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Ability of luteinizing hormone releasing hormone-Pseudomonas aeruginosa exotoxin 40 binding to LHRH receptor on human liver cancer cells

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World Journal of Gastroenterology 2004年第19期10卷 2870-2873页

作者： Shou-LiangGong GangZhao hong-guangzhao Wen-TianLü Guang-WeiLiu PingZhu RadiobiologyResearchUnitofMinistryofPublicHealth SchoolofPublicHealthJilinUniversityChangchun130021JilinProvinceChina InstituteofMilitaryVeterinaryMedicine QuartermasterUniversityofChinesePLAChangchun130062.JilinPrnvinceChina

AIM: TO explore the ability of recombinant toxin luteinizinghormone releasing hormone-Pseudomonas aeruginosaexotoxin 40 (LHRH-PE40) and LHRH binding to LHRH receptor(LHRHR) on the membrane surface of human liver cancerHEPG ***: LHRH was labeled by using 12sI with enzymaticreaction. The affinity and receptor volume of LHP, H-PE40and LHRH binding to LHRHR on the membrane surface ofhuman liver cancer cells were measured with radioligandreceptor ***: The specific activity of LHRH labeled with 12sIwas 2.7x 104 kBq/l^L, and its radiochemical purity reachedto 99.2-99.7%. The binding of 12sI to LHRH was maximalfor 240 min in the warm cultivation, and this binding wasstabilized. The inhibiting rates of ~2SI-LHRH and LHRH onthe proliferation of human liver cancer HEPG cells werenot significantly different. On the basis of the saturationcurve of ~2SI-LHRH binding to the membrane LHRHR of HEPGcells, ~2SI-LHRH of lx10s cpm was selected for radioligandreceptor assay. The affinity constants (Kd) of LHRH-PE40and LHRH binding to the membrane LHRHR of HEPG cellswere 0.43~0.12 nmol/L and 4.86~ 1.47 nmol/L, respectively,and their receptor volumes were 0.37~0.15 l^mol/g and0.42=I=0.13 l^mol/g, respectively. The binding of LHRH-PE40to the membrane protein of normal liver cells was ***: The recombinant toxin LHRH-PE40 binding tothe membrane surface of LHRHR of human liver cancer HEPGcells was very strong, while the specific binding of it to normalliver cells was not observed. The results provide an importantexperimental basis for the clinical application of LHRH-PE.

关键词：黄体激素激素释放荷尔蒙-假单胞激素铜绿色外毒素40 LHRH 粘合物受体肝细胞癌肿瘤

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Ring-Opening Polymerization of e-Caprolactone with BINOL Phosphoric Acid as the Catalyst

Ring-Opening Polymerization of e-Caprolactone with BINOL Pho...

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2012年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十二届全国高分子液晶态与超分子有序结构学术论文报告会）

作者： Liangzhi hong,Xi Zhou and guangzhao Zhang Faculty of Materials Science and Engineering,South China University of Technology

BINOL phosphoric acid(BPA) is found to be an efficient cationic organocatalyst for the living ring-opening polymerization(ROP) ofε-caprolactone (ε-CL) with 1-octanol as the *** living nature of the ROP ofε-CL catalyzed by BPA has been confirmed by the linearity of kinetic plot and chain extension experiments. The molar mass of the polycaprolactone(PCL) can be well controlled by varying the initial ratio ofε-CL to *** comparison with other acid organocatalyst,BPA can be used to prepare higher molar mass PCL with narrow molar mass distribution;the highest molar mass of PCL is 4.35×10 g/mol with polydispersity index of 1.20. More interestingly,ppm level of BPA is sufficient to catalyze ROP ofε-CL.

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利用铅锌银矿尾矿研制琉璃瓦

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中国陶瓷 2015年第6期51卷 54-58页

作者：邹小玲成岳洪光照华东交通大学土木建筑学院南昌330013 景德镇陶瓷学院材料科学与工程学院景德镇333403 景德镇陶瓷学院科技艺术学院景德镇333001

以铅锌银矿尾矿为主要原料,辅以红泥、高岭土,在1160~1170℃煅烧形成结构致密琉璃瓦。结果表明:采用配方组成为铅锌银矿尾矿36~37%、红泥45~46%高岭土18~19%、制得的琉璃瓦坯体,XRD分析主晶相有石英、钙长石、莫来石等,扫描电镜(SEM)结... 详细信息

以铅锌银矿尾矿为主要原料,辅以红泥、高岭土,在1160~1170℃煅烧形成结构致密琉璃瓦。结果表明:采用配方组成为铅锌银矿尾矿36~37%、红泥45~46%高岭土18~19%、制得的琉璃瓦坯体,XRD分析主晶相有石英、钙长石、莫来石等,扫描电镜(SEM)结果表明琉璃瓦坯体颗粒紧密排列,颗粒之间有少量的空隙。釉面较平整,釉坯中间层紧密。试样的吸水率、弯曲破坏荷重、热稳定性能和抗冻性等指标均能达到《建筑琉璃制品》JC/T765-2006标准要求。这不仅利用了铅锌尾矿,缓解其对环境的污染,又降低了琉璃瓦生产成本,变废为宝。

关键词：铅锌银矿尾矿红泥琉璃瓦

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3200m^3高炉工程旋风除尘器镶砖施工

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天津冶金 2007年第S1期 112-113,186页

作者：王磊洪光照张国银天津二十冶建设有限公司第一分公司 300301

介绍了旋风除尘器的除尘机理和选用的耐火材料的性能。结合实际,对施工前的准备工作,施工过程的作业方法等进行了可行性研究,使施工既方便快捷又能确保施工质量,除尘效果符合环保标准。

