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Clinical significance of serum intercellular adhesion molecule-i detection in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2000年第3期6卷 408-410页

作者： Ming Hui Mei Jing Xu Qin Fen Shi Jing hong Yang Qian chen li ling Qin Department of Hepatobiliary Surgery, Institute of Hepatobiliary Surgery,Guilin Medical College,Guilin 541001,Guangxi Province,China

INTRODUCTION Since the late 1980s,studies on the expression ofintercellular adhesion molecule-1(ICAM-1)inpatients with malignancies have demonstrated thatICAM-1 may strongly express in two forms in suchdiseases:membra... 详细信息

关键词： carcinoma hepatocellular/diagnosis intercellular adhesion molecule-1 liverneoplasms/diagnosis alpha-fetoprotein

基于八钼酸盐杂化网络的离子热合成、晶体结构和光催化性质

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高等学校化学学报 2012年第12期33卷 2623-2627页

作者：丁艳陈鸿利郭立泉傅海陈维林王恩波多酸科学教育部重点实验室东北师范大学化学学院长春130024 吉林工商学院基础部长春130062 河北民族师范学院化学系承德067000

采用离子热法合成了一个由八钼酸盐和过渡金属配合物构筑的新颖的三维(3D)自穿插网络的有机-无机杂化材料Cu5ⅠBBTZ3H2O[β-MoⅤMo7ⅥO26][1,BBTZ=1,4-二(三咪唑-1-乙基)苯].化合物1具有由3D聚圆环结构和(4,4)二维层构筑的3D自穿插框架... 详细信息

采用离子热法合成了一个由八钼酸盐和过渡金属配合物构筑的新颖的三维(3D)自穿插网络的有机-无机杂化材料Cu5ⅠBBTZ3H2O[β-MoⅤMo7ⅥO26][1,BBTZ=1,4-二(三咪唑-1-乙基)苯].化合物1具有由3D聚圆环结构和(4,4)二维层构筑的3D自穿插框架结构.通过单晶X射线衍射、元素分析、红外光谱和热重分析对化合物1的结构进行了表征,并初步研究了其光催化产氢活性.

关键词：八钼酸盐晶体结构光催化有机-无机杂化离子热合成

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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摇摆台负载自适应技术研究

光学精密工程 2008年第8期16卷 1436-1439页

作者：陈洪立翟林培肖占全中国科学院长春光学精密机械与物理研究所

为了对不同型号的航空相机进行地面试验,需要设计一套具有负载自适应功能的摇摆台系统,为此研究了摇摆台负载自适应技术。根据相机的重量变化范围,结合已设计好的摇摆台机电结构,通过理论分析及仿真试验研究了负载(航空相机)大小与电位... 详细信息

为了对不同型号的航空相机进行地面试验,需要设计一套具有负载自适应功能的摇摆台系统,为此研究了摇摆台负载自适应技术。根据相机的重量变化范围,结合已设计好的摇摆台机电结构,通过理论分析及仿真试验研究了负载(航空相机)大小与电位计(位置反馈器件)反馈信号幅值间的关系,结合数值计算法首次提出了一种易于实现的自动测量负载大小的新方法。对于大部分现有的数字控制系统不需要添加任何器件,只需加段程序即可使用。研究结果表明四次多项式拟合的相关系数R2为0.997 3,均方差RMS为0.171 6;五次多项式拟合的相关系数R2为0.99 96,均方差RMS为0.063 8。进一步分析认为,五次多项式拟合可满足研究的负载自适应摇摆台精度要求。

关键词：自适应能力摇摆台转动惯量自动测量

Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice

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Variation of lipopolysaccharide-induced acute lung injury in...

苏德尔特贝16断块兴安岭群复杂岩性识别方法

中华医学会第七届全国哮喘学术会议暨中国哮喘联盟第三次大会

作者： hong chen,Ka li,Diane Wang,Xiangdong Wang Department of Pulmonary Medicine,Zhongshan Hospital,Fudan University 200233

Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury(Ali).lipopolysaccharide(LPS)-induced Ali models has been widely applied for pathophysiological and pharmacological *** order to understand the variation of acute pulmonary reactions between mouse strains and find the

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科学技术与工程 2012年第8期20卷 1755-1759页

作者：陈红丽肖佃师东北石油大学现代教育技术中心大庆163318 东北石油大学地球科学学院大庆163318

苏德尔特贝16断块兴安岭群为火山碎屑沉积岩和正常沉积岩储层,发育沉凝灰岩、凝灰质砂岩、砂砾岩等10余种岩性,识别难度大,严重制约该区储层评价工作的开展。根据岩心薄片分析、录井及测井资料,对该区兴安岭群储层主要岩性及测井响应特... 详细信息

苏德尔特贝16断块兴安岭群为火山碎屑沉积岩和正常沉积岩储层,发育沉凝灰岩、凝灰质砂岩、砂砾岩等10余种岩性,识别难度大,严重制约该区储层评价工作的开展。根据岩心薄片分析、录井及测井资料,对该区兴安岭群储层主要岩性及测井响应特征进行了分析。优选交会图版对主要岩性进行定性识别。运用基于概率统计学理论岩性判别技术对该区复杂岩性进行自动识别,并将判别结果与薄片分析进行对比。结果表明,该方法计算速度快、判别精度高。

关键词：兴安岭群岩性识别交会图概率统计法

Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li hong Zhou Zhihao Ren cheng Xu chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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癌光啉在兔体内的药代动力学及生物利用度

中国药理学通报 2012年第4期28卷 573-577页

作者：郑立卿阴慧娟李迎新陈洪丽中国医学科学院.北京协和医学院生物医学工程研究所激光医学实验室天津300192 河北北方学院药理学教研室河北张家口075000

目的研究癌光啉在兔体内的药代动力学及生物利用度特点,为药物进一步研究提供依据。方法兔腹腔注射或静脉注射10 ***-1癌光啉,于给药后的10 min、30 min、1h、2 h、4 h、8 h、24 h、48 h、72 h耳缘静脉采血,以全波长酶标仪荧光法测定兔... 详细信息

目的研究癌光啉在兔体内的药代动力学及生物利用度特点,为药物进一步研究提供依据。方法兔腹腔注射或静脉注射10 ***-1癌光啉,于给药后的10 min、30 min、1h、2 h、4 h、8 h、24 h、48 h、72 h耳缘静脉采血,以全波长酶标仪荧光法测定兔血浆中癌光啉浓度,用3P97处理血药浓度-时间数据,分析房室模型,得到最佳房室模型和药代动力学参数。结果家兔腹腔注射癌光啉10 ***-1的时量曲线符合一室开放模型,静脉注射时的时量曲线符合三室模型,但其消除快于ip。主要药代动力学参数:ip给药组,T12Ke=11.6 h,Cmax=2.312 mg.L-1,AUC=43.177 mg.L-1.h,CL=0.232 ***-1.h-1,V/F(c)=3.888 ***-1;iv给药组,Vc=0.75 ***-1,T12α=2.824 h,T 12β=40.632 h,AUC=65.161 mg.L-1.h,CL(s)=0.153 ***-1.h-1。腹腔给药后绝对生物利用度是66.2%。结论癌光啉在兔体内吸收快、起效快、消除快,无蓄积现象,给药方式不同,药代动力学特点不同。

关键词：药代动力学癌光啉新西兰兔荧光血浆生物利用度

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming li Jianfeng li Guoliang chen Tao lin Penghui Zhang Kuileung Tong Ningning chen Shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2