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Thrombus aspiration plus intra-infarct-related artery administration of tirofiban improves myocardial perfusion during primary angioplasty for acute myocardial infarction

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chinese Medical Journal 2010年第7期123卷 877-883页

作者： yan hong-bing li Shi-ying song li wang jian wu zheng chi yun-peng zheng bin zhao han-jun li Qing-xiang ZhanG Xiao-jiang li Wen-zheng 8th Division Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background We developed a new combined strategy of thrombus aspiration plus intra-infarct-related artery （IRA） bolus administration of tirofiban via the aspiration catheter in patients with ST-segment elevation myocardial infarction （STEMI）. This strategy can reduce the distal embolism and achieve highly localized concentrations of tirofiban, which can improve myocardial reperfusion without increasing the risk of bleeding. The aim of this study was to investigate whether this combined strategy is superior to thrombus aspiration alone in improving myocardial perfusion in patients with STEMI undergoing primary *** Baseline characteristics of the two groups were well-balanced. The TIMI 3 flow showed a better tendency in the intra-IRA group than in the aspiration alone group （97.22% vs. 87.04%, X2=7.863, P=0.049）. The peak of CK-MB （83.9 （68.9-310.5） U/L vs. 126.1 （74.7-356.7） U/L, P=0.034） and Tnl （42.7 （14.7-113.9） ng/ml vs. 72.5 （59.8-135.3） ng/ml, FMD.029） were lower in the intra-IRA group than in the aspiration alone group. LVEF in the hospital favored the intra-IRA group, （45.7±8.3）% to （42.9±12.1）%, t=1.98, P=0.049. There was a tendency towards a lower MACE at 9-month follow-up in the intra-IRA group although it did not reach statistical difference （Log-rank X2=2.865, P=0.09）. There was no statistical difference in any bleeding events between the two *** Thrombus aspiration plus intra-IRA bolus administration of tirofiban combined with angioplasty may be related with improved myocardium perfusion, saved more myocardium, and resulted in a better clinical prognosis.

关键词： myocardial infarction tirofiban primary angioplasty thrombus aspiration myocardial perfusion

Comparison of Diver CE and ZEEK manual aspiration catheters for thrombectomy in ST-segment elevation myocardial infarction

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chinese Medical Journal 2009年第6期122卷 648-654页

作者： zhao han-jun yan hong-bing wang jian song li li Qing-xiang li Shi-ying chi yun-peng wu zheng ZhanG Xiao-jiang zhao Yong zheng bin 28th Division Beijing Anzhen Hospital of Capital Medical University Beijing 100029 China

Background A growing volume of data suggests that simple manual thrombus aspiration followed by direct stenting improves myocardial reperfusion and clinical outcome compared with conventional primary PCI, but there is still limited data comparing the in vivo performance among different devices. This study aimed to compare the efficacy and operability of thrombus aspiration by the Diver CE （Invatec, Brescia, Italy） and ZEEK （Zeon Medical Inc., Tokyo, Japan） aspiration catheters in ST-segment elevation myocardial infarction （STEMI） and their impact on 3-month outcome.Methods From September 2004 to june 2008, 298 consecutive patients with STEMI who received manual thrombus aspiration were involved in a single center retrospective analysis. Of them, 229 and 69 were treated with Diver CE and ZEEK aspiration catheters, respectively. Primary endpoints were myocardial blush grade （MBG）, thrombolysis in myocardial infarction （TIMI） flow grade, ST-segment elevation resolution （STR）, device pushability and trackability as judged by the frequency of usage of dual guide wires and aspiration efficacy as indicated by size distribution of aspirated thrombi. Secondary endpoints were 3-month outcome including left ventricular end diastolic diameter （LVEDD）, left ventricular ejection fraction （LVEF）, as well as cardiac death, target lesion revascularization （TLR）, re-infarction and their combination as major adverse cardiac events （MACE）. Results Baseline characteristics were not different between the two groups expect for a higher frequency of temporary cardiac pacing in the ZEEK group （ZEEK） than in the Diver CE group （Diver CE）（0.44% vs 5.8%, P=0.002）. Visible retrieved thrombi were achieved in 65.9% of the Diver CE and 68.1% of the ZEEK （P=0.74）. Aspirated thrombi were categorized as small thrombi （〈3.5 mm）, moderate thrombi （3.5-7.0 mm） and large thrombi （〉7.0 mm）. Small thrombi were more frequently seen in the Diver CE （61.6% vs 42.6%）, whereas moderate and larger thrombi wer