关键词：高炉旋风除尘器粗煤气镶砖焊缝

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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纳米粒子在骨组织工程化基因修饰治疗中的应用

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中国组织工程研究 2025年第22期29卷 4771-4783页

作者：李光照裴锡波王剑口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院修复科四川省成都市610041

背景:传统的骨组织工程技术治疗临界骨缺损存在成骨效率低、安全性差等问题。而以非病毒纳米粒子为基因载体构建的基因强化型骨组织工程移植物,具有更高的成骨效率和安全性,引起了国内外学者的广泛关注和研究。目的:对当前国内外有关纳... 详细信息

背景:传统的骨组织工程技术治疗临界骨缺损存在成骨效率低、安全性差等问题。而以非病毒纳米粒子为基因载体构建的基因强化型骨组织工程移植物,具有更高的成骨效率和安全性,引起了国内外学者的广泛关注和研究。目的:对当前国内外有关纳米粒子在组织工程成骨基因治疗研究中取得的新技术、新方法以及面临的挑战等进行综述,旨在为纳米粒子介导的骨组织工程基因治疗研究提供参考。方法:第一作者在Pub Med、Web of Science和中国知网数据库上进行文献检索,并以“Bone defect repair,Bone tissue engineering,Gene delivery,Nanoparticles,Non-viral gene vector,Sustained release technology,Sequential release,Targeted delivery”作为英文检索词,以“骨缺损修复,骨组织工程,基因递送,纳米粒子,非病毒基因载体,缓释技术,序贯释放,靶向递送”作为中文检索词,最终纳入84篇文献进行总结。结果与结论:(1)在骨缺损愈合的各个生理阶段进行针对性的基因递送可以显著增强骨修复效果。在早期炎症阶段,通过纳米粒子递送抗炎基因来调节炎症反应,可以为后续骨愈合奠定基础;在血管新生期,向局部递送促血管化基因有助于形成高度组织化、可灌注的血管系统,加快骨愈合速度;随着血管化的进行,骨骼的神经再支配也开始发生,此时递送促神经再生的功能性基因有利于促进神经化骨再生;在成骨阶段,通过构建纳米粒子-成骨基因复合物,可以直接提升支架及体内新骨形成的效率。(2)各种有机、无机纳米颗粒、金属有机框架和外泌体等非病毒纳米载体,在骨组织工程基因治疗中具有巨大的潜力,这些纳米基因载体各有其独特的优势和不足,因此在实际应用时,需要根据基因转染效率、生物安全性和成骨特性等因素选择最合适的类型。(3)为了全面提升递送基因的效果,目前主要通过对纳米载体进行各种功能设计来增强基因转染效率,包括增强缓释性和多基因递送序贯性等时间调控能力、增强对骨组织和成骨相关细胞的空间靶向能力、增强跨膜运输效率和细胞核靶向能力等全过程调控手段。(4)未来要进一步推动纳米粒子介导的骨组织工程基因治疗在临床上的应用,还需要克服诸多技术挑战,包括提高有机纳米基因载体的基因转染效率、降低无机纳米载体的生物安全性风险、优化新型纳米载体的生产工艺以及促进其它生理过程与成骨交互作用等,这些问题也是未来骨组织工程基因治疗的研究热点和潮流。

关键词：骨缺损修复骨组织工程基因递送纳米粒子非病毒基因载体缓释技术序贯释放靶向性递送

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei Li Jian-hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo Nie hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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Thermal transport properties of monolayer phosphorene： a mini-review of theoretical studies

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Frontiers in Energy 2018年第1期12卷 87-96页

作者： guangzhao QIN Ming HU Institute of Mineral Engineering Division of Materials Science andEngineering Faculty of Georesources and Materials EngineeringRWTH Aachen University Aachen 52064 Germany Institute of Mineral Engineering Division of Materials Science andEngineering Faculty of Georesources and Materials EngineeringRWTH Aachen University Aachen 52064 Germany Aachen Institutefor Advanced Study in Computational Engineering Science (AICES) RWTH Aachen University Aachen 52062 Germany

Phosphorene, a two-dimensional （2D） elemen- tal semiconductor with a high carrier mobility and intrinsic direct band gap, possesses fascinating chemical and physical properties distinctively different from other 2D materials. Its rapidly growing applications in nano-/opto- electronics and thermoelectrics call for fundamental understanding of the thermal transport properties. Con- sidering the fact that there have been so many studies on the thermal transport in phosphorene, it is on emerging demand to have a review on the progress of previous studies and give an outlook on future work. In this mini- review, the unique thermal transport properties of phos- phorene induced by the hinge-like structure are examined. There exists a huge deviation in the reported thermal conductivity of phosphorene in literature. Besides, the mechanism underlying the deviation is discussed by reviewing the effect of different functionals and cutoff distance in calculating the thermal transport properties of phosphorene. It is found that the van der Waals （vdW） interactions play a key role in the formation of resonant bonding, which leads to long-ranged interactions. Taking into account of the vdW interactions and including the long-ranged interactions caused by the resonant bonding with large cutoff distance are important for getting the accurate and converged thermal conductivity of phosphor- ene. Moreover, a fundamental insight into the thermal transport is provided based on the review of resonant bonding in phosphorene. This mini-review summarizes theprogress of the thermal transport in phosphorene and gives an outlook on future horizons, which would benefit the design of phosphorene based nano-electronics.

关键词： thermal transport phosphorene resonantbonding

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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