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Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-hong Sun Hai-Yan wang Xuan-guang Ye Jing-Xian Hu Ya-Jie wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

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How interfacial electron-donating defects influence the structure and charge of gold nanoparticles on TiO_(2)support

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Nano Research 2024年第7期17卷 5965-5974页

作者： guang-Jie Xia Yu Fu Wei Cao Jun Li Yang-Gang wang Department of Chemistry and guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055China School of Physical Sciences Great Bay UniversityDongguan 523000China Department of Chemistry Tsinghua UniversityBeijing 100084China

The reduction degree of TiO_(2)support is critical to the performances of metal *** many previous theoretical calculations,only the bridge oxygen vacancy(Ov)was considered as the electron-donating defect on reduced rutile TiO_(2)(r-TiO_(2−x))***,titanium adatoms(Tiad.),oxidized titanium islands(***),and acid hydroxyls(ObrH)also exist at the metal/support *** conducting density functional theory(DFT)calculations and ab initio molecular dynamics(AIMD)simulations,we compared r-TiO_(2−x)surfaces with Ov,Tiad.,***,and ObrH sites loaded with Au nanoparticles(NPs).The results showed the Au NPs were oxygen-phobic but titanium-philic,resulting in wetting of Ov and *** short contact with *** and *** Bader charges of Au NPs(QM)showed a good linear relationship with the ideal number of donating electrons(Ne)from the defective sites(QM=−KeNe+QM,S),demonstrating the intrinsic electron allocation at the *** Ov,Tiad.,and *** exhibited similar slopes(Ke),relatively steeper than that of *** means in the scope of Au NP charge state,the *** *** have a close electron-donating ability with Ov,but the ObrH donates relatively fewer *** linear relationship can be extended approximately to other *** higher the metal work function,the steeper the Ke for easier electron donation from defective *** stronger the metal oxygen affinity,the more positive the intercept(QM,S).That explains the easy generation of metallic or negative Pt and Au NPs on r-TiO_(2−x),but hard for Cu and Zn in *** provides theoretical guidance for regulating the charge of metal NPs over TiO_(2−x)supports.

关键词： metal-support interaction titanium oxide oxygen vacancy surface hydroxyl titanium adatom

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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO Mi YU Wan-li wang Pi-guang QU Yang DU Xiu-li Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Analytical Solution and Simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action

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China Ocean Engineering 2024年第1期38卷 54-67页

作者： wang Pi-guang LYU Si-yu QU Yang ZHAO Mi DU Xiu-li State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of Tech-nologyBeijing 100124China

This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water *** governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible *** governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary *** analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite *** main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion *** added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering *** calculation results show that the simplified formulas are in good agreement with the analytical solutions.

关键词： earthquake hydrodynamic pressure truncated cylinder added mass simplified formula

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Beam based alignment using a neural network

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Nuclear Science and Techniques 2024年第4期35卷 108-118页

作者： Guan-Liang wang Ke-Min Chen Si-Wei wang Zhe wang Tao He Masahito Hosaka guang-Yao Feng Wei Xu National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Diamond Light Source Oxfordshire OX110DEUK

Beams typically do not travel through the magnet centers because of errors in storage *** beam deviating from the quadrupole centers is affected by additional dipole fields due to magnetic field ***-based alignment(BBA)is often performed to determine a golden orbit where the beam circulates around the quadrupole center *** storage rings with many quadrupoles,the conventional BBA procedure is time-consuming,particularly in the commissioning phase,because of the necessary iterative *** addition,the conventional BBA method can be affected by strong coupling and the nonlinearity of the storage ring *** this study,a novel method based on a neural network was proposed to determine the golden orbit in a much shorter time with reasonable *** golden orbit can be used directly for operation or adopted as a starting point for conventional *** method was demonstrated in the HLS-II storage ring for the first time through simulations and online *** results of the experiments showed that the golden orbit obtained using this new method was consistent with that obtained using the conventional *** development of this new method and the corresponding experiments are reported in this paper.

关键词： Golden orbit Beam-based alignment Neural network Storage ring

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瞬态微弱信号输出稳定性分析

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核电子学与探测技术 2016年第12期36卷 1215-1218页

作者：渠红光王晶韩光王玲西北核技术研究所强脉冲辐射环境模拟与效应国家重点实验室西安710024

本文分析了在辐射探测瞬态微弱信号获取中,系统输出不稳定的原因,并通过改变放大电路中的反馈网络结构,利用频域特性,采用最佳相位补偿的方法实现微弱信号稳定放大输出。最后利用CZT探测器在低能γ射线的辐射探测系统中验证测试,实验表... 详细信息

本文分析了在辐射探测瞬态微弱信号获取中,系统输出不稳定的原因,并通过改变放大电路中的反馈网络结构,利用频域特性,采用最佳相位补偿的方法实现微弱信号稳定放大输出。最后利用CZT探测器在低能γ射线的辐射探测系统中验证测试,实验表明,辐射脉冲信号调理系统通过增加稳定性措施后,可有效提高CZT探测器对^(241)Am源的能量分辨率。

关键词：微弱信号放大器相位补偿 CZT

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Geophysical prediction of organic matter abundance in source rocks based on geochemical analysis:A case study of southwestern Bozhong Sag,Bohai Sea,China

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Petroleum Science 2024年第1期21卷 31-53页

作者： Xiang wang guang-Di Liu Xiao-Lin wang Jin-Feng Ma Zhen-Liang wang Fei-Long wang Ze-Zhang Song Chang-Yu Fan State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an710069ShaanxiChina Department of Geology Northwest UniversityXi'an710069ShaanxiChina CNOOC Tianjin Branch Company Tianjin300459China