关键词： primary percutaneous coronary intervention ST-segment elevation myocardial infarction manual thrombus aspiration

Associated factors with repeat coronary angioplasty during the drug eluting stent era： a high volume center investigation

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chinese Medical Journal 2013年第3期126卷 446-449页

作者： liU Chen yan hong-bing zhao han-jtm song li zheng bin chi yun-peng wang Shao-ping wang jian peng hong-yu wu zheng Department of Cardiology Cardiovascular Institute & Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Repeat percutaneous coronary intervention （PCI） is associated with unfavorable prognosis in patients with coronary artery disease, but there is a current lack of related systematic cross-sectional studies in china. The survey was to investigate a real world of repeat PCIs and their associated factors during the drug eluting stent era in a Beijing high volume center. Methods A comprehensive review of the institution＇s database between January 2006 and July 2009 was conducted. Demographic information, concomitant diseases, peri-procedure laboratory examinations and angiographic features were collected consecutively. Multivariate Logistic regression analysis was undertaken to explore the risk factors associated with repeat PCIs. Results A total of 13404 patients were included in the analysis. Of which, 1946 patients （14.5%） had prior PCI procedure. More males patients had previous PCI than the females （15.7% vs 10.9%, P 〈0.001）. After adjustment for age, gender, concomitant diseases, angiographic and procedural factors, a multivariate model showed that male, diabetes, hyperlipidemia and previous myocardial infarction, left main disease were identified as independent risk factors of repeat PCIs. Of which, previous myocardial infarction （odds ratio： 2.58, 95% confidence interval： 2.27-2.92） was highly related with repeat PCIs. Conclusion The frequency of repeat PCIs was 14.5% in this cross-sectional investigation, and their associated factors included male, diabetes, hyperlipidemia and previous MI and left main disease during drug eluting stent era.

关键词： percutaneous coronary intervention repeat coronary artery disease

Is it necessary to stent renal artery stenosis patients before cardiopulmonary bypass procedures？

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chinese Medical Journal 2011年第10期124卷 1453-1457页

作者： zheng bin yan hong-bing liU Rui-fang CHENG Shu-juan wang jian zhao han-jun song li Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Acute kidney injury （AKI） is associated with poor prognosis after cardiopulmonary bypass. The aim of this retrospective study was to investigate whether stent implantation before cardiopulmonary bypass has beneficial effect on development of AKI in renal artery stenosis （RAS） *** In this retrospective study, patients with abnormal baseline serum creatinine （SCr, 〉106 μmol/L） were not included. Included patients （n=69） were divided into two groups. Group 1 included 31 RAS patients receiving no stent implantation before cardiopulmonary bypass. Group 2 included 38 RAS patients having received stent implantation just before cardiopulmonary bypass. To assess AKI after cardiopulmonary bypass, serum urea nitrogen, SCr and creatinine clearance were recorded at baseline, at the end of operation, during the first and second postoperative 24 *** Baseline characteristics were similar between groups. Serum urea nitrogen, SCr, creatinine clearance before and after cardiopulmonary bypass were also similar class groups. Incidence of AKI in group 1 was not significantly different from group 2. In group 1, AKI defined by RIFLE between occurred in 7 （22.6%） patients： 5 （16.1%） with RIFLE-R,2 （6.5%） with RIFLE-I, and no patients with RIFLE-F. In group 2, 10 patients （26.3%） had an episode of AKI during hospitalization： 6 （15.8%） had RIFLE-R, 4 （10.5%） had RIFLE-I, and no patients had *** There are no data suggesting that it is necessary to stent RAS patients with normal SCr before cardiopulmonary bypass. However, it cannot be concluded that RAS is not associated with AKI after cardiopulmonary bypass

关键词： renal insufficiency cardiopulmonary bypass peripheral vascular disease renal artery

Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3298-3312页

作者： zheng-Wei Zhang Chun-Sheng Gao Heng Zhang jian yang Ya-Ping wang li-bin Pan hang Yu chi-Yu He Hai-bin Luo Zhen-Xiong zhao Xin-Bo Zhou Yu-li wang Jie Fu Pei han Yu-Hui Dong Gang wang song li yan wang jian-Dong jiang wu Zhong State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Beijing Institute of Pharmacology and Toxicology Beijing 100000China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China School of Pharmaceutical Sciences Hainan UniversityHainan 570228China National Engineering Research Center for the Emergence Drugs Beijing 100000China

Morinda officinalis oligosaccharides(MOO) are an oral drug approved in china for the treatment of depression in china. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota.

