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Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第7期10卷 512-521页

作者： Rui CHEN Shao-hong LU Qun-bo TONG Di LOU Dong-yan SHI bing-bing jia Guo-ping HUANG Jin-fu WANG College of Life Sciences Zhejiang University Hangzhou 310058 China Institute of Parasitology Zhejiang Academy of Medical Science Hangzhou 310013 China

The dense granule protein 4 （GRA4） is a granular protein from Toxoplasma gondii, and is a candidate for vaccination against this parasite. In this study, the plasmid pcDNA3, 1-GRA4 （pGRA4）, encoding for the GRA4 antigen, was incorporated by the dehydration-rehydration method into liposomes composed of 16 mmol/L egg phosphatidylcholine （PC）, 8 mmol/L dioleoyl phosphatidylethanolamine （DOPE）, and 4 mmol/L 1,2-diodeoyl-3-（trimethylammonium） propane （DOTAP）. C57BL/6 mice and BALB/c mice were immunized intramuscularly three times with liposome-encapsulated pGRA4 to determine whether DNA immunization could elicit a protective immune response to T. gondii. Enzyme-linked immunosorbent assay （ELISA） of sera from immunized mice showed that liposome-encapsulated pGRA4 generated high levels of IgG antibodies to GRA4. Production of primary interferon （IFN）-7 and interleukin （IL）-2 in GRA4-stimulated splenocytes from vaccinated mice suggested a modulated Th 1-type response. 72.7% of C57BL/6 mice immunized with liposome-encapsulated pGRA4 survived the challenge with 80 tissue cysts of ME49 strain, whereas C57BL/6 mice immunized with pGRA4 had only a survival rate of 54.5%. When immunized BALB/c mice were intraperitoneally challenged with 103 tachyzoites of the highly virulent RH strain, the survival time of mice immunized with liposome-encapsulated pGRA4 was markedly longer than that of other groups. Our observations show that liposome-encapsulated pGRA4 enhanced the protective effect against infection of T. gondii.

关键词： DNA vaccine Granule protein 4 (GRA4) Liposome Toxoplasma gondii

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang jia-Zhu Wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Trends of 7 Organic Solvent-induced Occupational Diseases in Guangdong,from 2006 to 2015

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Biomedical and Environmental Sciences 2020年第11期33卷 862-866页

作者： LI Xu Dong TU hong Wei CHEN jia bing YU hong Wei ZHANG Run Ze CHEN Pei Liang HU Shi Jie Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina Guangodng Provincial Center for Diseases Control and Prevention Guangzhou 511430GuangdongChina Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina

Occupational exposure to organic solvents and the resulting health damage caused by organic solvent-induced occupational diseases(OSODs)have raised concern[1],as they have accounted for more than 70%of occupational-poisoning cases in Guangdong province[2,3].However,there have been limited longitudinal studies examining OSOD patterns and temporal trends with a large sample in Guangdong.

关键词： Guangdong raised Occupational

The evolution and failure mechanism of lithium metal anode under practical working conditions

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Journal of Energy Chemistry 2020年第9期29卷 424-425,I0012页

作者： jia Liu hong Yuan Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing 100083China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Lithium(Li)metal is regarded as a promising anode material to render the Li batteries with high energy density and therefore satisfy the ever-growing energy demands of high-end storage devices[1].Unfortunately,the dendrite growth accompanied with accumulation of"dead Li"leads to low Coulombic efficiency,poor cycling lifespan,and even severe safety hazards,critically hindering the practical implementation of Li metal batteries[2,3].

关键词： Practical lithium metal anode Electrochemical diagram Failure mechanism Plating/stripping behavior

Crystal growth and electrical transport properties of niobium and tantalum monopnictide and dipnictide semimetals

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Frontiers of physics 2017年第3期12卷 1-17页

作者： hong Lu Shuang jia International Center for Quantum Materials School of Physics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

The discovery of the first Weyl semimetal tantalum monoarsenide has greatly promoted physical re- search on the niobium and tantalum pnictide compounds. Crystallizing into the NbAs- and OsGe2-type structures, these mono-and di-pnictide semimetals manifest exotic electrical transport properties in magnetic field, which only occur in their single-crystalline forms. All the unusual electrical properties correspond to their poor carriers, which are indeed vulnerable to various crystal defects. In this review article, we present a comprehensive comparison of the crystal growth and electrical transport prop- erties of the two semimetal families. We then discuss in detail the possible characteristic transport features, such as the chiral anomaly of Weyl quasiparticles. We emphasize the importance of crystal growth and sample manipulation for exploring the unique topological properties of Weyl semimetals in the future.

