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Increased southerly and easterly water vapor transport contributed to the dry-to-wet transition of summer precipitation over the Three-River Headwaters in the Tibetan Plateau

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Advances in Climate Change Research 2023年第4期14卷 502-510页

作者： Xuan liU Ming-Xiang YANG Ning-Peng DONG Wei-Ning XIE hong-gang li Zhen GUAN Fan WEN Hao WANG Deliang CHEN College of Civil Engineering Tianjin UniversityTianjin 300354China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing 100038China Cooperative Innovation Center for Water Safety&Hydro Science Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Hydrology and Water Resources Survey Bureau of Hainan Province Hainan 571126China Huaneng Lancang River Hydropower INC. Kunming 650214China Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg S-40530Sweden

The Three-River Headwaters(TRH)region in the Tibetan Plateau is vulnerable to climate change;changes in summer(June–August)precipitation have a significant impact on water security and sustainability in both local and downstream ***,the changes in summer precipitation of different intensities over the TRH region,along with their influencing factors,remain *** this study,we used observational and ERA5 reanalysis data and employed a precipitation categorization and water vapor budget analysis to quantify the categorized precipitation variations and investigate their possible linkages with the water vapor *** results showed an increasing trend in summer precipitation at a rate of 0.9 per year(p<0.1)during 1979–2020,with a significant dry-to-wet transition in *** category‘very heavy precipitation’(10 mm d−1)contributed 65.1%of the increased summer precipitation,which occurred frequently in the northern TRH *** dry-to-wet transition was caused by the effects of varied atmospheric circulations in each *** water vapor transport through the southern boundary was responsible for the increased net water vapor flux in the western TRH region(158.2%),while southeasterly water vapor transport through the eastern boundary was responsible for the increased net water vapor flux in the central TRH(155.2%)and eastern TRH(229.2%)***,we inferred that the dry-to-wet transition of summer precipitation and the increased‘very heavy precipitation’over the TRH was caused by increased easterly and southerly water vapor transport.

关键词： Summer precipitation Three-river headwaters region Precipitation intensity Water vapor budget

Jrokinase-type plasminogen activator： a new target for male contraception？

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Asian Journal of Andrology 2015年第2期17卷 269-273,I0009页

作者： Ying Qin Yan Han Cheng-liang Xiong hong-gang li lian Hu ling Zhang Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Urokinase-type plasminogen activator （uPA） is closely related to male reproduction. With the aim of investigating the possibility for uPA as a potential contraceptive target, in the present work, Kunming male mice were immunized by human uPA subcutaneous injection at three separate doses for 3 times. Then the potency of the anti-human uPA antibody in serum was analyzed, and mouse fertility was evaluated. Serum antibody titers for human uPA in immunized groups all reached 1：10,240 or higher levels by enzyme linked immunosorbent assay, and mating experiments revealed that pregnancy rates and the mean number of embryos implanted after mating declined obviously （P 〈 0.05） when compared with control groups. However, the mating capacity and reproductive organ weights had no obvious change, and histological analysis of the testes and epididymides also showed normal morphology for immunized male mice. Sperm function tests suggested that the sperm concentration, sperm viability, sperm motility, and in vitro fertilization rate for the cauda epididymis sperm in uPA-immunized groups were lower than those in the controls （P 〈 0.05）. Together, these observations indicated that subcutaneous injection human uPA to the male mice could effectively reduce their fertility, and uPA could become a new target for immunocontraception in male contraceptive development.

关键词： contraception male mouse urokinase-type plasminogen activator

Development of 600MPa Cold Rolled Dual Phase Steel for Automotive Application in BX Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 987-989页

作者： GAO hong-gang,CHEN li-hong,liU Ming-hui,YU Wen-tao,WANG Ya-fen (Technology Center of Benxi Iron and Steel (Group) Co,Ltd.Benxi 117000,liaoning,China) Benxi Iron & Steel Grp Co Ltd Ctr Technol Benxi 117000 Liaoning Peoples R China

BX STEEL has developed 600MPa cold rolled dual phase in order to adapt to the market *** paper introduces the design of chemical composition,hot rolling,cold rolling and annealing process of experimental *** finished product property meets the technical standard,the microstructure is typical dual phase,F+M(14-16%).This product has been produced commercially in BX STEEL,and has been approved by end users.

