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Interaction between hydrogen sulfide/cystathionine γ-lyase and carbon monoxide/heme oxygenase pathways in aortic smooth muscle cells

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Acta Pharmacologica Sinica 2006年第12期27卷 1561-1566页

作者： hong-fang jin~2 jun-bao du~(2,4)xiao-hui li~2 yan-fei wang~2 yin-fang liang~2 chao-shu tang~3.2 department of pediatrics,peking university first hospital,beijing 10003.,china 3 Institute of Cardiovascular Research,peking university first hospital,beijing 10003.,china department of pediatrics Peking University First Hospital Beijing 100034 China Institute of Cardiovascular Research Peking University First Hospital Beijing 100034 China

Aim:To investigate the interaction between hydrogen sulfide（H2S）/cystathion-ine γ-lyase（CSE）and carbon monoxide（CO）/heme oxygenase（HO）pathways inaortic smooth muscle cells（ASMC）.Methods:The ASMCs were divided into thefollowing groups:（1）the control group;（2）the zinc protoporphyrin（ZnPP）20μmol/L group;（3）the propargylglycine（PPG）2 mmol/L,4 mmol/L and 10 mmol/Lgroups;and（4）the sodium hydrosulfide（NariS）1×10-5mol/L,1×10-4mol/L and1×10-3mol/L *** of the groups was further divided into 6h,12h,18hand 24h *** CO level,represented by carboxyhemoglobin（HbCO）content was measured using a spectrophotometric method and H2S content wasdetected by a sensitive electrode *** and HO-1 expressions were de-tected by Western ***:The H2S content in the medium and CSEexpression by ASMC were markedly increased by ZnPP compared with the con-trol *** content in the medium and HO-1 expression by the ASMCstarted strengthening following 24h treatment with PPG at 2 mmol/L,but werefurther strengthened following 18h and 24h treatment with PPG at 4 mmol/Lcompared with the controls（Plin the medium following 18h treatment and increased HO-1 expression by theASMC following 12h ***,NariS at 1×10-5mol/L and 1×10-4mol/Ldecreased the HbCO level in the medium and HO-1 expression by the ASMC after6h and 12h treatment,while NariS at 1×10-3mol/L decreased them at all timepoints of the ***:The results suggested that endogenousCO/HO and H2S/CSE pathways inhibited each other in ASMC under physiologi-cal conditions.

关键词： hydrogen sulfide cystathionine γ-lyase carbon monoxide heme oxygenase

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen huirun Chen jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Consensus statement on layout and delivery of automatic external defibrillator in china

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Journal of Hainan Medical university 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen yan-Fen Chai xiao-hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding yang Deng Jie Fu Bang-Jiang fang Mai-ying Fan li Gui Ping Gong Wei Guo shu-Bin Guo liang Huang Ji-Yuan Han Zhong Ji Xian-fei Ji Xin-Cai Ji hong-Xu jin Xin-jun Jiang wang-Xiang Jiang Jia-liang liu xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li shuang-Ming li xiao-Gang li bao-jun li Pei-Wu li Chun-Sheng li Zhi-jun li Chang-Luo li Xiang-Min li yin-Ping li Zong-jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo xiao-Xing liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-yang Peng Peng Qiao Pei shu-Ming Pan Guo-Zhong Qing li-Jie Qin Wu-ying Qiao fei Shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang du-Juan Sha Gui-Lan Tao Guo-Gang Tian ying-Ping Tian Jian-Guang Tian chao-yang Tong Zi-Ren tang Meng-Xiong tang Guo-Ping Wu Zhi Wan Tao wang Xin wang Peng wang Zhong wang Tong wang Ri-Xing wang Yi-Xin wang xiao-Dan wang ling Wu Wei Wei Hua Xiang Feng Xu jun Xu Jie Xu Miao-Rong Xie shuo-Gui Xu Tie Xu Feng Yu Wen Yi li-Shan yang Shi-Jiao yan jin-Jian Yao Shou-Chun yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-hong Zhu hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-Min Zhu jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao yan Zhao Min Zhao Bin Zhao xiao-Dong Zhao xiao-jing Zhao hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical university

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in china[2].

关键词： cardiac death respiratory

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