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Vascular endothelial growth factor A promotes platelet adhesion to collagen Ⅳ and causes early brain injury after subarachnoid hemorrhage

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Neural Regeneration Research 2019年第10期14卷 1726-1733页

作者： Zun-Wei Liu Jun-Jie Zhao hong-gang pang Jin-Ning Song Department of Renal Transplantation Nephropathy Hospitalthe First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Institute of Organ Transplantation Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Neurosurgery the First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina The First Affiliated Hospital Medical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains *** this study,the endovascular puncture method was used to produce a rat model of subarachnoid ***,30 minutes later,vascular endothelial growth factor A antagonist anti-vascular endothelial growth factor receptor 2 antibody,10μg,was injected into the right *** and western blot assay were used to assess expression of vascular endothelial growth factor A,occludin and *** double labeling was conducted to examine co-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ *** was used to detect apoptosis in the *** score was used to assess behavioral *** subarachnoid hemorrhage,the expression of vascular endothelial growth factor A increased in the hippocampus,while occludin and claudin-5 expression levels ***-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ collagen and the number of apoptotic cells increased,whereas behavioral performance was markedly *** treatment with anti-vascular endothelial growth factor receptor 2 antibody,occludin and claudin-5 expression recovered,while co-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ collagen and the number of apoptotic cells ***,behavioral performance improved *** findings suggest that increased vascular endothelial growth factor A levels promote platelet adhesion and contribute to early brain injury after subarachnoid *** study was approved by the Biomedical Ethics Committee,Medical College of Xi’an Jiaotong University,China in December 2015.

关键词： nerve regeneration vascular endothelial growth factor A vascular endothelial growth factor receptor 2 subarachnoid hemorrhage brain injuries platelet adhesion collagen blood-brain barrier neural regeneration

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Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression

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Neural Regeneration Research 2016年第6期11卷 944-950页

作者： Yong-lin Zhao Jin-ning Song Xu-dong Ma Bin-fei Zhang Dan-dong Li hong-gang pang Department of Neurosurgery the First Affiliated Hospital of Xi'an Jiaotong University

Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau（phosphorylated at Ser^（404）（p-tau（S^（404）））, and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau（S^（404）） levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury.

关键词： axonal diffuse regulating amyloid cortex saline ameliorate minutes possibly inhibit

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Progress in the generation of spinal cord organoids over the past decade and future perspectives

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Neural Regeneration Research 2024年第5期19卷 1013-1019页

作者： gang Zhou Siyuan pang Yongning Li Jun Gao Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of International Medical Service Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in *** emerging bioengineering methods have led to the optimization of cell culture protocols,spinal cord organoids technology has made remarkable advancements in the past *** literature search found that current spinal cord organoids do not only dynamically simulate neural tube formation but also exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal ***,fused organoids that integrate motor neurons and other regionally specific organoids exhibit intricate neural circuits that allows for functional *** qualities make spinal cord organoids valuable tools for disease modeling,drug screening,and tissue *** utilizing this emergent technology,researchers have made significant progress in investigating the pathogenesis and potential therapeutic targets of spinal cord ***,at present,spinal cord organoid technology remains in its infancy and has not been widely applied in translational *** of the next generation of spinal cord organoids will depend on good manufacturing practice standards and needs to focus on diverse cell phenotypes and electrophysiological functionality evaluation.

关键词： development organoid-on-a-chip pluripotent stem cells progress spinal cord diseases spinal cord organoids vascularization

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Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern China

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Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： Jun-Qing Chen Fu-Jie Jiang Xiong-Qi pang Hai-Jun Yang Kan-Yuan Shi Bo pang hong pang Jian-Fa Chen Zhuo-Heng Chen Xin-gang Zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina Geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2+3)carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2+3 source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1%,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C28 steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a favorable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

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Method for determining the position of landslide slip-surface with a typical inclinometric curves

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Journal of Mountain Science 2024年第2期21卷 413-432页

作者： CHEN Hao WU hong-gang Ocean College Zhejiang UniversityZhoushan 316000China China Northwest Research Institute Co.Ltd.of CREC Lanzhou 730070China

