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TRIM14 promotes endothelial activation via activating NF-κB signaling pathway

Journal of Molecular Cell Biology 2020年第3期12卷 176-189页

作者： Xuan huang Yong Li Xiuzhen Li Daping Fan hong-bo Xin Mingui Fu Institute of Translational Medicine Nanchang UniversityNanchang 330031China Department of Biomedical Science and Shock/Trauma Research Center School of MedicineUniversity of Missouri-Kansas CityKansas CityMO 64108USA Department of Cell Biology and Anatomy University of South Carolina School of MedicineColumbiaSC 29209USA

Endothelial activation by proinflammatory cytokines is closely associated to the pathogenesis of atherosclerosis and other vascular diseases;however, the molecular mechanisms controlling endothelial activation are not fully understood. Here we identify TRIM14 as a new positive regulator of endothelial activation via activating NF-κB signal pathway. TRIM14 is highly expressed in human vascular endothelial cells (ECs) and markedly induced by inflammatory stimuli such as TNF-α, IL-1β, and LPS. Overexpression of TRIM14 significantly increased the expression of adhesion molecules such as VCAM-1, ICAM-1, E-selectin, and cytokines such as CCL2, IL-8, CXCL-1, and TNF-α in activated ECs and by which it facilitated monocyte adhesion to ECs. Conversely, knockdown of TRIM14 has opposite effect on endothelial activation. Upon TNF-α stimulation, TRIM14 is recruited to IKK complex via directly binding to NEMO and promotes the phosphorylation of IκBα and p65, which is dependent on its K63-linked ubiquitination. Meanwhile, p65 can directly bind to the promoter regions of human TRIM14 gene and control its mRNA transcription. Finally, TRIM14 protein level is significantly upregulated in mouse and human atheroma compared to normal arteries. Taken together, these results indicate that TRIM14-NF-κB forms a positive feedback loop to enhance EC activation and TRIM14 may be a potential therapeutic target for vascular inflammatory diseases such as atherosclerosis.

关键词： TRIM14 NF-κB endothelial activation atherosclerosis

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椎体骨皮质强化差异对骨质疏松性椎体压缩性骨折生物力学的影响

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中国组织工程研究 2025年第21期29卷 4430-4438页

作者：方伟黄兴桦屈波杨红胜重庆市云阳县中医院骨伤科重庆市404500 成都医学院附属第一医院骨科四川省成都市610500

背景:骨质疏松性椎体压缩性骨折经皮椎体成形过程中骨水泥在椎体内的骨皮质强化区域对脊柱生物力学及临床疗效有重要影响,但以往研究大多局限于二维层面。目的:采用有限元分析法探讨经皮椎体成形过程中骨水泥在椎体三维层面内骨皮质强... 详细信息

背景:骨质疏松性椎体压缩性骨折经皮椎体成形过程中骨水泥在椎体内的骨皮质强化区域对脊柱生物力学及临床疗效有重要影响,但以往研究大多局限于二维层面。目的:采用有限元分析法探讨经皮椎体成形过程中骨水泥在椎体三维层面内骨皮质强化差异对骨质疏松性椎体压缩性骨折椎体、邻近椎间盘及终板生物力学分布的影响,以评估其效果。方法:建立T12椎体骨质疏松性压缩性骨折行经皮椎体成形治疗的有限元模型,从横断面、矢状面、冠状面对骨水泥有无皮质强化情况进行分组分析,研究不同体位变化下,骨皮质强化对T12椎体松质骨、皮质骨、T11/T12椎间盘、T12/L1椎间盘、T11下终板、L1上终板生物力学的影响。结果与结论:(1)在垂直压缩力作用下,经皮椎体成形过程中有或无骨水泥皮质强化在不同体位变化下除伤椎皮质骨以外结构应力变化均不明显;(2)伤椎皮质骨Von Mises应力值在人体前屈、左/右侧弯和左/右轴向旋转时差异显著,同一平面内骨皮质完全强化组较无骨皮质强化组最大Von Mises应力值明显变小,随着骨皮质强化越广泛Von Mises应力值整体呈下降趋势;(3)提示行经皮椎体成形治疗时,横断面内骨水泥应尽量广泛对称水平分布于椎体骨皮质边缘,矢状面内骨水泥应广泛纵向分布且靠近上下终板及前后壁,冠状面内骨水泥应广泛分布于中线两侧同时对称接触上下终板及侧壁,可有效避免伤椎再骨折风险且不增加邻椎骨折、残留盘源性疼痛风险。

