute liver failure

Stable hydrogen isoscape in precipitation generated using data fusion for East China

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Science China Earth Sciences 2024年第9期67卷 2972-2988页

作者： Jiacheng CHEN jie CHEN Xunchang John ZHANG Peiyi peng State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China Hubei Key Laboratory of Water System Science for Sponge City Construction Wuhan UniversityWuhan 430072China USDA-ARS Oklahoma and Central Plains Agricultural Research Center El Reno OK 73036USA Southwest Research Institute for Hydraulic and Water Transport Engineering Chongqing Jiaotong UniversityChongqing 400016China

The stable hydrogen isotope in precipitation is an effective environmental tracer for climatic and hydrologic ***,accurate and high-precision precipitation hydrogen isoscapes are currently unavailable in *** this study,a data fusion method based on Convolutional Neural Networks(CNN)is used to fuse the hydrogen isotopic composition(δ^(2)H_(p))of observations and isotope-equipped general circulation model(iGCM)simulations.A precipitation hydrogen isoscape with a temporal resolution of monthly and a spatial resolution of 50-60 km is established for East China for the 1969-2017 *** to building the isoscape,the performance of three data fusion methods(DFMs)and two bias correction methods(BCMs)is *** results indicate that the CNN fusion method performs the best with a correlation coefficient larger than 0.90 and root mean square error smaller than 10.5‰ when using observation as a *** fusion methods based on back propagation and long short-term memory neural network perform similarly,while slightly outperforming the bias correction ***,the CNN method is used to generate the hydrogen isoscape,and the temporal and spatial distribution characteristics of the hydrogen isotope in precipitation are analyzed based on this *** generated isoscape shows similar spatial and temporal distribution characteristics to *** general,the distribution pattern of δ^(2)H_(p) is consistent with the temperature effect in northern China,and consistent with the precipitation amount effect in southern *** trend of the δ^(2)H_(p) time series is consistent with that of observed precipitation and ***,the generated isoscape effectively reproduces the observations,and has the characteristics of time continuity and relative spatial regularity,which can provide valuable data support for tracking atmospheric and hydrological processes.

关键词： Precipitation Precipitation isotope General circulation model Data fusion Dataset

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-hong Zhong Fang-Lin Wang Zhi-Hui Huang Zhe hong Yun-Fang Gao Hai-Dong Wang Jian-Wei Ren Sheng-jie peng Lei Li College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Research and Development Department Jiangxi Ganfeng LiEnergy Technology Co.Ltd.Xinyu 338000China Department of Mechanical Engineering Science University of JohannesburgAuckland ParkJohannesburg 2092South Africa

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***,the carbon nanotubes(CNTs)coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH(denoted as SN-Ni Co-LDH)nanosheets array are grown on Ni Co foam(NCF)substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation *** from the S–N co-doping and low-crystallinity of Ni Co-LDH,the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g^(-1)(4.94 C·cm^(-2))at 5 m A·cm^(-2).Furthermore,the fabricated asymmetry supercapacitor(ASC)achieves an extraordinary energy density of 77 Wh·kg^(-1)(0.617 m Wh·cm^(-2))at a power density of 438 W·kg^(-1)(3.5 m W·cm^(-2))and outstanding stability(91%capacity retention after 5000 cycles at20 m A·cm^(-2)).Impressively,the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman ***,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance,and also provides guidance for the rational design of the smart electrodes.

