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Significance and interaction of bonding parameters with bonding ratio in press bonding of TC4 alloy

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Rare Metals 2016年第3期35卷 235-241页

作者： hong Li Miao-Quan Li Wei-Xin Yu hong-bin liu School of Materials Science and Engineering Northwestern Polytechnical University

The variation of bonding ratio in the press bonding of TC4 alloy at temperatures from 850 to 900℃,pressures from 10 to 30 MPa,and time from 5 to 15 min was *** bonding ratio increases with the increase of temperature,time and *** maximum bonding ratio,i.e.98 %,can be obtained at 900℃,30 MPa and 15 *** significance and interaction of bonding parameters with the bonding ratio were *** results demonstrate that the effect of pressure on the bonding ratio is the most effective and the effect of temperature is secondary,while the effect of time is not very *** interaction of bonding parameter on the bonding ratio exists but that is distinguishing in different bonding parameter *** is concluded that increasing pressure can be considered as the primary method to increase the bonding ratio.

关键词： TC4 alloy Press bonding Orthogonal design Bonding ratio

NUMERICAL SIMULATION OF WIND-INDUCED MOTION IN SUSPENDED SEDIMENT TRANSPORT

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Journal of Hydrodynamics 2007年第6期19卷 698-704页

作者： CHEN Zhi-he FANG hong-wei liu bin Department of Hydraulic Engineering State Key Laboratory of Hydro-science and Engineering Tsinghua University 100084 Beijing China

In regions with broad water surfaces such as lakes, reservoirs and coastal areas, the wind stress on the flow motion generates a significant impact. The wind stress is an unsteady force which makes numerical simulation difficult. This paper presents a two-dimensional （2-D） mathematical model of the impact of wind-induced motion on suspended sediment transport at Beijing＇s 13-Ling Reservoir. The model uses the Diagonal Cartesian Method （DCM） with a wetting-drying dynamic boundary to trace variations in the water level. The calculation results have been tested against in situ measurements. The measurements confirm the model＇s accuracy and agreement with the actual situation at the reservoir. The calculations also indicate that wind stress holds the key to suspended sediment transport at Beijing＇s 13-Ling Reservoir, especially when westerly winds prevail.

关键词： wind stress two-dimensional (2-D)mathematical model Diagonal Cartesian Method (DCM),suspended sediment transport

Sphingosine 1 phosphate receptor-1 （S1PR1） signaling protects cardiac function by inhibiting cardiomyocyte autophagy

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Journal of Geriatric Cardiology 2018年第5期15卷 334-345页

作者： Yong-Zeng CHEN Fan WANG Hai-Jun WANG hong-bin liu Department of Geriatric Cardiology Chinese People's Liberation Army General Hospital Beijing China

Objective To investigate the role of sphingosine-l-phosphate （S1P） and its receptors in cardiomyocyte autophagy, cardiomyocyte hypertrophy and cardiac function. Methods Cardiomyocytes were isolated from neonatal Vista rats. Autophagy and hypertrophy of car- diomyocytes were induced via starvation culture and phenylephrine （PE）, respectively, and S 1 P was used to treat the cardiomyocytes. The effect of S1P on cardiomyocyte autophagy was evaluated by the number of autophagosomes, the expression of autophagy-related proteins and autophagic marker genes in cardiomyocytes. The effect of S1P on cardiomyocyte hypertrophy was evaluated by examining the surface area of cardiomyoeytes and the expression of hypertrophic genes. Subsequently, different small interfering RNAs （siRNAs） were used to knockdown the expression of the three types of S 1P receptors on cardiomyocytes and to analyze the type of receptor that mediates S 1P sig- naling in cardiomyocytes. Finally, sphingosine 1 phosphate receptor-1 （S1PR1） was knockout in the mouse cardiomyocytes using the Cas9 technique. The effect of S 1PR1 on cardiac autophagy and cardiac hypertrophy was examined by assessing cardiomyocyte autophagy, car- diomyocyte hypertrophy and cardiac function. Results Starvation-induced cardiomyocyte autophagy and PE -induced cardiomyocyte hy- pertrophy were significantly attenuated by SIP. The results showed that the formation of autophagosomes was decreased, the auto- phagy-associated protein LC3 II/I and the expression of autophagic marker genes Atg5, Atgl2, Beclinl and LC3B decreased after SIP treatment. The surface area of the cardiomyocytes was decreased, and the expression of hypertrophic genes, including atrial natriuretic factor （ANF）, skeletal muscle and cardiac actin （SKA）, myosin heavy chain （β-MHC） and brain natriuretic peptide （BNP） were all decreased after S 1 P treatment. The autophagy and hypertrophy of cardiomyocytes in the S 1PR 1 knocked-down group were significantly increased c

关键词： Autophagy Cardiomyocyte Hypertrophy S1PR1

Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 736-742页

作者： Geng QIAN hong-bin liu Jin-wen WANG Chen WU Yun-dai CHEN Department of Cardiology Chinese People’s Liberation Army General Hospital

Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of 10 202 consecutive AMI patients were recruited, and mechanical complications occurred in 72 patients. AMI patients without CR were chosen as control group. Clinical characteristics including bleeding-related factors were compared between the groups. The incidences of free wall rupture (FWR), ventricular septal rupture (VSR), and papillary muscle rupture (PMR) were 0.39%, 0.21%, and 0.09%, respectively, and the hospital mortalities were 92.5%, 45.5%, and 10.0%, respectively. Female proportion and average age were significantly higher in the groups of FWR and VSR than in the control group (Pbin were found in all CR groups (P<0.01). Compared to the control group, patients with CR were more likely to receive an administration of thrombolysis [26.39% vs. 13.19%, P<0.05], and were less likely to be treated with primary percutaneous coronary intervention (PCI) [41.67% vs. 81.60%, P<0.05]. The major bleeding scores (integer scores) of FWR, VSR, and PMR were (17.70±7.24), (21.91±8.33), and (18.60±7.88), respectively, and were significantly higher than that of the control group (11.72±7.71) (P<0.05). A regression analysis identified age, increased heart rate, anemia, higher white blood cell count, and thrombolysis as independent risk factors of CR, most of which were major bleeding-related factors. The patients with CR have a significantly higher risk of hemorrhage compared to the group without CR. Risk of CR after AMI is related to the risk of hemorrhage.

关键词： Acute myocardial infarction (AMI) Risk factor Hemorrhage

High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer:A singlecenter study

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World Journal of Gastroenterology 2023年第23期29卷 3645-3657页

作者： Xiao-Meng Cao Wen-Di Kang Tian-hong Xia Shao-bin Yuan Chang-An Guo Wen-Jie Wang hong-bin liu Department of General Surgery Gansu Provincial Hospital of TCMLanzhou 730050Gansu ProvinceChina The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730030Gansu ProvinceChina Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Clinical Medicine College Ningxia Medical UniversityClinical Medicine collegeNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Emergency Lanzhou University Second HospitalLanzhou 730030Gansu ProvinceChina Department of General Surgery Lanzhou University Second HospitalLanzhou 730030Gansu ProvinceChina Department of General Surgery The 940^(th)Hospital of Joint Logistics Support Force of Chinese People's Liberation ArmyLanzhou 730050Gansu ProvinceChina

BACKGROUND The prognostic assessment of patients after surgical resection of gastric cancer(GC)patients is ***,the role of the circadian clock gene NPAS2 expression in GC remains *** To explore the relationship between NPAS2 and the survival prognosis of GC patients and clarify its role in evaluating GC *** The tumor tissues and clinical data of 101 patients with GC were collected *** staining(IHC)was used to detect the expression of NPAS2 protein in GC and adjacent *** and multivariate Cox regression analysis was used to determine the independent prognostic factors of GC,and a nomogram prediction model was *** receiver operating characteristic(ROC)curve,the ROC area under the curve,the calibration curve,and C-index were used to evaluate the predictive effectiveness of the *** Meier analysis was used to compare the risk stratification of subgroups according to the median score in the nomogram model of each *** Microarray IHC analysis showed that the positive rate of NPAS2 protein expression in GC tissues was 65.35%,which was significantly higher than 30.69%in adjacent *** high expression of NPAS2 was correlated with tumor-node-metastasis(TNM)stage(P<0.05),pN stage(P<0.05),metastasis(P<0.05),venous invasion(P<0.05),lymphatic invasion(P<0.05),and lymph node positive(P<0.05)of *** Meier survival analysis showed that the 3-year overall survival(OS)of patients with high NPAS2 expression was significantly shortened(P<0.0001).Univariate and multivariate COX regression analysis showed that TNM stage(P=0.009),metastasis(P=0.009),and NPAS2 expression(P=0.020)were independent prognostic factors of OS in GC patients for 3 *** nomogram prediction model based on independent prognostic factors has a C-Index of 0.740(95%CI:0.713-0.767).Furthermore,subgroup analysis showed that the 3-year OS time of the high-risk group was significantly lower than th

关键词： NPAS2 Gastric cancer Tissue microarray Survival analysis Prediction model Nomogram

Should atrial fibrillation patients with hypertension as an additional risk factor of the CHA2DS2-VASc score receive oral anticoagulation？

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Journal of Geriatric Cardiology 2018年第3期15卷 229-234页

作者： Juan WANG Da-Peng ZHANG hong-bin liu Jiu-Chang Zhong Xin-Chun YANG Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing China Department of Cardiology People's Liberation Army General Hospital Beijing China

Hypertension has been found to be increased a risk of stroke in atrial fibrillation （AF）. Both the European and U.S. guidelines advocate the use of the CHA2DSz-VASc （congestive heart failure, hypertension, age 〉 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category） scheme for risk stratification. Although vitamin K antagonists is more effective than acetyl-salicylic acid at preventing ischaemic stroke, its benefit is offs by an increased haemorrhage risk. The risk of ischemic stroke in patients with AF and a CHA2DS2-VASc score of 1 are considered to be low risk and may be not expected to benefit from anticoagulation therapy. Hyper-tension carries an increased risk of ischemic stroke, however, it is also a clear risk factor for hemorrhage in AF. Therefore, the optimal anti-thrombotic management is highlighted in patients with AF with only one risk factor especially hypertension.

