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Preparation of true solutions of monomeric amyloidogenic protein/peptide:A critical prerequisite for aggregation kinetic study

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中国科学：化学 2012年第2期42卷 229-230页

作者： DIAO Shu ZHAO hong WANG WeiMao WU chi Department of Chemistry The Chinese University of Hong Kong Hong Kong China The Hefei National Laboratory of Physical Science at Microscale Department of Chemical Physics The University of Science and Technology ofChina Hefei 230022 China

Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and ***,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain *** resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are *** addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution.

关键词：聚合动力学淀粉样蛋白多肽单体关联动力学动态激光光散射正解制备

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飞行员全动模拟机复训问题求解

系统工程理论与实践 2014年第6期34卷 1462-1467页

作者：高敏刚许保光池宏中国科学院科技政策与管理科学研究所北京100190

针对无训练资源约束的飞行员全动模拟机复训问题,构建双目标整数规划模型对问题进行刻画,通过构造网络流、二部图和加权路等一系列网络规划模型,将原问题转化为最小费用最大流和最长路求解问题,并设计多项式启发式算法对问题进行求解,... 详细信息

针对无训练资源约束的飞行员全动模拟机复训问题,构建双目标整数规划模型对问题进行刻画,通过构造网络流、二部图和加权路等一系列网络规划模型,将原问题转化为最小费用最大流和最长路求解问题,并设计多项式启发式算法对问题进行求解,证明所得解为原问题的非劣解.最后,实证说明了模型和算法的有效性.

关键词：飞行员全动模拟机复训多目标分配问题网络规划多项式算法

Connectedness and systemic risk of the banking industry along the Belt and Road

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Journal of Management Science and Engineering 2022年第2期7卷 303-329页

作者： gang-Jin Wang Yusen Feng Yufeng Xiao You Zhu chi Xie Business School and Center for Finance and Investment Management Hunan UniversityChangsha410082China

This paper adopts the tail-event driven network(TENET)framework to explore the connectedness and systemic risk of the banking industry along the Belt and Road(B&R)based on weekly returns of 377 publicly-listed banks from 2014 to *** conduct the connectedness analysis from four levels(i.e.,system,region,country and institution)and identify the systemic risk contribution of *** find that the dynamic total connectedness reached its peak during the outbreak of the abnormal fluctuations of chinese stock market in 2015-2016 and its trough during the Brexit vote,and subsequently experienced several periodic fluctuations at a relatively high *** the B&R banking system,the intra-regional tail risk spillovers are remarkably stronger than the inter-regional tail risk spillovers during the post-crisis *** addition,the panel regressions estimated by the least squares dummy variable model show that the cross-border merger and acquisitions(M&As)and the merchandise trade export are important drivers for the tail-connectedness across the B&R *** study provides regulators with insightful implications on the systemic risk supervision of the B&R banking industry.

关键词： Systemic risk Connectedness The Belt and Road Initiative Banks Financial network

Investigation of in vitro antioxidant activity of dihydromyricetin and flavonoids rich extract from vine tea(Ampelopsis grossedentata)

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Traditional Medicine Research 2021年第1期6卷 48-62页

作者： Fu-Yan Li Shu-Mei chi hong-Bing Zhang Pharmaceutical Department Traditional Chinese Medicine Hospital of ZaozhuangZaozhuang 277000China

Background:Vine tea from fermented Ampelopsis grossedentata leaves has been used as a herbal tea and folk medicine in the southern region of china for hundreds of *** aim of this investigation was to analyze the total flavonoids found in vine tea,including three bioactive flavonoids,and the total phenolic contents in the aqueous methanol extracts of 10 vine tea *** addition,this study also aimed to examine the antioxidant activity of dihydromyricetin and vine tea’s flavonoid-rich ***:The total flavonoids and total phenolic content assay of extracts from vine tea were performed by ultraviolet-visible spectroscopy and epoch microplate spectrophotometer,*** bioactive flavonoids were quantified simultaneously using high performance liquid *** antioxidant activity of dihydromyricetin and vine tea’s flavonoid-rich extract was evaluated in vitro using six different ***:Vine tea contained a large number of flavonoids,with dihydromyricetin as its main *** flavonoid-rich extract exhibited a significant scavenging effect on superoxide anion radicals,and on 3-ethylbenzthiazoline-6-sulphonic acid and 1,1-diphenyl-2-picrylhydrazyl *** also possessed definite activity in lipid peroxidation inhibition,ferric reduction,and the moderation of Fe2+ion chelation *** was a significant negative correlation between dihydromyricetin content and antioxidant activity in the vine tea samples,including superoxide anion radical scavenging activity(P=−0.754,P<0.05),lipid peroxidation inhibition activity(P=−0.759,P<0.05),ferric-reducing antioxidant power(P=−0.843,P<0.01),*** played a dominant role in the antioxidant activities of the flavonoid-rich ***:Vine tea’s flavonoid-rich extract could be used as a new antioxidant source to safeguard against oxidative stress.

关键词： Vine tea Ampelopsis grossedentata Flavonoids Dihydromyricetin Phenols Antioxidant activity

Ten-channel mode-division-multiplexed silicon photonic integrated circuit with sharp bends

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Frontiers of Information Technology & Electronic Engineering 2019年第4期20卷 498-506页

作者： Chen-lei LI Xiao-hui JIANG Yung HSU Guan-hong CHEN chi-wai CHOW Dao-xin DAI Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical InstrumentationCollege of Optical Science and Engineering Zhejiang University Ningbo Research Institute Zhejiang University Department of Photonics and Institute of Electro-Optical Engineering Chiao Tung University

A multimode silicon photonic integrated circuit(PIC) comprising a pair of on-chip mode(de)multiplexers with 10-mode channels and a multimode bus waveguide with sharp bends is demonstrated to enable multi-channel on-chip transmissions. The core width of the multimode bus waveguide is chosen such that it can support 10 guided modes, of which there are four transverse-magnetic polarization modes and six transverse-electric polarization modes. This multimode bus waveguide comprises sharp bends based on modified Euler curves. Experimental results demonstrate that the present silicon PIC enables the 10-channel on-chip transmission with a low inter-mode crosstalk of approximately-20 dB over a broad bandwidth of 1520–1610 nm even when the bending radius of the S-bend is as small as 40 μm. Compared with a silicon PIC using a conventional arc-bend with the same bending radius, our proposed PIC demonstrates a significant improvement.

关键词： Silicon Multimode Waveguide Euler-bends

Inclusions and solidification structures of high pure ferritic stainless steels dual stabilized by niobium and titanium

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Rare Metals 2014年第6期33卷 761-766页

作者： hong-Po Wang Li-Feng Sun Jun-Jie Shi Cheng-Jun Liu Mao-Fa Jiang chi Zhang Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern University

As the raw materials in the post process of rolling and heat treatment, ingots have great effects on the properties of the final products. Inclusions and solidification structures are the most important aspects of the quality of ingots. Niobium and titanium are usually used to react with carbon and nitrogen to improve the properties of ferritic stainless steels. In this research, combined with thermodynamic calculation, effects of niobium and titanium on the inclusions and solidification structures in three kinds of high pure ferritic stainless steels with different titanium additions were investigated by optical microscope（OM）, scanning electron microscope（SEM）, transmission electron microscope（TEM）, and energy disperse spectrometer（EDS）. Results show that Al2O3 and a few（Nb,Ti）N particles form when titanium addition is 0.01 %.Furthermore, inclusions are mainly Ti N and Al2O3–Ti Ox–Ti N duplex inclusions when titanium addition is more than0.10 %. Those two types of inclusions are in well distribution, and can afford nuclei to the solidification ***, the ratio of equiaxed zone increases with the increase of titanium addition. The ratio increases from42.1 % to 64.0 % with the titanium addition increasing from 0.01 % to 0.10 %, and it increases to 85.7 % when the titanium addition reaches 0.34 %.

关键词： High pure ferritic stainless steel Inclusion Solidification structure Equiaxed zone Stabilization element

The efficacy of *** adjuvant chemotherapy on biliary tract cancer after R0 resection

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chinese Journal of Cancer 2017年第5期36卷 222-230页

作者： Young Saing Kim chi-Young Jeong Haa-Na Song Tae Hyo Kim hong Jun Kim Young-Joon Lee Soon Chan hong Division of Hematology and Oncology Department of Internal MedicineGachon University Gil Medical Center Incheon 405.706 South Korea Department of Surgery Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine 79 Gangnam-roJinju 660.702 South Korea Department of Internal Medicine Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine Jinju 660.702 South Korea.

Background: The optimal treatment strategy for biliary tract cancer(BTC) after curative?intent resection remains con?troversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine?based adjuvant chemotherapy for BTC patients undergoing microscopically margin?negative(R0) ***: We retrospectively analyzed the clinical data of BTC patients who underwent curative?intent R0 resection. Patients were eligible if they received either fluoropyrimidine?based adjuvant chemotherapy or observation after R0 ***: A total of 153 patients were included. In the entire patient cohort, no significant differences were observed in 5?year overall survival(OS) rates(48.4% vs. 39.6%, P = 0.439) or 3?year recurrence?free survival(RFS) rates(49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimidine?based adjuvant chemotherapy or observation. However, for patients with stages Ⅱ and Ⅲ BTC, chemotherapy significantly improved 5?year OS rate(52.4% vs. 35.6%, P = 0.002) and 3?year RFS rate(55.5% vs. 39.1%, P = 0.021) compared with ***: Fluoropyrimidine?based adjuvant chemotherapy may prolong the survival of patients with stages Ⅱ and Ⅲ BTC after R0 resection.

关键词： Biliary tract cancer Adjuvant chemotherapy Fluoropyrimidine R0 resection Prognosis

Text Mining of Rheumatoid Arthritis and Diabetes Mellitus to Understand the Mechanisms of chinese Medicine in Different Diseases with Same Treatment

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chinese Journal of Integrative Medicine 2018年第10期24卷 777-784页

作者： ZHAO Ning ZHENG Guang LI Jian ZHAO hong-yan LU Cheng JIANG Miao ZHANG chi GUO hong-tao LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences School of Information Science and Engineering Lanzhou University School of Basic Medical Sciences Beijing University of Chinese Medicine Institute of Basic Theory for chinese Medicine China Academy of Chinese Medical Sciences School of chinese Medicine Hong Kong Baptist University

Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.

关键词： text mining rheumatoid arthritis diabetes mellitus different diseases with same treatment chinese medicine

Analysis of mechanical strengths of extreme line casing joint considering geometric, material, and contact nonlinearities

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Petroleum Science 2024年第3期21卷 1992-2004页

作者： Ji-Yun Zhang chi Peng Jian-hong Fu Quan Cao Yu Su Jian-Yun Pang Zi-Qiang Yu Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Engineering Technology Research Institute of CNPC Southwest Oil and Gas Field Company Chengdu610017SichuanChina

To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional ***,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the *** address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse *** model investigates the stress distribution of each thread tooth subjected to various tensile forces and external ***,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental *** findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread *** end thread teeth are valuable spots for *** is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth *** external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield *** tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element *** tensile strength of the joint is 3091.9 k ***,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test resul

关键词： Extreme line casing Elastic-plastic mechanics Finite element analysis Tensile strength Collapse strength