In the actual monitoring of deep hole displacement,the identification of slip surfaces is primarily based on abrupt changes observed in the inclinometric *** conventional identification methods,inclinometric curves exhibiting indications of sliding can be categorized into three types:B-type,D-type,and *** position of the slip surface is typically determined by identifying the depth corresponding to the point of maximum displacement ***,this method is sensitive to the interval of measurement points and the observation scale of the coordinate axes and suffers from unclear sliding surfaces and uncertain *** on the variation characteristics of these diagonal curves,we classified the landslide into three components:the sliding body,the sliding interval,and the immobile ***,three different generalization models were established to analyze the relationships between the curve form and the slip surface location based on different physical indicators such as displacement rate,relative displacement,and *** results show that the displacement rate curves of an r-type slope exhibit a clustering feature in the sliding interval,and by solving for the depth of discrete points within the step phase,it is possible to determine the location of the slip *** the other hand,D-type slopes have inflection points in the relative displacement curve located at the slip *** acceleration curves of B-type slopes exhibit clustering characteristics during the sliding interval,while the scattered acceleration data demonstrate wandering ***,the slip surface location can be revealed by solving the depth corresponding to the maximum acceleration with cubic spline *** approach proposed in this paper was applied to the monitoring data of a landslide in Yunnan Province,*** results indicate that our approach can accurately identify the slip surface location and enable computability of its po

关键词： Inclinometric curve Slip-surface position Displacement rate Relative displacement Acceleration

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Improved Reall-Santos method for AdS black holes in general 4-derivative gravities

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 74-86页

作者： Peng-Ju Hu Liang Ma hong Lü Yi pang Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Peng Huanwu Center for Fundamental Theory Hefei 230026China

For asymptotically flat black holes,Reall-Santos method is a convenient tool to compute leading higher derivative corrections to the thermodynamic quantities without actually solving the modified field ***,there are subtleties in its generalization to asymptotically AdS black holes with general higher derivative *** of all,it is necessary to know all the higher derivative holographic counterterms and the surface terms implementing the variational principle and subtracting the *** then needs to solve for the modified AdS radius and rescale the time coordinate in an appropriate way such that the induced metric on the conformal boundary of AdS black hole is not *** observe that Reall-Santos method can be directly applied to a particular 4-derivative gravity model,known as the Einstein-Weyl gravity,which does not modify the AdS radius and requires only the Gibbons-Hawking-York term and holographic counterterms for the 2-derivative *** thus suggest that to compute the thermodynamic quantities of AdS black holes in general 4-derivative theories of gravity,one simply needs to transform it to a Einstein-Weyl gravity with identical thermodynamic variables by appropriate field *** explicitly verify this proposal with spherically-symmetric and static charged black holes in Einstein-Maxwell theory extended with generic 4-derivative interactions.

关键词： black holes thermodynamics higher-derivative corrections effective theories higher dimensional black holes quantum gravity

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Electrochemical reconstruction: a new perspective on Sn metal-organic complex microbelts as robust anode for lithium storage

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Rare Metals 2024年第1期43卷 76-86页

作者： Jin-Ke Shen Nai-Teng Wu Li-Yuan Wang gang Jiang Dong-Lei Guo Jin Li Gui-Long Liu hong-Yu Mi Huan pang Xian-Ming Liu Key Laboratory of Function-oriented Porous Materials of Henan Province College of Chemistry and Chemical EngineeringLuoyang Normal UniversityLuoyang 471934China State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources School of Chemical Engineering and TechnologyXinjiang UniversityUrumqi 830046China School of Chemistry and Chemical Engineering Institute for Innovative Materials and EnergyYangzhou UniversityYangzhou 225009JiangsuChina

Tin-based materials with high theoretical capacity and suitable working voltage are ideal anode materials for lithium-ion batteries(LIBs). However, to overcome their shortcomings(volume expansion and inferior stability), the preparation processes are usually complicated and expensive. Herein, a tin-based metal-organic complex(tin 1,2-benzenedicarboxylic acid, Sn-BDC)with one-dimensional microbelt morphology is synthesized by a facile, rapid and low-cost co-precipitation method, and served as anode material for LIBs without any post-treatment. Sn-BDC exhibits a high reversible capacity with609/440 m Ah·g^(-1) at 50/2000 m A·g^(-1), and robust cycling stability of 856 m Ah·g^(-1) after 200 cycles at 200 m A·g^(-1),which are obviously superior to that of the Sn Ox/C counterparts. Moreover, an electrochemical reconstruction perspective on the lithium storage mechanism of Sn-BDC is proposed by systematic ex-situ characterizations. The reconstructed SnO_(2) replaces Sn-BDC and becomes the active material in the subsequent cycles. As the by-product of the lithiation reaction, the formed Li-based metal-organic complex(Li-BDC, wrapped around the reconstructed SnO_(2)) plays an important role in alleviating volume expansion and accelerating the charge transfer *** work is beneficial to design and construct the new electrode materials based on the electrochemical reconstruction for advanced LIBs.