关键词： Atrial fibrillation Hypertension Stroke

Probiotics improve survival of septic rats by suppressing conditioned pathogens in ascites

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World Journal of Gastroenterology 2013年第25期19卷 4053-4059页

作者： Da-Quan liu Qiao-Ying Gao hong-bin liu Dong-Hua Li Shang-Wei Wu Department of Pharmacology Institute of Acute Abdominal Diseases Tianjin Nankai Hospital

AIM: To investigate the benefits of probiotics treatment in septic rats. METHODS: The septic rats were induced by cecal ligation and puncture. The animals of control, septic model and probiotics treated groups were treated with vehicle and mixed probiotics, respectively. The mixture of probiotics included Bifidobacterium longum , Lacto-bacillus bulgaricus and Streptococcus thermophilus . We observed the survival of septic rats using different amounts of mixed probiotics. We also detected the bacterial population in ascites and blood of experimental sepsis using cultivation and real-time polymerase chain reaction. The severity of mucosal inflammation in colonic tissues was determined. RESULTS: Probiotics treatment improved survival of the rats significantly and this effect was dose dependent. The survival rate was 30% for vehicle-treated septic model group. However, 1 and 1/4 doses of probiotics treatment increased survival rate significantly comparedwith septic model group (80% and 55% vs 30%, P < 0.05). The total viable counts of bacteria in ascites decreased significantly in probiotics treated group compared with septic model group (5.20 ± 0.57 vs 9.81 ± 0.67, P < 0.05). The total positive rate of hemoculture decreased significantly in probiotics treated group compared with septic model group (33.3% vs 100.0%, P < 0.05). The population of Escherichia coli and Staphy-lococcus aureus in ascites of probiotics treated group were decreased significantly compared with that of septic model group (3.93 ± 0.73vs 8.80 ± 0.83,P < 0.05; 2.80 ± 1.04 vs 5.39 ± 1.21, P < 0.05). With probiotics treatment, there was a decrease in the scores of inflammatory cell infiltration into the intestinal mucosa in septic animals (1.50 ± 0.25vs 2.88 ± 0.14,P < 0.01). CONCLUSION: Escherichia coli and Staphylococcus aureus may be primary pathogens in septic rats. Probiotics improve survival of septic rats by suppressing these conditioned pathogens.

关键词： Sepsis Probiotics Pathogens Escherichia coli Staphylococcus aureus

Mutational analysis of the GATA4 gene in Chinese men with nonobstructive azoospermia

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Asian Journal of Andrology 2021年第2期23卷 205-210页

作者： Xu Zhang Tai-Jian Zhang Wen liu Yun-Na Ning Yue-hong Bian Yong-Zhi Cao hong-bin liu Jin-Long Ma Hao-Bo Zhang Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China National Research Centre for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology School of Life SciencesShandong UniversityQingdao 266237China

As a crucial transcription factor for spermatogenesis,GATA-binding protein 4(GATA4)plays important roles in the functioning of Sertoli and Leydig *** knockout of GATA4 in mice results in age-dependent testicular atrophy and loss of ***,whether GATA4 is associated with human azoospermia has not been ***,we analyzed the GATA4 gene by direct sequencing of samples obtained from 184 Chinese men with idiopathic nonobstructive azoospermia(NOA).We identified a missense mutation(c.191G>A,p.G64E),nine single-nucleotide polymorphisms(SNPs),and one rare variant(c.^(*)84C>T)in the 3′untranslated region(UTR).Functional studies demonstrated that the p.G64E mutation did not affect transactivation ability of GATA4 for spermatogenesis-related genes(claudin-11 and steroidogenic acute regulatory protein,Star),and the 3′UTR rare variant c.^(*)84C>T did not generate microRNA-binding sites to repress GATA4 *** our knowledge,this is the first report to investigate the association between GATA4 and azoospermia;our results indicate that mutations in GATA4 may not be pathogenic for NOA in Chinese men.

关键词： biological function GATA-binding protein 4(GATA4)mutation nonobstructive azoospermia

Myocyte Enhancer Factor-2A Gene Mutation and Coronary Artery Disease

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Chinese Medical Journal 2015年第19期128卷 2688-2691页

作者： Ying Jiang hong-bin liu Department of Cardiology of South Building General Hospital of Chinese People's Liberation ArmyBeijing 100853China

INTRODUCTION Coronary artery disease （CAD） and its clinical manifestations,including myocardial infarction （MI）,are leading causes of death and infirmity worldwide.A variety of environmental and genetic risk factors are associated with CAD,including hypercholesterolemia,hypertension,obesity,diabetes,and a family history of early CAD.

关键词： Coronary Artery Disease Myocardial Infarction Myocyte Enhancer Factor-2A