关键词： Supercapacitor NiCo-LDH Carbon nanotubes Sulfur and nitrogen co-doped Convenient synthesis

Differences in Toxicokinetics and Maternal Transfer between Lipophilic and Proteinophilic Halogenated Organic Pollutants in Laying Hens

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Environment & Health 2024年第10期2卷 712-720页

作者： Xiao-Jun Luo Qun-jie Feng Chu-hong Zhu Xi Chen peng-peng Chen Yan-hong Zeng Bi-Xian Mai State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection and Guangdong-hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640P.R.China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophilic HOPs included polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),and dechlorane plus(DPs),while the proteinophilic HOPs included perfluorocarboxylic acids(PFCAs).The results revealed that most of lipophilic HOPs exhibit lower depuration rate(kd)than *** kd of lipophilic HOPs correlated with the octanol−water partition coefficient(log KOW)values in a V-shaped curve,whereas that of PFCAs correlated with the protein−water partition coefficient(log KPW)values in an inverted V-shaped *** depuration rate,rather than the uptake rate,was a leading factor in determining the bioaccumulation potential of HOPs in *** the dominant factors determining the tissue distribution of the two types of compounds were explicit(fats vs phospholipids),chemical-specific tissue distribution was still *** egg-maternal concentration ratio was dependent on the exposure status,concentration,and maternal tissue *** a single maternal tissue may not be an appropriate method for assessing chemical maternal transfer *** have a greater maternal transfer potential(>80%of the total body burden)than lipophilic HOPs(approximately 30%for BDE209 and DPs,and less than 10%for the others).Their lipophilic and partly proteinophilic nature makes the toxicokinetics and maternal transfer characteristics of BDE209 and DPs different from those of other lipophilic *** findings are crucial for enhancing our understanding of the behavior and fate of HOPs in egg-laying hens.

关键词： halogenated organic pollutants laying hens toxicokinetic maternal transfer

The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel

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Petroleum Science 2024年第1期21卷 1-13页

作者： Zi-Zhi Lin Jun-Qian Li Shuang-Fang Lu Qin-hong Hu peng-Fei Zhang Jun-jie Wang Qi Zhi hong-Sheng Huang Na Yin Yue Wang Tian-Chen Ge National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025HainanChina College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

The occurrence characteristics of shale oil are of great significance to the movability of shale *** this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization *** Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,*** which the silicon-rich shale has the best *** relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 *** the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 *** occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space.

关键词： Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

Multiwavelength Observations of the Infrared Dust Bubble N75 and its Surroundings

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Research in Astronomy and Astrophysics 2024年第4期24卷 262-270页

作者： Quan-Ling Cui Chuan-peng Zhang Jun-jie Wang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China College of Science Qiqihar UniversityQiqihar 161006China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China

Infrared dust bubbles play an important role in the study of star formation and the evolution of the interstellar *** this work,we study the infrared dust bubble N75 and the infrared dark cloud G38.93 mainly using the tracers C^(18)O,HCO^(+),HNC and N_(2)H^(+)observed by the 30 m IRAM *** also study the targets using data from large-scale surveys:GLIMPSE,MIPSGAL,GRS,NRAO VLA Sky Survey and Bolocam Galactic Plane *** found that the C^(18)O emission is morphologically similar to the Spitzer IRAC 8.0μm ***1.1 mm cold dust emission of G38.93 shows an elongated structure from southwest to *** ionized gas from G38.93 is surrounded by polycyclic aromatic hydrocarbon emission,which may be excited by radiation from *** found that the identified young stellar objects tend to cluster around G38.93 and are mostly in class II with several class I cases distributed around N75,but no class II *** also found evidence of expanding feedback,which could have triggered star formation.

关键词： ISM:bubbles infrared:ISM galaxies:star formation

Possible Habitats for NH_(3),NH_(2)D,H^(13)CN,HC^(15)N,SO,and C^(18)O in the Initial Conditions of High-mass Star Formation

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Research in Astronomy and Astrophysics 2024年第4期24卷 237-252页