关键词： automotive application dual phase microstructure

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基于双向长短时记忆模型的中文分词方法

华南理工大学学报（自然科学版） 2017年第3期45卷 61-67页

作者：张洪刚李焕北京邮电大学信息与通信工程学院北京100876

中文分词是中文自然语言处理中的关键基础技术之一.目前,传统分词算法依赖于特征工程,而验证特征的有效性需要大量的工作.基于神经网络的深度学习算法的兴起使得模型自动学习特征成为可能.文中基于深度学习中的双向长短时记忆(BLSTM)神... 详细信息

中文分词是中文自然语言处理中的关键基础技术之一.目前,传统分词算法依赖于特征工程,而验证特征的有效性需要大量的工作.基于神经网络的深度学习算法的兴起使得模型自动学习特征成为可能.文中基于深度学习中的双向长短时记忆(BLSTM)神经网络模型对中文分词进行了研究.首先从大规模语料中学习中文字的语义向量,再将字向量应用于BLSTM模型实现分词,并在简体中文数据集(PKU、MSRA、CTB)和繁体中文数据集(HKCity U)等数据集上进行了实验.实验表明,在不依赖特征工程的情况下,基于BLSTM的中文分词方法仍可取得很好的效果.

关键词：深度学习神经网络双向长短时记忆中文分词

Quick recovery and characterization of cell-free DNA in seminal plasma of normozoospermia and azoospermia： implications for non-invasive genetic utilities

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Asian Journal of Andrology 2009年第6期11卷 703-709页

作者： hong-gang li Shi-Yun Huang Hui Zhou Ai-Hua liao Cheng-liang Xiong Family Planning Research Institute and Centre for Reproductive Medicine Tongji Medical College Huazhong Universityof Science and Technology Wuhan 430030 China

We established a quick and reliable method for recovering cell-free seminal DNA （cfsDNA）, by using the binding-washing-elution procedure on the DNA purification column. Low variations （below 15%） among the triplicate values of cfsDNA quantity verified the reproducibility of our cfsDNA recovery method. Similar cfsDNA yield and size distribution between seminal plasma acquired by filtration and centrifugation confirmed the presence of cfsDNA. To investigate the general characterization of cfsDNA, the quantitation and size distribution of cfsDNA from normozoospermic and azoospermic semen were analyzed by real-time PCR and electrophoresis, respectively. CfsDNA concentration in semen with normozoospermia （n = 11） was 1.34 ± 0.65 μg ·mL^-1, whereas a higher cfsDNA concentration was observed in azoospermia （2.56 ± 1.43 μg ·mL^-1, n = 9）. The continuous distribution of DNA fragments ranging from -1 kb to 15 kb and a spectrum of multiples of 180-bp fragments were observed in each normozoospermic and azoospermic sample. Distinct characteristic DNA ladder fragmentations in some azoospermic samples implicated that cfsDNA originate partly from apoptotic cells. CfsDNAs of 36 selected azoospermic patients with known information of Y chromosome microdeletion were subjected to the same microdeletion analysis by multiplex PCR and PCR amplification of sY114 （1 450 bp）. All multiplex PCR reactions with cfsDNA amplified successfully and provided the same result as leukocyte DNA. PCR amplification of sY114 gave a 1 450-bp amplicon as expected. Our data suggested the potential use of cfsDNA in search of biomarker or diagnostic procedures.