关键词： Depression Morinda oficinalis oligosaccharides Gut microbiota Tryptophan hydroxylase 5-Hydroxytryptophan decarboxylase 5-Hydroxytryptophan Serotonin Drug metabolism

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(ChanCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li Ming-Sheng Huang Wei-Zhu yang Guo-Wen Yin bin-yan Zhong jun-Hui Sun Zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-bin Ding Wen-Hui li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping li Hui zhao Shu-Wei Wen yan-Ming Lei Yu-Sheng song Chun-wang Yuan Wei-Dong wang Ming Huang Wei zhao jian-bing wu song wang Xu Zhu jian-jun han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu hong-Ying Su Chuan-Sheng zheng Yong Chen Xu-Ya zhao Zhu-Ting Fang Qi wang Jin-Wei zhao Ai-bing Xu jian Xu Qing-Hua wu Huan-Zhang Niu jian wang Feng Dai Dui-Ping Feng Qing-Dong li Rong-Shu Shi Jia-Rui li Guang yang Hai-bin Shi jian-song Ji Yu-E liu zheng Cai Po yang yang zhao Xiao-li Zhu li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;Pbination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

M Dwarf catalog of LAMOST general survey data release one

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Research in Astronomy and Astrophysics 2015年第8期15卷 1182-1196页

作者： yan-Xin Guo Zhen-Ping Yi A-li Luo You-Fen wang Yu Bai Hai-Feng yang Yi-han song jian-jun Chen Xiao-yan Chen Fang Zuo bing Du jian-Nan Zhang Yin-Bi li Xiao Kong Meng-Xin wang Yue wu Ke-Fei wu Yong-Heng zhao Yong Zhang Yong-Hui Hou Yue-Fei wang Ming yang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences University of chinese Academy of Sciences School of Mechanical Electical & Information EngineeringShandong University at Weihai School of Computer Science and Technology Taiyuan University of Science and Technology Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contamination was eliminated using2 MASS photometry and Ca H/TiO molecular indices. For each spectrum, the spectral subtype and values are provided including radial velocity, Hα equivalent width, a series of prominent molecular band indices, and the metal–sensitive parameter ζ, as well as distances and the space motions for high S/N objects. In addition, Hα emission lines are measured to examine the magnetic activity properties of M dwarfs and 7179 active ones are found. In particular, a subsample with significant variation in magnetic activity is revealed through observations from different epochs. Finally, statistical analysis for this sample is performed, including the metallicity classification, the distribution of molecular band indices and their errors.

关键词： catalogs—methods: analytical—stars: statistical—stars : late-type—stars: magnetic-activity—stars

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng zhao Gang zhao li-Cai Deng Xiao-Wei liu Yi-peng Jing Gang wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue wu yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong bing Du Dong-Wei Fan Lei Feng jian-Ning Fu peng Gao Xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-Wen han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li Ye-Ping li Yuan liang chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-jun Ni zhao-Xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi Jing song Yi-han song Ding-Qiang Su hong-jun Su zheng-hong Tang Qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang hong-chi wang jian wang Jia-Ning wang jian-ling wang jian-Ping wang jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang peng Wei Ming-Zhi Wei hong wu Ke-Fei wu Xue-bing wu Yu-Zhong wu Xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-peng Zhang Hua-Wei Zhang jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang yan-Xia Zhang zheng-Chao Zhang Ming zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of china Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi peng Dong-Ya Guo zheng-Hua An Ke Gong Jin-Yuan liao yan-Qiu Zhang Yue Huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi peng Zhang Qi-bin Yi Chao-yang li yan-bing Xu Xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng yang Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi zhao wang-Chen Xue Chao zheng Jia-Cong liu Xing-Bo han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo li Ping wang Xin-Ying song li-Ming song Shi-Jie zheng bing li hong-Mei Zhang Yue Zhu Wei Chen jian-jian He Zhen Zhang Jin Hou hong-jun wang yan-Chao Hao Xiang-Yu wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan yan-Guo li Gang li Xu-Fang li Fang-jun Lu hong Lu bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-peng Xu Jia-Wei yang Xue-Juan yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational