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Therapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats

World Journal of Pediatrics 2015年第1期11卷 74-82页

作者： hong-fang ding Hui Zhang Hui-fang ding Dong Li Xin-Hao Yi Xin-Yi Gao Wei-Wei Mou Xiu-Li Ju Department of Pediatrics Qilu HospitalShandong UniversityJinan 250012China Department of Pediatrics Shengli Oil Field Central HospitalDongying 257034China Department of Neurology Qingdao Municipal HospitalQingdao 266000China

Background:Oxidative stress is involved in the development of hypoxic-ischemic brain damage(HIBD).In this study,we investigated the therapeutic efcts of placenta-derived mesenchymal stem cells(PD-MSCs)and explored the N F-E2-related factor-2/heme oxygenase-1(Nrf2/HO-1)signaling pathway in treating ***:P7 rats were subjected to hypoxic-ischemic brain injury and randomly divided into four groups(control,HIBD,HIBD+PD-MSCs,and HIBD+fbroblasts).Forty-eight hours after the induction of HIBD,5×10^(5)of PD-MSCs were injected into cerebral tissue in the HIBD+PD-MSCs group,while the same dose of fibroblas ts were injected in the HIBD+fibroblasts *** Water Maze,gross and pathological changes were tested at *** level of malondialdehyde(MDA)was detected in rats'***-PCR and western blot analysis were used to evaluate the changes of Nrf2/***:The HIBD group showed significantly longer escape latency and a lower frequency of original platform crossing in the Morris Water M laze compared with the control *** receiving PD MSCs showed significant improvement of *** pathological changes were evident after HIBD,but ameliorated in the PD-MSCs *** with the control group,HO-1 and Nrf2 were up-regulated at gene and protein levels in the HI brain,beginning at 6 hours and peaking at 48 hours(P<0.05).The expression of HO-1 and Nrf2 in the PD-MSCs treatment group was more pronounced than in the HBD group(P<0.01).PD MSCs also decreased MDA production in the brain ***:These results demonstrate that PD-MSCs have neuroprotective effect during the treatment of HIBD and that the mechanism may be partly due to alleviating oxidative stress.

关键词： hypoxia-ischemia mesenchymal stem cells neonatal rat oxidative stress

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin Zhang Yang ding Pan Pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhou, Chengwang ding, Zhezheng Ying, Shengzhe Jiang, Hao Wang, Yan fang, Timing Zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

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CAPRL Scoring System for Prediction of 30-day Mortality in 949 Patients with Coronavirus Disease 2019 in Wuhan,China:A Retrospective,Observational Study

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Infectious Diseases & Immunity 2021年第1期1卷 28-35页

作者： Hui-Long Chen Wei-Ming Yan Guang Chen Xiao-Yun Zhang Zhi-Lin Zeng Xiao-Jing Wang Wei-Peng Qi Ming Wang Wei-Na Li Ke Ma Dong Xu Ming Ni Jia-Quan Huang Lin Zhu Shen Zhang Liang Chen hong-Wu Wang Chen ding Xiao-Ping Zhang Jia Chen Hai-Jing Yu hong-fang ding Liang Wu Ming-You Xing Jian-Xin Song Tao Chen Xiao-Ping Luo Wei Guo Mei-fang Han Di Wu Qin Ning Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Background:Coronavirus disease 2019(COVID-19)is a serious and even lethal respiratory *** mortality of critically ill patients with COVID-19,especially short term mortality,is *** is crucial and urgent to develop risk models that can predict the mortality risks of patients with COVID-19 at an early stage,which is helpful to guide clinicians in making appropriate decisions and optimizing the allocation of hospital ***:In this retrospective observational study,we enrolled 949 adult patients with laboratory-confirmed COVID-19 admitted to Tongji Hospital in Wuhan between January 28 and February 12,***,clinical and laboratory data were collected and analyzed.A multivariable Cox proportional hazard regression analysis was performed to calculate hazard ratios and 95%confidence interval for assessing the risk factors for 30-day ***:The 30-day mortality was 11.8%(112 of 949 patients).Forty-nine point nine percent(474)patients had one or more comorbidities,with hypertension being the most common(359[37.8%]patients),followed by diabetes(169[17.8%]patients)and coronary heart disease(89[9.4%]patients).Age above 50 years,respiratory rate above 30 beats per minute,white blood cell count of more than 10×109/L,neutrophil count of more than 7×109/L,lymphocyte count of less than 0.8×109/L,platelet count of less than 100×109/L,lactate dehydrogenase of more than 400 U/L and high-sensitivity C-reactive protein of more than 50 mg/L were independent risk factors associated with 30-day mortality in patients with COVID-19.A predictive CAPRL score was proposed integrating independent risk *** 30-day mortality were 0%(0 of 156),1.8%(8 of 434),12.9%(26 of 201),43.0%(55 of 128),and 76.7%(23 of 30)for patients with 0,1,2,3,≥4 points,***:We designed an easy-to-use clinically predictive tool for assessing 30-day mortality risk of *** can accurately stratify hospitalized patients with COVID-19 into rel

关键词： COVID-19 Mortality Risk factor SARS-CoV-2

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1980年4月2372活动区中黑子群的快速浮现

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天文学报 1982年第4期 327-332页

作者：洪琴芳丁有济栾蒂中国科学院云南天文台

本文给出了SESC 2372活动区中主要的双极β黑子群及中部小的双极δ-结构的快速浮现过程;测量了小黑子的平均汇聚速度和中心大黑子半径增长率的相关曲线。

关键词：黑子群 UT 黑子半影光球太阳大气

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Estimation method for parameters of overlapping nuclear pulse signal

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Nuclear Science and Techniques 2017年第1期28卷 80-87页

作者： hong-Quan Huang Xiao-Feng Yang Wei-Cheng ding fang fang College of Nuclear Technology and Automation Engineering Chengdu University of Technology Fundamental Science on Radioactive Geology and Exploration Technology Laboratory East China Institute of Technology

Identification of nuclear pulse signal is of importance in radioactive measurements,especially in recognizing adjacent overlapping nuclear *** this article,we propose an estimation method for parameters of typical overlapping nuclear pulse ***,the nuclear pulses are regarded as individual genes and the norm is set as the fitness ***,the global optimal solution is found by searching the population of genetic algorithm,so as to estimate the parameters of nuclear *** high precision,this method can identify parameters of overlapping nuclear pulses in the Sallen-Key Gaussian signal decomposition *** pulse recognition method is of great significance to improve the precision of radioactive measurement and is suitable for serious overlap of nuclear pluses.

关键词： Nuclear pulse Overlapping Parameter identification

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MC-ICP-MS 测定岩石标准物质的钒同位素组成

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岩矿测试 2025年第1期44卷 63-74页

作者：徐丽怡于慧敏丁昕黄方中国科学技术大学地球和空间科学学院岩石圈演化与环境演变全国重点实验室安徽合肥230026 中国科学院比较行星学卓越创新中心中国科学技术大学安徽合肥230026

随着分析方法的发展和分析精度的提升,钒同位素已经越来越多地被用于各种地质过程研究。为了确保钒同位素分析测试过程中,可以有效地监控数据的准确度和精度,方便国际各实验室之间的数据对比,同时考虑到早期国际上常用美国地质调查局(US... 详细信息

随着分析方法的发展和分析精度的提升,钒同位素已经越来越多地被用于各种地质过程研究。为了确保钒同位素分析测试过程中,可以有效地监控数据的准确度和精度,方便国际各实验室之间的数据对比,同时考虑到早期国际上常用美国地质调查局(USGS)的标准物质面临着库存不足等问题,本文采用多接收电感耦合等离子体质谱仪(MC-ICP-MS)测定了一系列国际地质标准物质和国家地质标准物质的钒同位素组成,δ51V值的测试精度优于0.08‰。本文选取的标准物质主要来自日本地质调查局(GSJ)和中国地质科学院地球物理地球化学勘查研究所(IGGE),包括一个安山岩(JA-1),三个玄武岩(JB-3、JB-1b和GBW07105),一个辉长岩(JGb-1),一个辉绿岩(GBW07123)以及一个土壤(GBW07454),钒含量范围为77~635μg/g,涵盖了目前大部分火成岩和部分土壤等天然样品含量的范围。这些标准物质除了土壤GBW07454,其他标准物质的钒同位素组成未曾被报道。经测量表明,辉长岩标准物质JGb-1具有最高δ51V值,为−1.05‰±0.08‰,安山岩标准物质JA-1具有最低δ51V值,为−0.34‰±0.06‰,其余标准物质的δ51V值变化范围为−0.72‰~−0.81‰,均落在MORB范围内。本文对这些标准物质钒同位素组成的报道,丰富了钒同位素研究的标准物质数据库,有助于未来在更多领域开展钒同位素研究。

关键词：钒同位素火成岩 MC-ICP-MS 标准物质高精度分析方法

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Macrophage activation syndrome as a complication of dermatomyositis: A case report

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World Journal of Clinical Cases 2020年第11期8卷 2339-2344页