关键词： azoospermia cell-free DNA normozoospermia seminal plasma Y chromosome microdeletion

Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages

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Asian Journal of Andrology 2007年第5期9卷 679-683页

作者： Dong-Hui Huang Hu Zhao Yong-hong Tian hong-gang li Xiao-Fang Ding Cheng-liang Xiong Family Planning Research Institute Tongji Medical College Huazhong University of Science ＆ Technology Wuhan 43003 China Department of Human Anatomy Tongji Medical College Huazhong University of Science ＆ Technology Wuhan 43003 China

Aim： To investigate the gene expression changes of urokinase plasminogen activator （uPA）/urokinase receptor （uPAR） in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis. Methods： The mRNAs of uPA and uPAR in rat testes were measured by using real-time quantitative polymerase chain reaction （PCR） at postnatal days 0, 5, 10, 15, 21, 28, 35, 42, 49 and 56, respectively. Results： The tendencies of uPA and uPAR mRNA expression were similar at most postnatal stages except for Do. The expression of uPAR mRNA in rats testes was relatively higher than that of uPA at postnatal Do, and both were decreased until D21, increased obviously at postnatal D28, reached a peak at postnatal D35, then declined sharply at postnatal D42 and retained at a low level afterwards. Conclusion： The uPA/uPAR system may be strongly linked to spermiation and spermatogenesis via regulating germ cell migration and proliferation, as well as promoting the spermiation and detached residual bodies from the mature spermatids.

关键词： rats spermatogenesis urokinase plasminogen activator urokinase receptor quantitative polymerase chain reaction

The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa

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Asian Journal of Andrology 2006年第3期8卷 301-306,386页

作者： hong-gang li Ai-Hua liao Xiao-Fang Ding Hui Zhou Cheng-liang Xiong Centre of Reproductive Medicine.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Aim:To investigate the distribution of cation channel of sperm 1(CATSPER1)protein and the presence of CATSPER1 mRNA in human testis and ejaculated *** influence of anti-human CATSPER1 antibody upon human sperm motility was used to evaluate the function of human CATSPER1 and to estimate its possible use as a target for ***:Human ejaculated sperm from normozoospermic donors(n=12)and liquid nitro- gen frozen human testis were used for the study of mRNA and protein expression of CATSPER1 by reverse transcliption polymerase chain reaction(RT-PCR)and immunohistochemistry,*** from nonnozoospermic donors(n=12)were individually processed using a swim-up procedure and were then incubated with CATSPER 1 antibody at final concentrations of 20,4 and 0.8μg/*** 1,2 and 6h incubation,progressive motility and fast progressive motility were measured by means of computer-assisted semen ***:CATSPER1 transcript was detected in both human testis and each human ejaculated semen ***1 protein expressed in the membrane of spermatid and was localized in the principal piece of the sperm *** application of CATSPER1 antibody at all concentrations significantly inhibited both progressive motility and fast progressive motility after 1,2 and 6h incubation,and significant dose-dependent changes were ***:CATSPER1 is meiotically and post-meiotically expressed in human testis ***1 mRNA in human ejaculated spermatozoa could be a more feasible target for study and infertility screening than testis *** addition,our results suggest that human CATSPER1 could be a possible target for immunocontraception.(Asian J Androl 2006 May:8:301-306)

关键词： (?)ation channel of sperm 1 testis spermatozoa motility immunocontraception human

The Correlation Between Decreased Ornithine Level and Alleviation of Rheumatoid Arthritis Patients Assessed by a Randomized,Placebo-Controlled,Double-Blind Clinical Trial of Sinomenine

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Engineering 2022年第9期16卷 93-99页

作者： Ying Shi Hu-Dan Pan Jian-lin Wu Qing-Hua Zou Xin-Yi Xie hong-gang li Hua Zhou Xi-Qing Bian Wen-Fei Leng Can-Jian Wang Ya-Feng Wang Yong-Fei Fang liang liu Department of Rheumatology The Southwest Hospital of Army Military Medical UniversityChongqing 400038China State Key Laboratory of Dampness Syndrome Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine&Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao 999078China People’s Hospital of Changshou Chongqing Chongqing 401220China Traditional Chinese Medicine Hospital Dianjiang Chongqing Chongqing 408300China Medical Management Center World Federation of Chinese Medicine SocietiesBeijing 100101China

Sinomenine(SIN)is commonly used as part of rheumatoid arthritis(RA)therapy in China,but there is still no published evidence of the efficacy of SIN *** work investigates the efficacy and safety of SIN in treating RA patients and analyzes the correlation between ornithine level and the alleviation of disease activity in RA *** this 24 week,randomized,placebo-controlled,double-blind clinical trial,people with mild to moderate RA were randomly assigned(1:1:1,stratified by hospital)to receive SIN(120 mg,twice daily),methotrexate(MTX)(10 mg per week),or SIN+MTX *** primary outcome was the proportion of patients who achieved a 50%improvement in the American College of Rheumatology(ACR50)criteria at week 24 and who showed improvement according to the clinical disease activity index(CDAI).In this prospective subgroup analysis,we also assessed whether the 24-week alterations of disease activity in the treatment group were significantly correlated to the levels of blood *** the 135 enrolled participants,38,39,and 36 patients were treated with SIN,MTX,and SIN+MTX,*** the SIN-treated group,52.63%of patients achieved ACR50 after 24-weeks of treatment,which was comparable to the results in the MTX-treated and SIN+MTX-treated *** and gastrointestinal disorders were the main adverse events;however,the ratio of patients suffering from hepatic disorder in the SIN group(1/38)was much lower than that in the MTX(10/39)and SIN+MTX(8/36)groups.A total of 221 serum samples were collected at the four follow-up time points in the three treatments,and the levels of ornithine,citrulline,and arginine were obtained through ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF/MS).The serum ornithine level decreased after the 24-week treatment along with a decrease in disease activity,and may reflect therapeutic responses with a sensitivity value of 80%.In conclusion,SIN revealed a comparabl

关键词： Rheumatoid arthritis Sinomenine Efficacy Safety Inflammatory biomarker

HER2 and topoisomerase Ⅱα： possible predictors of response to neoadjuvant chemotherapy for breast cancer patients

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Chinese Medical Journal 2008年第20期121卷 1965-1968页

作者： ZHU li li Ya-fen CHEN Wei-guo HE Jian-rong PENG Chen-hong ZHU Zheng-gang li hong-wei Department of Surgery Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Background Surrogate markers may be used to assess the response to neoadjuvant treatment. The association between HER2 overexpression and favorable response to specific therapy in breast cancer is controversial, and the mechanism unclear. The purpose of the study was to evaluate HER2 and topoisomerase Ⅱα （Topo Ⅱα） as candidates for predicting the response to neoadjuvant chemotherapy in breast cancer patients.Methods Between 1999 and 2006, seventy-six breast cancer patients who had received neoadjuvant chemotherapy were studied. Regimens including either CEF （cyclophosphamide, epirubicin, 5-fluorouracil） or CMF （cyclophosphamide, methotrexate, 5-fluorouracil） were given in more than three cycles to this group of patients. Protein expression of HER2 and Topo Ⅱα were determined by immunohistochemistry. The primary endpoint was pathological and clinical response.Results Of 76 primary breast cancer samples, 27 （35.5%） showed overexpression of either HER2 （25%） or Topo Ⅱα protein （10.5%）, whereas in 7 tumors （9.2%） both proteins were found to be overexpressed. Ten patients （13.2%） had a clinical complete response and 21 （27.6%） had a clinical partial response. Five women （6.6%） had a pathological complete response, 5 （6.6%） had microscopic residual disease, and 46 （60.5%） had macroscopic residual disease. HER2 and Topo Ⅱα overexpression was significantly associated with a favorable response （P 〈0.001 and P=0.005 respectively）.Conclusion Our study suggests that HER2 and Topo Ⅱα overexpression could be predictors of the response to neoadjuvant chemothrapy in both the CEF and CMF arms.

关键词： genes, HER2 DNA topoisomerase II alpha neoadjuvant chemotherapy breast neoplasms