关键词： Electrochemical reconstruction Metal-organic complex Anode Lithium storage mechanism Lithium-ion batteries

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Mathematical Analysis on a General Delayed HBV Model with Capsids and Two Infection Routes

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 508-525页

作者： Li-li LIU hong-gang WANG Ya-zhi LI Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention Complex Systems Research CenterShanxi UniversityTaiyuan 030006China School of Mathematics and Statistics Qiannan Normal University for NationalitiesDuyun 558000China

Considering that HBV belongs to the DNA virus family and is hepatotropic,we model the HBV DNA-containing capsids as a *** this paper,a delayed HBV infection model is established,where the general incidence function and two infection routes including cell-virus infection and cell-cell infection are *** to some preliminaries,including well-posedness,basic reproduction number and existence of two equilibria,we obtain the threshold dynamics for the *** illustrate numerical simulations to verify the above theoretical results,and furthermore explore the impacts of intracellular delay and cell-cell infection on the global dynamics of the model.

关键词： delayed HBV model capsids general incidence function two infection routes global stability

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A Non-Parametric Scheme for Identifying Data Characteristic Based on Curve Similarity Matching

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1424-1437页

作者： Quanbo Ge Yang Cheng hong Li Ziyi Ye Yi Zhu gang Yao School of Automation Nanjing University of Information Science&TechnologyJiangsu Provincial University Key Laboratory of Big Data Analysis and Intelligent SystemsNanjing University of Information Science&Technologyand the Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET)Nanjing University of Information Science&TechnologyNanjing 210044China School of Department of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China China Classification Society Nantong Office Nantong 226006China Chinese Flight Test Establishment Xi’an 710089China School of Mathematics Tsinghua UniversityBeijing 100084China School of Automation Nanjing University of Information Science&TechnologyNanjing 210044China Department of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China IEEE

For accurately identifying the distribution charac-teristic of Gaussian-like noises in unmanned aerial vehicle(UAV)state estimation,this paper proposes a non-parametric scheme based on curve similarity *** the framework of the pro-posed scheme,a Parzen window(kernel density estimation,KDE)method on sliding window technology is applied for roughly esti-mating the sample probability density,a precise data probability density function(PDF)model is constructed with the least square method on K-fold cross validation,and the testing result based on evaluation method is obtained based on some data characteristic analyses of curve shape,abruptness and *** com-parison simulations with classical methods and UAV flight exper-iment shows that the proposed scheme has higher recognition accuracy than classical methods for some kinds of Gaussian-like data,which provides better reference for the design of Kalman filter(KF)in complex water environment.

关键词： Curve similarity matching Gaussian-like noise non-parametric scheme parzen window.

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Investigation of Material Properties Based on 3D Graphite Morphology for Compacted Graphite Iron

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1077-1086页

作者： Chenglu Zou Yan Zhao gang Zhu Jianchao pang Shaogang Wang Yangzhen Liu Feng Liu Shouxin Li Zhefeng Zhang Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Mechanical Engineering Liaoning Petrochemical UniversityFushun113001China Institute of Advance Wear and Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Jihua Laboratory Foshan528200China Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai200237China

The strength and thermal conductivity of compacted graphite iron(CGI)are crucial performance indicators in its engineering *** presence of graphite in CGI significantly influences the two *** the previous studies,graphite in CGI was often described using two-dimensional(2D)*** this study,the three-dimensional(3D)size,shape,and distribution of graphite in CGI were analyzed using X-ray *** on this,a new method is introduced to calculate the 3D vermicularity and compare it with the 2D vermicularity in terms of tensile properties and thermal *** results demonstrate that vermicular graphite exhibits greater connectivity in 3D observation compared to 2D ***,the calculation method of 3D vermicularity is determined by considering the surface area and volume of the connected *** a linear relationship between 3 and 2D vermicularity has been *** comparing the correlation coefficient,it has been found that the 3D vermicularity offers a more accurate method to establish the relationship among graphite morphology,thermal conductivity and tensile property of CGI.

关键词： Compacted graphite iron 3D graphite morphology X-ray tomography Thermal conductivity Tensile property

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