作者： ding-Xian Zhu Jian-Jun Qiao hong fang Department of Dermatology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Macrophage activation syndrome(MAS)can be a fatal complication of rheumatic disorders,which occurs most commonly in patients with systemic juvenile idiopathic arthritis or systemic lupus *** has rarely been reported in patients with ***,we describe a fatal case of MAS that developed in an adult patient with *** SUMMARY A 44-year-old woman was admitted to our hospital with fever,generalized rash and muscle *** days later,the fever persisted after the use of antibiotics,and repeat blood culture was *** patient then exhibited a typical Gottron sign and diffuse erythema on the face and neck,which were consistent with a diagnosis of *** patient exhibited limb muscle strength of 2,and electromyography was suggestive of muscle-derived damage,which also supported a diagnosis of *** addition,the patient exhibited high serum ferritin level,cytopenia,liver dysfunction,coagulopathy,enlarged spleen and hypertriglyceridemia,all of which are typical manifestations of *** patient was diagnosed with dermatomyositis complicated by *** a high dose of methylprednisolone was administered for 15 d,the patient’s condition continued to deteriorate and central nervous system symptoms ***,treatment was discontinued,and the patient *** MAS is an important,potentially fatal,complication of *** MAS is rare in dermatomyositis,it should be considered in the differential diagnosis of an unexplained change of hemoglobin,platelet,fibrinogen,ferritin and triglyceride,which may complicate dermatomyositis.

关键词： Macrophage activation syndrome Dermatomyositis Hyperferritinemia Case report Systemic juvenile idiopathic arthritis Inflammatory

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Phase transformation-induced Mg isotope fractionation in Mgmediated CaCO_(3)mineralization

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Nano Research 2023年第2期16卷 3597-3602页

作者： Yi-Ming Ju fang Huang Xin ding Li-Bo Mao Shu-hong Yu Department of Chemistry Institute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology University of Science and Technology of ChinaHefei 230026China

The biomineralization of CaCO_(3)often involves the transformation of amorphous precursors into crystalline phases,which is regulated by various proteins and inorganic ions such as Mg^(2+)*** the effects of Mg^(2+)ions on the polymorph and shape of the crystalline CaCO_(3)have been observed and studied,the interplay between Mg^(2+)ions and CaCO_(3)during the mineralization remains *** work focuses on the mechanism of Mg^(2+)ion-regulated mineralization of CaCO_(3).By tracing the Mg isotope fractionation,the different mineralization pathways of CaCO_(3)under different Mg^(2+)ion concentrations had been *** regulatory role of Mg^(2+)ions at the different stages of mineralization had been proposed through combining the fractionation data with the analyses of the CaCO_(3)polymorph and shape *** results provide a clear view of the Mg-mediated crystallization process of amorphous CaCO_(3),which can be used to finely control the phase of the crystalline products according to different needs.

关键词： mineralization calcium carbonate magnesium isotope fractionation

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Vertically aligned W(Mo)S_(2)/N-W(Mo)C-based light-assisted electrocatalysis for hydrogen evolution in acidic solutions

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Rare Metals 2023年第5期42卷 1535-1544页

作者： Lan-fang Wang Rui-Xia Yang Jin-Zhi Fu Yue-Yue Cao Rui-fang ding Xiao-hong Xu Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&School of Chemistry and Materials Science of Shanxi Normal University Taiyuan030032China Kunshan Superior Silk Screen Printing Material Co. Ltd.Suzhou215300China

The development of non-noble-metal hydrogen evolution electrocatalysts holds great promises for a sustainable energy ***,a hybrid W(Mo)S_(2)/NW(Mo)C nanosheet with array structures was reported for an efficient light-as sis ted hydrogen evolution electrocatalysts in acidic *** resulting vertically aligned W(Mo)S_(2)/N-W(Mo)C was supported on a conductive carbon fiber paper,which can be produced through annealing W(Mo)S_(2)nanosheets by simultaneous carbonization and N-doping in Ar/H_(2)*** optimized WS_(2)/NWC and MoS_(2)/N-MoC electrode exhibits remarkable lightassisted electrocatalysis activity with overpotentials of0.120 and 0.122 V at 10 mA·cm^(-1)in acidic solutions,*** high hydrogen evolution activities should be attributed to the electrocatalytic synergistic effects of the abundant active sites existing in different phase boundaries and the absorption for ultraviolet-visible *** study shows that synthesis of low-cost and highly active W(Mo)S_(2)-based hydrogen evolution electrocatalyst opens up a route toward the development of scalable production of hydrogen fuels.

关键词： W(Mo)S_(2)/N-W(Mo)C heterostructures Vertically aligned nanosheets Hydrogen evolution Lightassisted electrocatalysis

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