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基于NF-κB通路研究平肝活血合剂对脑缺血再灌注损伤的作用机制

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中南药学 2024年第4期22卷 902-907页

作者：刘宗梅王晓玲宋发萍姚硕唐勇陕西中医药大学第一临床医学院陕西咸阳712046 安康市中医医院陕西安康725000

目的探讨平肝活血合剂对脑缺血再灌注损伤(CIRI)的作用机制。方法采用线栓法制备CIRI模型。SD大鼠随机分为假手术组,模型组,平肝活血合剂低、中、高剂量组(2.08、4.16、8.32 mL·kg^(-1)),阳性对照组(丁苯酞软胶囊6.25 mg·kg^(-1)),... 详细信息

目的探讨平肝活血合剂对脑缺血再灌注损伤(CIRI)的作用机制。方法采用线栓法制备CIRI模型。SD大鼠随机分为假手术组,模型组,平肝活血合剂低、中、高剂量组(2.08、4.16、8.32 mL·kg^(-1)),阳性对照组(丁苯酞软胶囊6.25 mg·kg^(-1)),每组10只。灌胃治疗7d,每日1次。造模后第1、3、7日观察大鼠神经功能评分。给药7日后观察大鼠脑缺血组织病理改变,测定脑梗死体积百分比,检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)的水平,脑缺血组织中的TNF-α、IL-1β、IL-8 mRNA表达,脑缺血组织中磷酸化的NF-κB抑制蛋白α(p-IκBα)、核转录因子-κBp65(NF-κBp65)、磷酸化的核转录因子-κBp65(p-NF-κBp65)蛋白的表达。结果与假手术组比较,模型组大鼠给药7日后Longa评分显著升高,右脑出现鲜明的苍白色梗死灶(P <0.01),TNF-α、IL-1β、IL-8及TNF-α、IL-1β、IL-8 mRNA表达均显著上升,p-IκBα、NF-κBp65、p-NF-κBp65蛋白表达均明显上调(P <0.05或P <0.01)。HE染色显示脑缺血组织区网状结构疏松,细胞错乱、结构缺损甚至萎缩变形、数量变少,核固缩及碎裂。与模型组比较,给药7日后平肝活血合剂各剂量组Longa评分显著降低,其余检测指标亦明显下降(P <0.05或P <0.01)。结论平肝活血合剂可显著改善CIRI的炎症因子水平,减轻脑损伤,其机制可能与调控NF-κB信号通路有关。

关键词：平肝活血合剂脑缺血再灌注损伤炎症抑制 NF-κB信号通路

住宅立面公建化设计在城市滨水CBD中的应用——以黄浦江沿岸E10单元E04-2地块住宅项目为例

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城市建筑 2024年第12期21卷 202-205页

作者：姚远华东建筑设计研究院有限公司

随着我国城市化进程的稳步推进,城市风貌愈发现代化。为了更好地统一城市风貌,尤其是在一些城市重点地段,越来越多的住宅建筑开始采用公建化立面,以期与现代化的城市风貌相协调。文章通过分析住宅立面公建化的形成原因、应用场景、设计... 详细信息

随着我国城市化进程的稳步推进,城市风貌愈发现代化。为了更好地统一城市风貌,尤其是在一些城市重点地段,越来越多的住宅建筑开始采用公建化立面,以期与现代化的城市风貌相协调。文章通过分析住宅立面公建化的形成原因、应用场景、设计要点等方面,结合黄浦江沿岸E10单元E04-2地块住宅项目,研究在特定城市环境下对公建化住宅立面的应用,为将来的住宅立面设计提供一些新的思路。

关键词：住宅立面公建化设计城市滨水CBD

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一种软质包覆+激光打孔的无线快充面板设计

汽车科技 2024年第2期 80-84页

作者：程发良于来水姚佩杨光亮贠涛岚图汽车科技有限公司武汉430056

目前市面搭载的手机无线快充面板外观品质较差,给用户一种廉价感。基于此,本文创造性的提出了一种高品质的软质包覆+激光打孔的无线快充面板设计概念,并通过设计和制造方案实现了该设计概念的量产化。结果表明:该全新设计的无线快充面... 详细信息

目前市面搭载的手机无线快充面板外观品质较差,给用户一种廉价感。基于此,本文创造性的提出了一种高品质的软质包覆+激光打孔的无线快充面板设计概念,并通过设计和制造方案实现了该设计概念的量产化。结果表明:该全新设计的无线快充面板产品满足剥离力性能、耐热老化环境实验性能及充电性能要求,相比市面传统无线快充面板,其外观质量及触感有了质的提升。

关键词：软质包覆激光打孔无线快充外观质量

基于神经网络PI的电静液作动器温度补偿控制方法研究

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液压气动与密封 2024年第6期44卷 48-56页

作者：黄昊刘家辉朱威霖高光发姚建勇南京理工大学中法工程师学院江苏南京210094 南京理工大学机械工程学院江苏南京210094

电静液作动器(Electro-hydrostatic Actuator,EHA)作为一种高性能集成化的动力执行器,广泛应用于航天航空、工业生产和军事领域。在不同油液温度下,液压油的体积弹性模量、黏度等性质会发生变化,从而对EHA的控制精度产生影响。针对此问... 详细信息

电静液作动器(Electro-hydrostatic Actuator,EHA)作为一种高性能集成化的动力执行器,广泛应用于航天航空、工业生产和军事领域。在不同油液温度下,液压油的体积弹性模量、黏度等性质会发生变化,从而对EHA的控制精度产生影响。针对此问题,首先建立了EHA数学模型;其次,设计了反向传播(BP)神经网络对比例积分控制器(PI)控制参数进行在线调节,补偿温度变化对跟踪精度的影响;最后,通过实验验证了传统PI控制的EHA跟踪精度与温度变化有着密切关系,并将BPPI控制器与PI控制器进行实验对比。实验结果表明,所设计的BPPI控制器在不同油液温度下平均跟踪误差之间的差值较PI控制器降低80%以上;且在相同温度下,平均跟踪误差较PI控制器降低60%以上。

关键词：电静液作动器反向传播神经网络温度补偿比例积分控制

Differences in Nuclear DNA Between Male-Sterile and Male-Fertile Lines of Sorghum bicolor

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Agricultural Sciences in China 2003年第7期2卷 736-741页

作者： faNChang-fa SUNChun-yun GUOXiao-cai NIUTian-tang ZHANGFu-yao ChengduInstituteofBiology ChineseAcademyofSciencesChengdu610041P.R.China BiotechnologyCenter Shan:ciAcademyofAgriculturalSciencesTaiyuan030031P.R.China SorghumResearchInstitute Shan:ciAcademyofAgriculturalSciencesYuci030600P.R.China

Cytoplasmic male sterility(cms)is determined by nuclear-cytoplasmic interactions. Up to now, most studies are focused on the comparison of cytoplasmic DNAs of male-sterile lines and male-fertile lines, and analysis of nuclear DNA has not been documented yet. In order to find out the possible difference in nuclear genome of male-sterile line A1 Tx623 and corresponding male-fertile line Tx623 of sorghum, random amplified polymorphic DNA(RAPD)approach was used to analyze their cytoplasmic and nuclear genomes. Total DNAs of them were amplified at first to screen primers, which were able to generate reproducible bands specific to male-sterile line or male-fertile line. Then the selected primers were used to amplify their mitochon-drial DNA(mtDNA)and chloroplast DNA(cpDNA). The origins of all the polymorphic fragments were analyzed. After ruling out those amplified from cytoplasmic DNA, seventeen polymorphic fragments were determined to be amplified from nuclear DNA. These fragments originated from nuclear DNA indicate that differences in sequence exist between the nuclear DNA of male-sterile line and male-fertile line of sorghum, which do not agree with the traditional standpoint that they have identical nucleus.

关键词： Cytoplasmic male sterility Sorghum bicolor RAPD Male-sterile line Male-fertile line Difference in nuclear DNA

粉煤灰基P型沸石吸附水中Cu^(2+)和Cd^(2+)

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中国环境科学 2024年第6期44卷 3132-3141页

作者：孙昊勇汪泽华姚亦扬吴代赦南昌大学资源与环境学院江西南昌330031 萍乡学院材料与化学工程学院江西萍乡337000

以粉煤灰(fa)为原料经水热反应合成了P型沸石(Z-P).采用X射线荧光光谱仪、X射线衍射仪、场发射环境扫描电子显微镜、比表面孔径分析仪、傅里叶变换红外光谱仪和X射线光电子能谱对Z-P进行表征,并研究了其对Cu^(2+)和Cd^(2+)的吸附性能.... 详细信息

以粉煤灰(fa)为原料经水热反应合成了P型沸石(Z-P).采用X射线荧光光谱仪、X射线衍射仪、场发射环境扫描电子显微镜、比表面孔径分析仪、傅里叶变换红外光谱仪和X射线光电子能谱对Z-P进行表征,并研究了其对Cu^(2+)和Cd^(2+)的吸附性能.结果表明,Z-P的BET比表面积和孔隙体积分别为38.46m^(2)/g和0.2180cm^(3)/g,均高于fa的1.273m^(2)/g和0.0120cm^(3)/***、Z-P对Cu^(2+)和Cd^(2+)的吸附更符合拟二级动力学模型和Langmuir等温线模型.Z-P对Cu^(2+)和Cd^(2+)的最大吸附量分别为157.48,131.57mg/g,远高于于fa的30.88,25.47mg/g.Z-P对Cd^(2+)的循环再生吸附效果好,但对Cu^(2+)的循环再生吸附效果较差.离子强度对Z-P吸附Cu^(2+)和Cd^(2+)分别起促进和抑制作用.表明Z-P可以作为有效且廉价的Cu^(2+)、Cd^(2+)吸附剂,为fa的资源化利用和含Cu^(2+)、Cd^(2+)重金属离子废水吸附剂的开发提供了一种方法.