The Bozhong Sag is the largest petroliferous sag in the Bohai Bay Basin,and the source rocks of Paleogene Dongying and Shahejie Formations were buried *** of the drillings were located at the structural high,and there were few wells that met good quality source rocks,so it is difficult to evaluate the source rocks in the study area precisely by geochemical analysis *** on the Rock-Eval pyrolysis,total organic carbon(TOC)testing,the organic matter(OM)abundance of Paleogene source rocks in the southwestern Bozhong Sag were evaluated,including the lower of second member of Dongying Formation(E_(3)d2L),the third member of Dongying Formation(E_(3)d_(3)),the first and second members of Shahejie Formation(E_(2)s_(1+2)),the third member of Shahejie Formation(E_(2)s_(3)).The results indicate that the E_(2)s_(1+2)and E_(2)s_(3)have better hydrocarbon generative potentials with the highest OM abundance,the E_(3)d_(3)are of the second good quality,and the E_(3)d2L have poor to fair hydrocarbon generative ***,the well logs were applied to predict TOC and residual hydrocarbon generation potential(S_(2))based on the sedimentary facies classification,usingΔlogR,generalizedΔlogR,logging multiple linear regression and BP neural network *** various methods were compared,and the BP neural network method have relatively better prediction *** on the pre-stack simultaneous inversion(P-wave impedance,P-wave velocity and density inversion results)and the post-stack seismic attributes,the three-dimensional(3D)seismic prediction of TOC and S_(2)was carried *** results show that the seismic near well prediction results of TOC and S_(2)based on seismic multi-attributes analysis correspond well with the results of well logging methods,and the plane prediction results are identical with the sedimentary facies map in the study *** TOC and S_(2)values of E_(2)s_(1+2)and E_(2)s_(3)are higher than those in E_(3)d_(3)and E_(3)d_(2)L,basicall

关键词： Total organic carbon(TOC) Residual hydrocarbon generation potential(S_(2)) Geophysical prediction Seismic attribute Bozhong Sag Bohai Bay Basin

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Research on shell-side heat and mass transfer with multi-component in LNG spiral-wound heat exchanger under sloshing conditions

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Petroleum Science 2024年第2期21卷 1333-1345页

作者： Xue-Ping Du guang-Lei Yu Ya-Cheng Xu Zhi-Jie Chen Nai-Liang Li Huan-guang wang School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina Key Laboratory of Thermo-Fluid Science and Engineering MOEXi'an Jiaotong UniversityXi'an710049ShaanxiChina Xi'an Aerospace Propulsion Test Technology Institute Xi'an710100ShaanxiChina

The spiral-wound heat exchanger(SWHE) is the primary low-temperature heat exchanger for large-scale LNG plants due to its high-pressure resistance, compact structure, and high heat exchange efficiency. This paper studied the shell-side heat and mass transfer characteristics of vapor-liquid two-phase mixed refrigerants in an SWHE by combining a multi-component model in FLUENT software with a customized multicomponent mass transfer model. Besides, the mathematical model under the sloshing condition was obtained through mathematical derivation, and the corresponding UDF code was loaded into FLUENT as the momentum source term. The results under the sloshing conditions were compared with the relevant parameters under the steady-state condition. The shell-side heat and mass transfer characteristics of the SWHE were investigated by adjusting the component ratio and other working conditions. It was found that the sloshing conditions enhance the heat transfer performance and sometimes have insignificant effects. The sloshing condition is beneficial to reduce the flow resistance. The comprehensive performance of multi-component refrigerants has been improved and the improvement is more significant under sloshing conditions, considering both the heat transfer and pressure *** results will provide theoretical support for the research and design of multi-component heat and mass transfer enhancement of LNG SWHE under ocean sloshing conditions.

关键词： Spiral-wound heat exchanger Sloshing conditions Two-phase flow Multi-component Heat and mass transfer

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Ti_(3)C_(2)T_(x)/SnO_(2)P–N heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： Yue Zhang Ming-Yue wang Xiao-guang San Yan-Bai Shen Guo-Sheng wang Lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily ***,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical ***,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important *** this study,Ti_(3)C_(2)Tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good longterm *** functional theory(DFT)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with ***,Ti_(3)C_(2)T_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room ***,the formation of p-n heterostructures between SnO_(2)and Ti_(3)C_(2)T_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde *** perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： Ti_(3)C_(2)T_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFT calculations

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Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel

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China Foundry 2024年第3期21卷 205-212页

作者： Guan-yu Jiang Meng-wu Wu Xiao-guang Yang Hui wang Yu-yuan Zhu Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina Wescast Industries(China)Co. Ltd.Wuhan 430100China

Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents(2wt.%,6wt.%,and 12wt.%).Thermodynamic calculation,microstructure characterization and mechanical property tests were conducted to investigate the effect of Mn addition on the microstructure and mechanical properties of the austenitic heat resistant *** show that the matrix structure in all the three types of steels at room temperature is completely *** NbC and M_(23)C_(6)precipitate at grain boundaries of austenite *** the increase of Mn content,the number of carbides increases and their distribution becomes more *** the Mn content increases from 1.99%to 12.06%,the ultimate tensile strength,yield strength and elongation increase by 14.6%,8.0%and 46.3%,*** improvement of the mechanical properties of austenitic steels can be explained by utilizing classic theories of alloy strengthening,including solid solution strengthening,precipitation strengthening,and grain *** increase in alloy strength can be attributed to solid solution strengthening and precipitation strengthening caused by the addition of *** improvement of the plasticity of austenitic steels can be explained from two aspects:grain refinement and homogenization of precipitated phases.

关键词： austenitic heat resistant steel manganese microstructure mechanical properties

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