The initial condition of high-mass star formation is a complex area of study because of the high densities(n_(H_(2))>106cm^(-3))and low temperatures(T_(dust)<18 K)*** such conditions,many molecules become depleted from the gas phase by freezing out onto dust ***,the N-bearing and deuterated species could remain gaseous under these extreme conditions,suggesting that they may serve as ideal *** this paper,using the Plateau de Bure Interferometer and Very Large Array observations at 1.3 mm,3.5 mm,and 1.3 cm,we investigate the possible habitats for NH_(3),NH_(2)D,H^(13)CN,HC^(15)N,SO,and C^(18)O in eight massive precluster and protocluster clumps G18.17,G18.21,G23.97N,G23.98,G23.44,G23.97S,G25.38,and *** found that the NH3cores are in good agreement with the 3.5 mm peak emission,but the NH_(3)is much more extended than the 3.5 mm emission *** SO distributions agree well with the 3.5 mm peaks for the evolved star formation stage,but we did not detect any SO emission in the four earliest star formation sources.C^(18)O is a poor tracer in conditions of the cold(■18 K)and dense(■10^(4)cm^(-3))cores,e.g.,the prestellar *** also found that the NH_(2)D cores are mainly located in the temperature range of 13.0-20.0 K,and the NH_(2)D lines may be strongly depleted above 20 K.

关键词： galaxies:star formation techniques:interferometric methods:observational

Identification of TSS in the Human Genome Based on a RBF Neural Network

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International Journal of Automation and computing 2006年第1期3卷 35-40页

作者： Zhi-hong peng jie Chen Li-Jun Cao Ting-Ting Gao College of Information Science and Technology Beijing Institute of Technology Beijing 100081 PRC

The identification of functional motifs in a DNA sequence is fundamentally a statistical pattern recognition problem. This paper introduces a new algorithm for the recognition of functional transcription start sites （TSSs） in human genome sequences, in which a RBF neural network is adopted, and an improved heuristic method for a 5-tuple feature viable construction, is proposed and implemented in two RBFPromoter and ImpRBFPromoter packages developed in Visual C＋＋ 6.0. The algorithm is evaluated on several different test sequence sets. Compared with several other promoter recognition programs, this algorithm is proved to be more flexible, with stronger learning ability and higher accuracy.

关键词： Promoter recognition human genome transcription start site RBF neural network.

Gas film/regenerative composite cooling characteristics of the liquid oxygen/liquid methane (LOX/LCH4) rocket engine

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 631-649页

作者： Xinlin LIU Jun SUN Zhuohang JIANG Qinglian LI peng CHENG jie SONG Science and Technology on Scramjet Laboratory College of Aerospace Science and EngineeringNational University of Defense TechnologyChangsha 410073China

The thermal protection of rocket engines is a crucial aspect of rocket engine *** this paper,the gas film/regenerative composite cooling of the liquid oxygen/liquid methane(LOX/LCH4)rocket engine thrust chamber was investigated.A gas film/regenerative composite cooling model was developed based on the Grisson gas film cooling efficiency formula and the one-dimensional regenerative cooling *** accuracy of the model was validated through experiments conducted on a 6 kg/s level gas film/regenerative composite cooling thrust ***,key parameters related to heat transfer performance were *** results demonstrate that the model is sufficiently accurate to be used as a preliminary design *** temperature rise error of the coolant,when compared with the experimental results,was found to be less than 10%.Although the pressure drop error is relatively large,the calculated results still provide valuable guidance for heat transfer *** addition,the performance of composite cooling is observed to be superior to regenerative *** the gas film flow rate results in higher cooling efficiency and a lower gas-side wall ***,the position at which the gas film is introduced greatly impacts the cooling *** optimal introduction position for the gas film is determined when the film is introduced from a single row of *** optimal introduction position results in a more uniform wall temperature distribution and reduces the peak ***,it is observed that a double row of holes,when compared to a single row of holes,enhances the cooling effect in the superposition area of the gas film and further lowers the gas-side wall *** results provide a basis for the design of gas film/regenerative composite cooling systems.

关键词： Liquid oxygen/liquid methane(LOX/LCH4)rocket engine Gas film cooling Regenerative cooling Heat transfer characteristics