关键词：粉煤灰 P型沸石吸附 Cu^(2+) Cd^(2+)

β2-Microglobulin exacerbates neuroinflammation,brain damage,and cognitive impairment after stroke in rats

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Neural Regeneration Research 2023年第3期18卷 603-608页

作者： Feng Chen Jing Liu fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu fang-fang Hu Rui-Qin yao Department of Neurology Xuzhou Cancer HospitalXuzhouJiangsu ProvinceChina Department of Neurobiology Xuzhou Key Laboratory of NeurobiologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou No.1 People’s Hospitalthe Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

β2-Microglobulin(β2M),a component of the major histocompatibility complex class I molecule,is associated with aging-related cognitive impairment and Alzheimer’s *** upregulation ofβ2M is considered to be highly related to ischemic stroke,the specific role and underlying mechanistic action ofβ2M are poorly *** this study,we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral *** found thatβ2M levels in the cerebral spinal fluid,serum,and brain tissue were significantly increased in the acute period but gradually decreased during the recovery *** interference was used to inhibitβ2M expression in the acute period of cerebral *** staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreasedβ2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive deficits,***,glial cell,caspase-1(p20),and Nod-like receptor pyrin domain containing 3(NLRP3)inflammasome activation as well as production of the inflammatory cytokines interleukin-1β,interleukin-6,and tumor necrosis factor-αwere also effectively inhibited byβ2M *** findings suggest thatβ2M participates in brain injury and cognitive impairment in a rat model of ischemic stroke through activation of neuroinflammation associated with the NLRP3 inflammasome.

关键词： cognitive impairment cognitive improvement glial activation infarct volume ischemia middle cerebral artery occlusion neuroinflammation NLRP3 inflammasome stroke β2 microglobulin

Structural Analysis of In xGa1−xN/GaN MQWs by Different Experimental Methods

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Chinese Physics Letters 2011年第7期28卷 305-308页

作者： DING Bin-Beng PAN Feng FENG Zhe-Chuan fa Tao CHENG Feng-Feng yao Shu-De State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871 Department of Physics and Electronic Information Langfang Teachers CollegeLangfang 065000 Department of Physics Shaanxi University of TechnologyHanzhong 723001 Institute of Photonics&Optoelectronics and Department of Electrical Engineering National Taiwan UniversityTaipei 10617China

Structural properties of InxGa_(1−x)N/GaN multi-quantum wells(MQWs)grown on sapphire by metal organic chemical vapor deposition are investigated by synchrotron radiation x-ray diffraction(SRXRD),Rutherford backscattering/channelling(RBS/C)and high-resolution transmission electron *** sample consists of eight periods of InxGa_(1−x)N/GaN wells of 2.1 nm thickness and 8.5 nm thickness of GaN barrier,and the results are very close,which verifies the accuracy of the three *** indium content in InxGa_(1−x)N/GaN MQWs by SRXRD and RBS/C is estimated,and results are in general the *** RBS/C random spectra,the indium atomic lattice substitution rate is 94.0%,indicating that almost all indium atoms in InxGa_(1−x)N/GaN MQWs are at substitution,that the indium distribution of each layer in InxGa_(1−x)N/GaN MQWs is very homogeneous and that the InxGa_(1−x)N/GaN MQWs have a very good crystalline *** is not accurate to estimate indium content in InxGa_(1−x)N/GaN MQWs by photoluminescence(PL)spectra,because the result from the PL experimental method is very different from the results by the SRXRD and RBS/C experimental methods.

关键词： N/Ga MQWs sapphire

Hypertension:microbiota-targeting treatment

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Chinese Medical Journal 2020年第11期133卷 1353-1354页

作者： yao Liu fa-Ming Zhang Wen-Zhi Hu Department of Cardiology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Key Lab of Holistic Integrative Enterology Nanjing Medical UniversityNanjingJiangsu 210011China

Hypertension,as the most common cardiovascular disease(CVD),occurs with a high *** disease attacked a population of about 1.13 billion in 2015 globally,and its prevalence exceeds 27.9%in Chinese aged>18 years.[1]Unfortunately,lifestyle modifications and medical interventions fail to control the disease in a third of *** gut microbiota can regulate immunity,inflammation,and *** decades,increasing evidence has shown that the activity and composition of microbiota are related to health status(like influencing blood lipid and glucose),which provides a new insight into the mechanism of hypertension.[2,3]

关键词： immunity cardiovascular inflammation