关键词： Weyl semimtal crystal growth electrical transport

Random-injection-based two-channel chaos with enhanced bandwidth and suppressed time-delay signature by mutually coupled lasers: Proposal and numerical analysis

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Chinese Physics B 2021年第1期30卷 239-247页

作者： Shi-Rong Xu Xin-hong jia Hui-Liang Ma jia-bing Lin Wen-Yan Liang Yu-Lian Yang College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China

Simultaneous bandwidth(BW) enhancement and time-delay signature(TDS) suppression of chaotic lasing over a wide range of parameters by mutually coupled semiconductor lasers(MCSLs) with random optical injection are proposed and numerically investigated. The influences of system parameters on TDS suppression(characterized by autocorrelation function(ACF) and permutation entropy(PE) around characteristic time) and chaos BW are investigated. The results show that, with the increasing bias current, the ranges of parameters(detuning and injection strength) for the larger BW(> 20 GHz) are broadened considerably, while the parameter range for optimized TDS( 20 GHz)and perfect TDS suppression. In addition, the system can generate two-channel high-speed truly physical random number sequences at 200 Gbits/s for each channel.

关键词： random distributed feedback-based optical injection two-channel chaos lasing bandwidth enhancement and time-delay signature suppression physical random number generation

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脑卒中全周期康复的思考与策略

中国全科医学 2025年第2期28卷 129-134页

作者：贾杰复旦大学附属华山医院康复医学科上海市200040 福建医科大学附属第一医院福建省福州市350004 国家老年疾病临床医学研究中心(华山) 上海市200040 国家神经疾病医学中心上海市200040 国家区域医疗中心福建省福州市350000

脑卒中后患者常会遗留不同程度功能障碍,从医疗机构返回至社区家庭过程中,需要各级医疗机构配合互动、上下转介,形成良好的全周期康复闭环。目前,脑卒中全周期康复的落地应用正逐步推进,但仍存在一些阻力。本文以脑卒中全周期康复理念... 详细信息

脑卒中后患者常会遗留不同程度功能障碍,从医疗机构返回至社区家庭过程中,需要各级医疗机构配合互动、上下转介,形成良好的全周期康复闭环。目前,脑卒中全周期康复的落地应用正逐步推进,但仍存在一些阻力。本文以脑卒中全周期康复理念为基础,结合脑卒中社区康复发展现状,思考脑卒中全周期康复-社区康复环节的发展,强调“社区拐点康复”的重要意义以及基层社区康复标准建立的必要性,重视脑卒中患者康复的全周期阶段,探讨社区基层康复的发展策略,切实提高脑卒中患者社区及家庭生存质量。

关键词：脑卒中全周期康复社区康复康复标准

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The Post-Embryonic Development of Digestive System and the Demand of Energy of Hucho taimen

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Agricultural Sciences in China 2010年第2期9卷 286-293页

作者： GUAN Hai-hong XU Qi-you ZHI bing-jie KUANG You-yi XU Wei YIN jia-sheng Heilongjiang River Fisheries Research Institute Chinese Academy of Fishery Sciences Harbin 150070 P.R.China

With the technology of morphology, histology and nutrition, the characteristics of organ development and the source and demand of nutritional at different stages in post-embryonic （water temperature 3-14℃） of Hucho taimen were discussed. The results showed that the membrane of H. taimen fertilized ovum was ruptured in 30 d, the prototype of U-type stomach was formed, the mouth could open and close freely, and nutrition was supplied from its yolk sac. The membrane ruptured after 8 d, teeth formed, and anus communicated with outsiders. The oropharyngeal cavity, esophagus, U-type stomach, intestine, and anus initially formed in the digestive tube, which nutrition was supplied from the huge yolk sac. The membrane ruptured after 16 d, pancreas and pyloric caeca appeared, larvae could intake and digest exogenous food, fish mixed nutrition, which was from yolk sac and outsiders, mainly depended on endogenous. The membrane ruptured after 24 d, the fish began floating and intaking actively, the fish mixed nutrition which mainly depended on exogenous. The membrane ruptured after 30 d, the yolk sac was completely absorbed, the function and structure of each digestive organs developed consummately, fish was from mixed nutrition into the stage of exogenous nutrition, the nutritional need of juveniles was below 10% fat, level of the optimal protein was 50%.

关键词： Hucho taimen post-embryonic development energy requirement

ALK gene copy number gain and its clinical significance in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第1期20卷 183-192页

作者： Shou-Wei jia Sha Fu Fang Wang Qiong Shao hong-bing Huang jian-Yong Shao Department of Pharmacy Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center on Cancer Medicine Department of Molecular Diagnostics Sun Yat-Sen University Cancer Center

AIM: To examine the status and clinical significance of anaplastic lymphoma kinase (ALK) gene alterations in hepatocellular carcinoma (HCC) patients.

关键词： Anaplastic lymphoma kinase gene Hepatocellular carcinoma Prognostic predictor