关键词：经皮椎体成形骨皮质强化骨质疏松性椎体压缩性骨折邻近椎间盘终板三维有限元分析生物力学

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A virtual network mapping algorithm based on integer programming

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第12期14卷 899-908页

作者： bo LU Jian-ya CHEN hong-yan CUI Tao huang Yun-jie LIU Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and Telecommunications

The virtual network(VN) embedding/mapping problem is recognized as an essential question of network virtualization. The VN embedding problem is a major challenge in this field. Its target is to efficiently map the virtual nodes and virtual links onto the substrate network resources. Previous research focused on designing heuristic-based algorithms or attempting two-stage solutions by solving node mapping in the first stage and link mapping in the second stage. In this study, we propose a new VN embedding algorithm based on integer programming. We build a model of an augmented substrate graph, and formulate the VN embedding problem as an integer program with an objective function and some constraints. A factor of topology-awareness is added to the objective function. The VN embedding problem is solved in one stage. Simulation results show that our algorithm greatly enhances the acceptance ratio, and increases the revenue/cost(R/C) ratio and the revenue while decreasing the cost of the VN embedding problem.

关键词： Virtual network embedding Integer programming Topology-awareness Network virtualization

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Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2018年第6期24卷 693-705页

作者： Tian-Ran Zhou Jing-Jing huang Zi-Tong huang hong-Ying Cao bo Tan The Research Center for Integrative Medicine School of Basic Medical Sciences Guangzhou University of Chinese Medicine School of Chinese Materia Medica Guangzhou University of Chinese Medicine

AIM To elucidate the mechanism of patchouli alcohol(PA) in treatment of rat models of diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS We studied the effects of PA on colonic spontaneous motility using its cumulative log concentration(3 × 10^(-7) mol/L to 1 × 10^(-4)mol/L). We then determined the responses of the proximal and distal colon segments of rats to the folowing stimuli:(1) carbachol(1 × 10^(-9) mol/L to 1 × 10^(-5) mol/L);(2) neurotransmitter antagonists including N~ω-nitro-l-arginine methyl ester hydrochloride(10μmol/L) and(1 R~*, 2 S~*)-4-[2-Iodo-6-(methylamino)-9 Hpurin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt(1 μmol/L);(3) agonist α,β-methyleneadenosine 5′-triphosphate trisodium salt(100 μmol/L); and(4) single KCl doses(120 mmol/L). The effects of blockers against antagonist responses were also assessed by pretreatment with PA(100 μmol/L) for 1 min. Electrical-field stimulation(40 V, 2-30 Hz, 0.5 ms pulse duration, and 10 s) was performed to observe nonadrenergic, noncholinergic neurotransmitter release in IBS-D rat colon. The ATP level of Kreb's solution was also *** PA exerted a concentration-dependent inhibitory effect on the spontaneous contraction of the colonic longitudinal smooth muscle, and the half maximal effective concentration(EC_(50)) was 41.9 μmol/L. In comparison with the KCl-treated IBS-D group, the contractile response(mg contractions) in the PA + KCl-treated IBS-D group(11.87 ± 3.34) was significantly decreased in the peak tension(P < 0.01). Compared with CCh-treated IBS-D rat colon, the cholinergic contractile response of IBS-D rat colonic smooth muscle(EC_(50) = 0.94 μmol/L) was significantly decreased by PA(EC_(50) = 37.43 μmol/L)(P < 0.05). Lack of nitrergic neurotransmitter release in stress-induced IBS-D rats showed contraction effects on colonic smooth muscle. Pretreatment with PA resulted in inhibitory effect on l-NAME-induced(10 μmol/L) con

关键词： Patchouli alcohol Colonic longitudinal smooth muscles Diarrhea-predominant irritable bowel syndrome Enteric nervous system Cholinergic nerves Non-adrenergic non-cholinergic Potassium channel

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Mechanoluminescent-Triboelectric Bimodal Sensors for Self-Powered Sensing and Intelligent Control

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Nano-Micro Letters 2023年第5期15卷 313-325页

作者： bo Zhou Jize Liu Xin huang Xiaoyan Qiu Xin Yang hong Shao Changyu Tang Xinxing Zhang State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065People’s Republic of China Chengdu Development Center of Science and Technology China Academy of Engineering PhysicsChengdu 610200People’s Republic of China

Self-powered flexible devices with skin-like multiple sensing ability have attracted great attentions due to their broad applications in the Internet of Things(IoT).Various methods have been proposed to enhance mechano-optic or electric performance of the flexible devices;however,it remains challenging to realize the display and accurate recognition of motion trajectories for intelligent ***,we present a fully self-powered mechanoluminescent-triboelectric bimodal sensor based on micronanostructured mechanoluminescent elastomer,which can patterned-display the force *** deformable liquid metals used as stretchable electrode make the stress transfer stable through overall device to achieve outstanding mechanoluminescence(with a gray value of 107 under a stimulus force as low as 0.3 N and more than 2000 cycles reproducibility).Moreover,a microstructured surface is constructed which endows the resulted composite with significantly improved triboelectric performances(voltage increases from 8 to 24 V).Based on the excellent bimodal sensing performances and durability of the obtained composite,a highly reliable intelligent control system by machine learning has been developed for controlling trolley,providing an approach for advanced visual interaction devices and smart wearable electronics in the future IoT era.

关键词： Bimodal sensors Mechanoluminescence Triboelectric nanogenerator Intelligent control Self-powered

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Formic acid dehydrogenation reaction on high-performance Pd_(x)Au_(1−x) alloy nanoparticles prepared by the eco-friendly slow synthesis methodology

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Frontiers in Energy 2023年第6期17卷 751-762页

作者： Yibo GAO Erjiang HU bo huang Zuohua huang State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Institute of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 712000China

Dehydrogenation of formic acid (FA) is considered to be an effective solution for efficient storage and transport of hydrogen. For decades, highly effective catalysts for this purpose have been widely investigated, but numerous challenges remain. Herein, the Pd_(x)Au_(1−x) (x = 0, 0.2, 0.4, 0.5, 0.6, 0.8, 1) alloys over the whole composition range were successfully prepared and used to catalyze FA hydrogen production efficiently near room temperature. Small PdAu nanoparticles (5–10 nm) were well-dispersed and supported on the activated carbon to form PdAu solid solution alloys via the eco-friendly slow synthesis methodology. The physicochemical properties of the PdAu alloys were comprehensively studied by utilizing various measurement methods, such as X-ray diffraction (XRD), N2 adsorption–desorption, high angle annular dark field-scanning transmission electron microscope (HAADF-STEM), X-ray photoelectrons spectroscopy (XPS). Notably, owing to the strong metal-support interaction (SMSI) and electron transfer between active metal Au and Pd, the Pd0.5Au0.5 obtained exhibits a turnover frequency (TOF) value of up to 1648 h−1 (313 K, nPd+Au/nFA = 0.01, nHCOOH/nHCOONa = 1:3) with a high activity, selectivity, and reusability in the FA dehydrogenation.

关键词： FA dehydrogenation face-centred cubic structures PdAu solid solution alloy nanoparticles slow synthesis methodology SMSI effect

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Nonhypertensive male with multiple paragangliomas of the heart and neck:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5707-5714页

作者： Qi Wang Zhe-Yong huang Jun-bo Ge Xian-hong Shu Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China

BACKGROUND Paraganglioma is a rare disease that can be lethal if ***,quick recognition is very *** paragangliomas are found in patients who have *** classic symptoms are the triad of headaches,palpitations,and profuse *** describe a very rare case of multiple paragangliomas of the heart and bilateral carotid artery without hypertension and outline the management strategies for this *** SUMMARY A 46-year-old man presented with the chief complaint of recently recurrent chest pain with a history of hemangioma of the bilateral carotid artery that had been surgically *** was found to have an intracardiac mass in the right atrioventricular groove and underwent successful *** final pathology demonstrated that the intracardiac mass was a cardiac paraganglioma,and the patient had an increased level of normetanephrine in the *** pathology and immunohistochemistry results showed that the bilateral carotid masses were also *** the 3 mo follow-up period,the patient did not experience recurrence of chest *** To our knowledge,this is the first case of multiple paragangliomas of the heart and neck without *** rare disease can be lethal if left ***,quick recognition is very *** key to the diagnosis of cardiac paraganglioma is the presence of typical symptoms,including headaches,palpitations,profuse sweating,hypertension,and chest *** can demonstrate the intracardiac *** is important to determine the levels of normetanephrine in the *** detection of genetic mutations is also *** resection is necessary to treat the disease and obtain pathological evidence.

关键词： Chest pain Intracardiac mass Cardiac paraganglioma Normetanephrine Pathological evidence Case report

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Synergistic Effects of Gamma Irradiation,Tensile Stress and Moisture on the Radiolysis of Silicone Foam

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Chinese Journal of Polymer Science 2023年第12期41卷 1969-1978,I0011页

作者： Pu-Cheng Wang Qiang Liu bo Liu Wei huang You An Jian-Yong Liu hong-Bing Chen Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621000China

The present work involves the investigation of the synergistic effects of gamma irradiation,tensile stress and absorbed moisture on the radiolysis behaviors of silicone foams by experiments and theoretical *** both the pristine and dehydrated samples,the permanent tensile set increases with the initial tensile *** analysis uncovers that the dehydrated samples exhibit greater permanent tensile sets,lower further elongation and higher Young’s modulus than the counterparts of the pristine samples with the same initial tensile strain and gamma dose,verifying the vital synergistic effects on crosslinking network and aggregation structures caused by moisture and gamma *** synergistic effects unveiled by reactive molecular dynamics at the atomic scale are due to the moisture-induced neutralization and stabilization of the macromolecular *** steric hindrance of moisture located at the interface of silica and polymer chains also conduces to the observed synergistic effects due to the inhibited crosslinking reactions.

关键词： Silicone foam Synergistic effect Gamma irradiation Tensile stress Moisture

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Large-scale production of holey graphite as high-rate anode for lithium ion batteries

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Journal of Energy Chemistry 2020年第9期29卷 122-127,I0004页

作者： Feng Xiao Xianghong Chen Jiakui Zhang Chunmao huang Tong Hu bo hong Jiantie Xu Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control National Engineering Laboratory for VOCs Pollution Control Technology and EquipmentSchool of Environment and EnergySouth China University of TechnologyGuangzhou 510640GuangdongChina School of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina

Lithium ion batteries(LIBs)have been widely used in portable and smart devices because of their high energy densities,long cycle life and environmental *** order to meet the evergrowing demand for human-beings utilizi... 详细信息

关键词： H2O Holey graphite Rate capability Anode Lithium ion batteries

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Gas channeling control with an in-situ smart surfactant gel during water-alternating-CO_(2) enhanced oil recovery

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Petroleum Science 2023年第5期20卷 2835-2851页

作者： Xin-Jie Luo Bing Wei Ke Gao bo Jing bo huang Ping Guo hong-Yao Yin Yu-Jun Feng Xi Zhang Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500SichuanChina National Key Laboratory of Offshore Oil Exploitation CNOOC Research Institute Ltd.Beijing 102209China

Undesirable gas channeling always occurs along the high-permeability layers in heterogeneous oil reservoirs during water-alternating-CO_(2)(WAG)flooding,and conventional polymer gels used for blocking the“channeling”paths usually suffer from either low injectivity or poor gelation ***,we for the first time developed an in-situ high-pressure CO_(2)-triggered gel system based on a smart surfactant,N-erucamidopropyl-N,N-dimethylamine(UC22AMPM),which was introduced into the aqueous slugs to control gas channeling inWAG *** water-like,low-viscosity UC22AMPM brine solution can be thickened by high-pressure CO_(2) owing to the formation of wormlike micelles(WLMs),as well as their growth and shear-induced structure buildup under shear *** thickening power can be further potentiated by the generation of denser WLMs resulting from either surfactant concentration augmentation or a certain range of heating,and can be impaired via pressurization above the critical pressure of CO_(2) because of its soaring solvent *** flooding tests using heterogeneous cores demonstrated that gas channeling was alleviated by plugging of high-capacity channels due to the in-situ gelation of UC22AMPM slugs upon their reaction with the pre-or post-injected CO_(2) slugs under shear flow,thereupon driving chase fluids into unrecovered low-permeability areas and producing an 8.0% higher oil recovery factor than the conventional WAG *** smart surfactant enabled high injectivity and satisfactory gelation control,attributable to low initial viscosity and the combined properties of one component and CO_(2)-triggered gelation,*** work could provide a guide towards designing gels for reducing CO_(2) spillover and reinforcing the CO_(2) sequestration effect during CO_(2) enhanced oil recovery processes.

关键词： CO_(2)flooding Enhanced oil recovery Gas channeling Water-alternating-CO_(2) Smart surfactant Gel

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